Testosterone replacement in hypogonadal men during inpatient rehabilitation following traumatic brain injury: Results from a double-blind, placebo-controlled clinical pilot study.

Abstract:

BACKGROUND:Endocrinopathy, including hypogonadism, is common following traumatic brain injury (TBI). Prior evidence suggests hypogonadism is associated with poorer function. OBJECTIVE:Determine the feasibility, safety, and efficacy of testosterone (T) therapy in hypogonadal men following TBI in acute rehabilitation. DESIGN:Randomized, double blind, placebo-controlled pilot trial. SETTING:Inpatient rehabilitation brain injury unit. PARTICIPANTS:Men ages 18 -65, post moderate to severe TBI receiving inpatient rehabilitation. INTERVENTIONS:Transdermal T gel or placebo. MAIN OUTCOME MEASURES:Revised FIM™ score, strength, adverse events. RESULTS:Of 498 screened, 70 participants were enrolled, and 22 meeting all criteria were randomized into placebo (n = 10) or physiologic T therapy (n = 12). There was no significant difference between groups in rate of improvement on the FIM™ (intercepts t = -0.31, p = 0.7593, or slopes t = 0.61, p = 0.5472). The Treatment group demonstrated the greatest absolute improvement in FIM™ scores and grip strength compared to Placebo or Normal T groups. There was no difference in adverse events between groups. Percentage of time with agitation or aggression was highest in the Placebo group. CONCLUSIONS:Although there were no significant differences in rates of recovery, treatment group subjects showed greater absolute functional and strength improvement compared to the Placebo or Normal T groups.

journal_name

NeuroRehabilitation

journal_title

NeuroRehabilitation

authors

Ripley DL,Gerber D,Pretz C,Weintraub AH,Wierman ME

doi

10.3233/NRE-192992

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

355-368

issue

3

eissn

1053-8135

issn

1878-6448

pii

NRE192992

journal_volume

46

pub_type

杂志文章,随机对照试验
  • Tutorial on maximum inspiratory and expiratory mouth pressures in individuals with idiopathic Parkinson disease (IPD) and the preliminary results of an expiratory muscle strength training program.

    abstract::Respiratory symptoms are recognized as sequelae of motor dysfunction in idiopathic Parkinson's disease (IPD) and these symptoms have the potential to cause problems with swallow, cough, voice and speech. Specifically, maneuvers that require rapid activation and coordination of upper airway and chest wall musculature b...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:

    authors: Silverman EP,Sapienza CM,Saleem A,Carmichael C,Davenport PW,Hoffman-Ruddy B,Okun MS

    更新日期:2006-01-01 00:00:00

  • A systematic review of assessment tools for adults used in traumatic brain injury research and their relationship to the ICF.

    abstract:BACKGROUND AND AIMS:Good assessment is an essential component of effective patient management. Yet the sheer volume of available assessment instruments presents a barrier for the clinician or researcher to (a) be knowledgeable about suitable measures and (b) keep up-to-date with new measures that are published. In orde...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,评审

    doi:10.3233/NRE-130898

    authors: Tate RL,Godbee K,Sigmundsdottir L

    更新日期:2013-01-01 00:00:00

  • Cognitive functioning following traumatic brain injury: A five-year follow-up.

    abstract:OBJECTIVE:To describe the long-term prevalence and severity of cognitive deficits following significant (i.e., ventilation required for >24 hours) traumatic brain injury. To assess a comprehensive range of cognitive functions using psychometric measures with established normative, reliability, and validity data. METHO...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-151297

    authors: Marsh NV,Ludbrook MR,Gaffaney LC

    更新日期:2016-01-01 00:00:00

  • Assessing the sensitivity and specificity of cognitive screening measures for people with Parkinson's disease.

    abstract:INTRODUCTION:While cognitive impairment is a recognised feature of Parkinson's disease (PD), few studies have evaluated the validity of brief cognitive screening measures compared to a comprehensive neuropsychological assessment. This studies aim was to evaluate the sensitivity and specificity of the Mini-Mental State ...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-182433

    authors: Foley T,McKinlay A,Warren N,Stolwyk RJ

    更新日期:2018-01-01 00:00:00

  • Depression following traumatic brain injury: Impact on post-hospital residential rehabilitation outcomes.

    abstract:BACKGROUND:A need exists to better understand the impact of depression on functional outcomes following TBI. OBJECTIVES:To evaluate the prevalence and severity of depression among a large group of chronic TBI adults; to determine the impact of depression on outcomes of post-hospital residential rehabilitation programs...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-161427

    authors: Lewis FD,Horn GJ

    更新日期:2017-01-01 00:00:00

  • Life expectancy for people with disabilities.

