Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum Crispum and Apium Graveolens against Experimental Hyperuricemia.

abstract：:Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) GC remain unclear. We investigated the basal and inducible PD-L1 e...

journal_title：Scientific reports

authors： Moon JW,Kong SK,Kim BS,Kim HJ,Lim H,Noh K,Kim Y,Choi JW,Lee JH,Kim YS

更新日期：2017-12-19 00:00:00

abstract：:A series of three remarkable complexes [PMo12O40]@[Cu6O(TZI)3(H2O)9]4·OH·31H2O (H3TZI = 5-tetrazolylisophthalic acid; denoted as HLJU-1, HLJU = Heilongjiang University), [SiMo12O40]@[Cu6O(TZI)3(H2O)9]4·32H2O (denoted as HLJU-2), and [PW12O40]@[Cu6O(TZI)3(H2O)6]4·OH·31H2O (denoted as HLJU-3) have been isolated by using...

journal_title：Scientific reports

authors： Sun JW,Yan PF,An GH,Sha JQ,Li GM,Yang GY

更新日期：2016-05-09 00:00:00

abstract：:Guanylate binding proteins (GBPs) belongs to the interferons (IFNs) induced guanylate-binding protein family (Guanosine triphosphatases, GTPases) consisting of seven homologous members, termed GBP1 to GBP7. We used multidimensional survey ways to explore GBPs expression, regulation, mutations, immune infiltration and ...

journal_title：Scientific reports

authors： Wu ZH,Cai F,Zhong Y

更新日期：2020-04-08 00:00:00

abstract：:The prevalence of patients on automated peritoneal dialysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues and patient option. Whether socioeconomic factors at the patient level may influence the decision for the initial peritoneal dialysis (PD) modality is unknown. This ...

journal_title：Scientific reports

authors： Pecoits-Filho R,Ribeiro SC,Kirk A,da Silva HS,Pille A,Falavinha RS Jr,Filho SS,Figueiredo AE,Barretti P,de Moraes TP

更新日期：2017-07-12 00:00:00

abstract：:The coupling of the surface plasmon near-field into the sensing medium is key to the sensitivity of surface plasmon-based sensing devices. A low-index dielectric is necessary for the sensing medium to support a highly-penetrating surface plasmon evanescent field that extends well into the dielectric medium. The air-li...

journal_title：Scientific reports

authors： Kim Y,Baek S,Gupta P,Kim C,Chang K,Ryu SP,Kang H,Kim WS,Myoung J,Park W,Kim K

更新日期：2019-02-19 00:00:00

abstract：:Heterogeneity is inherent to biology, thus it is imperative to realize methods capable of obtaining spatially-resolved genomic and transcriptomic profiles of heterogeneous biological samples. Here, we present a new method for local lysis of live adherent cells for nucleic acid analyses. This method addresses bottlenec...

journal_title：Scientific reports

authors： Kashyap A,Autebert J,Delamarche E,Kaigala GV

更新日期：2016-07-14 00:00:00

abstract：:This report describes development of spherical equivalent refraction (SER) and axial length (AL) in two population-based cohorts of white, European children. Predictive factors for myopic growth were explored. Participants were aged 6-7- (n = 390) and 12-13-years (n = 657) at baseline. SER and AL were assessed at base...

journal_title：Scientific reports

authors： McCullough S,Adamson G,Breslin KMM,McClelland JF,Doyle L,Saunders KJ

更新日期：2020-09-16 00:00:00

abstract：:Erythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effec...

journal_title：Scientific reports

authors： Liu Y,Luo B,Shi R,Wang J,Liu Z,Liu W,Wang S,Zhang Z

更新日期：2015-10-13 00:00:00

abstract：:Processing the meaning of action language correlates with somatotopic activity in premotor cortex (PMC). A previous neurostimulation study supported a causal contribution of PMC activity to action verb understanding, but the direction of the effect was unexpected: inhibiting PMC made participants respond faster to act...

