Identification and molecular characterization of the first complete genome sequence of Human Parechovirus type 15.

abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...

journal_title：Scientific reports

authors： Zou Y,Wang S

更新日期：2015-07-07 00:00:00

abstract：:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...

journal_title：Scientific reports

authors： Weinberg RP,Koledova VV,Subramaniam A,Schneider K,Artamonova A,Sambanthamurthi R,Hayes KC,Sinskey AJ,Rha C

更新日期：2019-12-09 00:00:00

abstract：:Clostridial neurotoxins (CNTs), which include botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT), are the most potent toxins known to science and are the causative agents of botulism and tetanus, respectively. The evolutionary origins of CNTs and their relationships to other proteins remains an intriguing que...

journal_title：Scientific reports

authors： Mansfield MJ,Wentz TG,Zhang S,Lee EJ,Dong M,Sharma SK,Doxey AC

更新日期：2019-02-07 00:00:00

abstract：:A variety of post-translational modifications of Plasmodium falciparum proteins, including phosphorylation and ubiquitination, are shown to have key regulatory roles during parasite development. NEDD8 is a ubiquitin-like modifier of cullin-RING E3 ubiquitin ligases, which regulates diverse cellular processes. Although...

journal_title：Scientific reports

authors： Bhattacharjee M,Adhikari N,Sudhakar R,Rizvi Z,Das D,Palanimurugan R,Sijwali PS

更新日期：2020-11-19 00:00:00

abstract：:An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 °C on multiple length ...

journal_title：Scientific reports

authors： Sun Z,Song G,Sisneros TA,Clausen B,Pu C,Li L,Gao Y,Liaw PK

更新日期：2016-03-16 00:00:00

abstract：:The use of engineered viral strains such as gene therapy vectors and oncolytic viruses (OV) to selectively destroy cancer cells is poised to make a major impact in the clinic and revolutionize cancer therapy. In particular, several studies have shown that OV therapy is safe and well tolerated in humans and can infect ...

journal_title：Scientific reports

authors： Dornan MH,Krishnan R,Macklin AM,Selman M,El Sayes N,Son HH,Davis C,Chen A,Keillor K,Le PJ,Moi C,Ou P,Pardin C,Canez CR,Le Boeuf F,Bell JC,Smith JC,Diallo JS,Boddy CN

更新日期：2016-05-26 00:00:00

abstract：:We characterized an anti-cancer fusion protein consisting of anthrax lethal factor (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids and by (ii) reductive methylation to dimethylate all lysines. Dimethylation of lysines was achieved quantitatively and specifically witho...

journal_title：Scientific reports

authors： Bachran C,Gupta PK,Bachran S,Leysath CE,Hoover B,Fattah RJ,Leppla SH

更新日期：2014-04-23 00:00:00

abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

journal_title：Scientific reports

authors： Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

更新日期：2021-01-21 00:00:00

abstract：:The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) ...

journal_title：Scientific reports

authors： El-Assaad F,Qi M,Gordon AK,Qi J,Dong S,Passam F,Weaver JC,Giannakopoulos B,Krilis SA

更新日期：2017-08-15 00:00:00

abstract：:Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infan...

journal_title：Scientific reports

authors： Anblagan D,Pataky R,Evans MJ,Telford EJ,Serag A,Sparrow S,Piyasena C,Semple SI,Wilkinson AG,Bastin ME,Boardman JP

更新日期：2016-12-01 00:00:00

abstract：:CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched ...

journal_title：Scientific reports

authors： Xin X,Zeng X,Gu H,Li M,Tan H,Jin Z,Hua T,Shi R,Wang H

更新日期：2016-09-09 00:00:00

abstract：:Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...

journal_title：Scientific reports

authors： Yamanashi T,Maki M,Kojima K,Shibukawa A,Tsukamoto T,Chowdhury S,Yamanaka A,Takagi S,Sudo Y

更新日期：2019-05-27 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNST) are aggressive cancers that occur spontaneously (sporadic MPNST) or from benign plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients. MPNSTs metastasize easily, are therapy resistant and are frequently fatal. The molecular changes underlying the malignant ...

journal_title：Scientific reports

authors： Amirnasr A,Verdijk RM,van Kuijk PF,Kartal P,Vriends ALM,French PJ,van Royen ME,Taal W,Sleijfer S,Wiemer EAC

更新日期：2020-02-19 00:00:00

abstract：:Calcium oxalate monohydrate (COM) crystals cause kidney stone disease by still unclear mechanisms. The present study aimed to characterize changes in secretion of proteins from basolateral compartment of renal tubular epithelial cells after exposure to COM crystals and then correlated them with the stone pathogenesis....

journal_title：Scientific reports

authors： Chiangjong W,Thongboonkerd V

更新日期：2016-04-05 00:00:00

abstract：:Short-term exposures to outdoor air pollutants have been associated with lower lung function, but the results are inconsistence. The effects of different pollutant levels on lung function changes are still unclear. We quantified the effects of outdoor air pollution exposure (NO2, PM10, O3, and PM2.5) on lung function ...

journal_title：Scientific reports

authors： Zhou Y,Liu Y,Song Y,Xie J,Cui X,Zhang B,Shi T,Yuan J,Chen W

更新日期：2016-10-13 00:00:00

abstract：:Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings pr...

journal_title：Scientific reports

authors： Morra ME,Kien ND,Elmaraezy A,Abdelaziz OAM,Elsayed AL,Halhouli O,Montasr AM,Vu TL,Ho C,Foly AS,Phi AP,Abdullah WM,Mikhail M,Milne E,Hirayama K,Huy NT