    abstract::This article reviews the literature on life expectancy in the disabled population. The literature is surveyed with regard to the main elements that reduce life expectancy for people with disabilities. These are immobility, cognitive and intellectual impairment, swallowing problems and tube feeding, epilepsy and incont...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,评审

    doi:10.3233/NRE-2010-0597

    authors: Thomas R,Barnes M

    更新日期:2010-01-01 00:00:00

  • Examination of validity in spoken language evaluations: Adult onset stuttering following mild traumatic brain injury.

    abstract:BACKGROUND:Reports of increased incidence of adult onset stuttering in veterans and service members with mild traumatic brain injury (mTBI) from combat operations in Iraq and Afghanistan lead to a reexamination of the neurogenic vs. psychogenic etiology of stuttering. OBJECTIVE:This article proposes to examine the mer...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-151230

    authors: Roth CR,Cornis-Pop M,Beach WA

    更新日期:2015-01-01 00:00:00

  • Effects of case management after brain injury: a systematic review.

    abstract:BACKGROUND:Adults who survive traumatic brain injury (TBI) often receive case (care) management to overcome the difficulties commonly faced negotiating a number of different health and social care services and systems. Little is known about the effectiveness of a case management intervention. OBJECTIVE:To examine the ...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,meta分析,评审

    doi:10.3233/NRE-141161

    authors: Lannin NA,Laver K,Henry K,Turnbull M,Elder M,Campisi J,Schmidt J,Schneider E

    更新日期:2014-01-01 00:00:00

  • Efficacy of self-perception after traumatic brain injury.

    abstract:BACKGROUND:Anosognosia is a lack of awareness of personal deficits that is commonly observed in people with a traumatic brain injury (TBI). OBJECTIVE:The purpose of this paper is to examine whether self-appraisal of executive functioning differs for students with and without TBI. METHODS:Students who had survived a T...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-161337

    authors: English M,St Pierre ME,Delahay A,Parente R

    更新日期:2016-06-13 00:00:00

  • Verbal fluency tests: Normative data for the Latin American Spanish speaking adult population.

    abstract:OBJECTIVE:To generate normative data for the Verbal Fluency Tests across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate. METHOD:The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemal...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-151279

    authors: Olabarrieta-Landa L,Rivera D,Galarza-Del-Angel J,Garza MT,Saracho CP,Rodríguez W,Chávez-Oliveros M,Rábago B,Leibach G,Schebela S,Martínez C,Luna M,Longoni M,Ocampo-Barba N,Rodríguez G,Aliaga A,Esenarro L,García de la Ca

    更新日期:2015-01-01 00:00:00

  • Caregiver burden, quality of life and walking ability in different disability levels of multiple sclerosis.

    abstract:BACKGROUND:The caregivers of Multiple Sclerosis (MS) individuals are usually burdened with a wide range of MS-related caregiving tasks which may result in damages of their daily life and quality of life (QOL). OBJECTIVES:This study was designed to compare according to the disability level (1) the walking ability, qual...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-131037

    authors: Ertekin Ö,Özakbaş S,İdiman E

    更新日期:2014-01-01 00:00:00

  • Impact of balance on functional independence after stroke: A cross-sectional study at rehabilitation settings in Nigeria.

    abstract:BACKGROUND:Functional independence is often compromised after stroke and its restoration is one of the goals of stroke rehabilitation. OBJECTIVE:This study assessed the impact of balance on functional independence after stroke. METHODS:Ninety-five stroke patients undergoing physical rehabilitation at two health insti...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-172305

    authors: Vincent-Onabajo G,Joseph E,Musa HY

    更新日期:2018-01-01 00:00:00

  • Inflammation and rehabilitation outcomes in patients with nontraumatic intracranial haemorrhage.

    abstract:BACKGROUND:Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS:We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-182362

    authors: Boselli M,Aquilani R,Maestri R,Achilli MP,Arrigoni N,Pasini E,Condino AM,Boschi F,Dossena M,Buonocore D,Verri M

    更新日期:2018-04-07 00:00:00

  • Ability of three motor measures to predict functional outcomes reported by stroke patients after rehabilitation.

    abstract:OBJECTIVE:This investigation examined the demographic characteristics along with 3 measures of motor function in determining outcomes in activities of daily living (ADL) after distributed constraint-induced therapy (dCIT). METHODS:The study recruited 69 stroke patients who received 3 weeks of dCIT for 2 hours daily, 5...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-2012-0755

    authors: Li KY,Lin KC,Wang TN,Wu CY,Huang YH,Ouyang P

    更新日期:2012-01-01 00:00:00

  • The current state of personal assistance services: implications for policy and future research.

