Abstract：
BACKGROUND:Early during the current coronavirus disease 19 (COVID-19) pandemic, hydroxychloroquine (HCQ) received a significant amount of attention as a potential antiviral treatment, such that it became one of the most commonly prescribed medications for COVID-19 patients. However, not only has the effectiveness of HCQ remained questionable, but mainly based on preclinical and a few small clinical studies, HCQ is known to be potentially arrhythmogenic, especially as a result of QT prolongation. OBJECTIVE:The purpose of this study was to investigate the arrhythmic effects of HCQ, as the heightened risk is especially relevant to COVID-19 patients, who are at higher risk for cardiac complications and arrhythmias at baseline. METHODS:An optical mapping technique utilizing voltage-sensitive fluorescent dyes was used to determine the arrhythmic effects of HCQ in ex vivo guinea pig and rabbit hearts perfused with the upper therapeutic serum dose of HCQ (1000 ng/mL). RESULTS:HCQ markedly increased action potential dispersion, resulted in development of repolarization alternans, and initiated polymorphic ventricular tachycardia. CONCLUSION:The study results further highlight the proarrhythmic effects of HCQ.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Uzelac I,Iravanian S,Ashikaga H,Bhatia NK,Herndon C,Kaboudian A,Gumbart JC,Cherry EM,Fenton FHdoi
10.1016/j.hrthm.2020.05.030subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1445-1451issue
9eissn
1547-5271issn
1556-3871pii
S1547-5271(20)30526-9journal_volume
17pub_type
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