LINC00473 promotes lung adenocarcinoma progression by regulating miR-1294/ROBO1 axis.

Abstract:

:Long noncoding RNA (lncRNA) LINC00473 has been reported to be involved in the regulation of several human cancers. However, the regulatory mechanism of LINC00473 is still unknown in lung adenocarcinoma. In this study, RT-qPCR was used to measure the expression of LINC00473, miR-1294 and ROBO1. The functional mechanism of the LINC00473/miR-1294/ROBO1 pathway was investigated by CCK-8, Transwell and dual luciferase reporter assays. The results showed that LINC00473 was up-regulated and miR-1294 was down-regulated in lung adenocarcinoma tissues and cells. LINC00473 can bind to miR-1294, and reciprocal inhibition between LINC00473 and miR-1294 expression was identified in lung adenocarcinoma. Functionally, LINC00473 promoted cell proliferation and motility in lung adenocarcinoma by downregulating miR-1294. In addition, miR-1294 directly targets ROBO1. ROBO1 served as an oncogene in lung adenocarcinoma. In particular, LINC00473 promoted the progression of lung adenocarcinoma by upregulating ROBO1. In conclusion, LINC00473 acts as a tumor promoter in lung adenocarcinoma by regulating the miR-1294/ROBO1 axis.

authors

Wang S,Wang X,Xu SL

doi

10.23812/20-75A

subject

Has Abstract

pub_date

2020-04-29 00:00:00

issue

2

eissn

0393-974X

issn

1724-6083

pii

28

journal_volume

34

pub_type

杂志文章
  • Pubic osteolysis simulating a malignant lesion. A case report with long-term follow-up.

    abstract::Pubic osteolysis is a rare pathology characterized by a painful radiographic destructive changes in the pubic rami, pubis or pubic symphysis that often follows a post-traumatic event. The etiology is unclear but it is a benign lesion, frequently misinterpreted as malignant. We report a case of a 54-year-old woman with...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: XIX CONGRESSO NAZIONALE S.I.C.O.O.P. SOCIETA' ITALIANA CHIRURGHI ORTOPEDICI DELL'OSPEDALITA' PRIVATA ACCREDITATA.,De Maio F,Caterini A,Marsiolo M,Farsetti P

    更新日期:2019-03-01 00:00:00

  • Buccal bone dimensions and aesthetic outcome at maxillary incisors replaced by conventional dental implants. A case series with a 5-year follow-up.

    abstract::In the aesthetic field, successful replacement of a tooth with a dental implant requires blend and harmony within the existing dentition. The influence of the dimension of buccal bone at implant sites on aesthetic outcomes and the relation between buccal bone horizontal and vertical dimensions are unclear. The aim of ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Menchini Fabris GB,Marconcini S,Barone A,Velasco Ortega E,Bressan E,Balleri P

    更新日期:2017-04-01 00:00:00

  • The comparison between vitamin d concentration in upper silesia patients with prostate cancer and with benign prostatic hyperplasia.

    abstract::A number of studies have shown that vitamin D has a protective effect against the development of cancer, which may also be related to prostate cancer. Low serum vitamin D concentration has also been demonstrated in benign prostate hyperplasia. We compared serum vitamin D concentration in two groups of Polish men with ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Wieczorek K,Braczkowski RS,Skrzypek M,Stryjewski PJ,Kuczaj A,Al-Srory G

    更新日期:2015-01-01 00:00:00

  • Different signals induce mast cell inflammatory activity: inhibitory effect of Vitamin E.

    abstract::Vitamin supplementation in disease reduces morbidity and mortality in humans by promoting the activation of different genes which influence several pathways. The purpose of this article is to clarify the role of vitamin E in mast cell inflammation. Vitamin E is a fat soluble antioxidant which protects from low-density...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 社论

    doi:

    authors: Tettamanti L,Caraffa Al,Mastrangelo F,Ronconi G,Kritas S,Frydas I,Conti P

    更新日期:2018-01-01 00:00:00

  • THIN-LAYER CHROMATOGRAPHY IDENTIFICATION FOR RHUBARB AND PHELLODENDRI AMURENSIS CORTEX IN SHUANG-BAI CATAPLASM AND STUDY OF SKIN IRRITATION ASSAY.

