Comparison of platelet-rich plasma and inverted internal limiting membrane flap for the management of large macular holes: A pilot study.

Abstract:

Purpose:To compare the safety and efficacy of 25-gauge pars plana vitrectomy (PPV) with either platelet-rich plasma (PRP) or inverted internal limiting membrane (ILM) flap for the treatment of large macular hole. Methods:Pseudophakic patients with idiopathic macular holes with a minimum diameter (MD) of 600-1500 μm were randomized into two groups (30 patients each): 25-gauge PPV with either inverted ILM flap (group A) or PRP (group B). Results:Mean MD in groups A and B were 803.33 ± 120.65 μm and 784.73 ± 120.10 μm, respectively (P = 0.552). Mean base diameter in groups A and B was 1395.17 ± 240.57 μm and 1486.90 ± 281.61 μm, respectively (P = 0.180). The median presenting best-corrected visual acuity (BCVA) was logMAR 0.78 (range 0.78-1.00) and logMAR 0.78 (Range 0.60-1.00) in groups A and B, respectively (P = 0.103). Anatomical closure was achieved in 90% (n = 27/30) and 93.3% (n = 28/30) eyes in groups A and B, respectively (P = 0.158). Type 1 closure was achieved in 76.7% (n = 23/30) and 83.3% (n = 25/30) eyes in groups A and B, respectively. Median BCVA at postoperative 3-month in groups A and B was logMAR 0.60 (range 0.48-0.60) and logMAR 0.60 (range 0.48-0.78), respectively (P = 0.312). The average visual improvement was 2.0 and 2.5 early treatment diabetic retinopathy study (ETDRS) lines in groups A and B, respectively (P = 0.339). None of the patients developed postoperative exaggerated inflammatory reactions. Conclusion:Using platelets for the treatment of large macular holes is as safe and effective as an inverted ILM flap.

journal_name

Indian J Ophthalmol

authors

Babu N,Kohli P,Ramachandran NO,Adenuga OO,Ahuja A,Ramasamy K

doi

10.4103/ijo.IJO_1357_19

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

880-884

issue

5

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2020_68_5_880_282928

journal_volume

68

pub_type

杂志文章
  • Ocular and orbital metastasis from systemic malignancies.

    abstract::One hundred and seventy adult patients and one hundred and forty-eight children with systemic malignancies were examined for ocular and/or orbital metastases. Thirty-six patients (11.3%) had intraocular and/or orbital metastasis. Twenty-nine of the 36 patients (80.5%) had orbital metastasis, five patients (13.9%) had ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Jain IS,Dinesh K,Mohan K

    更新日期:1987-01-01 00:00:00

  • Evaluation of corneal topography and tomography in fellow eyes of unilateral keratoconus patients for early detection of subclinical keratoconus.

    abstract:Purpose:To analyse topographic and tomographic changes in fellow eyes of unilateral keratoconus patients by comparing them with normal eyes. Methods:This five-year retrospective observational comparative case study included 15 advanced keratoconus eyes of unilateral keratoconus (KCN group), 15 normal fellow eyes of un...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_2129_19

    authors: Thulasidas M,Teotia P

    更新日期:2020-11-01 00:00:00

  • Facilitating factors in overcoming barriers to cataract surgical services among the bilaterally cataract blind in Southern India: A cross-sectional study.

    abstract:Purpose:To effectively address cataract blindness, increasing sight-restoring surgeries among the bilaterally blind are essential. To improve uptake of surgical services among this group, evidence regarding the problems of access is vital. Barriers in accessing eye care services have previously been reported but not sp...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_216_18

    authors: Amritanand A,Jasper S,Paul P,Kuriakose T

    更新日期:2018-07-01 00:00:00

  • Community care for diabetic retinopathy and glaucoma in India: A panel discussion.

    abstract::Diabetic retinopathy (DR) and glaucoma are emerging causes of blindness and visual impairment in India and the world. Both diseases do not have any early warning symptoms, and once the symptoms appear, the diseases are reasonably advanced. Because of the long-standing nature of the diseases, one cannot adopt the catar...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.4103/ijo.IJO_910_17

    authors: Rani PK,Nangia V,Murthy KR,Khanna RC,Das T

    更新日期:2018-07-01 00:00:00

  • Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions.

    abstract:PURPOSE:To determine the association of demographics, leprosy and ocular characteristics with altered levels of lactoferrin in the tears of normal subjects and leprosy patients, and to detect the presence of antibodies to lactoferrin in these tear samples. METHOD:We collected light-stimulated tears from 298 leprosy pa...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Daniel E,Duriasamy M,Ebenezer GJ,Shobhana,Job CK

