Current state-of-art of the application of serum neurofilaments in multiple sclerosis diagnosis and monitoring.

abstract：:In the last two decades clinicians have become increasingly aware of the frequency, importance and functional impact of cognitive dysfunction in multiple sclerosis. There is, however, a dearth of research in this area. In order to further progress in the field of neuropsychological diagnosis it is essential to validat...

journal_title：Expert review of neurotherapeutics

authors： Amato MP,Zipoli V

更新日期：2002-09-01 00:00:00

abstract：:There have been remarkable strides in the last decade in unraveling the mystery of primary headache disorders, such as migraine and cluster headache. The vascular theory has been superseded by the neurovascular phenomena which seems to be the permissive triggering factor in migraine and cluster headache. This has been...

journal_title：Expert review of neurotherapeutics

authors： Aurora S

更新日期：2003-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of β-amyloid peptides and neurofibrilllary tangles in brain, resulting in neuronal death and loss of cognitive abilities. It has been hypothesized that longstanding psychological stress can result in neural degenerat...

journal_title：Expert review of neurotherapeutics

authors： Johansson L

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials...

journal_title：Expert review of neurotherapeutics

authors： Fragoso YD,Carra A,Macias MA

更新日期：2020-08-01 00:00:00

abstract：:Advances in research and better understanding of the pathophysiology of diseases have resulted in an increase in the number of available health interventions that compete for finite public resources. Explicit choices must therefore be made about funding. ...

journal_title：Expert review of neurotherapeutics

authors： Kobelt G

更新日期：2013-12-01 00:00:00

abstract：:Introduction: Headache is the fifth most common reason to visit an emergency department (ED). In most of the cases, headache is benign and has a primary origin, with migraine as the most common diagnosis. Inappropriate use of ED for non-emergency conditions causes overcrowding, unnecessary testing, and increased medic...

journal_title：Expert review of neurotherapeutics

authors： Luciani M,Negro A,Spuntarelli V,Bentivegna E,Martelletti P

更新日期：2021-01-04 00:00:00

abstract：:The saga of harmful administration of levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal trials and cell culture studies. They were initiated after the clinical observation of onset of motor complications related to the short plasma half-life of the drug in PD patients. This di...

journal_title：Expert review of neurotherapeutics

authors： Müller T

更新日期：2008-06-01 00:00:00

abstract：:In the 1990s, cladribine was developed as an adenosine deaminase-resistant nucleoside analog with selective lymphotoxic specificity in the hope that it might become useful in the treatment of some lymphoid neoplasms and autoimmune disorders. Several clinical trials demonstrated very significant effectiveness and safet...

journal_title：Expert review of neurotherapeutics

authors： Sipe JC

更新日期：2005-11-01 00:00:00

abstract：:Guanfacine is an α2A-adrenoreceptor agonist currently indicated for the treatment of attention deficit hyperactivity disorder (ADHD). This article reviews the chemistry, pharmacodynamics and pharmacokinetics of guanfacine, as well as the clinical trial literature on guanfacine for the treatment of ADHD in children and...

journal_title：Expert review of neurotherapeutics

authors： Rizzo R,Martino D

更新日期：2015-04-01 00:00:00

abstract：:Introduction: Almotriptan (ALT), a serotonin 5-HT1B/1D agonist has been used in the acute treatment of migraine with or without aura for 20 years, accumulating data on more than 15,000 patients in studies and from an estimated >150 million treated migraine attacks in daily clinical practice. The last major review of A...

journal_title：Expert review of neurotherapeutics

authors： Pascual J,Vila C

更新日期：2019-08-01 00:00:00

abstract：:Cortical spreading depression (CSD) has been at the center stage of migraine pathophysiology for approximately six decades. Reanalysis of CSD reveals several major unbridgeable gaps in this experimental neurophysiologic concept for migraine. Key phenotypic and pharmacological features of migraine challenge the assumed...

