Neutrophil-to-lymphocyte ratio in bronchoalveolar lavage from IPF patients: a novel prognostic biomarker?

Abstract:

BACKGROUND:This is the first time that a bronchoalveolar lavage (BAL) neutrophil-to-lymphocyte ratio (NL-ratio) has been demonstrated in sarcoidosis and chronic Hypersensitivity Pneumonitis (cHP) than in idiopathic pulmonary fibrosis (IPF) patients. SUBJECTS AND METHODS:Consecutive BAL samples from the 167 interstitial lung disease (ILD) patients were retrospectively enrolled in the study and clustered into three diagnostic categories: IPF, cHP and sarcoidosis. RESULTS:NL-ratio which proved higher in IPF (mean±SD, 2.1±3.8) than sarcoidosis (mean±SD 0.7±1.9; p<1E-04) and cHP patients (mean±SD 1.6±3.1; p=7.7E-03). ROC curve analysis to discriminate between Sarcoidosis and other ILDs showed an area under the curve (AUC) of 83.7%, (56% sensitivity and 96% specificity) while IPF and the other ILD were discriminated with AUC of 73% using a NL-ratio threshold value of 0.48 (73% sensitivity and 63% specificity). Interestingly, the NL-ratio was significantly correlated with other prognostic parameters: it was inversely correlated with forced vital capacity (FVC) (r=-0.3; p=2.5E-02) and forced expiration volume in 1 second (FEV1) (r=-0.3; p=2E-02) percentages and directly correlated with composite pulmonary index (CPI) score (r=0.3; p=3.2E-02). A decision-tree statistical algorithm was applied. CONCLUSIONS:This is the first time that a lower NL-ratio has been demonstrated in sarcoidosis and cHP than in IPF patients. The present preliminary report indicates a relationship between BAL NL- ratio and lung function parameters in patients with IPF: this ratio may help to optimize management of IPF patients and to improve follow-up and outcome.

journal_name

Minerva Med

journal_title

Minerva medica

authors

D'alessandro M,Bergantini L,Carleo A,Cameli P,Perrone A,Fossi A,Sestini P,Bargagli E

doi

10.23736/S0026-4806.20.06614-8

subject

Has Abstract

pub_date

2020-05-14 00:00:00

eissn

0026-4806

issn

1827-1669

pii

S0026-4806.20.06614-8

pub_type

杂志文章
  • [Myxoma of the left atrium. General considerations and description of a case].

    abstract::A case of left atrial myxoma is described. The neoplasia was observed in a female with no previous rheumatic history in whom cardiopathy was diagnosed only a few months before hospitalisation. The rapid and erratic course of the cardiopathy, the fact that changes of posture modified objective symptoms, the presence of...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Giuliani GC,Liberali L,Catapano F,Verdun di Cantogno L

    更新日期:1984-10-06 00:00:00

  • [Evaluation of the biocompatibility of medical devices based on European standards].

    abstract::Several issues concerning the biocompatibility) testing of medical devices as stated in European directive 90/385 and 93/42 are discussed. The authors describe the fundamental characteristics that biomaterials should have to be employed in the human body, the assays useful for testing different aspects of biocompatibi...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Pizzoferrato A,Arciola CR,Cenni E,Ciapetti G,Granchi D,Savarino L,Stea S

    更新日期:1995-10-01 00:00:00

  • [Radioisotope methods and technics in obstetrical and gynecological diagnosis].

    abstract::Certain applications of radioisotopes to obstetric and gynaecological diagnosis are illustrated. Radioisotopes have been widely employed since the improvement in instrumental methods and the availability of short-life radioisotopes has removed the basic limitation which once prevented their use during the entire fecun...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Laconi A,Caffarelli F,Melfi F

    更新日期:1975-12-12 00:00:00

  • Is heme oxygenase-1 turning out to be a key positive regulator for oxidative stress?

    abstract:: ...

    journal_title:Minerva medica

    pub_type: 信件

    doi:10.23736/S0026-4806.18.05708-7

    authors: Ravarotto V,Pagnin E,Simioni F,Calò LA

    更新日期:2019-02-01 00:00:00

  • [Liver pathology caused by drugs. Pathogenetic, histopathological and clinical notes and case reports].

    abstract::After a brief review of drug metabolic pathways in the liver, the various mechanisms leading to liver damage are described. The different histological lesions and the clinical situations that can arise are discussed. A case survey is reported. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Forte G,D'Amico N,Lopilato R,Teti V

