Abstract:
:Today, about 50% of men and 15-30% of women suffer from hair loss as well as the associated psychological impact. Drug therapy, especially through topical administration, is the main treatment strategy for stimulating hair regrowth. However, challenges exist due to the skin barrier that hinders drug penetration. To this end, many efforts have been made to enhance drug penetration efficiency. This review focuses on the advancement of the transdermal drug delivery strategies for hair loss therapy reported in the last five years, especially those via nanoformulations for topical administration and microneedles for transdermal delivery. In addition, physical or chemical penetration enhancers are also introduced, which are often applied with the drug delivery systems to achieve a synergy effect.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Yang G,Chen G,Gu Zdoi
10.1021/acs.molpharmaceut.0c00041subject
Has Abstractpub_date
2021-02-01 00:00:00pages
483-490issue
2eissn
1543-8384issn
1543-8392journal_volume
18pub_type
杂志文章abstract::In this study, a facile strategy for efficient codelivery of gene and drug was developed. Using a coprecipitation method, doxorubicin hydrochloride (DOX), an antitumor drug, and p53 expression plasmid were encapsulated in alginate/CaCO(3)/DNA/DOX nanoparticles with high encapsulation efficiency. The in vitro cell inhi...
journal_title:Molecular pharmaceutics
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更新日期:2012-10-01 00:00:00
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doi:10.1021/mp900024z
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doi:10.1021/acs.molpharmaceut.6b01052
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