更新日期：2017-11-22 00:00:00

abstract：:Clouds play a major role in the climate system, but large uncertainties remain about their decadal variations. Here we report a widespread decrease in cloud cover since the 1970 s over the Mediterranean region, in particular during the 1970 s-1980 s, especially in the central and eastern areas and during springtime. C...

journal_title：Scientific reports

authors： Sanchez-Lorenzo A,Enriquez-Alonso A,Calbó J,González JA,Wild M,Folini D,Norris JR,Vicente-Serrano SM

更新日期：2017-02-02 00:00:00

abstract：:Primary cultured cardiomyocytes show spontaneous Ca2+ oscillations (SCOs) which not only govern contractile events, but undergo derangements that promote arrhythmogenesis through Ca2+ -dependent mechanism. We systematically examined influence on SCOs of an array of ion channel modifiers by recording intracellular Ca2+...

journal_title：Scientific reports

authors： Li X,Shen L,Zhao F,Zou X,He Y,Zhang F,Zhang C,Yu B,Cao Z

更新日期：2017-01-19 00:00:00

abstract：:Nitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1-100 nm length scales. However, the spectral linewidth is typically limited to the kHz level, both by the NV sensor coherence time and ...

journal_title：Scientific reports

authors： Schwartz I,Rosskopf J,Schmitt S,Tratzmiller B,Chen Q,McGuinness LP,Jelezko F,Plenio MB

更新日期：2019-05-06 00:00:00

abstract：:Carbonic anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repe...

journal_title：Scientific reports

authors： Ferreira-Martins D,McCormick SD,Campos A,Lopes-Marques M,Osório H,Coimbra J,Castro LF,Wilson JM

更新日期：2016-10-05 00:00:00

abstract：:The elemental two-dimensional (2D) materials such as graphene, silicene, germanene, and black phosphorus have attracted considerable attention due to their fascinating physical properties. Structurally they possess the honeycomb or distorted honeycomb lattices, which are composed of six-atom rings. Here we find a new ...

journal_title：Scientific reports

authors： Li P,Luo W

更新日期：2016-05-06 00:00:00

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:Spirometry is required to confirm a chronic obstructive pulmonary disease (COPD) diagnosis, but it is difficult to perform in resource-limited settings. This study aimed to evaluate symptom-based questions for screening of individuals with COPD among Chinese populations. We recruited 3969 adult subjects from the First...

journal_title：Scientific reports

authors： Zhang Q,Wang M,Li X,Wang H,Wang J

更新日期：2016-07-26 00:00:00

abstract：:Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Cav1.2 have been implicated in arrhythmic syndromes. We screened patients with Brugada syndrome, short QT syndrome, early repolarisation syndrome, and idiopathic ventricular fibrillation to determine the frequency and ...

journal_title：Scientific reports

authors： Blancard M,Debbiche A,Kato K,Cardin C,Sabrina G,Gandjbakhch E,Probst V,Haissaguerre M,Extramiana F,Hocini M,Olivier G,Leenhardt A,Guicheney P,Rougier JS

更新日期：2018-10-02 00:00:00

abstract：:Gene set enrichment analysis (GSEA) associates gene sets and phenotypes, its use is predicated on the choice of a pre-defined collection of sets. The defacto standard implementation of GSEA provides seven collections yet there are no guidelines for the choice of collections and the impact of such choice, if any, is un...

journal_title：Scientific reports

authors： Bateman AR,El-Hachem N,Beck AH,Aerts HJ,Haibe-Kains B

更新日期：2014-02-13 00:00:00

abstract：:Early ontogenetic periods and postnatal maturation in organisms are sex-specifically sensitive to hypothalamic-pituitary-adrenal (HPA)-axis activities, related glucocorticoid secretions, and their effects on energy balance and homeostasis. Dietary polyunsaturated (PUFAs) and saturated (SFAs) fatty acids potentially pl...

journal_title：Scientific reports

authors： Nemeth M,Millesi E,Schuster D,Quint R,Wagner KH,Wallner B

更新日期：2018-01-11 00:00:00

abstract：:The rare-earth monopnictide family is attracting an intense current interest driven by its unusual extreme magnetoresistance (XMR) property and the potential presence of topologically non-trivial surface states. The experimental observation of non-trivial surface states in this family of materials are not ubiquitous. ...

journal_title：Scientific reports

authors： Hosen MM,Dhakal G,Wang B,Poudel N,Singh B,Dimitri K,Kabir F,Sims C,Regmi S,Neff W,Sarkar AB,Agarwal A,Murray D,Weickert F,Gofryk K,Pavlosiuk O,Wiśniewski P,Kaczorowski D,Bansil A,Neupane M

更新日期：2020-07-31 00:00:00

abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

journal_title：Scientific reports

authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

更新日期：2020-11-26 00:00:00

abstract：:Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...

journal_title：Scientific reports

authors： Tsou LK,Yeh SH,Ueng SH,Chang CP,Song JS,Wu MH,Chang HF,Chen SR,Shih C,Chen CT,Ke YY

更新日期：2020-10-08 00:00:00

abstract：:We hereby report for the first time on the design, manufacturing and testing of a three-dimensional (3D) nearly-periodic, locally resonant phononic crystal (PnC). Most of the research effort on PnCs and metamaterials has been focused on the enhanced dynamic properties arising from their periodic design. Lately, additi...

journal_title：Scientific reports

authors： Meng H,Bailey N,Chen Y,Wang L,Ciampa F,Fabro A,Chronopoulos D,Elmadih W

更新日期：2020-11-04 00:00:00