Abstract：
BACKGROUND:Psoriasis is an inflammatory disease that is mostly immune-derived. It causes proliferation of skin cells, forming plaques. Psoriasis etiology is unknown. It might be multifactorial. AIMS:This work aimed to study Smad7 expression in psoriasis vulgaris patients in comparison with normal skin. PATIENTS/METHODS:Thirty patients with psoriasis vulgaris in comparison with 20 age- and sex-matched seemingly healthy individuals were selected. We used psoriasis area and severity index (PASI) to evaluate psoriasis severity. Skin biopsies were prepared from skin lesions (30), perilesions (30) and control (20) groups for histopathological and immunostaining evaluation of Smad7. RESULTS:Smad7 was progressively upregulated in proliferating keratinocytes from controls (58.18 ± 30.93) to perilesional (106 ± 38.93) and lesional (156.33 ± 62.01) skin (P < .001). Also, dermal inflammatory cells showed upregulation of Smad7 expression from control skin (40 ± 28.28) to skin lesions (137.33 ± 73.86) (P < .010). Smad7 expression showed a positive significant correlation with psoriasis severity (r = .452; P < .012). CONCLUSION:Smad7 may be involved in increased keratinocyte proliferation as well as skin inflammation in psoriasis vulgaris patients.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Hemida AS,Hammam MA,Salman ATA,Shehata WAdoi
10.1111/jocd.13425subject
Has Abstractpub_date
2020-12-01 00:00:00pages
3395-3402issue
12eissn
1473-2130issn
1473-2165journal_volume
19pub_type
杂志文章abstract：BACKGROUND:Gender-related price inequalities for over-the-counter dermatologic products such as shampoos and conditioners, razors, deodorants, and lotions remain prevalent in the marketplace. This trend has also been found to apply to topical minoxidil, a common treatment for male and female pattern hair loss. OBJECTI...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12954
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Masseteric hypertrophy is a benign condition characterized by the enlargement of the masseter muscles. A square-shaped jawline due to masseter muscle prominence or hypertrophy is one of the general characteristics of the Asian face, making it a frequent target for esthetic treatment requests. While the appli...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.12721
更新日期：2018-10-01 00:00:00
abstract：:Cutaneous hypermelanoses are frequently encountered conditions that can have severe adverse psychosocial and emotional effects on affected patients. Melasma, postinflammatory hyperpigmentation, drug-induced pigmentation, and erythema dischromicum perstans are among the most common cutaneous disorders leading to acquir...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1473-2165.2006.00276.x
更新日期：2006-12-01 00:00:00
abstract：:In recent years, popularity of radiofrequency (RF) has increased significantly. They are characterized by a low risk of complications and relatively high effectiveness. RF use high-frequency currents causing oscillating motion of ions resulting in temperature rise stimulating skin regeneration processes. The aim of th...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12775
更新日期：2018-09-17 00:00:00
abstract：:Hydroquinone (HQ) has been used since the 1950s in commercially available over-the-counter skin lightener products and since the 1960s as a commercially available medical product. It is also used in cosmetic products such as hair dyes and products for coating finger nails. Beginning in 2001, HQ is no longer authorized...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1473-2165.2006.00253.x
更新日期：2006-09-01 00:00:00
abstract：:Recently, both doctors and patients pay particular attention to aesthetic medical services quality and efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis, and improving of botulinum toxin therapy quality and provide patients' orientation on the adjustment schedule, which include...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13584
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Pigmentary disorders are commonly seen in dermatology practice and can have a negative psychosocial impact on patients. OBJECTIVE:This study aims to examine the prevalence of pigmentary disorders and their level of psychological and physical impact on patients. METHODS:A prospective cohort study involved a...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2008.00384.x
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Numerous oncology patients who receive targeted therapy suffer from the skin adverse effects induced. Novel agents, that is tyrosine kinase inhibitors and RAS-RAF-MEK-ERK pathway, have given good results in patient survival while decreasing the systemic toxicities in comparison to conventional cytotoxic chem...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.13211
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. OBJECTIVES:To evaluate the effects of the topical EGF ointment on wou...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12691
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The demand for personalized skin care is increasing rapidly in recent years. In order to provide suitable products for different customers, an accurate assessment of the skin condition is required. It is necessary to establish a remote and convenient method for quantifying skin condition. MATERIALS AND METH...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13576
更新日期：2021-02-01 00:00:00
abstract：:We report the case of a woman who presented with several facial scars following a road accident. Treatment was carried out using combined laser treatment with pulsed dye laser (PDL) and Q-switched neodymium:yttrium-aluminum-garnet laser (QS Nd:YAG laser). No side effects or complications from treatment were noted or r...
