Hyperkeratotic hand eczema: Eczema or not?

Abstract:

BACKGROUND:Hyperkeratotic hand eczema (HHE) is a typical clinical hand eczema subtype with a largely unknown pathophysiology. OBJECTIVE:To investigate histopathology, expression of keratins (K), epidermal barrier proteins, and adhesion molecules in HHE. METHODS:Palmar skin biopsies (lesional and perilesional) were obtained from seven HHE patients and two healthy controls. Moreover, 135 candidate genes associated with palmoplantar keratoderma were screened for mutations. RESULTS:Immunofluorescence staining showed a significant reduction of K9 and K14 in lesional skin. Upregulation was found for K5, K6, K16, and K17 in lesional skin compared with perilesional and healthy palmar skin. Further, upregulation of involucrin and alternating loricrin staining, both in an extracellular staining pattern, was found. Filaggrin expression was similar in lesional, perilesional, and control skin. No monogenetic mutations were found. CONCLUSION:Currently, the phenotype of HHE is included in the hand eczema classification system; however, it can be argued whether this is justified. The evident expression of filaggrin and involucrin in lesional skin does not support a pathogenesis of atopic eczema. The upregulation of K6, K16, and K17 and reduction of K9 and K14 might contribute to the underlying pathogenesis. Unfortunately, comparison with hand eczema studies is not possible yet, because similar protein expression studies are lacking.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Politiek K,Loman L,Pas HH,Diercks GFH,Lemmink HH,Jan SZ,van den Akker PC,Bolling MC,Schuttelaar MLA

doi

10.1111/cod.13572

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

196-205

issue

3

eissn

0105-1873

issn

1600-0536

journal_volume

83

pub_type

杂志文章
  • Exploring the mango-poison ivy connection: the riddle of discriminative plant dermatitis.

    abstract::A relationship between sensitivity to poison oak or poison ivy and mango dermatitis has been suggested by previous publications. The observation that acute allergic contact dermatitis can arise on first exposure to mango in patients who have been sensitized beforehand by contact with other urushiol-containing plants h...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.0105-1873.2005.00454.x

    authors: Hershko K,Weinberg I,Ingber A

    更新日期:2005-01-01 00:00:00

  • Contact sensitivity to flavourings and perfumes in atopic dermatitis.

    abstract::16 children with atopic dermatitis and 4 nonatopics were skin tested with flavourings and perfumes. Immediate reactions to balsam of Peru and fragrance-mix were found in 9 atopics, and none among nonatopics. An irritant is more probable than an immunologic mechanism. Allergen solutions should probably be assayed at a ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1992.tb05196.x

    authors: Abifadel R,Mortureux P,Perromat M,Ducombs G,Taieb A

    更新日期:1992-07-01 00:00:00

  • Surfactants and experimental irritant contact dermatitis.

    abstract::Surface-active agents (surfactants) are characterized by the possession of 2 different moieties, both polar and non-polar regions on the same molecule. Surfactants are broadly classified as anionic, cationic, amphoteric, or non-ionic, according to the nature of the hydrophile yielded in aqueous solution. In currently ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1995.tb00470.x

    authors: Effendy I,Maibach HI

    更新日期:1995-10-01 00:00:00

  • Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene.

    abstract::Generalized dermatitis due to trichloroethylene is rare. A 21-year-old printer developed exfoliative dermatitis with mucous membrane involvement, fever and liver dysfunction after a 2-week occupational exposure to trichloroethylene. Positive patch-test reactions to trichloroethylene and to one of its metabolites, tric...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1988.tb02867.x

    authors: Nakayama H,Kobayashi M,Takahashi M,Ageishi Y,Takano T

    更新日期:1988-07-01 00:00:00

  • Zinc effects on nickel dermatitis in the guinea pig.

    abstract::Prevention of NiSO4 induced allergic contact dermatitis (ACD) using ZnSO4 in drinking water was studied in a guinea pig model. Without ZnSO4 interventions, nickel (Ni)-exposure resulted in significantly higher (p less than 0.05) stimulation indices (SIs) as compared to non-exposed controls, using NiSO4 as an allergen ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1988.tb05505.x

    authors: Warner RD,Dorn CR,Blakeslee JR,Gerken DF,Gordon JC,Angrick EJ

    更新日期:1988-08-01 00:00:00

  • PAFS: population-adjusted frequency of sensitization. (I) Influence of sex and age.