    abstract::This paper aimed to raise a thin-layer chromatography (TLC) identification method for rhubarb and Phellodendri Amurensis Cortex and inspected skin irritation induced by them. It applied the TLC identification for Rhubarb and Phellodendri Amurensis Cortex in Shuang-bai cataplasm prescription. In this study six rabbits ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Tian YG,Qin SM,Ding L

    更新日期:2015-04-01 00:00:00

  • Hyperbilirubinemia and management of breastfeeding.

    abstract::Hyperbilirubinemia and jaundice are natural, physiological phenomena which are only to be expected in the neonatal period, within certain limits. The highest percentage of jaundice in breastfed newborns should be evaluated in connection with inadequate management of breastfeeding rather than a direct effect of breast ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章,评审

    doi:

    authors: Soldi A,Tonetto P,Chiale F,Varalda A,Peila C,Sabatino G,Occhi L,Giuliani F,Perathoner C,Prandi G

    更新日期:2012-07-01 00:00:00

  • Expression of mTOR and its inhibitory effect on cell proliferation and apoptosis of breast cancer cells.

    abstract::The aim of this study is to investigate the expression of mTOR in breast cancer and observe the effect of CCI-779 on proliferation and apoptosis of MDA-MB-231 cells. Immunohistochemical staining was used to detect the expression of mTOR protein in breast cancer tissues and MDA-MB-231 cells. MTT assay was used to asses...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Cheng XF,Liu Q,Zhang XF,Zhao HD,Wang W,Chu AJ

    更新日期:2015-10-01 00:00:00

  • Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium.

    abstract::Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Lumetti S,Calciolari E,Parisi L,Toffoli A,Mazzotta S,Ferrillo S,Ierardo G,Macaluso GM,Galli C,Manfredi E

    更新日期:2017-07-01 00:00:00

  • Immunohistochemical study of osteopontin in oral squamous cell carcinoma allied to fractal dimension.

    abstract::The aim of the study was to consider a possible correlation between the intensity of expression of osteopontin and grading established by the pathologist. Furthermore, a correlation was investigated between the increase of fractal dimension and osteopontin in order to use this marker as an early and reliable diagnosti...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: D'Addazio G,Artese L,Traini T,Rubini C,Caputi S,Sinjari B

    更新日期:2018-07-01 00:00:00

  • Antimicrobial resistance pattern of methicillin-resistant Staphylococcus aureus in the food industry.

    abstract::There is increasing concern about the impact on public health of methicillin-resistant Staphylococcus aureus (MRSA) associated with animal food products. MRSA remains a serious problem because of the high incidence and multidrug resistance of the strains, even for strains isolated from foods, food environments and foo...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Paludi D,Vergara A,Festino AR,Di Ciccio P,Costanzo C,Conter M,Zanardi E,Ghidini S,Ianieri A

    更新日期:2011-10-01 00:00:00

  • Expression of cartilage antitumor component RanBP9 in osteosarcoma.

    abstract::This study was carried out to investigate the expression changes of RanBP9 in tissue specimens and osteosarcoma cell strains and preliminarily explore its mechanism in osteosarcoma, so as to provide a theoretical foundation for follow-up experiments. The expression of RanBP9 in human osteosarcoma tissue specimens was ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Zhu LL,Wang CH,Yang HP,Shu WH

    更新日期:2016-01-01 00:00:00

  • Cyclosporin A in combination with HAART in primary HIV-1 infection.

    abstract::HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Rizzardi GP,Vaccarezza M,Capiluppi B,Tambussi G,Lazzarin A,Pantaleo G

    更新日期:2000-01-01 00:00:00

  • A short novel about the spread of two important diseases in history: syphilis and SARS.

    abstract::Throughout the centuries, the undefended nature of man has very often manifested in cases of epidemics, which have determined scenarios of suffering and death. Through “historical” observation lens, it is possible to understand the relationship between the spread of viruses, bacteria and parasites responsible for thes...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Rovesti M,Satolli F,Zucchi A,Gandolfi M,Fioranelli M,Roccia MG,Boccalari M,França K,Lotti J,Zerbinati N,Lotti T,Feliciani C

    更新日期:2017-04-01 00:00:00

  • Time course of the upper limb motor recovery in subacute stroke patients undergoing conventional or robotic rehabilitation. A preliminary report.