journal_title：Expert review of neurotherapeutics

authors： Gupta VK

更新日期：2009-11-01 00:00:00

abstract：:Altered levels of cytokines and acute-phase proteins have been described in the blood and brain of patients with Alzheimer's disease. Microglia are resident cells of the brain and metabolic upregulation of these cells may play a crucial role in the development of the neurodegeneration associated with Alzheimer's disea...

journal_title：Expert review of neurotherapeutics

authors： Chiappelli M,Tumini E,Porcellini E,Licastro F

更新日期：2006-09-01 00:00:00

abstract：:Introduction: Most preventive migraine treatments modify the brain's excitation/inhibition balance and/or serotonin metabolism, which likely accounts for their unfavorable adverse effect profile. Novel biological therapies blocking CGRP transmission are effective and better tolerated, but they are expensive and may no...

journal_title：Expert review of neurotherapeutics

authors： Lisicki M,Schoenen J

更新日期：2020-03-01 00:00:00

abstract：:Natalizumab is an α-4 integrin antagonist used for the treatment of relapsing multiple sclerosis (MS). Concerns with the drug have a risen owing to a heightened risk of progressive multifocal leukoencephalopathy, which has caused some physicians to interrupt or stop treatment altogether. The article under review evalu...

journal_title：Expert review of neurotherapeutics

authors： Schaaf SM,Pitt D,Racke MK

更新日期：2011-09-01 00:00:00

abstract：:Divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in Alzheimer's disease. With the advent of other mood stabilizers and anticonvulsants, the use of divaplroex sodium has been slightly decreased; however, it has been a major mediation...

journal_title：Expert review of neurotherapeutics

authors： Han C,Shim DS,Lee SJ,Patkar AA,Masand PS,Pae CU

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Pharmaceutical companies and the NIH have invested heavily in a variety of potential disease-modifying therapies for Alzheimer's disease (AD) but unfortunately all double-blind placebo-controlled Phase III studies of these drugs have failed to show statistically significant results supporting their clinica...

journal_title：Expert review of neurotherapeutics

authors： Amanatkar HR,Papagiannopoulos B,Grossberg GT

更新日期：2017-01-01 00:00:00

abstract：:Schizophrenia is a debilitating and pervasive mental illness with devastating effects on psychological, cognitive and social wellbeing, and for which current treatment options are far from ideal. Gender differences and the influence of the female reproductive life cycle on the onset, course and symptoms of schizophren...

journal_title：Expert review of neurotherapeutics

authors： Kulkarni J,Gavrilidis E,Hayes E,Heaton V,Worsley R

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Spinal muscular atrophy (SMA) is an autosomal recessive degenerative neuromuscular disorder characterized by loss of spinal motor neurons leading to muscle weakness. This review article focuses on a novel antisense oligonucleotide treatment, first ever approved for SMA (nusinersen, SpinrazaTM) and describe...

journal_title：Expert review of neurotherapeutics

authors： Chiriboga CA

更新日期：2017-10-01 00:00:00

abstract：:According to the corticoid receptor hypothesis of depression, hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system is one of the major pathophysiological factors for the development of depression and opens a broad range of new antidepressant treatment options that are related to direct interventions...

journal_title：Expert review of neurotherapeutics

authors： Schüle C,Baghai TC,Eser D,Rupprecht R

更新日期：2009-07-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) includes demyelinating and axonal subtypes with different immunopathologic mechanisms. In acute inflammatory demyelinating polyradiculoneuropathy, segmental demyelination and conduction block are the pathological and electrophysiological correlates of muscle weakness. Slowed conductions a...

journal_title：Expert review of neurotherapeutics

authors： Uncini A,Yuki N

更新日期：2009-06-01 00:00:00

abstract：:Hypertension is an important risk factor for stroke. The latter results in disability and premature death and represents a major public health problem. Various studies have established a strong relationship between increasing blood pressure and stroke risk, as well as clear evidence of a reduction in the incidence of ...