    更新日期:2004-03-01 00:00:00

  • Clinical presentations and comparative outcomes of primary versus deferred intraocular lens explantation in delayed-onset endophthalmitis.

    abstract:Purpose:To describe clinical presentations and comparative outcomes of primary versus deferred intraocular lens (IOL) explantation in delayed-onset endophthalmitis. Methods:In this retrospective study, a total of 77 eyes of 77 patients that were diagnosed clinically as delayed-onset endophthalmitis and underwent IOL e...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1494_18

    authors: Dave VP,Pathengay A,Sharma S,Govindhari V,Karolia R,Pappuru RR,Das T

    更新日期:2019-07-01 00:00:00

  • Management of dislocated transscleral fixated intraocular lens with one-side broken polypropylene suture.

    abstract::This video demonstrates the successful surgical technique for refixation of the same intraocular lens (IOL) by tying the same IOL to the sclera with the help of 9-0 polypropylene suture. A 62-year-old male patient presented with sudden loss of vision in the left eye. He had a history of undergoing transscleral fixatio...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1512_19

    authors: Tigari B,Moharana B,Dogra M,Singh SR,Singh A,Ravikumar B,Singh R

    更新日期:2020-06-01 00:00:00

  • Culture-positive unilateral panophthalmitis in a serology-positive case of dengue hemorrhagic fever.

    abstract::Dengue fever, a mosquito-borne disease commonly found in the tropics, is one of the most prevalent forms of Flavivirus infection in humans. Symptomatically, it is characterized by fever, arthralgia, headache, and rash. Ophthalmic manifestations can involve both the anterior and posterior segment. Panophthalmitis is ra...

    journal_title:Indian journal of ophthalmology

    pub_type:

    doi:10.4103/ijo.IJO_113_18

    authors: Kamal R,Shah D,Sharma S,Janani MK,Kar A,Saurabh K,Roy R,Madhavan HNR

    更新日期:2018-07-01 00:00:00

  • Diurnal variation of central corneal thickness and intraocular pressure in eyes with pseudoexfoliation.

    abstract:Purpose:Pseudoexfoliation syndrome (PXS) is an age related microfibrillopathy characterized by deposition of whitish flaky material over various ocular tissues. PXS eyes are known to have thinner corneas and thus can lead to an underestimation in intraocular pressure measurement. The purpose of this study was to find i...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1899_18

    authors: Syed Z,Srikanth K,Nagarajan S

    更新日期:2019-10-01 00:00:00

  • Retinitis as the presenting feature of subacute sclerosing panencephalitis in an Indian male: A case report.

    abstract::Measles virus is a rare but important cause for acute retinitis as it can eventually lead to the fulminant complication of SSPE. We report a case of a young Indian male with acute viral retinitis who subsequently developed SSPE. It is of paramount importance to consider measles virus and SSPE as a cause in an immunoco...

    journal_title:Indian journal of ophthalmology

    pub_type:

    doi:10.4103/ijo.IJO_251_18

    authors: Shah A,Babu R,Biswas J

    更新日期:2018-10-01 00:00:00

  • Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing.

    abstract:PURPOSE:The purpose of this study was to compare screening methods for the early detection of maculopathy in patients treated with chloroquine (CQ) or hydroxychloroquine (HCQ) and to identify the risk factors for the development of toxic maculopathy. METHODS:We performed a prospective study of all 217 patients taking ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/0301-4738.195018

    authors: Kunavisarut P,Chavengsaksongkram P,Rothova A,Pathanapitoon K

    更新日期:2016-10-01 00:00:00

  • What the comprehensive economics of blindness and visual impairment can help us understand.

    abstract::Since the year 2000, the amount written about the economics of blindness and visual impairment has increased substantially. In some cases, the studies listed under this heading are calculations of the costs related to vision impairment and blindness at a national or global level; in other cases the studies examine the...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.4103/0301-4738.100535

    authors: Frick KD

    更新日期:2012-09-01 00:00:00

  • Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: ten year data from a tertiary care center in a developing country.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is an important cause of childhood blindness in developing countries. AIM:To report the spectrum of ROP and associated risk factors in babies weighing > 1250 g at birth in a developing country. SETTING AND DESIGN:Institutional, retrospective, non-randomized, observational c...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/0301-4738.33817

    authors: Vinekar A,Dogra MR,Sangtam T,Narang A,Gupta A

    更新日期:2007-09-01 00:00:00

  • Assessment of diabetic retinopathy in type 1 diabetes in a diabetes care center in South India-Feasibility and awareness improvement study.

