当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway.

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway.

Abstract：

:Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction and interruption of the PDE5A-cGMP-PKG pathway. Sixty percent total body surface area (TBSA) scald burned rats (±sildenafil) were used in this study. A transmission electron microscope (TEM), real-time qPCR, O2K-respirometer, and electron transport chain assays were used to characterized molecular function. Cardiac mitochondrial morphological shapes were disfigured with a decline in mitochondrial number, area, and size, resulting in deficiency of cardiac mitochondrial replication. Burn induced a decrease in all mitDNA encoded genes. State 3 oxygen consumption was significantly decreased. Mitochondrial complex I substrate-energized or complex II substrate-energized and both of respiratory control ratio (RCRs) were decreased after burn. All mitochondrial complex activity except complex II were decreased in the burn group, correlating with decreases in mitochondrial ATP and MnSOD activity. Sildenafil, a inhibitor of the PDE5A-cGMP-PKG pathway, preserved the mitochondrial structure, respiratory chain efficiency and energy status in cardiac tissue. Furthermore, sildenafil treatment significantly restored ADP-conjugated respiration in burned groups. In conclusion, cardiac mitochondrial damage contributes to burn-induced heart dysfunction via the PDE5A-cGMP-PKG pathway.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Wen JJ,Cummins CB,Radhakrishnan RS

doi

10.3390/ijms21072350

subject

Has Abstract

pub_date

2020-03-28 00:00:00

issue

7

issn

1422-0067

pii

ijms21072350

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells.

    abstract：:Epithelial ovarian cancer (EOC) is the deadliest tumor among gynecological cancer in the industrialized countries. The EOC incidence and mortality have remained unchanged over the last 30 years, despite the progress in diagnosis and treatment. In order to develop novel and more effective therapeutic approaches, the mo...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17091387

    authors： Roggiani F,Mezzanzanica D,Rea K,Tomassetti A

    更新日期：2016-08-23 00:00:00

  • Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit During Gestation.

    abstract：:Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective properties and their concentrations in the fetoplacental unit must be tightly regulated...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21207578

    authors： Abad C,Karahoda R,Kastner P,Portillo R,Horackova H,Kucera R,Nachtigal P,Staud F

    更新日期：2020-10-14 00:00:00

  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells.

    abstract：:Chondrocyte hypertrophy is a hallmark of osteoarthritis (OA) pathology. In the present study, we elucidated the mechanism underlying the relationship between the hypertrophy/apoptotic phenotype and OA pathogenesis in bone marrow-derived mesenchymal stem cells (BM-MSCs) via gene targeting of distal-less homeobox 5 (DLX...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21144823

    authors： Twomey-Kozak J,Desai S,Liu W,Li NY,Lemme N,Chen Q,Owens BD,Jayasuriya CT

    更新日期：2020-07-08 00:00:00

  • Similarities in the General Chemical Composition of Colon Cancer Cells and Their Microvesicles Investigated by Spectroscopic Methods-Potential Clinical Relevance.

    abstract：:Colon cancer constitutes 33% of all cancer cases in humans and the majority of patients with metastatic colon cancer still have poor prognosis. An important role in cancer development is the communication between cancer and normal cells. This may occur, among others, through extracellular vesicles (including microvesi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21051826

    authors： Depciuch J,Klębowski B,Stec M,Szatanek R,Węglarczyk K,Baj-Krzyworzeka M,Parlińska-Wojtan M,Baran J

    更新日期：2020-03-06 00:00:00

  • Porcine Breast Extracellular Matrix Hydrogel for Spatial Tissue Culture.

    abstract：:Porcine mammary fatty tissues represent an abundant source of natural biomaterial for generation of breast-specific extracellular matrix (ECM). Here we report the extraction of total ECM proteins from pig breast fatty tissues, the fabrication of hydrogel and porous scaffolds from the extracted ECM proteins, the struct...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19102912

    authors： Rijal G,Wang J,Yu I,Gang DR,Chen RK,Li W

    更新日期：2018-09-25 00:00:00

  • Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids.

    abstract：:Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17040569

    authors： Kawser Hossain M,Abdal Dayem A,Han J,Yin Y,Kim K,Kumar Saha S,Yang GM,Choi HY,Cho SG

    更新日期：2016-04-15 00:00:00

  • Synergistic Reaction of SO2 with NO2 in Presence of H2O and NH3: A Potential Source of Sulfate Aerosol.

    abstract：:Effect of H2O and NH3 on the synergistic oxidation reaction of SO2 and NO2 is investigated by theoretical calculation using the molecule system SO2-2NO2-nH2O (n = 0, 1, 2, 3) and SO2-2NO2-nH2O-mNH3 (n = 0, 1, 2; m = 1, 2). Calculated results show that SO2 is oxidized to SO3 by N2O4 intermediate. The additional H2O in ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20153746

    authors： Wang Z,Zhang C,Lv G,Sun X,Wang N,Li Z

    更新日期：2019-07-31 00:00:00

  • Influence of Cationic meso-Substituted Porphyrins on the Antimicrobial Photodynamic Efficacy and Cell Membrane Interaction in Escherichia coli.

