Treatment for acute flares of gout: A protocol for systematic review.

Abstract:

INTRODUCTION:The current evidence confirms the effectiveness and safety of several drug interventions in the treatment of acute flares of gout, however, the most preferred drugs are still unclear. We, therefore, seek to conduct a network meta-analysis that can systematically compare non-steroidal anti-inflammatory drugs (NSAIDs), COXIBs, colchicine, hormones, or IL-1 receptor antagonists, etc. for acute gout based on the latest evidence. METHODS AND ANALYSIS:Nine online databases are searched with inception to September 1, 2019; there will be no language restrictions on the included trials. Randomized controlled trials that include patients with acute flares of gout receiving drug therapy versus a control group will be included. The selection of studies, risk of bias assessment and data extraction will be conducted by 2 independent researchers. Bayesian network meta-analysis is applied using the Markov chain Monte Carlo method with Stata or R. The dichotomous data will be presented as risk ratios with 95% CIs and the continuous data will be presented as weighted mean differences or standardized mean differences with 95% CIs. Evidence quality will be evaluated using the GRADE system. ETHICS AND DISSEMINATION:This network meta-analysis will not involve private information from personal or imperil their rights, so, ethical approval is not required. The results of this network meta-analysis may be published in a journal or publicized in concerned conferences.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Tang H,Xu G,Zheng Q,Cheng Y,Zheng H,Li J,Yin Z,Liang F,Chen J

doi

10.1097/MD.0000000000019668

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

e19668

issue

14

eissn

0025-7974

issn

1536-5964

pii

00005792-202004030-00045

journal_volume

99

pub_type

杂志文章

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