Abstract：
:Almost a half of patients diagnosed with nonesmall-cell lung cancer (NSCLC) present with incurable disease, and a significant number of patients who are treated with curative intent for early-stage disease will eventually recur. Systemic therapy is selected based on tumor histology, squamous versus nonsquamous NSCLC, molecular testing, and PD-L1 score. Depending on PD-L1 score, patients are eligible for immunotherapy alone or in combination with chemotherapy in the first-line setting. Oncogenic driver mutations can be detected in approximately 50% of patients with nonsquamous NSCLC of which several can be targeted therapeutically with small molecular inhibitors. Continued research is needed for more specific agents with less toxicity and better central nervous system penetration, and agents to treat patients who develop resistance against targeted treatments and immunotherapy.
journal_name
Thorac Surg Clinjournal_title
Thoracic surgery clinicsauthors
Horn L,Cass ASdoi
10.1016/j.thorsurg.2020.01.011subject
Has Abstractpub_date
2020-05-01 00:00:00pages
121-125issue
2eissn
1547-4127issn
1558-5069pii
S1547-4127(20)30011-6journal_volume
30pub_type
杂志文章,评审abstract：:Assessment for thoracic surgery in elderly patients should be based on physiologic rather than chronologic age. Thoracic surgery has been shown to be safe in selected elderly patients, and age should not be a contraindication to a therapy that offers the best chance of cure for patients with early-stage cancer. A targ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2014.07.001
更新日期：2014-11-01 00:00:00
abstract：:Surgical treatment of locally advanced or recurrent breast cancer involving the chest wall continues to play a role in the therapeutic armamentarium as part of the multidisciplinary treatment regimen. Significant progress has been made in chest wall resections and reconstructions, thanks to the availability of novel m...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2017.01.009
更新日期：2017-05-01 00:00:00
abstract：:Unilateral vocal-cord paralysis after esophagectomy involving a cervical anastomosis is uncommon in experienced hands but can cause marked morbidity because of pulmonary complications. It is important for the surgeon to understand the anatomy of the recurrent laryngeal nerve to avoid this complication. The diagnosis i...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2006.01.006
更新日期：2006-02-01 00:00:00
abstract：:A thorough knowledge of thoracic anatomy is of fundamental importance to the thoracic surgeon. Surface anatomy is an often-neglected component of traditional topographic anatomic teaching, but a proper understanding of the relationship of surface features to deeper structures is invaluable in the clinical assessment o...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2006.12.002
更新日期：2007-11-01 00:00:00
abstract：:This article summarizes the pertinent points of tracheal and bronchial anatomy, including the relationships to surrounding structures. Tracheal and bronchial anatomy is essential knowledge for the thoracic surgeon, and an understanding of the anatomic relationships surrounding the airway is crucial to the safe perform...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2006.12.006
更新日期：2007-11-01 00:00:00
abstract：:The current convention is for bilateral one-stage lung volume reduction surgery. Unilateral surgery results in a symptomatic improvement in most patients. A staged approach to the second lung may reduce the risk of surgery and lead to a slower decline in physiologic improvement. The timing of the second operation can ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2009.02.001
更新日期：2009-05-01 00:00:00
abstract：:Nanotechnology is an emerging field with potential as an adjunct to cancer therapy, particularly thoracic surgery. Therapy can be delivered to tumors in a more targeted fashion, with less systemic toxicity. Nanoparticles may aid in diagnosis, preoperative characterization, and intraoperative localization of thoracic t...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2015.12.009
更新日期：2016-05-01 00:00:00
abstract：:Postoperative pain following thoracic surgery presents a significant challenge, and multiple factors complicate recovery and pain management for this population. Considerable comorbidities often exist in thoracic surgical patients, further limiting therapeutic options. Elements of nociceptive and neuropathic pain may ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2015.07.005
更新日期：2015-11-01 00:00:00
abstract：:Concerns regarding the sequelae of neoadjuvant chemotherapy or chemoradiotherapy on the pleural space and tissue planes had previously deterred the application of video-assisted thoracoscopic (VATS) lobectomy for patients who underwent neoadjuvant therapy. As experience with VATS has increased, however, its applicatio...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2014.07.013
更新日期：2014-11-01 00:00:00
abstract：:The benefits derived from comprehensive PR, when applied to patients who have lung cancer, should have significant impact on both survival and health status. Because PR is known to improve exercise capacity, it is reasonable to expect that this treatment modality may provide more patients with a potential cure. In add...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2007.10.003
更新日期：2008-02-01 00:00:00
abstract：:Nonintubated video-assisted thoracoscopic surgery for the treatment of primary and secondary pneumothorax was first reported in 1997 by Nezu. However, studies on this technique are few. Research in the past 20 years has focused on the perioperative outcomes, including the surgical duration, length of hospital stay, an...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2019.08.001
更新日期：2020-02-01 00:00:00
abstract：:There is mounting recognition that, to aid surgical decision making, treatment efficacy needs to be measured in a variety of ways, with health-related quality of life now widely regarded as an important outcome in pulmonary surgical populations. The aim of this review is to provide a comprehensive overview of the key ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2012.07.007
更新日期：2012-11-01 00:00:00
abstract：:Practically, hiatal hernias are divided into sliding hiatal hernias (type I) and PEH (types II, III, or IV). Patients with PEH are usually symptomatic with GERD or obstructive symptoms, such as dysphagia. Rarely, patients present with acute symptoms of hernia incarceration, such as severe epigastric pain and retching....