    abstract::Sensitization rates are influenced by sex and age. Crude rates from different departments cannot be compared without taking into account these variables. However, the influence of sex and age has never been considered quantitatively. In 2 hypothetical populations with identical age-specific sensitizations rates, but d...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1996.tb02236.x

    authors: Schnuch A

    更新日期:1996-06-01 00:00:00

  • Validity and ethics of the human 4-h patch test as an alternative method to assess acute skin irritation potential.

    abstract::For more than 50 years, the Draize rabbit skin irritation test has reigned supreme as the regulatory method of choice for the identification of skin irritant chemicals. To date no in vitro alternative test has been validated as an adequate replacement. However, one potential option, to test the endpoint of concern (sk...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0536.2001.045001001.x

    authors: Robinson MK,McFadden JP,Basketter DA

    更新日期:2001-07-01 00:00:00

  • Contact allergy trends in Sweden - a retrospective comparison of patch test data from 1992, 2000, and 2009.

    abstract:BACKGROUND:Contact allergy prevalence rates change over time as a result of variations in allergen exposure. Data from patch test clinics are often used as markers for allergy trends. OBJECTIVES:The aim of the present retrospective study was to describe trends in rates of sensitization to allergens in the Swedish base...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12346

    authors: Fall S,Bruze M,Isaksson M,Lidén C,Matura M,Stenberg B,Lindberg M

    更新日期:2015-05-01 00:00:00

  • Occupational contact allergy to cocamidopropyl betaine and its impurities.

    abstract:BACKGROUND:Contact allergy to cocamidopropyl betaine has been attributed to its impurities dimethylaminopropylamine and cocamidopropyl dimethylamine. OBJECTIVES:To describe patients with positive patch test reactions to cocamidopropyl betaine-related compounds in an occupational dermatology clinic. METHODS:We reviewe...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2011.02036.x

    authors: Suuronen K,Pesonen M,Aalto-Korte K

    更新日期:2012-05-01 00:00:00

  • Shiitake (Lentinus edodes) dermatitis.

    abstract::Shiitake (Lentinus edodes) is a mushroom which is eaten in Chinese and Japanese meals and is nowadays the second most commonly produced edible mushroom in the world. Shiitake dermatitis was first described by Nakamura in 1977. This disease presents with very characteristic skin manifestations. From April 1974 to April...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1992.tb05211.x

    authors: Nakamura T

    更新日期:1992-08-01 00:00:00

  • Identification of IgE-reactive proteins in patients with wheat protein contact dermatitis.

    abstract:BACKGROUND:Wheat protein and its derivatives can cause protein contact dermatitis (PCD), which mainly occurs in bakers. Few studies have attempted to identify the allergens responsible for wheat PCD. OBJECTIVES:The aim of this study was to identify allergenic wheat proteins in patients with wheat PCD. METHODS:Water-s...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2010.01741.x

    authors: Matsuo H,Uemura M,Yorozuya M,Adachi A,Morita E

    更新日期:2010-07-01 00:00:00

  • The effects of protective occlusive gloves on stratum corneum barrier properties.

    abstract::Data suggests that protection from gloves is paradoxically reduced because of effects of occlusion on the skin. The aim of this study was to characterize these effects on physical and functional properties of stratum corneum. Volunteer trials were conducted using patches of polyvinyl chloride (PVC) glove material on t...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1995.tb00542.x

    authors: Graves CJ,Edwards C,Marks R

    更新日期:1995-09-01 00:00:00

  • Self-reported skin symptoms in metal workers.

    abstract::Machinists and machine maintenance men working in the metal industry use metal-working fluids capable of causing irritant and allergic contact dermatitis. The objectives of this study were to find out the frequency of skin symptoms in machinists and machine maintenance men (metal workers) and to compare the risk of th...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2007.01207.x

    authors: Suuronen K,Jolanki R,Luukkonen R,Alanko K,Susitaival P

    更新日期:2007-10-01 00:00:00

  • Contact sensitization in Dutch children and adolescents with and without atopic dermatitis - a retrospective analysis.

    abstract:BACKGROUND:Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups. OBJECTIVES:To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatit...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12711

    authors: Lubbes S,Rustemeyer T,Sillevis Smitt JH,Schuttelaar ML,Middelkamp-Hup MA