    abstract::The prevalence of youth-onset diabetes, both type 1 diabetes (T1D) and young-onset type 2 diabetes (YT2D) are gradually increasing in India. Early and repetitive screening for diabetic retinopathy (DR) is essential to provide timely management, and thereby prevent visual impairment due to the silent sight-threatening ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1851_19

    authors: Rajalakshmi R,Shanthirani CS,Anandakumar A,Anjana RM,Murthy GVS,Gilbert C,Mohan V

    更新日期:2020-02-01 00:00:00

  • Neuroprotection in glaucoma.

    abstract::Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells and their axons. Recent evidence suggests that intraocular pressure (IOP) is only one of the many risk factors for this disease. Current treatment options for this disease have been limited to the reduction of IOP; however, it is c...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.4103/0301-4738.73700

    authors: Vasudevan SK,Gupta V,Crowston JG

    更新日期:2011-01-01 00:00:00

  • Choroidal thickness in normal Indian eyes using swept-source optical coherence tomography.

    abstract:Purpose:The purpose of this study is to provide normative database for subfoveal choroidal thickness in Indian eyes using swept-source optical coherence tomography. Methods:This is a cross-sectional study based at a tertiary eye care center in Northern India. Two hundred and thirty eight eyes of 119 healthy subjects w...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_668_18

    authors: Bhayana AA,Kumar V,Tayade A,Chandra M,Chandra P,Kumar A

    更新日期:2019-02-01 00:00:00

  • Effect of fluidics on corneal endothelial cell density, central corneal thickness, and central macular thickness after phacoemulsification with torsional ultrasound.

    abstract:AIM:To study the relative effects of high and low fluidic parameters on endothelial cell density (ECD), central corneal thickness (CCT), and central macular thickness (CMT) after phacoemulsification with torsional ultrasound. SETTINGS AND DESIGN:Prospective, randomized clinical trial based on a tertiary eye hospital. ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,随机对照试验

    doi:10.4103/0301-4738.169786

    authors: Das S,Nanaiah SG,Kummelil MK,Nagappa S,Shetty R,Shetty BK

    更新日期:2015-08-01 00:00:00

  • Cost-effectiveness of screening for open angle glaucoma in developed countries.

    abstract::As all developed countries are struggling with health care costs growing too large and too fast, the current performance and overburden of glaucoma services demand a reappraisal of current management strategies. The performance of the glaucoma care in western countries offers several opportunities to improve the simul...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/0301-4738.73684

    authors: Tuulonen A

    更新日期:2011-01-01 00:00:00

  • Correlation between the pressure-to-cornea index and both structural and functional measures of glaucoma.

    abstract:PURPOSE:the pressure-to-cornea index (PCI) was proposed in order to integrate intraocular pressure and central cornea thickness as a single-risk factor for glaucoma. The purpose of this study was to correlate the PCI with a structural and two functional measures of glaucoma. SETTING:University Hospital in South Americ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/0301-4738.143924

    authors: Franco AM,Kasahara N

    更新日期:2014-09-01 00:00:00

  • Trash to treasure Retcam.

    abstract::Digital fundus imaging is being used in diagnosis, documentation, and sharing of many retinal diseases and hence forms an essential part of ophthalmology. The use of smartphones for the same has been ever increasing. There is a need for simpler devices to couple the 20D lens and smartphone so as to take fundus photogr...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1524_18

    authors: Chandrakanth P,Ravichandran R,Nischal NG,Subhashini M

    更新日期:2019-04-01 00:00:00

  • Lipemia retinalis in a 27 day old neonate: A case report.

    abstract::Familial combined hyperlipidemia, which presents as hypercholesterolemia or hypertriglyceridemia, is the commonest form of genetic hyperlipidemia and is associated with premature coronary artery disease. This is a rare case report of a 27 day-old neonate born out of a third-degree consanguineous marriage, with grade I...

    journal_title:Indian journal of ophthalmology

    pub_type:

    doi:10.4103/ijo.IJO_1310_18

    authors: Shinkre ND,Usgaonkar UPS

    更新日期:2019-06-01 00:00:00

  • The evaluation of intraocular pressure fluctuation in glaucoma subjects during submaximal exercise using an ocular telemetry sensor.