journal_title：Journal of cosmetic dermatology
pub_type： 信件
doi：10.1111/j.1473-2165.2008.00394.x
更新日期：2008-09-01 00:00:00
abstract：:Chemical peeling, also known as chemoexfoliation or dermapeeling, is performed to improve the skin's appearance as it reduces the wrinkles caused by aging and the features of photoaged skin. Although the best results are obtained with deep peels, the medium-depth peels allow to obtain excellent results without the dan...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2005.40213.x
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Abobotulinum- toxin A is used extensively for the treatment of frown (glabellar) lines. AIMS:The aim of this study was to evaluate the efficacy and complications of a new injection technique and to assess the amount of satisfaction in patients with the frown lines. METHODS:This cross-sectional study was co...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12529
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Microdermabrasion is a nonchemical superficial resurfacing procedure that removes the stratum corneum. Because it is a somewhat subtle procedure, it may be difficult to demonstrate its cosmetic benefit. OBJECTIVES:To assess the efficacy of microdermabrasion in treatment of melasma, postacne scarring, striae...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12252
更新日期：2016-12-01 00:00:00
abstract：:We described-along with a genetic predisposition and exposure to sunlight, as the main factors for melasma development-pregnancy, hormonal therapies, and oral contraceptive pills. Whilst hormonal alteration or therapies are frequently reported in literature in association with melasma, studies analyzing the laboratori...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.12877
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Palmar hyperhidrosis (PH) can produce social and occupational difficulties and reduce the quality of life of those who suffer from this kind of problem. When dealing with focal hyperhidrosis, the patients' attitudes and their subjective approaches regarding the process may influence the objective evaluation ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2005.00304.x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Platelet-rich plasma is highly enriched plasma that contains a large concentration of platelets that secrete various growth factors and is used in a wide variety of surgical and cosmetic procedures, including hair regrowth and skin rejuvenation. METHODS:Microneedling therapy is being combined with platelet-...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12772
更新日期：2019-06-01 00:00:00
abstract：:Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.13752
更新日期：2020-09-30 00:00:00
abstract：BACKGROUND:Human skin aging is a multifactorial and complex biological process affecting the different skin constituents. Even if the skin aging mechanism is not yet fully unravelled is evident that epidermis loses the principal molecule responsible for binding and retaining water molecules, resulting in loss of skin m...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12120
更新日期：2014-12-01 00:00:00
abstract：:Today, most do not go a day without practicing or hearing about new hair removal methods. However, little is discussed about the history of hair removal and the development of most hair removal methods since the period of cavemen. Avoiding decapitation and fitting in with society are two of many reasons for the develo...
journal_title：Journal of cosmetic dermatology
pub_type： 历史文章,杂志文章
doi：10.1111/jocd.12021
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:The intracellular form of action of retinoids requires these agents to reach deeper layers of the skin with viable cells to ensure therapeutic efficiency. However, studies on swine skin models show that some retinoids have low skin permeability. Thus, the association of innovative formulations with technolog...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13826
更新日期：2020-11-03 00:00:00
abstract：BACKGROUND:Spasmodic senile entropion (SE) is characterized by the inward turning of the eyelid. SE typically occurs spontaneously, but sometimes after ocular surgery. As of today, it is still lacking a gold standard technique. AIMS:To report the results of 11 cases of involutional entropion of the lower lid successfu...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.12210
更新日期：2016-06-01 00:00:00
abstract：:The nail is the largest skin appendage. In addition to its important physiological and sensory functions, it is also of great esthetic importance. Complaints of brittle or soft nails are frequent, particularly among women. Innumerable preparations claiming to improve the nail quality are being sold; however, most have...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1473-2165.2006.00232.x
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Synthetic hair fiber implantation first achieved widespread use in the 1970s, but in 1983, the US Federal Drug Administration banned the fibers due to its complications. Currently available synthetic fibers consist of polyamide material, which has been claimed to be effective and safe. Nevertheless, its use ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13318
更新日期：2020-02-15 00:00:00
abstract：:Controversy exists as to whether topical antioxidants can be effective in protecting against and reversing photodamage to the skin. Topical vitamins C and E, as well as topical selenium, protect skin against sunburn, suntan and skin cancer and also reverse the mottled pigmentation and wrinkles of photoageing. However,...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2130.2004.00067.x
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Hair transplant procedure is a surgical procedure which affects the sensitivity of the scalp. OBJECTIVES:To compare scalp two-point discrimination (2PD) values in healthy controls and patients who had hair transplant surgery. PATIENTS/METHODS:The comparative study was conducted in 25 healthy individuals an...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13326
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Numerous fillers can be used for midface revolumization. While rheological data, physiochemical properties, and durability measured in clinical studies can inform selection, direct comparisons between equal volumes of different fillers are lacking. AIMS:To compare aesthetic improvement achieved with 3 cc of...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13881
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS:Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS:This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatr...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/jocd.12290
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low. Thus,...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13570
更新日期：2021-02-01 00:00:00
abstract：:Botulinum toxin type A is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It has been used extensively in the field of dermatology for the treatment of dynamic rhytides and in the treatment of hyperhidrosis. Botulinum toxin has an excellent safety profile and few s...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1473-2165.2006.00255.x
更新日期：2006-09-01 00:00:00
