Efficacy and safety of intravenous thiamylal in pediatric procedural sedation for magnetic resonance imaging.

Abstract:

OBJECTIVE:To evaluate the efficacy and safety of intravenous (i.v.) thiamylal in pediatric magnetic resonance imaging (MRI) sedation. METHODS:Infants and children from 1 month up to 8 years of age who underwent MRI in our hospital between April 2017 and March 2019 were included in this prospective observational study. Initial dose of 2 mg/kg thiamylal was given intravenously; however, additional doses were administered as needed. MRI was performed after adequate sedation was achieved. The primary endpoint was the success rate of MRI, while secondary endpoints were adverse events related to sedation, time to sedate, recovery time, and the dose of thiamylal. RESULTS:A total of 118 patients were included in the analysis with median age and weight of 31.5 months (14.0-56.8 months) and 12.6 kg (9.5-15.7 kg), respectively. The success rate of MRI was 96.6% (114/118), and the median dose of thiamylal per body weight was 3.6 (2.8-4.0) mg/kg. The median time from the first dose of thiamylal to MRI was 7 min (4-10 min) and that from the end of MRI scanning to the confirmation of emergence was 8 min (5-25 min). Adverse events encountered included respiratory arrests (n = 3) and reduction in oxygen saturation (SpO2; n = 9). There were no significant differences in the age, dose of thiamylal, sex, body weight, the American Society of Anesthesiologists physical status, and neurological abnormalities between the groups with and without respiratory complications. CONCLUSION:This study demonstrated an adequate efficacy and safety of i.v. thiamylal, with rapid sedation and patient recovery.

journal_name

Brain Dev

journal_title

Brain & development

authors

Irie S,Hirai K,Kano K,Yanabe S,Migita M

doi

10.1016/j.braindev.2020.04.005

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

477-483

issue

7

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(20)30123-6

journal_volume

42

pub_type

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