journal_title：Scientific reports

authors： Gijssels T,Ivry RB,Casasanto D

更新日期：2018-07-30 00:00:00

abstract：:The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ([Formula: see text]) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor depositio...

journal_title：Scientific reports

authors： Wang X,Gao D,Li M,Li H,Li C,Wu X,Yang B

更新日期：2017-08-01 00:00:00

abstract：:Recent studies have shown that the representation of an item in visual working memory (VWM) can bias the deployment of attention to stimuli in the visual scene possessing the same features. When multiple item representations are simultaneously held in VWM, whether these representations, especially those held in a non-...

journal_title：Scientific reports

authors： Zhang B,Liu S,Doro M,Galfano G

更新日期：2018-09-17 00:00:00

abstract：:The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...

journal_title：Scientific reports

authors： Saiz M,Alvarez-Cubero MJ,Lorente JA,Alvarez JC,Martinez-Gonzalez LJ

更新日期：2019-03-26 00:00:00

abstract：:Here, we characterized the basic properties of repetitive sequences in essential A and supernumerary B chromosomes of Festuca pratensis Huds. This was performed by comparative analysis of low-pass Illumina sequence reads of B chromosome lacking (-B) and B chromosome containing (+B) individuals of F. pratensis. 61% of ...

journal_title：Scientific reports

authors： Ebrahimzadegan R,Houben A,Mirzaghaderi G

更新日期：2019-12-27 00:00:00

abstract：:Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The majority of desmoid tumors are related to T41A and S45F muta...

journal_title：Scientific reports

authors： Mercier KA,Al-Jazrawe M,Poon R,Acuff Z,Alman B

更新日期：2018-01-12 00:00:00

abstract：:Acetylcholine binding proteins (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they reproduce some pharmacological properties of nAChRs. X-ray crystal structures of AСhBP in complex with α-conotoxins provide important insights into the interactions ...

journal_title：Scientific reports

authors： Lin B,Xu M,Zhu X,Wu Y,Liu X,Zhangsun D,Hu Y,Xiang SH,Kasheverov IE,Tsetlin VI,Wang X,Luo S

更新日期：2016-03-01 00:00:00

abstract：:Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...

journal_title：Scientific reports

authors： Bełcik M,Lenda M,Amano T,Skórka P

更新日期：2020-11-23 00:00:00

abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...

journal_title：Scientific reports

authors： Stock MJ,Taylor RN,Gernon TM

更新日期：2012-01-01 00:00:00

abstract：:The bacterial flagellar motor is a unique supramolecular complex which converts ion flow into rotational force. Many biological devices mainly use two types of ions, proton and sodium ion. This is probably because of the fact that life originated in seawater, which is rich in protons and sodium ions. The polar flagell...

journal_title：Scientific reports

authors： Onoue Y,Iwaki M,Shinobu A,Nishihara Y,Iwatsuki H,Terashima H,Kitao A,Kandori H,Homma M

更新日期：2019-08-02 00:00:00

abstract：:Transplantation of stem cell-derived insulin producing cells (IPCs) has been proposed as an alternative to islet transplantation for the treatment of diabetes mellitus. However, current IPC differentiation protocols are focused on generating functional cells from the pluripotent stem cells and tend to rely on multiste...

journal_title：Scientific reports

authors： Oh JE,Choi OK,Park HS,Jung HS,Ryu SJ,Lee YD,Lee SA,Chung SS,Choi EY,Lee DS,Gho YS,Lee H,Park KS

更新日期：2019-03-29 00:00:00

abstract：:An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer (NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically target and inhibit human NCI-H460 cells in vitro and xenograft tumors in vivo. Here, in a follow-up study, we obtained a chemically-synthesized v...

journal_title：Scientific reports

authors： Wang H,Qin M,Liu R,Ding X,Chen ISY,Jiang Y

更新日期：2019-12-11 00:00:00

abstract：:Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, ...

