Abstract:
:Optical microscopy improves in resolution and signal-to-noise ratio by correcting for the system's point spread function; a measure of how a point source is resolved, typically determined by imaging nanospheres. Optical-resolution optoacoustic (photoacoustic) microscopy could be similarly corrected, especially to account for the spatially-dependent signal distortions induced by the acoustic detection and the time-resolved and bi-polar nature of optoacoustic signals. Correction algorithms must therefore include the spatial dependence of signals' origins and profiles in time, i.e. the four-dimensional total impulse response (TIR). However, such corrections have been so far impeded by a lack of efficient TIR-characterization methods. We introduce high-quality TIR determination based on spatially-distributed optoacoustic point sources (SOAPs), produced by scanning an optical focus on an axially-translatable 250 nm gold layer. Using a spatially-dependent TIR-correction improves the signal-to-noise ratio by >10 dB and the axial resolution by ~30%. This accomplishment displays a new performance paradigm for optoacoustic microscopy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Seeger M,Soliman D,Aguirre J,Diot G,Wierzbowski J,Ntziachristos Vdoi
10.1038/s41467-020-16565-2subject
Has Abstractpub_date
2020-06-09 00:00:00pages
2910issue
1issn
2041-1723pii
10.1038/s41467-020-16565-2journal_volume
11pub_type
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