    更新日期:2017-03-01 00:00:00

  • An update on airborne contact dermatitis: 2007-2011.

    abstract:BACKGROUND:Reviews on irritant and allergic airborne contact dermatitis have been previously reported in the literature. MATERIALS AND METHODS:Here, we present an update based on recently published airborne-induced skin reactions. For this survey, we screened the journals Contact Dermatitis, Dermatitis, and included r...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/cod.12022

    authors: Swinnen I,Goossens A

    更新日期:2013-04-01 00:00:00

  • Effect of sodium lauryl sulfate (SLS) on in vitro percutaneous penetration of water, hydrocortisone and nickel.

    abstract::The dose- and time-related effect of sodium lauryl sulfate (SLS) on in vitro percutaneous penetration was studied using 3 radiolabeled tracer compounds with different physicochemical properties: tritiated water, hydrocortisone and nickel. Human cadaver abdominal skin from caucasian women was used as membrane in static...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1995.tb00622.x

    authors: Frankild S,Andersen KE,Nielsen GD

    更新日期:1995-06-01 00:00:00

  • Laser Doppler perfusion imaging for the documentation of flare-up in contact allergy to gold.

    abstract::A healed or healing allergic contact dermatitis is easily reactivated to a flare-up if the patient is provoked systemically with his particular allergen. 5 patients with contact allergy to gold were patch tested with a serial dilution of gold sodium thiosulfate. 1 to 2 months later, when positive test reactions were h...

    journal_title:Contact dermatitis

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0536.1999.tb06103.x

    authors: Möller H,Björkner B,Bruze M,Lundqvist K,Wollmer P

    更新日期:1999-09-01 00:00:00

  • Occupational contact urticaria and protein contact dermatitis: causes and concomitant airway diseases.

    abstract:BACKGROUND:Contact urticaria (CU) and protein contact dermatitis (PCD) are mainly induced by an immediate, IgE-mediated immunological mechanism. Immediate sensitization is also linked to asthma and/or allergic rhinitis. OBJECTIVES:To report causes of work-induced CU and PCD, and to evaluate the occurrence of concomita...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/cod.12856

    authors: Helaskoski E,Suojalehto H,Kuuliala O,Aalto-Korte K

    更新日期:2017-12-01 00:00:00

  • Skin irritant reactivity following experimental cumulative irritant contact dermatitis.

    abstract::Despite the frequency of irritant contact dermatitis, very little is known about the duration of barrier function impairment following cumulative irritant contact dermatitis. We studied post-irritation irritant reactivity by assessing the response to SLS irritation in previously irritated sites. Cumulative irritant co...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1994.tb00725.x

    authors: Widmer J,Elsner P,Burg G

    更新日期:1994-01-01 00:00:00

  • Release of thiurams and carbamates from rubber gloves.

    abstract::A method for quantitative determination of thiuram and carbamate derivatives released from rubber gloves into synthetic sweat is presented. The analysis was based upon determination of ester derivatives using gas-chromatography/mass spectrometry and isotope-dilution. The detection limit was 0.1 mg thiuram/carbamate in...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1993.tb03343.x

    authors: Knudsen BB,Larsen E,Egsgaard H,Menné T

    更新日期:1993-02-01 00:00:00

  • Sensitivity to some rubber additives.

    abstract::The frequency of positive patch tests to 13 rubber accelerators in Poland was recorded. Of particular interest was the relatively large group of patients positive to several, mostly chemically unrelated, accelerators. The mechanism of this multiple sensitivity is discussed. Positive tests to N-isopropyl-N-phenyl-p-phe...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1976.tb02974.x

    authors: Rudzki E,Ostaszewski K,Grzywa Z,Kozlowska A

    更新日期:1976-02-01 00:00:00

  • Contact dermatitis from the epoxy resins tetraglycidyl-4,4'-methylene dianiline and o-diglycidyl phthalate in composite material.

    abstract::An outbreak of dermatitis occurred in an aircraft factory using epoxy resin composite material. Of 25 operatives, 14 gave positive patch test reactions to the composite material and/or diglycidylether of bisphenol A (DGEBA), tetraglycidyl-4,4'-methylene dianiline (TGMDA), and o-diglycidyl phthalate. This report seems ...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1984.tb00931.x

    authors: Burrows D,Fregert S,Campbell H,Trulsson L

    更新日期:1984-08-01 00:00:00

  • Lichenoid photocontact dermatitis to musk ambrette.