journal_title：Expert review of neurotherapeutics

authors： Karthikeyan VJ,Lip GY

更新日期：2006-02-01 00:00:00

abstract：:Generalized anxiety disorder is characterized by excessive chronic anxiety in association with many somatic symptoms. The disorder has pervasive effects on quality of life, including work, social and educational aspects and requires long-term therapy. Available studies in patients are the Diagnostic and Statistical Ma...

journal_title：Expert review of neurotherapeutics

authors： Struzik L,Vermani M,Coonerty-Femiano A,Katzman MA

更新日期：2004-03-01 00:00:00

abstract：:The proper management of acute pain has been identified as a primary indicator of quality assurance in US trauma centers. Nearly half of all trauma patients are injured while intoxicated and 75% of these patients have chronic alcohol problems. The management of pain caused by injuries in patients with alcohol problems...

journal_title：Expert review of neurotherapeutics

authors： Askay SW,Bombardier CH,Patterson DR

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron degeneration in the brain and spinal cord. Treatment development for ALS is complicated by complex underlying disease factors. Areas covered: Numerous tested drug compounds have shown no benefits in ALS p...

journal_title：Expert review of neurotherapeutics

authors： Garbuzova-Davis S,Thomson A,Kurien C,Shytle RD,Sanberg PR

更新日期：2016-12-01 00:00:00

abstract：:An influence of climate upon cerebrovascular risk is both biologically plausible and supported by epidemiological evidence. These relationships are important as they could yield public health strategies to help protect the vulnerable from the increased death rates arising during extreme cold and heat waves. Change in ...

journal_title：Expert review of neurotherapeutics

authors： McArthur K,Dawson J,Walters M

更新日期：2010-02-01 00:00:00

abstract：:Memory problems are generally quite prominent in dementia and they have a significant impact on everyday functioning. Medication developed for Alzheimer's disease, for example, acetylcholinesterase inhibitors, can slow down the increase of cognitive impairment for a while. In addition to pharmacotherapy, psychosocial ...

journal_title：Expert review of neurotherapeutics

authors： Dröes RM,van der Roest HG,van Mierlo L,Meiland FJ

更新日期：2011-12-01 00:00:00

abstract：:Recent evidence suggests that active trigger points (TrPs) in neck and shoulder muscles contribute to tension-type headache. Active TrPs within the suboccipital, upper trapezius, sternocleidomastoid, temporalis, superior oblique and lateral rectus muscles have been associated with chronic and episodic tension-type hea...

journal_title：Expert review of neurotherapeutics

authors： Alonso-Blanco C,de-la-Llave-Rincón AI,Fernández-de-las-Peñas C

更新日期：2012-03-01 00:00:00

abstract：:Advances in molecular biology and virology in recent years have enabled the technology of gene transfer to proceed forward. Parkinson's disease (PD) is a particularly appropriate target for gene therapy since the brain pathology is fully characterized and relatively well circumscribed largely within the nigrostriatal ...

journal_title：Expert review of neurotherapeutics

authors： Mochizuki H

更新日期：2007-08-01 00:00:00

abstract：:Cyclooxygenase-2 specific inhibitors have anti-inflammatory and analgesic properties, and are effective in managing a wide range of chronic and acute painful conditions such as adult rheumatoid arthritis, osteoarthritis, migraine, primary dysmenorrhea and postoperative pain. Valdecoxib, an orally administered cyclooxy...

journal_title：Expert review of neurotherapeutics

authors： Joshi GP

更新日期：2005-01-01 00:00:00

abstract：:Side effects to antiparkinsonian drugs constitute an important component of the daily management of patients with Parkinson's disease. Treatment with levodopa frequently leads to motor fluctuations and dyskinesias. Hallucinosis, nausea and vomiting, drowsiness, orthostatic hypotension and peripheral edema can be manag...

journal_title：Expert review of neurotherapeutics

authors： Singer C

更新日期：2002-01-01 00:00:00