    更新日期:1986-02-28 00:00:00

  • [After the 2001 European Society of Cardiology Guidelines: is it possible to reduce the number of patients with syncope to be hospitalized?].

    abstract:AIM:The aim of this paper was to evaluate how many patients with syncope should be hospitalized according to the 2001 European Society of Cardiology (ESC) Guidelines on the management of syncope. METHODS:Starting from August 2002 we prompted a Syncope Unit (SU), as a multi-disciplinary functional structure including t...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Bartoletti A,Fabiani P,Gianni R,Cappelletti C,Santoro GM,Fortini A,Adriani P,Baccetti F,Buffini G,Lavacchi A,Ticali PF,Viganò S

    更新日期:2004-10-01 00:00:00

  • [Clinical aspects of viral respiratory infections].

    abstract::The Authors deal with some clinical aspect of the commonest types of respiratory tract viral infections. After a description of the characteristics of the most important diseases (common cold, ARD, influenza, viral pneumonia) they deal with some particular problem difficult in resolution, both from a pathogenetic and ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Pescetti G,Gozzelino F

    更新日期:1980-12-08 00:00:00

  • [Behavior of plasma/insulin, somatropin and NEFA after intravenous administration of tolbutamide in hepatic cirrhosis].

    abstract::Cirrhotics presented higher insulin production, in the presence of a drop in glycaemia significantly less than controls, following 1 g of tolbutamide i.v. The drug also brought on a rapid drop in NEFA and a rise in plasma growth hormone. The pathogenesis of altered glucose tolerance in liver cirrhosis is discussed. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Greco AV,Ghirlanda G,Rebuzzi A,Altomonte L,Manna R

    更新日期:1976-11-10 00:00:00

  • [Xanthogranulomatous pyelonephritis. Radiological and ultrasonographic aspects].

    abstract::Clinical, radiological and ultrasonographical features of three cases of xanthogranulomatous pyelonephritis, one of which in a child, are reported. Presurgical diagnosis of xanthogranulomatous pyelonephritis is difficult and infrequent to date (10-14% of cases according to different workers). This complaint is general...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Orzincolo C,Daniele C,Corcione S,Romano A

    更新日期:1985-11-30 00:00:00

  • [Doping and sports].

    abstract::Doping is widely known as the use of banned substances and practices by athletes in an attempt to improve sporting performances. The term doping likely derives from "dope", an ancient expression referred to a primitive alcoholic drink that was used as a stimulant in South African ceremonial dances; gradually, the term...

    journal_title:Minerva medica

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Lippi G,Guidi G

    更新日期:1999-09-01 00:00:00

  • [Prognostic value of the ratio of bone marrow plasma cells in multiple myeloma].

    abstract::The relationship between initial percentage of bone marrow plasma cells and survival was studied in a group of 70 patients affected with multiple myeloma. All patients had a complete follow-up. The initial percentage of plasma cells shows a highly significant correlation with survival. Moreover, the percentage of bone...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Pasqualetti P,Colantonio D,Casale R

    更新日期:1990-03-01 00:00:00

  • Meta-analysis on the curative effect of neoadjuvant chemotherapy for gastric cancer.

    abstract:AIM:Aim of the study was to discuss the effectiveness of neoadjuvant chemotherapy for gastric cancer by meta-analysis. METHODS:Retrieve Chinese periodical full-text database, Medline, Wanfang database, Coehrane library, and preoperative neoadjuvant chemotherapy efficacy of gastric cancer in Embase. The keywords used w...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Hongzhen Q,Aizhen C,Hongqing X,Lin C

    更新日期:2015-10-01 00:00:00

  • [Spectrophotofluorimetric enzymatic determination of total serum bile acids].

    abstract::A new enzymatic fluorimetric assay for the determination of total serum bile acids is described. The enzyme 3 alpha-idroxysteroid NAD oxireductase by oxydising the free OH in position 3 alpha of bile acid molecule, reduce NAD previously added. Afterwards the hydrogen of the generated NADH is transferred by a diaphoras...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Annoni G,Barbi G,Benzio G

    更新日期:1980-02-25 00:00:00

  • [Tissue polypeptide antigen (TPA) as a tumor marker in disorders of the digestive tract: comparison with CEA].

