Oral Candida Mannan Concentrations Correlate with Symptoms/Signs of Ill Health and the Immune Status.

Abstract:

BACKGROUND:A relationship has been proposed between increases in oral Candida concentrations and host immunity. Therefore, the present study was conducted to investigate the relationship between oral Candida mannan concentrations and symptoms/signs of ill health and the immune status and also to examine whether health/the immune status may be evaluated based on oral Candida mannan concentrations. PATIENTS AND METHODS:The health conditions of 25 healthy individuals and 10 cancer patients receiving cytotoxic chemotherapy were assessed using a questionnaire and oral rinse solutions collected on consecutive days. Candida mannan concentrations in oral rinse solutions were measured using a commercial sandwich ELISA kit. RESULTS:The use of dentures was identified as a significant independent factor increasing Candida mannan concentrations. In a stratified analysis based on the use of dentures, significantly increased Candida mannan concentrations were detected in healthy volunteers with chills and in cancer patients with slight/moderate fever (37.5-38.4 °C) (multivariate analysis, p < 0.01) who were non-denture users. These symptoms/signs may be associated with (pre-)infection, during which the immune system is activated and needs to function well. CONCLUSIONS:The present results suggest that oral Candida mannan concentrations are a predictive marker for health/the immune status.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Hakoyama Y,Yamada SI,Nishimaki F,Hayashi K,Koizumi T,Kurita H

doi

10.1007/s11046-020-00458-5

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

629-637

issue

4

eissn

0301-486X

issn

1573-0832

pii

10.1007/s11046-020-00458-5

journal_volume

185

pub_type

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