Adjuvant and Neoadjuvant Immunotherapy in Non-small Cell Lung Cancer.

Abstract:

:The advent of immune checkpoint blockade has revolutionized the management of advanced non-small cell lung cancer (NSCLC). Impressive results in the metastatic setting have prompted substantial interest in the application of these agents in earlier-stage disease. Applications of checkpoint blockade in the adjuvant setting are under investigation in several clinical trials. Early trials have demonstrated the safety and feasibility of the administration of checkpoint inhibitors in the neoadjuvant setting. Resection specimens demonstrate encouraging rates of pathologic response. There are several ongoing phase 3 studies comparing neoadjuvant combination chemotherapy and checkpoint blockade to chemotherapy alone in patients with resectable NSCLC.

journal_name

Thorac Surg Clin

journal_title

Thoracic surgery clinics

authors

Broderick SR

doi

10.1016/j.thorsurg.2020.01.001

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

215-220

issue

2

eissn

1547-4127

issn

1558-5069

pii

S1547-4127(20)30001-3

journal_volume

30

pub_type

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