    abstract::A patient is described with a pigmentary dermatitis of the face with histological features of a lichenoid reaction, which proved to be a photocontact dermatitis to musk ambrette. Photopatch tests produced a pigmented dermatitis that reflected the clinical and histological features of a lichenoid reaction, which occurr...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1987.tb01406.x

    authors: Parodi G,Guarrera M,Rebora A

    更新日期:1987-03-01 00:00:00

  • The phototoxic and allergenic potential of EDS liquids.

    abstract::Liquid fuels derived by direct coal liquefaction may be similar in boiling range and chemical composition to coal tar products. In the past, phototoxicity, an occupational skin disorder, has been associated with coal distillation. Consequently, the phototoxic properties of 5 materials representing the full boiling ran...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1985.tb02508.x

    authors: McKee RH,Maibach HI

    更新日期:1985-08-01 00:00:00

  • Prognosis and work absence due to occupational contact dermatitis.

    abstract::The consequences of a diagnosis of occupational contact dermatitis (OCD) were investigated using cases available from the voluntary surveillance scheme, EPIDERM. Cases of OCD reported from November 1994 to September 1995 were identified and sampled to give at least 100 cases of allergic, irritant and mixed OCD reporte...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1034/j.1600-0536.2002.460505.x

    authors: Adisesh A,Meyer JD,Cherry NM

    更新日期:2002-05-01 00:00:00

  • Sensitization potential of benzotriazole.

    abstract::Predictive guinea pig sensitization studies have been performed with commercial and purified 1H-benzotriazole. In only 3 animals, induced and challenged according to the maximization protocol with more than 100 times the normal use concentration, were slight erythemas elicited with the commercial grade of benzotriazol...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1984.tb00024.x

    authors: Maurer T,Meier F

    更新日期:1984-03-01 00:00:00

  • Allergic contact dermatitis to copolymers in cosmetics--case report and review of the literature.

    abstract::Copolymers or heteropolymers are large molecules with high molecular weights (>1000 D). They have been underestimated for a long time as to their sensitizing capacities. Allergic contact dermatitis to 6 copolymers in cosmetics and 1 in a medical dressing has been described; however, the nature of the hapten is still u...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.2006.00960.x

    authors: Quartier S,Garmyn M,Becart S,Goossens A

    更新日期:2006-11-01 00:00:00

  • Down-regulation of protein kinase C isoforms in irritant contact dermatitis.

    abstract::Protein kinase C (PKC) isoforms are important in cell signal transduction associated with regulation of cell proliferation and differentiation. In this study, alterations of PKC isoform levels in irritant patch test reactions were detected by Western immunoblots. 4 chemically and structurally different irritants, 4% a...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.1998.tb05766.x

    authors: Li LF,Fiedler VC,Kumar R

    更新日期:1998-06-01 00:00:00

  • Contact allergy to epoxy (meth)acrylates.

    abstract:BACKGROUND:Contact allergy to epoxy (meth)acrylates, 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA), 2,2-bis[4-(2-hydroxy-3-acryloxypropoxy)phenyl]-propane (bis-GA), 2,2-bis[4-(methacryl-oxyethoxy)phenyl] propane (bis-EMA), 2,2-bis[4-(methacryloxy)phenyl]-propane (bis-MA), and glycidyl methacrylat...

    journal_title:Contact dermatitis

    pub_type: 杂志文章

    doi:10.1111/j.1600-0536.2009.01574.x

    authors: Aalto-Korte K,Jungewelter S,Henriks-Eckerman ML,Kuuliala O,Jolanki R

    更新日期:2009-07-01 00:00:00

  • Occupational allergic contact dermatitis caused by thiourea compounds.

    abstract::Thiourea compounds are mainly used as accelerators in the rubber industry, but also in other industries, e.g., as antioxidants in the graphics industry. Thiourea compounds may provoke allergic contact dermatitis, although the number of reported cases is relatively low. During 1985-1991, we had 5 patients with allergic...

    journal_title:Contact dermatitis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0536.1994.tb01996.x

    authors: Kanerva L,Estlander T,Jolanki R

    更新日期:1994-10-01 00:00:00