    abstract::TPA and CEA were both assayed in a population of 352 diseases of the gastroenteric tract and control subjects. The results show that TPA though sensitive has no predictive value or specificity comparable to CEA. However should specific tumour markers prove negative TPA may be an extremely useful aid in monitoring pati...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Piantino P,Tappero G,Cerchier A,Pecchio F,Tridico F,Cattaneo U

    更新日期:1986-04-14 00:00:00

  • [Regulation of the renin-angiotensin-aldosterone system. Role of the prostaglandins].

    abstract::PRA (in the supine and erect subject) and urinary sodium before and after acute treatment (100 mg i.m.) and chronic treatment (100 mg per os for 8 days) were examined in two groups of subjects with no signs of cardiovascular or renal disease. It was found that indomethacin, which is a well-known inhibitor of prostagla...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Frisina N,Buemi M,Lasco A,Bellinghieri G,Lo Schiavo F,Ceruso D

    更新日期:1978-09-15 00:00:00

  • Effect of acupressure on nausea and vomiting induced by chemotherapy in cancer patients.

    abstract:AIM:Corticosteroids, antidopaminergig agents and 5-HT3 antagonists are the most commonly used drugs in the treatment of chemotherapy-induced vomiting. Acupuncture and acupressure have also appeared to exert antiemetic effects. The aim of this study was to evaluate the efficacy of acupressure in the treatment of chemoth...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Gardani G,Cerrone R,Biella C,Mancini L,Proserpio E,Casiraghi M,Travisi O,Meregalli M,Trabattoni P,Colombo L,Giani L,Vaghi M,Lissoni P

    更新日期:2006-10-01 00:00:00

  • [Dysmyelopoietic syndrome 7 years after melphalan treatment of multiple myeloma. Clinical case].

    abstract::A case of myelodysplasia (refractory anaemia with excessive blasts) arising 7 years after a 3 year period of intermittent monthly treatment cycles with melphalan for multiple myelomas is reported. This is another example of preleukaemic syndrome possibly caused by melphalan. Among the possible pathogenetic mechanisms,...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Scolozzi R,Boccafogli A

    更新日期:1983-07-14 00:00:00

  • M1 macrophage-derived exosome-encapsulated cisplatin can enhance its anti-lung cancer effect.

    abstract:BACKGROUND:To study the efficacy of cisplatin-loaded M1 macrophage secreted-exosomes (DDP-M1-Exos) in enhancing DDP anti-tumor effect. METHODS:M1-Exos were first extracted using density gradient centrifugation, and the DDP-M1-Exos system was established via electroporation. Then, the morphology, particle size and make...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:10.23736/S0026-4806.20.06564-7

    authors: Li J,Li N,Wang J

    更新日期:2020-04-08 00:00:00

  • Decisions and ethical issues among BRCA carriers and the use of preimplantation genetic diagnosis.

    abstract::The lifetime risks for both breast and ovarian cancer for BRCA mutation carriers far exceeds the general population risk of 13% for breast cancer and 1.4% for ovarian cancer. BRCA carriers have unique and medically complicated decisions to make regarding their cancer treatment or risk reduction. As BRCA testing become...

    journal_title:Minerva medica

    pub_type: 杂志文章,评审

    doi:

    authors: Quinn GP,Vadaparampil ST,Bower B,Friedman S,Keefe DL

    更新日期:2009-10-01 00:00:00

  • [Hutchinson-Horton giant cell arteritis and rhizomelic polymyalgia. III. Current pathogenetic and nosographic aspects].

    abstract::There is much evidence to suggest that temporal arteritis and rhizomelic polymyalgia are both immunological diseases. The classic results of experimental pathology are discussed, together with the relations between rhizomelic polymyalgia and both virus hepatitis B and the HLA system. From the clinical standpoint, it i...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Lovisetto P,Marchi L,Gilardi E,Mairano D,Biarese V

    更新日期:1984-05-07 00:00:00

  • [Maternal-fetal transmission of hepatitis B virus. Follow-up study of 21 infants born to HBSAG-positive mothers, and 6 born to HBSAG-negative mothers with anti-HBV antibodies].

    abstract::Vertical transmission of hepatitis B virus (HBV) was studied in 21 mother-infant pairs. A transient HBs-antigenemia was observed in 60% of the 10 children born to HBsAg healthy carrier mothers and 91% of the 11 babies born to mothers with HBsAg-positive CAH. Among the 16 children showing HBs-antigenemia, 3 developed a...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Manzillo G,Sagnelli E,Da Villa G,Maio G,Izzo CM,Felaco F,Filippini P,Buonocore S,Piccinino F