    abstract::Upper limb recovery is a complex process and a strong challenge in the rehabilitation of patients after stroke. Several studies have been conducted to compare the efficacy of conventional and robotic rehabilitation to restore the upper limb motor impairment following a stroke. However, the evolution of the upper limb ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type:

    doi:

    authors: Germanotta M,Cruciani A,Galli C,Cattaneo D,Spedicato A,Aprile I

    更新日期:2020-09-01 00:00:00

  • Impact of Sjögren's syndrome on oral health and quality of life: an observational cross-sectional study.

    abstract::Sjögren's Syndrome is a complex disease, due to an autoimmune physiopathology, that strongly impacts both patients' primary needs (nutrition and speaking), and patients' relationship life related factors (psychological health and quality of life). In Literature, few studies had investigated oral health status in Sjögr...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: DENTAL SUPPLEMENT.,Giuca MR,Miceli M,Carli E,Lardani L,Marchio V,Baldini C

    更新日期:2020-05-01 00:00:00

  • Comparison of the accuracy of intraoral scanning and conventional impression techniques on implants: a review.

    abstract::The aim of this review was to collect available evidence and evaluate accuracy outcomes of dental implant impression techniques, and to compare the accuracy of conventional implant impression versus digital implant impression. Inclusion and exclusion criteria were defined by the authors before the start of the study. ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章,评审

    doi:

    authors: DENTAL SUPPLEMENT.,Arcuri L,Lorenzi C,Vanni A,Bianchi N,Dolci A,Arcuri C

    更新日期:2020-01-01 00:00:00

  • Hypnotic approach during dental treatment: analysis of descriptive data of a case series.

    abstract::Anxiety and worry are important components that affect the patient’s behaviour during dental sessions and influence the effectiveness of dental treatment. Psychological approach and hypnotic approach (HA) have in recent years assumed increasing prominence as effective treatment regimes. Dentists have used a number of ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Ferdeghini R,Lauritano D,Tagliabue A,Tettamanti L

    更新日期:2018-01-01 00:00:00

  • Loss of hydrophobic motif and activation loop phosphorylation is a consequence and not the mechanism of S6 kinase 1 inhibition by rapamycin.

    abstract::S6K1 regulation associates a central role with dynamics of sequential phosphorylations at the hydrophobic motif (T412) and activation loop (T252) of the enzyme, such that the hydrophobic motif phosphorylation supposedly brought about by mTOR- kinase, primes the enzyme for PDK1 dependent phosphorylation at the activati...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Beigh MA,Showkat M,Hussain MU,Andrabi KI

    更新日期:2013-04-01 00:00:00

  • The effects of collagenase of Clostridium Histolitycum (CCH) in Dupuytren's disease: a histological study on cell mediated mechanisms that allow enzymatic fasciotomy.

    abstract::Dupuytren Disease is a benign fibromatosis of palmar fascia of the hand, whose pathophysiology is not completely understood. The present study is intended to provide a description of the effects of Collagenase of Clostridium Hystoliticum (CCH) into an injected cord of Dupuytren. Our experimental study wanted to evalua...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type:

    doi:

    authors: Passiatore M,De Vitis R,Saracco M,Brunelli C,Castri F,Taccardo G

    更新日期:2020-07-01 00:00:00

  • Peripheral T lymphocyte immunity and l-dopamine in patients with Parkinson's disease.

    abstract::This study aimed to evaluate the efficacy of T-cell immune function and L-dopamine (L-DOPA) in patients with Parkinson’s disease (PD). Sixty subjects (included in the study group) with PD who were patients of the Neurology Department of The Affiliated Hospital of Hangzhou Normal University from July 2015 to March 2017...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Hu ZX,Song WN,Lu XD,Zhou ML,Shao JH

    更新日期:2018-05-01 00:00:00

  • Bronchodilation test in allergic adolescents.

    abstract::This study highlights the close link between upper and lower airways and the relevance of bronchodilation test in patients presenting with moderate-severe persistent allergic rhinitis and mild persistent asthma. ...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Marseglia GL,Marchi A,Caimmi D,Caimmi S,Di Gioacchino M,Ciprandi G

    更新日期:2008-10-01 00:00:00

  • HIV therapy in the post-eradication era.

    abstract::Over the past three years, most efforts of virologists and immunologists involved in the field of Human Immunodeficiency Virus (HIV) have been focussed on strategies aimed at eradicating the infection. So far, however, all the approaches have been unsuccessful. Indeed, even if the currently available potent antiretrov...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Vella S,Palmisano L

