Cognitive and physical impairment and the risk of stroke - A prospective cohort study.

abstract：:Chronic kidney disease (CKD) is a public health problem that increases the risk of cardiovascular morbidity and mortality. Heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction is a common cardiovascular complication of CKD. MicroRNA-212 (m...

journal_title：Scientific reports

authors： Sárközy M,Gáspár R,Zvara Á,Siska A,Kővári B,Szűcs G,Márványkövi F,Kovács MG,Diószegi P,Bodai L,Zsindely N,Pipicz M,Gömöri K,Kiss K,Bencsik P,Cserni G,Puskás LG,Földesi I,Thum T,Bátkai S,Csont T

更新日期：2019-02-04 00:00:00

abstract：:There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite thi...

journal_title：Scientific reports

authors： Smith EAK,Henthorn NT,Warmenhoven JW,Ingram SP,Aitkenhead AH,Richardson JC,Sitch P,Chadwick AL,Underwood TSA,Merchant MJ,Burnet NG,Kirkby NF,Kirkby KJ,Mackay RI

更新日期：2019-12-27 00:00:00

abstract：:In the present work, we introduce two new metrics i.e. hydrogen-bond strength and charge-transfer between the donor/acceptor water molecules as a measure of hydrogen-bond rearrangement dynamics. Further, we also employ a simple model based on energy flux through the donor-acceptor water pairs to quantify the extent of...

journal_title：Scientific reports

authors： Ojha D,Karhan K,Kühne TD

更新日期：2018-11-15 00:00:00

abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...

journal_title：Scientific reports

authors： Obana A,Gohto Y,Gellermann W,Ermakov IV,Sasano H,Seto T,Bernstein PS

更新日期：2019-06-27 00:00:00

abstract：:Widely regarded as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins. Projected changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, which will in turn lead to substantial changes in marine ...

journal_title：Scientific reports

authors： Fox L,Stukins S,Hill T,Miller CG

更新日期：2020-01-31 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in the transfer of biomolecules between cells. To elucidate the intercellular transfer fate of EVs in vivo, we generated a new transgenic (Tg) rat model using green fluorescent protein (GFP)-tagged human CD63. CD63 protein is highly enriched on EV membranes via traff...

journal_title：Scientific reports

authors： Yoshimura A,Kawamata M,Yoshioka Y,Katsuda T,Kikuchi H,Nagai Y,Adachi N,Numakawa T,Kunugi H,Ochiya T,Tamai Y

更新日期：2016-08-19 00:00:00

abstract：:Free-living animals must make dietary choices in terms of chemical and physical properties, depending on their digestive physiology and availability of food resources. Here we comprehensively evaluated the dietary choices of proboscis monkeys (Nasalis larvatus) consuming young leaves. We analysed the data for leaf tou...

journal_title：Scientific reports

authors： Matsuda I,Clauss M,Tuuga A,Sugau J,Hanya G,Yumoto T,Bernard H,Hummel J

更新日期：2017-02-17 00:00:00

abstract：:Controlling light and heat via metamaterials has presented interesting technological applications using transformation optics (TO) and transformation thermodynamics (TT). However, such devices are commonly mono-physics and mono-purpose, because the used metamaterial is designed to deal with one type of physical mechan...

journal_title：Scientific reports

authors： Barros WKP,Pereira E

更新日期：2018-07-30 00:00:00

abstract：:Elymus nutans is an herbaceous plant that can be used to restore degraded alpine and subalpine ecosystems. Here, we evaluated how sowing density affects soil reinforcement and slope stabilization properties of vegetation-concrete structures. To investigate the optimal sowing density of E. nutans in vegetation-concrete...

journal_title：Scientific reports

authors： Tan X,Huang Y,Xiong D,Lv K,Chen F

更新日期：2020-11-24 00:00:00

abstract：:Despite the importance of urban trees, their growth reaction to climate change and to the urban heat island effect has not yet been investigated with an international scope. While we are well informed about forest growth under recent conditions, it is unclear if this knowledge can be simply transferred to urban enviro...