    更新日期:1980-10-31 00:00:00

  • [Functional compromise of the small airways in subjects exposed to SiO2].

    abstract::Aims of our study were: to evaluate small airway function of subjects with past or present silica dust exposure and normal spirometric values; to investigate whether small airway disease is related to radiographic signs of silicosis, to cumulative dust exposure (ES) and to cigarette smoking. Maximal expiratory flow at...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Avolio G,Cacciabue M,Rolla G,Caria E,Oliaro A,Carlino F,Pepino E,Polizzi S,Bucca C

    更新日期:1986-11-30 00:00:00

  • [Pneumothorax in AIDS].

    abstract::A total of 237 patients with AIDS have been observed in the infectious Disease Division of the United Hospitals of Bergamo during the past six years. Five patients (4.21%), suffering from TB and PCP, revealed PNX which was characterised by being bilateral and recurrent; it was a concomitant cause of death in 2 patient...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Delvecchio G,Fracassetti O,Lorenzi N,Michetti L

    更新日期:1992-05-01 00:00:00

  • The glaucomas.

    abstract::Glaucoma is the leading cause of irreversible blindness worldwide. The World Health Organization reported in 1995 that 5.1 million persons were bilaterally blind from glaucoma. Its morbidity and prevalence make it a significant public health problem. Because it is a treatable condition, it is important that medical pr...

    journal_title:Minerva medica

    pub_type: 杂志文章,评审

    doi:

    authors: Coleman AL,Brigatti L

    更新日期:2001-10-01 00:00:00

  • [The training of family members in treatment with suggestive and autogenic psychotherapies. The advantages and limits].

    abstract::The first part of the paper examines the reasons for involving the patient's family in suggestion and autogenous therapy, giving details of the advantages and limitations of this involvement and listing the pathologies in which it is employed. Finally, the use of autogenous techniques as an aid in the diagnosis of the...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Merra S

    更新日期:1990-03-01 00:00:00

  • [Toxicological risks from industrial pesticides. Preliminary results of a study].

    abstract::An examination of various commercially available pesticides was made in an evaluation of the potential risks presented by phytopharmaceuticals. It was found that insecticides anticryptogamic products, and weed-killers are most commonly used. Insecticides mainly contain organophosphoric compounds, followed by organochl...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Perrelli G,Druetta F,Capellaro E

    更新日期:1981-09-26 00:00:00

  • [Clinical aspects and surgical therapy of cerebral gliomas].

    abstract::The Authors describe the clinical symptoms of malignant brain tumors emphasizing the relationship to raised intracranial pressure and to their different localizations. Problems involved in surgical therapy are described stating the limits and aims of conventional oncologic neurosurgery. The need for adequate pre and p...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Paoletti P,Butti G

    更新日期:1984-05-19 00:00:00

  • [Double-blind study of the bronchodilating action of the aminophylline-clenbuterol combination in asthmatic patients].

    abstract::The results obtained with the administration of aminophylline and clenbuterol either separately or in association, to a group of patients with chronic obstructive bronchopneumopathies are reported. The two drugs had a more or less identical broncho-dilatory effect with the beta 2-stimulant acting earlier but for a sho...

    journal_title:Minerva medica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Osella D,Giorgis GE,Galietti F,Miravalle C,Ardizzi A

    更新日期:1986-04-21 00:00:00

  • [Changes in the angiographic pictures in Raynaud's disease following acupuncture treatment].

    abstract::Angiograms obtained before and after acupuncture in a small series of patients with Raynaud's disease did not give positive evidence of its therapeutic effect. A marked vasodilatatory action was noted, however, suggesting that the technique can be usefully applied along with other forms of management. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Celoria R,Conci F,Bonelli T

    更新日期:1977-03-03 00:00:00

  • [Anatomopathological, clinical, radiological diagnostic and therapeutic aspects of intraluminal duodenal diverticulum].

    abstract::Anatomopathological, clinical, therapeutical aspects of intraluminal duodenal diverticulum are analyzed. This is an illness of which are described in all literature of world about 47 to 70 cases. On intraluminal duodenal diverticulum is described with x rays examinations. The diagnosis of this illness is made by radio...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Rusconi U,Limido G,Donnini S,Maspero U,Borghi A

    更新日期:1980-06-30 00:00:00