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2009.08.006
更新日期：2009-11-01 00:00:00
abstract：:Tracheobronchomalacia is an uncommon acquired disorder of the central airways. Common symptoms include dyspnea, constant coughing, inability to raise secretions, and recurrent respiratory infections. Evaluation includes an inspiratory-expiratory chest CT (dynamic CT), an awake functional bronchoscopy, and pulmonary fu...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2018.01.006
更新日期：2018-05-01 00:00:00
abstract：:Hydatid disease is caused by the parasite Echinococcus granulosus. The liver and the lungs are common sites. When a cystic lesion is seen on CT scan, diagnosis is made based on the patient having lived in an endemic area. Serologic tests are used for differential diagnosis. Medical treatment is centered on albendazole...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2012.04.004
更新日期：2012-08-01 00:00:00
abstract：:Surgical treatment of idiopathic scoliosis has classically included posterior, anterior, or combined open surgical techniques. In recent years, a videothoracoscopic approach to the spine has been increasingly employed either in combination with the posterior open approach or as a stand-alone treatment including anteri...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2010.01.004
更新日期：2010-05-01 00:00:00
abstract：:Surgical education in 2019 faces may challenges to maintain the high standards of excellence achieved in prior generations of learners and trainers in cardiothoracic surgery. This compendium hopes to review the current and future strategies in surgical education. The topics include the adult learner, assessing compete...
journal_title：Thoracic surgery clinics
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.thorsurg.2019.03.001
更新日期：2019-08-01 00:00:00
abstract：:This article focuses on new materials available to thoracic surgeons for the reconstruction of chest wall defects. Each surgeon is called to select the best reconstructive strategy based on the disease for which the resection is needed, the possible extension to adjacent structures, the availability of professional co...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2010.06.005
更新日期：2010-11-01 00:00:00
abstract：:Adequate lymphadenectomy represents a fundamental procedure in lung cancer surgery for accurate staging and potential survival benefit. Various techniques are used in current surgical practice for the intraoperative lymph node removal associated with pulmonary resection, without definitive indications concerning the p...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2011.12.001
更新日期：2012-05-01 00:00:00
abstract：:The Stretta procedure is safe and effective for the treatment of GERD. There are well-documented clinical trial data supporting its use, including a randomized sham-controlled study, single- and multi-center prospective trials, and community practice reports. The complication rate is within the acceptable range for th...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2005.03.006
更新日期：2005-08-01 00:00:00
abstract：:Most cases of hemothorax are related to blunt or penetrating chest trauma. Criteria for surgical intervention for initial hemothorax are well defined. Appropriate management of retained hemothorax following initial trauma management is critical, and the best approach remains controversial. Spontaneous hemothorax is mu...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2012.10.003
更新日期：2013-02-01 00:00:00
abstract：:This article provides an overview of current literature on blunt tracheobronchial injury, and discusses the presentation of tracheobronchial injuries in clinical and radiographic forms. A review of the current data on repair is provided with an outline of surgical management. ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2018.04.008
更新日期：2018-08-01 00:00:00
abstract：:Cervical mediastinoscopy is a frequently used technique to assess the mediastinum, in particular the mediastinal lymph nodes in patients presenting with non-small cell lung cancer (NSCLC). The senior author of this article is credited for developing in 1989 the concept of what is now called videomediastinoscopy. The i...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2010.01.006
更新日期：2010-05-01 00:00:00
abstract：:Recurrent symptomatic paraesophageal hernias (PEHs) can lead to significant morbidity if untreated. Surgical treatment of recurrent PEH can pose a great challenge. Several different surgical options are available and need to be considered on an individual basis. Before embarking on the repair of a recurrent hernia, a ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2019.07.011
更新日期：2019-11-01 00:00:00
abstract：:The role of surgical resection in malignant pleural mesothelioma (MPM) is based on the principle of macroscopic resection of a solid tumor with adjuvant therapy to treat micrometastatic disease. Extrapleural pneumonectomy (EPP) and pleurectomy decortication (P/D) have been developed in this context. Cancer-directed su...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2016.04.003
更新日期：2016-08-01 00:00:00
abstract：:Detection of clinically occult lung neoplasms may represent an opportunity for early curative intervention. Fluorescent bronchoscopy is a sensitive technique for detecting early endobronchial tumors that may be combined with CT scanning as part of a comprehensive lung cancer screening program. Identification and longi...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/S1547-4127(04)00041-6
更新日期：2004-02-01 00:00:00
abstract：:This article has reviewed radiation treatment of thoracic malignancies in elderly patients. In general the literature suggests that thoracic irradiation is equally efficacious in elderly patients as in younger patients and is associated with increased but acceptable toxicity. Technical advances are allowing a further ...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2009.06.003
更新日期：2009-08-01 00:00:00
abstract：:Gastroesophageal reflux disease (GERD) is a well-defined disease characterized by symptoms or complications caused by an abnormal amount of GER, which is a retrograde movement of gastric contents into the esophagus. Laryngopharyngeal reflux (LPR) is a subset of GERD and given its own identity, because the main symptom...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2011.08.001
更新日期：2011-11-01 00:00:00
abstract：:In summary, from the different alternatives to conventional hospitalization developed in the last decades, outpatient surgery has been the one with the greatest growth. However, only few studies have been reported on thoracic surgery and there is still great potential for an increase in outpatient thoracic surgery. Th...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2008.04.003
更新日期：2008-08-01 00:00:00
abstract：:As we enter the 21st century, thoracic surgeons can look back with pride and gratitude to their predecessors who placed a high premium on clinical practice and certification. Thoracic surgery, however, is dynamic, not static. So, too, should be thoracic surgery recertification. In recent years, considerable effort has...
journal_title：Thoracic surgery clinics
pub_type： 杂志文章,评审
doi：10.1016/j.thorsurg.2007.07.001
更新日期：2007-08-01 00:00:00
