Effects of electrical stimulation on cell activity, cell cycle, cell apoptosis and β‑catenin pathway in the injured dorsal root ganglion cell.

abstract：:The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction...

journal_title：Molecular medicine reports

authors： Zhong QL,Liu FR,Liu DW,Peng Y,Zhang XR

更新日期：2011-03-01 00:00:00

abstract：:Several lysosomal cathepsins have been implicated in a number of diseases, from arthritis to cancer. A recent member of the cathepsin family, cathepsin S (Cat S) has been associated with several types of cancer in humans. However, to date, no report has linked Cat S to human hepatocellular carcinoma (HCC). Here, we in...

journal_title：Molecular medicine reports

authors： Xu J,Li D,Ke Z,Liu R,Maubach G,Zhuo L

更新日期：2009-09-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is involved in the regulation of inflammation‑associated genes. NF-κB forms dimers which bind with sequences referred to as NF-κB sites (9-11 bp). A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of proteoglycanase, which proteolytically cleaves ...

journal_title：Molecular medicine reports

authors： Altuntas A,Halacli SO,Cakmak O,Erden G,Akyol S,Ugurcu V,Hirohata S,Demircan K

更新日期：2015-07-01 00:00:00

abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

journal_title：Molecular medicine reports

authors： Zhou MK,Liu XJ,Zhao ZG,Cheng YM

更新日期：2015-04-01 00:00:00

abstract：:In the present study, it was demonstrated that the protein level of the apoptosis inhibitor Aven is regulated by the Akt signaling pathway, evidenced by the observation that Aven levels were significantly increased in MCF7 constitutively active (CA)‑Akt cells and significantly inhibited following treatment with LY2940...

journal_title：Molecular medicine reports

authors： Han KY,Hwang JW,Bae GU,Kim SN,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) often develops drug resistance following radiotherapy. The molecular basis of radiotherapy-related multidrug resistance (MDR) remains unclear. In the present study, we investigated the effect of fractionated irradiation on the expression of the MDR-1 gene and the MDR-associated protein P...

journal_title：Molecular medicine reports

authors： Ji XN,Yang F,Sui XM,Wang FG,Ge RG,Quan XL,Zhao T,Gao BW,Wang RY

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to identify potential biomarkers associated with colorectal cancer (CRC). The GSE32323 and GSE53592 mRNA and microRNA (miRNA) expression profiles were selected from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs...

journal_title：Molecular medicine reports

authors： Hu J,Yue X,Liu J,Kong D

更新日期：2018-12-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:Nutrients are known to display pharmacologic activity against viruses and to exert cooperative effects in cells. To study the influence of nutrient cooperation on HIV production in chronically infected T lymphocytes, we evaluated the individual and combined effects of nutrients on HIV-1 reverse transcriptase (RT) rele...

journal_title：Molecular medicine reports

authors： Jariwalla RJ,Gangapurkar B,Pandit A,Kalinovsky T,Niedzwiecki A,Rath M

更新日期：2010-05-01 00:00:00

abstract：:Sepsis is a serious issue in the geriatric population due to its association with high mortality rates in the elderly. The increase in mortality in the elderly correlates with inflammation. We have previously demonstrated that the inflammatory response is exacerbated in a rodent endotoxemia model of sepsis in aged rat...

journal_title：Molecular medicine reports

authors： Lufrano M,Jacob A,Zhou M,Wang P

更新日期：2013-08-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a life-threatening type of stroke. Previous studies have reported that bone marrow mesenchymal stem cells (BMSCs) may exert beneficial effects on the treatment of ICH. However, it remains unknown whether the neuroprotection exerted by BMSCs on ICH is due to the differentiation of BMSC...

journal_title：Molecular medicine reports

authors： Cui C,Cui Y,Gao J,Li R,Jiang X,Tian Y,Wang K,Cui J

更新日期：2017-04-01 00:00:00

abstract：:In the present study, the effect of fatty acid synthase (FASN) inhibition on cell invasion and migration in vitro was investigated. A recombinant plasmid containing a microRNA targeting the FASN gene was used to inhibit FASN expression in U2‑OS cells. Cell migration and invasion were investigated using wound healing a...

journal_title：Molecular medicine reports

authors： Liu ZL,Mao JH,Peng AF,Yin QS,Zhou Y,Long XH,Huang SH

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymeras...

journal_title：Molecular medicine reports

authors： Zhang Y,Li Y,Wang J,Lei P

更新日期：2018-11-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is a common risk factor for renal failure. Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease. The present study was designed to investigate the association between inflammation and ET‑1/ETA exp...

journal_title：Molecular medicine reports

authors： Niu J,Wu J,Li X,Zhang F

更新日期：2015-05-01 00:00:00

abstract：:The pathogenesis and therapy of hypertrophic scars (HS) have not yet been established. The aim of the present study was to investigate the potential effect of naringenin on HS and its underlying mechanisms. The mouse model of HS was prepared by a mechanical stretch device and then treated with naringenin at various co...

journal_title：Molecular medicine reports

authors： Shan S,Zhang Y,Wu M,Yi B,Wang J,Li Q

更新日期：2017-10-01 00:00:00

abstract：:Accumulating evidence suggests that Rho-associated kinase (ROCK) may be important in the pathogenesis of atherosclerosis and coronary vasospasm. In the present study, we investigated whether ROCK activity is increased in acute coronary syndrome (ACS) patients. Twenty-one patients with ACS (12 males, mean age 58.0±8.0 ...