journal_title：Scientific reports

authors： Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

更新日期：2020-03-12 00:00:00

abstract：:Chronic airway infections caused by Pseudomonas aeruginosa contribute to the progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF, within-patient adaptation of a P. aeruginosa strain generates phenotypic diversity that can complicate microbiological analysis of patient sample...

journal_title：Scientific reports

authors： Clark ST,Diaz Caballero J,Cheang M,Coburn B,Wang PW,Donaldson SL,Zhang Y,Liu M,Keshavjee S,Yau YC,Waters VJ,Elizabeth Tullis D,Guttman DS,Hwang DM

更新日期：2015-06-05 00:00:00

abstract：:An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occu...

journal_title：Scientific reports

authors： Katigbak A,Cencic R,Robert F,Sénécha P,Scuoppo C,Pelletier J

更新日期：2016-12-16 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...

journal_title：Scientific reports

authors： Giel-Moloney M,Goncalvez AP,Catalan J,Lecouturier V,Girerd-Chambaz Y,Diaz F,Maldonado-Arocho F,Gomila RC,Bernard MC,Oomen R,Delagrave S,Burdin N,Kleanthous H,Jackson N,Heinrichs J,Pugachev KV

更新日期：2018-09-04 00:00:00

abstract：:Liquid biopsy can provide a strong basis for precision medicine. We aimed to identify novel single-nucleotide variants (SNVs) in circulating tumor DNA (ctDNA) in patients with hepatocellular carcinoma (HCC). Deep sequencing of plasma-derived ctDNA from 59 patients with HCC was performed using a panel of 2924 SNVs in 6...

journal_title：Scientific reports

authors： Kim SS,Eun JW,Choi JH,Woo HG,Cho HJ,Ahn HR,Suh CW,Baek GO,Cho SW,Cheong JY

更新日期：2020-10-20 00:00:00

abstract：:It has been reported that the ATM kinase inhibitor KU60019 preferentially radiosensitizes orthotopic high grade gliomas (HGG) driven by established U87 and U1242 cell lines bearing specific TP53 mutations. We wished to determine whether those results could be extended to tumors driven by primary glioma initiating cell...

journal_title：Scientific reports

authors： Frosina G,Ravetti JL,Corvò R,Fella M,Garrè ML,Levrero F,Marcello D,Marubbi D,Morana G,Mussap M,Neumaier CE,Profumo A,Raso A,Rosa F,Vagge S,Vecchio D,Verrico A,Zona G,Daga A

更新日期：2018-09-21 00:00:00

abstract：:Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...

journal_title：Scientific reports

authors： Mishra Z,Ganegoda A,Selicha J,Wang Z,Sadda SR,Hu Z

更新日期：2020-06-12 00:00:00

abstract：:Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

journal_title：Scientific reports

authors： Tao M,Isas JM,Langen R

更新日期：2020-03-24 00:00:00

abstract：:Active methane seepage occurs congruent with a high density of up to 1 km-wide and 35 m deep seafloor craters (>100 craters within 700 km2 area) within lithified sedimentary rocks in the northern Barents Sea. The crater origin has been hypothesized to be related to rapid gas hydrate dissociation and methane release ar...

journal_title：Scientific reports

authors： Waage M,Serov P,Andreassen K,Waghorn KA,Bünz S

更新日期：2020-05-21 00:00:00

abstract：:Most ice polymorphs have order-disorder "pairs" in terms of hydrogen positions, which contributes to the rich variety of ice polymorphs; in fact, three recently discovered polymorphs- ices XIII, XIV, and XV-are ordered counter forms to already identified disordered phases. Despite the considerable effort to understand...

journal_title：Scientific reports

authors： Komatsu K,Noritake F,Machida S,Sano-Furukawa A,Hattori T,Yamane R,Kagi H

更新日期：2016-07-04 00:00:00