Abstract:
BACKGROUND:Endocrinopathy, including hypogonadism, is common following traumatic brain injury (TBI). Prior evidence suggests hypogonadism is associated with poorer function. OBJECTIVE:Determine the feasibility, safety, and efficacy of testosterone (T) therapy in hypogonadal men following TBI in acute rehabilitation. DESIGN:Randomized, double blind, placebo-controlled pilot trial. SETTING:Inpatient rehabilitation brain injury unit. PARTICIPANTS:Men ages 18 -65, post moderate to severe TBI receiving inpatient rehabilitation. INTERVENTIONS:Transdermal T gel or placebo. MAIN OUTCOME MEASURES:Revised FIM™ score, strength, adverse events. RESULTS:Of 498 screened, 70 participants were enrolled, and 22 meeting all criteria were randomized into placebo (n = 10) or physiologic T therapy (n = 12). There was no significant difference between groups in rate of improvement on the FIM™ (intercepts t = -0.31, p = 0.7593, or slopes t = 0.61, p = 0.5472). The Treatment group demonstrated the greatest absolute improvement in FIM™ scores and grip strength compared to Placebo or Normal T groups. There was no difference in adverse events between groups. Percentage of time with agitation or aggression was highest in the Placebo group. CONCLUSIONS:Although there were no significant differences in rates of recovery, treatment group subjects showed greater absolute functional and strength improvement compared to the Placebo or Normal T groups.
journal_name
NeuroRehabilitationjournal_title
NeuroRehabilitationauthors
Ripley DL,Gerber D,Pretz C,Weintraub AH,Wierman MEdoi
10.3233/NRE-192992subject
Has Abstractpub_date
2020-01-01 00:00:00pages
355-368issue
3eissn
1053-8135issn
1878-6448pii
NRE192992journal_volume
46pub_type
杂志文章,随机对照试验abstract::Respiratory symptoms are recognized as sequelae of motor dysfunction in idiopathic Parkinson's disease (IPD) and these symptoms have the potential to cause problems with swallow, cough, voice and speech. Specifically, maneuvers that require rapid activation and coordination of upper airway and chest wall musculature b...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Good assessment is an essential component of effective patient management. Yet the sheer volume of available assessment instruments presents a barrier for the clinician or researcher to (a) be knowledgeable about suitable measures and (b) keep up-to-date with new measures that are published. In orde...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-130898
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To describe the long-term prevalence and severity of cognitive deficits following significant (i.e., ventilation required for >24 hours) traumatic brain injury. To assess a comprehensive range of cognitive functions using psychometric measures with established normative, reliability, and validity data. METHO...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-151297
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:While cognitive impairment is a recognised feature of Parkinson's disease (PD), few studies have evaluated the validity of brief cognitive screening measures compared to a comprehensive neuropsychological assessment. This studies aim was to evaluate the sensitivity and specificity of the Mini-Mental State ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-182433
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:A need exists to better understand the impact of depression on functional outcomes following TBI. OBJECTIVES:To evaluate the prevalence and severity of depression among a large group of chronic TBI adults; to determine the impact of depression on outcomes of post-hospital residential rehabilitation programs...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-161427
更新日期:2017-01-01 00:00:00
abstract::This article reviews the literature on life expectancy in the disabled population. The literature is surveyed with regard to the main elements that reduce life expectancy for people with disabilities. These are immobility, cognitive and intellectual impairment, swallowing problems and tube feeding, epilepsy and incont...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-2010-0597
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Reports of increased incidence of adult onset stuttering in veterans and service members with mild traumatic brain injury (mTBI) from combat operations in Iraq and Afghanistan lead to a reexamination of the neurogenic vs. psychogenic etiology of stuttering. OBJECTIVE:This article proposes to examine the mer...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-151230
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Adults who survive traumatic brain injury (TBI) often receive case (care) management to overcome the difficulties commonly faced negotiating a number of different health and social care services and systems. Little is known about the effectiveness of a case management intervention. OBJECTIVE:To examine the ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-141161
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Anosognosia is a lack of awareness of personal deficits that is commonly observed in people with a traumatic brain injury (TBI). OBJECTIVE:The purpose of this paper is to examine whether self-appraisal of executive functioning differs for students with and without TBI. METHODS:Students who had survived a T...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-161337
更新日期:2016-06-13 00:00:00
abstract:OBJECTIVE:To generate normative data for the Verbal Fluency Tests across 11 countries in Latin America, with country-specific adjustments for gender, age, and education, where appropriate. METHOD:The sample consisted of 3,977 healthy adults who were recruited from Argentina, Bolivia, Chile, Cuba, El Salvador, Guatemal...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-151279
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The caregivers of Multiple Sclerosis (MS) individuals are usually burdened with a wide range of MS-related caregiving tasks which may result in damages of their daily life and quality of life (QOL). OBJECTIVES:This study was designed to compare according to the disability level (1) the walking ability, qual...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-131037
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Functional independence is often compromised after stroke and its restoration is one of the goals of stroke rehabilitation. OBJECTIVE:This study assessed the impact of balance on functional independence after stroke. METHODS:Ninety-five stroke patients undergoing physical rehabilitation at two health insti...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-172305
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS:We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-182362
更新日期:2018-04-07 00:00:00