    abstract::Personal assistant services (PAS) are designed to support persons with disabilities in their routine performance of activities of daily living (ADLs) and to provide individuals with disability the opportunity to go to school, volunteer, obtain active employment, and participate in social and recreational activities. P...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,评审

    doi:

    authors: Hagglund KJ,Clark MJ,Mokelke EK,Stout BJ

    更新日期:2004-01-01 00:00:00

  • The medical avatar and its role in neurorehabilitation and neuroplasticity: A review.

    abstract:BACKGROUND:One of the most interesting emerging medical devices is the medical avatar - a digital representation of the patient that can be used toward myriad ends, the full potential of which remains to be explored. Medical avatars have been instantiated as telemedical tools used to establish a representation of the p...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,评审

    doi:10.3233/NRE-203063

    authors: Mann J

    更新日期:2020-01-01 00:00:00

  • Demonstration of motor recovery process in a patient with intracerebral hemorrhage.

    abstract:OBJECTIVES:Little is known about the mechanism of motor recovery for patients with intracerebral hemorrhage (ICH). We attempted to demonstrate the motor recovery mechanism in a hemiparetic patient with ICH using diffusion tensor tractography (DTT), transcranial magnetic stimulation (TMS), and functional MRI (fMRI). SU...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:

    authors: Jang SH,Kim SH,Cho SH,Choi BY,Cho YW

    更新日期:2007-01-01 00:00:00

  • Acute effect of repeated passive motion exercise on shoulder position sense in patients with hemiplegia: a pilot study.

    abstract:OBJECTIVE:To determine the effect of repeated passive motion (RPM) exercise on position sense of the shoulder joint in patients with hemiplegia. METHODS:Shoulder flexion position sense was evaluated for the affected side of 15 patients with hemiplegia, using an assessment board set at five angles (30 degrees, 60 degre...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-2009-0504

    authors: Baek JH,Kim JW,Kim SY,Oh DW,Yoo EY

    更新日期:2009-01-01 00:00:00

  • Does additional exercise improve trunk function recovery in stroke patients? A meta-analysis.

    abstract:BACKGROUND:The restoration of trunk function following stroke is a key component of rehabilitation, however there is limited evidence of the efficacy of additional trunk training. OBJECTIVES:To evaluate the efficacy of trunk exercises added to conventional rehabilitation on functional outcomes. METHODS:Relevant rando...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,meta分析,评审

    doi:10.3233/NRE-141123

    authors: Sorinola IO,Powis I,White CM

    更新日期:2014-01-01 00:00:00

  • Effect of a 4-week period of unloaded leg cycling exercise on spasticity in multiple sclerosis.

    abstract::We conducted a small pilot study that examined the effect of a 4-week period of unloaded leg cycling on spasticity in individuals with multiple sclerosis (MS). The sample included 22 individuals with MS who were assigned using a quasi-experimental method into either exercise (n = 12) or control (n = 10) conditions. Th...

    journal_title:NeuroRehabilitation

    pub_type: 临床试验,杂志文章

    doi:10.3233/NRE-2009-0486

    authors: Sosnoff J,Motl RW,Snook EM,Wynn D

    更新日期:2009-01-01 00:00:00

  • Relation of executive functioning and social communication measures to functional outcomes following traumatic brain injury.

    abstract::Neuropsychologists are increasingly asked to provide recommendations regarding functional abilities based on test results, particularly within the rehabilitation setting. Yet, the empirical basis for making such recommendations is limited. The current study examines relationships between executive functioning and soci...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:

    authors: Struchen MA,Clark AN,Sander AM,Mills MR,Evans G,Kurtz D

    更新日期:2008-01-01 00:00:00

  • Age-related comparisons of people with multiple sclerosis: demographic, disease, and treatment characteristics.

    abstract:OBJECTIVE:To determine if the demographic characteristics and health care needs of younger people with MS differ from older people with MS. PARTICIPANTS:The study analyzed enrollment data from the NARCOMS Registry to compare 1,987 younger adults with MS (30 years and younger) to 29,245 other adults with MS (over 30 ye...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-2009-0525

    authors: Buchanan RJ,Chakravorty BJ,Tyry T,Hatcher W,Vollmer T

    更新日期:2009-01-01 00:00:00

  • Neuropsychological rehabilitation and quality of life in patients with cognitive impairments: a meta-analysis study in Spanish-speaking populations.

