A primer on tissue pH and local anesthetic potency.

Abstract:

:The relationship between pH, pKa, and degree of local anesthetic ionization is quantified by the Henderson-Hasselbalch equation. As presented in standard textbooks, the effect of pH on the degree of ionization of any particular local anesthetic is not immediately clear due to the x-axis displaying pH - pKa, which requires conversion to pH, based on the pKa for each local anesthetic, a complex process. We present a graphical solution that clarifies the interrelationships between pH, pKa, and degree of ionization by plotting pKa on the x-axis versus the percentage of unionized local anesthetic on the y-axis. The vertical intercept from the x-axis to the pH curves allows rapid and accurate estimation of the degree of ionization of any local anesthetic of known pKa.

journal_name

Adv Physiol Educ

authors

Pope RLE,Brown AM

doi

10.1152/advan.00018.2020

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

305-308

issue

3

eissn

1043-4046

issn

1522-1229

journal_volume

44

pub_type

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