journal_title：Molecular medicine reports

authors： Hou HW,Li XG,Yan M,Hu ZQ,Song YE

更新日期：2013-07-01 00:00:00

abstract：:Platanus acerifolia is one of the major sources of outdoor allergens to humans, and can induce allergic asthma, rhinitis, dermatitis and other allergic diseases. Pla a 2 is a polygalacturonase and represents the major allergen identified in P. acerifolia pollen. The aim of the present study was to express and purify P...

journal_title：Molecular medicine reports

authors： Wang DW,Ni WW,Zhou YJ,Huang W,Cao MD,Meng L,Wei JF

更新日期：2018-01-01 00:00:00

abstract：:Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the fun...

journal_title：Molecular medicine reports

authors： You DG,Lee HR,Kim WK,Kim HJ,Lee GY,Yoo YD

更新日期：2017-12-01 00:00:00

abstract：:Potassium channels can be affected by epileptic seizures and serve a crucial role in the pathophysiology of epilepsy. Dimethylation of histone 3 lysine 9 (H3K9me2) and its enzyme euchromatic histone‑lysine N‑methyltransferase 2 (G9a) are the major epigenetic modulators and are associated with gene silencing. Insight i...

journal_title：Molecular medicine reports

authors： Zhang SP,Zhang M,Tao H,Luo Y,He T,Wang CH,Li XC,Chen L,Zhang LN,Sun T,Hu QK

更新日期：2018-01-01 00:00:00

abstract：:Dengue virus (DENV) causes self‑limiting dengue fever (DF), severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It is generally considered that cytokine storm leads to the increased plasma leakage characteristic of DHF/DSS. In the present study, peripheral blood m...

journal_title：Molecular medicine reports

authors： Qi Y,Li Y,Zhang L,Huang J

更新日期：2013-03-01 00:00:00

abstract：:Quantification of testosterone serves an important role in the differential diagnosis of androgen‑related endocrine diseases. Mass spectrometry exhibits higher accuracy and lower variability than immunoassays, especially at low testosterone concentrations. The present study developed and validated an isotope dilution ...

journal_title：Molecular medicine reports

authors： Sun G,Xue J,Li L,Li X,Cui Y,Qiao B,Wei D,Li H

更新日期：2020-08-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor cell survival and proliferation and thus has become a major focus in the development of anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of cancer. However, the precise mechanism o...

journal_title：Molecular medicine reports

authors： Peng J,Chen Y,Lin J,Zhuang Q,Xu W,Hong Z,Sferra TJ

更新日期：2011-03-01 00:00:00

abstract：:To identify the key genes and pathways in the development of hepatocellular carcinoma (HCC) from hepatitis B virus (HBV)‑positive liver cirrhosis, differentially expressed genes (DEGs) between HCC and liver cirrhosis tissue samples from the GSE17548 gene expression profile dataset were screened. A total of 1,845 DEGs ...

journal_title：Molecular medicine reports

authors： Chen QF,Xia JG,Li W,Shen LJ,Huang T,Wu P

更新日期：2018-12-01 00:00:00

abstract：:Non‑alcoholic steatohepatitis (NASH) is a common clinicopathological condition. Currently, the pathogenesis of NASH remains unknown, and no optimal therapy option currently exists. It has previously been demonstrated that diallyl disulfide (DADS) was capable of attenuating liver dysfunction, as DADS supplementation ha...

journal_title：Molecular medicine reports

authors： Zhang N,Wang Y,Zhang J,Liu B,Li G,Xin S,Xu K

更新日期：2019-08-01 00:00:00

abstract：:The splicing factor is important in cancer development, modulation numerous tumor suppressors and oncogenes, and regulation of multiple signaling pathways. Splicing factor 2/alternative splicing factor (SF2/ASF) is a proto‑oncogene, which has been implicated in the development of hepatocellular carcinoma. However, the...

journal_title：Molecular medicine reports

authors： Zhao Y,Zhu T,Zhang X,Wang Q,Zhang J,Ji W,Ma Y

更新日期：2015-09-01 00:00:00

abstract：:The present study aimed to investigate whether brain death (BD) induces the activation of endoplasmic reticulum stress (ERS) and protein phosphatase 2A (PP2A), and reveal the possible association with BD‑induced liver cell apoptosis. A total of 30 healthy adult male Sprague‑Dawley rats were randomized into three group...

journal_title：Molecular medicine reports

authors： Lan J,Zhong Z,Wang Y,Xiong Y,Ye Q

更新日期：2020-02-01 00:00:00

abstract：:Neutrophilic asthma (NA) is characterized by neutrophil‑mediated inflammation and the presence of Th17 cells. However, the mechanisms underlying Th17 cell responses in NA remain unknown. The aim of the present study was to examine the effects of interleukin (IL)‑7 on Th17 cell responses in NA. A NA mouse model was sen...

journal_title：Molecular medicine reports

authors： Zhang X,Zhang M,Jiang M,Nong G

更新日期：2020-08-01 00:00:00

abstract：:In the pathophysiology of osteoarthritis (OA), articular cartilage degeneration exhibits a significant role. Vascular endothelial growth factor (VEGF) is considered to be an effective angiogenic factor and a crucial regulator of articular cartilage degeneration in the development of OA. Therefore, the present study ai...

journal_title：Molecular medicine reports

authors： Deng S,Zhou JL,Peng H,Fang HS,Liu F,Weng JQ

更新日期：2018-05-01 00:00:00

abstract：:The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). The study included 91 females with PCOS and 99 healthy controls. Phenotypic hypera...

journal_title：Molecular medicine reports

authors： Baldani DP,Skrgatic L,Cerne JZ,Oguic SK,Gersak BM,Gersak K

更新日期：2015-05-01 00:00:00