Abstract:
:Oral vaccination enables pain-free and self-administrable vaccine delivery for rapid mass vaccination during pandemic outbreaks. Furthermore, it elicits systemic and mucosal immune responses. This protects against infection at mucosal surfaces, which may further enhance protection and minimize the spread of disease. The gastrointestinal (GI) tract presents a number of prospective mucosal inductive sites for vaccine targeting, including the oral cavity, stomach, and small intestine. However, currently available oral vaccines are effectively limited to live-attenuated and inactivated vaccines against enteric diseases. The GI tract poses a number of challenges,including degradative processes that digest biologics and mucosal barriers that limit their absorption. This review summarizes the approaches currently under development and future opportunities for oral vaccine delivery to established (intestinal) and relatively new (oral cavity, stomach) mucosal targets. Special consideration is given to recent advances in oral biologic delivery that offer promise as future platforms for the administration of oral vaccines.
journal_name
Annu Rev Pharmacol Toxicoljournal_title
Annual review of pharmacology and toxicologyauthors
Coffey JW,Gaiha GD,Traverso Gdoi
10.1146/annurev-pharmtox-030320-092348subject
Has Abstractpub_date
2021-01-06 00:00:00pages
517-540eissn
0362-1642issn
1545-4304journal_volume
61pub_type
杂志文章abstract::This essay is an account of the author's experience in trying to interpret the action of drugs as seen in in vitro bioassays. The central theme is how the development of simple mathematical models has assisted in the interpretation of drug actions. Starting from encounters with partial agonists, the essay describes th...
journal_title:Annual review of pharmacology and toxicology
pub_type: 传,历史文章,杂志文章,评审
doi:10.1146/annurev.pa.36.040196.000245
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abstract::Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or enviro...
journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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abstract::The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimenta...
journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
doi:10.1146/annurev.pharmtox.37.1.143
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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更新日期:2020-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
doi:10.1146/annurev.pharmtox.38.1.97
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
doi:10.1146/annurev-pharmtox-010716-104926
更新日期:2017-01-06 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
doi:10.1146/annurev-pharmtox-010611-134525
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
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abstract::The application of rapid methods currently used for screening discovery drug candidates for metabolism and pharmacokinetic characteristics is discussed. General considerations are given for screening in this context, including the criteria for good screens, the use of counterscreens, the proper sequencing of screens, ...
journal_title:Annual review of pharmacology and toxicology
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abstract::CB1 and CB2 cannabinoid receptors are the primary targets of endogenous cannabinoids (endocannabinoids). These G protein-coupled receptors play an important role in many processes, including metabolic regulation, craving, pain, anxiety, bone growth, and immune function. Cannabinoid receptors can be engaged directly by...
journal_title:Annual review of pharmacology and toxicology
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of pharmacology and toxicology
pub_type: 杂志文章,评审
doi:10.1146/annurev-pharmtox-011112-140309
更新日期:2013-01-01 00:00:00