journal_title：Scientific reports

authors： Pretzsch H,Biber P,Uhl E,Dahlhausen J,Schütze G,Perkins D,Rötzer T,Caldentey J,Koike T,Con TV,Chavanne A,Toit BD,Foster K,Lefer B

更新日期：2017-11-13 00:00:00

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:Cancer dissemination is initiated by the movement of cells into the vasculature which has been reported to be triggered by EMT (epithelial to mesenchymal transition). Cellular dissemination also requires proteases that remodel the extracellular matrix. The protease, plasmin is a prominent player in matrix remodeling a...

journal_title：Scientific reports

authors： Bydoun M,Sterea A,Weaver ICG,Bharadwaj AG,Waisman DM

更新日期：2018-09-20 00:00:00

abstract：:FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory ...

journal_title：Scientific reports

authors： Cejas RB,Ferguson DC,Quiñones-Lombraña A,Bard JE,Blanco JG

更新日期：2019-06-17 00:00:00

abstract：:Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying the genes that regulate the TS network is one of the main challenges in understanding its aetiology. Here, we studied the regulatory network from manually curated genes reported in the literatu...

journal_title：Scientific reports

authors： Farooqui A,Tazyeen S,Ahmed MM,Alam A,Ali S,Malik MZ,Ali S,Ishrat R

更新日期：2018-07-04 00:00:00

abstract：:Quantitative reverse transcription PCR (RT-qPCR) is one of the most efficient, reliable and widely used techniques to quantify gene expression. In this study, we evaluated the performance of six southern corn rootworm, Diabrotica undecimpunctata howardi (Barber), housekeeping genes (HKG), β-actin (Actin), β-tubulin (T...

journal_title：Scientific reports

authors： Basu S,Pereira AE,Pinheiro DH,Wang H,Valencia-Jiménez A,Siegfried BD,Louis J,Zhou X',Vélez AM

更新日期：2019-07-24 00:00:00

abstract：:Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic I...

journal_title：Scientific reports

authors： Kérourédan O,Ribot EJ,Fricain JC,Devillard R,Miraux S

更新日期：2018-10-25 00:00:00

abstract：:Rumen microbiota is of paramount importance for ruminant digestion efficiency as the microbial fermentations supply the host animal with essential sources of energy and nitrogen. Early separation of newborns from the dam and distribution of artificial milk (Artificial Milking System or AMS) could impair rumen microbia...

journal_title：Scientific reports

authors： Chaucheyras-Durand F,Ameilbonne A,Auffret P,Bernard M,Mialon MM,Dunière L,Forano E

更新日期：2019-12-16 00:00:00

abstract：:Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of t...

journal_title：Scientific reports

authors： Forkert ECO,Moraes ACF,Carvalho HB,Manios Y,Widhalm K,González-Gross M,Gutierrez A,Kafatos A,Censi L,De Henauw S,Moreno LA

更新日期：2019-04-23 00:00:00

abstract：:Peritoneal fibrosis (PF) is a severe complication of peritoneal dialysis, but there are few effective therapies for it. Recent studies have revealed a new biological function of trehalose as an autophagy inducer. Thus far, there are few reports regarding the therapeutic effects of trehalose on fibrotic diseases. There...

journal_title：Scientific reports

authors： Miyake T,Sakai N,Tamai A,Sato K,Kamikawa Y,Miyagawa T,Ogura H,Yamamura Y,Oshima M,Nakagawa S,Sagara A,Shinozaki Y,Toyama T,Kitajima S,Hara A,Iwata Y,Shimizu M,Furuichi K,Kaneko S,Wada T

更新日期：2020-08-31 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...

journal_title：Scientific reports

authors： Zhu J,Zhang T,Cao L,Li A,Zheng K,Zhang N,Su B,Chen Z,Chen N,Wu H,He Q

更新日期：2017-09-29 00:00:00

abstract：:The high density nucleation of α-Al2O3 nanocrystallites was observed by rapid heating of the aluminum formate hydroxide-based precursor powder at 1200 °C for 50 s. The nucleation of α-Al2O3 nanocrystallites with less 10 nm in size from high purity aluminum oxide matrix has not been observed to our knowledge. Based on ...