    更新日期:2000-01-01 00:00:00

  • The use of autologous platelet and plasma products in salvage neck dissections: a prospective clinical study evaluating early and late wound healing.

    abstract:OBJECTIVES:To evaluate the effect of autologous platelet and plasma adhesives (APA) on postoperative drainage and soft-tissue fibrosis following neck dissections. DESIGN:This was a blinded comparative prospective cohort study done as two parts: part one evaluated early post-surgical outcomes and part two evaluated lat...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Yoo J,Chandarana S,Fung K,Franklin JH,Nichols AC,Doyle PC

    更新日期:2012-04-01 00:00:00

  • JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling.

    abstract::The Janus kinase-signal transducers and activators of transcription signaling pathway (JAK/STAT pathway) have displayed a critical role in tumor development and progression in multiple malignancies. Previous studies showed that inhibition of JAK/STAT signaling blocked cell growth and metastasis in cancer cells, howeve...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Fu LX,Lian QW,Pan JD,Xu ZL,Zhou TM,Ye B

    更新日期:2017-01-01 00:00:00

  • The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity.

    abstract::Minoxidil is the only US FDA-approved topical drug for the treatment of female and male pattern hair loss. Previously, it was demonstrated that topical minoxidil is metabolized to its active metabolite, minoxidil sulfate, by sulfotransferase enzymes located in the outer root sheath of hair follicles. The expression of...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Goren A,Mccoy J,Kovacevic M,Situm M,Chitalia J,Dhurat R,Naccarato T,Lotti T

    更新日期:2018-07-01 00:00:00

  • Evaluation of real-time PCR data.

    abstract::If real-time PCR is to be of much worth to its user, some idea regarding the reliability of its data is essential. We discuss here some of the problems associated with interpreting numerical real-time PCR data that lend themselves to analytical evaluation. We translate into the language of molecular biology some of th...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Vaerman JL,Saussoy P,Ingargiola I

    更新日期:2004-04-01 00:00:00

  • HPV-16 E6-E7 differential transcription induced in Siha cervical cancer cell line by interferons.

    abstract::The transcription of HPV-16 E6/E7 RNA has been studied by the polymerase chain reaction (PCR) in the Siha cervical carcinoma cell line. With this technique, all three different transcripts have been detected: the cDNA colinear E6 form, and the two differentially spliced forms E6*I and E6*II. All types of RNA appear le...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: De Marco F,Marcante ML

    更新日期:1993-01-01 00:00:00

  • May nasal hyperreactivity be a sequela of recurrent common cold?

    abstract::Respiratory viral infections may worsen bronchial hyperreactivity. However, there is no data on the possible role of recurrent infectious rhinitis in nose hyperreactivity. This study was therefore designed to investigate whether subjects suffering from recurrent common cold have nasal hyperreactivity, assessed by hist...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Cassano M,Cassano P,Ciprandi G

    更新日期:2011-04-01 00:00:00

  • Correlation between SPARC, TGFβ1, Endoglin and angiogenesis mechanism in lung cancer.

    abstract::To study the relationship between Secreted protein, acidic and rich in cysteine (SPARC), Transforming growth factorβ1 (TGFβ1), Endoglin and angiogenesis in lung cancer, 40 cases of lung cancer specimens and 40 adjacent normal lung tissues specimens were collected and 10 cases from each were selected for preparation of...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 信件

    doi:

    authors: Wang B,Zhang Z,Tang J,Tao H,Zhang Z

    更新日期:2018-11-01 00:00:00

  • Human papilloma virus in the tonsillar microbiota of an Afghan population group.

    abstract::Cancer of the oral cavity is known to have a diverse aetiology that includes infectious agents. Human papilloma virus has been found to be associated with several types of human cancer, inclusive of cervical, vulvar, vaginal, penile, anal, and cancer of tonsil. The aim of this manuscript is to investigate the presence...

    journal_title:Journal of biological regulators and homeostatic agents

    pub_type: 杂志文章

    doi:

    authors: Ruggiero F,Carbone D,Mugavero R,Cura F,Baggi L,Arcuri C,Nardone M,Gaudio RM,Gatto R,Scapoli L,Carinci F

    更新日期:2018-01-01 00:00:00