Abstract:
OBJECTIVE:To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma. DESIGN:Population based case-control study. In addition, patterns of tea drinking and temperature at which tea was drunk were measured among healthy participants in a cohort study. SETTING:Golestan province, northern Iran, an area with a high incidence of oesophageal squamous cell carcinoma. PARTICIPANTS:300 histologically proved cases of oesophageal squamous cell carcinoma and 571 matched neighbourhood controls in the case-control study and 48 582 participants in the cohort study. MAIN OUTCOME MEASURE:Odds ratio of oesophageal squamous cell carcinoma associated with drinking hot tea. RESULTS:Nearly all (98%) of the cohort participants drank black tea regularly, with a mean volume consumed of over one litre a day. 39.0% of participants drank their tea at temperatures less than 60 degrees C, 38.9% at 60-64 degrees C, and 22.0% at 65 degrees C or higher. A moderate agreement was found between reported tea drinking temperature and actual temperature measurements (weighted kappa 0.49). The results of the case-control study showed that compared with drinking lukewarm or warm tea, drinking hot tea (odds ratio 2.07, 95% confidence interval 1.28 to 3.35) or very hot tea (8.16, 3.93 to 16.9) was associated with an increased risk of oesophageal cancer. Likewise, compared with drinking tea four or more minutes after being poured, drinking tea 2-3 minutes after pouring (2.49, 1.62 to 3.83) or less than two minutes after pouring (5.41, 2.63 to 11.1) was associated with a significantly increased risk. A strong agreement was found between responses to the questions on temperature at which tea was drunk and interval from tea being poured to being drunk (weighted kappa 0.68). CONCLUSION:Drinking hot tea, a habit common in Golestan province, was strongly associated with a higher risk of oesophageal cancer.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Islami F,Pourshams A,Nasrollahzadeh D,Kamangar F,Fahimi S,Shakeri R,Abedi-Ardekani B,Merat S,Vahedi H,Semnani S,Abnet CC,Brennan P,Møller H,Saidi F,Dawsey SM,Malekzadeh R,Boffetta Pdoi
10.1136/bmj.b929subject
Has Abstractpub_date
2009-03-26 00:00:00pages
b929eissn
0959-8138issn
1756-1833journal_volume
338pub_type
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journal_title:BMJ (Clinical research ed.)
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-01-17 00:00:00