Abstract：
:Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cieluch A,Uruska A,Zozulinska-Ziolkiewicz Ddoi
10.3390/ijms21082852subject
Has Abstractpub_date
2020-04-19 00:00:00issue
8issn
1422-0067pii
ijms21082852journal_volume
21pub_type
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