Abstract:
:The relationship between pH, pKa, and degree of local anesthetic ionization is quantified by the Henderson-Hasselbalch equation. As presented in standard textbooks, the effect of pH on the degree of ionization of any particular local anesthetic is not immediately clear due to the x-axis displaying pH - pKa, which requires conversion to pH, based on the pKa for each local anesthetic, a complex process. We present a graphical solution that clarifies the interrelationships between pH, pKa, and degree of ionization by plotting pKa on the x-axis versus the percentage of unionized local anesthetic on the y-axis. The vertical intercept from the x-axis to the pH curves allows rapid and accurate estimation of the degree of ionization of any local anesthetic of known pKa.
journal_name
Adv Physiol Educjournal_title
Advances in physiology educationauthors
Pope RLE,Brown AMdoi
10.1152/advan.00018.2020subject
Has Abstractpub_date
2020-09-01 00:00:00pages
305-308issue
3eissn
1043-4046issn
1522-1229journal_volume
44pub_type
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