abstract:OBJECTIVE:This investigation examined the demographic characteristics along with 3 measures of motor function in determining outcomes in activities of daily living (ADL) after distributed constraint-induced therapy (dCIT). METHODS:The study recruited 69 stroke patients who received 3 weeks of dCIT for 2 hours daily, 5...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2012-0755
更新日期:2012-01-01 00:00:00
abstract::Personal assistant services (PAS) are designed to support persons with disabilities in their routine performance of activities of daily living (ADLs) and to provide individuals with disability the opportunity to go to school, volunteer, obtain active employment, and participate in social and recreational activities. P...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:One of the most interesting emerging medical devices is the medical avatar - a digital representation of the patient that can be used toward myriad ends, the full potential of which remains to be explored. Medical avatars have been instantiated as telemedical tools used to establish a representation of the p...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:10.3233/NRE-203063
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Little is known about the mechanism of motor recovery for patients with intracerebral hemorrhage (ICH). We attempted to demonstrate the motor recovery mechanism in a hemiparetic patient with ICH using diffusion tensor tractography (DTT), transcranial magnetic stimulation (TMS), and functional MRI (fMRI). SU...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To determine the effect of repeated passive motion (RPM) exercise on position sense of the shoulder joint in patients with hemiplegia. METHODS:Shoulder flexion position sense was evaluated for the affected side of 15 patients with hemiplegia, using an assessment board set at five angles (30 degrees, 60 degre...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2009-0504
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The restoration of trunk function following stroke is a key component of rehabilitation, however there is limited evidence of the efficacy of additional trunk training. OBJECTIVES:To evaluate the efficacy of trunk exercises added to conventional rehabilitation on functional outcomes. METHODS:Relevant rando...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-141123
更新日期:2014-01-01 00:00:00
abstract::We conducted a small pilot study that examined the effect of a 4-week period of unloaded leg cycling on spasticity in individuals with multiple sclerosis (MS). The sample included 22 individuals with MS who were assigned using a quasi-experimental method into either exercise (n = 12) or control (n = 10) conditions. Th...
journal_title:NeuroRehabilitation
pub_type: 临床试验,杂志文章
doi:10.3233/NRE-2009-0486
更新日期:2009-01-01 00:00:00
abstract::Neuropsychologists are increasingly asked to provide recommendations regarding functional abilities based on test results, particularly within the rehabilitation setting. Yet, the empirical basis for making such recommendations is limited. The current study examines relationships between executive functioning and soci...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine if the demographic characteristics and health care needs of younger people with MS differ from older people with MS. PARTICIPANTS:The study analyzed enrollment data from the NARCOMS Registry to compare 1,987 younger adults with MS (30 years and younger) to 29,245 other adults with MS (over 30 ye...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2009-0525
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to conduct a meta-analysis on the effects of neuropsychological rehabilitation procedures on the quality of life in Spanish-speaking individuals with cognitive deficits. METHOD:Twenty four studies published during the last ten years were analyzed, and relevant information was ext...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析
doi:10.3233/NRE-2012-0725
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Brain-computer interfaces (BCIs) allow persons with impaired mobility to communicate and interact with the environment, supporting goal-directed thinking and cognitive function. Ideally, a BCI should be able to recognize a user's internal state and adapt to it in real-time, to improve interaction. OBJECTIVE...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.3233/NRE-151266
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the effects of action observation training and motor imagery training on recovery from chronic stroke. METHODS:Thirty patients who were more than six months post stroke participated in this study and were randomly allocated to three groups. The action observation tr...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-130991
更新日期:2013-01-01 00:00:00
abstract::We investigated the long-term effects of comprehensive hand repetitive intensive strengthening training (CHRIST) on strength, morphological muscle size, kinematics, and associated motor functional changes in children with cerebral palsy (CP). Ten children (5 boys, 5 girls; age range, 6-11 years, mean age, 8.6 years) p...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-130846
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:We conducted a systematic review and meta-analysis to identify the effect of computer-based cognitive rehabilitation (CBCR) on improving cognitive functions in patients with stroke. METHODS:Researchers performed a literature search using computerized databases such as the Cochrane Database, EBSCO (CINAHL), P...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,收录出版,评审
doi:10.3233/NRE-130856
更新日期:2013-01-01 00:00:00
abstract::Cognitive rehabilitation has evolved to be a common clinical practice, despite questions regarding the scientific basis for its effectiveness. A selective interpretation of existing studies suggests that non-specific treatment factors play an important role in the efficacy of cognitive rehabilitation. Some future dire...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1997-8103
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The Functional Assessment for Control of Trunk (FACT) was developed to evaluate trunk function after stroke. However, only a few studies used FACT to show functional outcome. OBJECTIVE:This study aimed to validate the FACT predictive ability for functional outcome following stroke and create an English vers...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-201533
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Persons with moderate to severe TBI are at increased risk for unintentional injury or harm in the home and community; however, there is currently no standard measure of safety risk they face now and in the future. OBJECTIVE:To develop comprehensive and content valid scales and item pools for assessing safet...
journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-161369
更新日期:2016-06-30 00:00:00