journal_title：Scientific reports

authors： Yoshida M,Kato Y,Oumi Y,Sakurada O,Tanaka M,Wada M,Kitaoka S

更新日期：2019-10-17 00:00:00

abstract：:The Plasmodium life cycle within the mosquito involves the gamete, zygote, motile ookinete, and the oocyst stage that supports sporogony and sporozoite formation. We mapped the P. falciparum transcriptome as the parasite progresses through the oocyst stage of development on days 2, 4, 6, and 8 post-P. falciparum infec...

journal_title：Scientific reports

authors： Oakley MS,Verma N,Myers TG,Zheng H,Locke E,Morin MJ,Tripathi AK,Mlambo G,Kumar S

更新日期：2018-08-01 00:00:00

abstract：:Cytochrome P450 monooxygenases (P450s) are heme-thiolate proteins whose role as drug targets against pathogens, as well as in valuable chemical production and bioremediation, has been explored. In this study we performed comprehensive comparative analysis of P450s in 13 newly explored oomycete pathogens. Three hundred...

journal_title：Scientific reports

authors： Sello MM,Jafta N,Nelson DR,Chen W,Yu JH,Parvez M,Kgosiemang IKR,Monyaki R,Raselemane SC,Qhanya LB,Mthakathi NT,Sitheni Mashele S,Syed K

更新日期：2015-07-01 00:00:00

abstract：:The recently evolved field of synthetic biology has revolutionized the way we think of biology as an "engineerable" discipline. The newly sprouted branch is constantly in need of simple, cost-effective and automatable DNA-assembly methods. We have developed a reliable DNA-assembly system, ZeBRα (Zero-Background Redα),...

journal_title：Scientific reports

authors： Richter D,Bayer K,Toesko T,Schuster S

更新日期：2019-02-27 00:00:00

abstract：:Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...

journal_title：Scientific reports

authors： Sharma AK,Leppla SH,Pomerantsev AP,Shiloach J

更新日期：2018-10-31 00:00:00

abstract：:Human platelet antigens (HPAs) are membranous glycoproteins considered as alloantigens due to their polymorphisms. HPA-incompatibility in multiple pregnancies or blood transfusion can induce the development of alloantibodies leading to thrombocytopenia. The frequency of HPAs varies among populations, so that deep know...

journal_title：Scientific reports

authors： Kazemi MH,Malakootikhah F,Momeni-Varposhti Z,Falak R,Delbandi AA,Tajik N

更新日期：2020-05-04 00:00:00

abstract：:DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regul...

journal_title：Scientific reports

authors： Fields BD,Kennedy S

更新日期：2019-06-21 00:00:00

abstract：:The prevalence and the distribution characteristics of corneal astigmatism (CA) and anterior segment biometry before surgery in Chinese congenital cataract (CC) patients are not completely understood. This study involved 400 CC patients from the Zhongshan Ophthalmic Center enrolled from February 2011 to August 2015. D...

journal_title：Scientific reports

authors： Lin D,Chen J,Liu Z,Wu X,Long E,Luo L,Lin Z,Li X,Zhang L,Chen H,Liu J,Chen W,Lin H,Liu Y

更新日期：2016-02-25 00:00:00

abstract：:There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present stu...

journal_title：Scientific reports

authors： Khan M,Jabeen N,Khan T,Hussain HMJ,Ali A,Khan R,Jiang L,Li T,Tao Q,Zhang X,Yin H,Yu C,Jiang X,Shi Q

更新日期：2018-03-21 00:00:00

abstract：:The CRISPR-Cas9 system has a potential for wide application in organisms that particularly present low homologous integration rates. In this study, we developed three different methods using this system to replace a gene through homology-directed repair in the plant pathogenic fungus Colletotrichum sansevieriae, which...

journal_title：Scientific reports

authors： Nakamura M,Okamura Y,Iwai H

更新日期：2019-12-12 00:00:00