    abstract:OBJECTIVE:The purpose of this study is to conduct a meta-analysis on the effects of neuropsychological rehabilitation procedures on the quality of life in Spanish-speaking individuals with cognitive deficits. METHOD:Twenty four studies published during the last ten years were analyzed, and relevant information was ext...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,meta分析

    doi:10.3233/NRE-2012-0725

    authors: Guàrdia-Olmos J,Jarne Esparcia A,Urzua Morales A,Gudayol Ferré E

    更新日期:2012-01-01 00:00:00

  • Extracting neurophysiological signals reflecting users' emotional and affective responses to BCI use: A systematic literature review.

    abstract:BACKGROUND:Brain-computer interfaces (BCIs) allow persons with impaired mobility to communicate and interact with the environment, supporting goal-directed thinking and cognitive function. Ideally, a BCI should be able to recognize a user's internal state and adapt to it in real-time, to improve interaction. OBJECTIVE...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,meta分析,评审

    doi:10.3233/NRE-151266

    authors: Liberati G,Federici S,Pasqualotto E

    更新日期:2015-01-01 00:00:00

  • Action observation training for functional activities after stroke: a pilot randomized controlled trial.

    abstract:OBJECTIVE:The objective of this study was to compare the effects of action observation training and motor imagery training on recovery from chronic stroke. METHODS:Thirty patients who were more than six months post stroke participated in this study and were randomly allocated to three groups. The action observation tr...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/NRE-130991

    authors: Kim JH,Lee BH

    更新日期:2013-01-01 00:00:00

  • Effects of functional movement strength training on strength, muscle size, kinematics, and motor function in cerebral palsy: a 3-month follow-up.

    abstract::We investigated the long-term effects of comprehensive hand repetitive intensive strengthening training (CHRIST) on strength, morphological muscle size, kinematics, and associated motor functional changes in children with cerebral palsy (CP). Ten children (5 boys, 5 girls; age range, 6-11 years, mean age, 8.6 years) p...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-130846

    authors: Lee JA,You JH,Kim DA,Lee MJ,Hwang PW,Lee NG,Park JJ,Lee DR,Kim HK

    更新日期:2013-01-01 00:00:00

  • Effect of computer-based cognitive rehabilitation (CBCR) for people with stroke: a systematic review and meta-analysis.

    abstract:OBJECTIVE:We conducted a systematic review and meta-analysis to identify the effect of computer-based cognitive rehabilitation (CBCR) on improving cognitive functions in patients with stroke. METHODS:Researchers performed a literature search using computerized databases such as the Cochrane Database, EBSCO (CINAHL), P...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章,meta分析,收录出版,评审

    doi:10.3233/NRE-130856

    authors: Cha YJ,Kim H

    更新日期:2013-01-01 00:00:00

  • Cognitive rehabilitation: learning from experience and planning ahead.

    abstract::Cognitive rehabilitation has evolved to be a common clinical practice, despite questions regarding the scientific basis for its effectiveness. A selective interpretation of existing studies suggests that non-specific treatment factors play an important role in the efficacy of cognitive rehabilitation. Some future dire...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-1997-8103

    authors: Cicerone KD

    更新日期:1997-01-01 00:00:00

  • The functional assessment for control of trunk (FACT): An assessment tool for trunk function in stroke patients.

    abstract:BACKGROUND:The Functional Assessment for Control of Trunk (FACT) was developed to evaluate trunk function after stroke. However, only a few studies used FACT to show functional outcome. OBJECTIVE:This study aimed to validate the FACT predictive ability for functional outcome following stroke and create an English vers...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-201533

    authors: Sato K,Maeda K,Ogawa T,Shimizu A,Nagami S,Nagano A,Murotani K,Inoue T,Suenaga M

    更新日期:2021-01-01 00:00:00

  • The Safety Assessment Measure for persons with traumatic brain injury: Item pool development and content validity.

    abstract:BACKGROUND:Persons with moderate to severe TBI are at increased risk for unintentional injury or harm in the home and community; however, there is currently no standard measure of safety risk they face now and in the future. OBJECTIVE:To develop comprehensive and content valid scales and item pools for assessing safet...

    journal_title:NeuroRehabilitation

    pub_type: 杂志文章

    doi:10.3233/NRE-161369

    authors: Seel RT,Macciocchi S,Velozo CA,Shari K,Thompson N,Heinemann AW,Sander AM,Sleet D

    更新日期:2016-06-30 00:00:00