    abstract:Purpose:To evaluate the effect of acute submaximal exercise on intraocular pressure (IOP) fluctuations in open-angle glaucoma (OAG) subjects using an ocular telemetry sensor (OTS, Sensimed TriggerFish®). Methods:Twelve OAG subjects aged 45-65 years with no medical limitation for exercise were included in this prospect...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_585_18

    authors: Bozkurt B,Okudan N,Belviranli M,Oflaz AB

    更新日期:2019-01-01 00:00:00

  • Optical coherence tomography angiography-based analysis of intrinsic vasculature in juxtapapillary melanoma after ruthenium-106 plaque brachytherapy.

    abstract::In this case report, we demonstrate the use of optical coherence tomography angiography (OCTA) as a tool to evaluate intrinsic vasculature in a case of juxtapapillary melanoma which underwent ruthinium.106 plaque brachytherapy. In this case, OCTA could demonstrate a decrease in caliber and density of the intrinsic vas...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_1928_18

    authors: Shanmugam PM,Konana VK,Ramanjulu R,Mishra KCD,Sagar P,Kumar D

    更新日期:2019-12-01 00:00:00

  • An experimental study to evaluate safety/toxicity of intravitreal natalizumab.

    abstract:Purpose:The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab). Methods:Twelve New Zealand albino rabbits were divided into three groups (n = 4). Unilateral intravitreal injections of three different ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_425_18

    authors: Chawla R,Nath M,Moksha L,Nag TC,Velpandian T

    更新日期:2018-10-01 00:00:00

  • Posterior polar annular and hemispheric choroidal and retinal dystrophy: Optical coherence tomographic angiography description of a rare case.

    abstract::Posterior polar annual choroidal dystrophy is a rare disease which affects the retina and choroid in an annular pattern. Our patient was referred to us a case of atypical retinitis pigmentosa. Fundus examination showed a normal optic disc, normal arterioles, and no bone spicules. The right eye showed a hemispheric pat...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/ijo.IJO_367_18

    authors: Narayanan R

    更新日期:2018-12-01 00:00:00

  • Extrusion of hydrogel exoplant into upper eyelid 16 years after a scleral buckle procedure.

    abstract::Sixteen years after scleral buckle surgery with a hydrogel episcleral exoplant, a 43-year-old woman presented with progressive binocular diplopia, ptosis, and an expanding mass in her upper eyelid. She underwent surgical removal of the hydrogel exoplant through an anterior approach. The exoplant proved to be friable, ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:10.4103/0301-4738.81047

    authors: Shah CP,Garg SJ,Penne RB

    更新日期:2011-05-01 00:00:00

  • Orbital lymphoma: role of radiation.

    abstract::The purpose of this article is to review the literature for clinical presentation, treatment, outcome and complications of using radiotherapy for the treatment of orbital lymphoma. For this, MEDLINE, EMBASE, and the Cochrane Library were searched through January 2007 for published data on primary non-Hodgkin's lymphom...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.4103/0301-4738.44516

    authors: Yadav BS,Sharma SC

    更新日期:2009-03-01 00:00:00

  • Itraconazole therapy for fungal keratitis.

    abstract::110 cases of keratomycosis were treated with itraconazole administered either orally or topically or by both routes. Excellent or moderate response was obtained in 69 percent of the patients. Ulcers due to Aspergillus and dematiaceous fungi and non-sevee ulcers responded better than did severe ulcers and ulcers due to...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Rajasekaran J,Thomas PA,Kalavathy CM,Joseph PC,Abraham DJ

    更新日期:1987-01-01 00:00:00

  • Pneumatic retinopexy: principles and practice.

    abstract::Pneumatic retinopexy (PR) is an alternative to scleral buckling for the surgical repair of selected retinal detachments. A gas bubble is injected into the vitreous cavity, and the patient is positioned so that the bubble closes the retinal break (s), allowing absorption of the subretinal fluid. Cryotherapy or laser ph...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:

    authors: Hilton GF,Das T,Majji AB,Jalali S

    更新日期:1996-09-01 00:00:00

  • Droplets on posterior surface of intraocular lens in silicone oil filled eye.

    abstract::Silicone oil adherence to silicone IOLs after silicone oil removal is a known complication in pseudophakic patients. Droplet removal is difficult and may require IOL exchange. We describe two cases in which silicone oil droplets were observed early in the postoperative period in PMMA pseudophakic eyes and disappeared ...

    journal_title:Indian journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Sharma Y,Sudan R,Gaur A

    更新日期:2003-06-01 00:00:00