    abstract：:Photodynamic inactivation (PDI) is a non-antibiotic option for the treatment of infectious diseases. Although Gram-positive bacteria have been shown to be highly susceptible to PDI, the inactivation of Gram-negative bacteria has been more challenging due to the impermeability properties of the outer membrane. In the p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20010134

    authors： Hurst AN,Scarbrough B,Saleh R,Hovey J,Ari F,Goyal S,Chi RJ,Troutman JM,Vivero-Escoto JL

    更新日期：2019-01-01 00:00:00

  • Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth.

    abstract：:Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeutic targets, nine u...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19072093

    authors： Bothwell PJ,Kron CD,Wittke EF,Czerniak BN,Bode BP

    更新日期：2018-07-19 00:00:00

  • Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy.

    abstract：:In the post-genome era, pathologies become associated with specific gene expression profiles and defined molecular lesions can be identified. The traditional therapeutic strategy is to block the identified aberrant biochemical activity. However, an attractive alternative could aim at antagonizing key transcriptional e...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21072301

    authors： Moustaqil M,Gambin Y,Sierecki E

    更新日期：2020-03-26 00:00:00

  • Applications of circular dichroism for structural analysis of gelatin and antimicrobial peptides.

    abstract：:Circular dichroism (CD) is a useful technique for monitoring changes in the conformation of antimicrobial peptides or gelatin. In this study, interactions between cationic peptides and gelatin were observed without affecting the triple helical content of the gelatin, which was more strongly affected by anionic surfact...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms13033229

    authors： Gopal R,Park JS,Seo CH,Park Y

    更新日期：2012-01-01 00:00:00

  • Pine bark and green tea concentrated extracts: antioxidant activity and comprehensive characterization of bioactive compounds by HPLC-ESI-QTOF-MS.

    abstract：:The consumption of polyphenols has frequently been associated with low incidence of degenerative diseases. Most of these natural antioxidants come from fruits, vegetables, spices, grains and herbs. For this reason, there has been increasing interest in identifying plant extract compounds. Polymeric tannins and monomer...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms151120382

    authors： de la Luz Cádiz-Gurrea M,Fernández-Arroyo S,Segura-Carretero A

    更新日期：2014-11-06 00:00:00

  • Plant DNA Polymerases.

    abstract：:Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair. Interestingly, all eukaryotes possess a large repertoire of polymerases. Three protein c...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20194814

    authors： Pedroza-Garcia JA,De Veylder L,Raynaud C

    更新日期：2019-09-27 00:00:00

  • Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan.

    abstract：:Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of Aspidosperma pyrifolium in reducing carrageenan-indu...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18112248

    authors： Souza Lima MCJ,Oliveira Bitencourt MA,Furtado AA,Torres-Rêgo M,Siqueira EMDS,Oliveira RM,Oliveira Rocha HA,Ferreira Rocha KB,Silva-Júnior AAD,Zucolotto SM,Fernandes-Pedrosa MF

    更新日期：2017-11-11 00:00:00

  • Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?

    abstract：:In previous studies we produced autism like behavioral changes in mice by Valproic acid (VPA) with significant differences between genders. S-adenosine methionine (SAM) prevented the autism like behavior in both genders. The expression of 770 genes of pathways involved in neurophysiology and neuropathology was studied...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20215278

    authors： Weinstein-Fudim L,Ergaz Z,Turgeman G,Yanai J,Szyf M,Ornoy A

    更新日期：2019-10-24 00:00:00

  • Effects of Ketamine on Rodent Fear Memory.

    abstract：:Ketamine, a multimodal anesthetic drug, has become increasingly popular in the treatment of pain following traumatic injury as well as treatment-resistant major depressive disorders. However, the psychological impact of this dissociative medication on the development of stress-related disorders such as post-traumatic ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21197173

    authors： Choi KH,Berman RY,Zhang M,Spencer HF,Radford KD

    更新日期：2020-09-28 00:00:00

  • Comparative Transcriptome Analysis Provides Novel Insight into Morphologic and Metabolic Changes in the Fat Body during Silkworm Metamorphosis.

    abstract：:The fat body plays key roles in energy storage and utilization as well as biosynthetic and metabolic activities in insects. During metamorphosis from larva to pupa, the fat body undergoes dramatic changes in morphology and metabolic processes. However, the genetic basis underlying these changes has not been completely...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19113525

    authors： Peng J,Li Z,Yang Y,Wang P,Zhou X,Zhao T,Guo M,Meng M,Zhang T,Qian W,Xia Q,Cheng D,Zhao P

    更新日期：2018-11-09 00:00:00

  • Disease progression mediated by egr-1 associated signaling in response to oxidative stress.

    abstract：:When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms131013104

    authors： Pagel JI,Deindl E

    更新日期：2012-10-12 00:00:00

  • How the Pathological Microenvironment Affects the Behavior of Mesenchymal Stem Cells in the Idiopathic Pulmonary Fibrosis.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological microenvironment may af...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218140

    authors： Bonifazi M,Di Vincenzo M,Caffarini M,Mei F,Salati M,Zuccatosta L,Refai M,Mattioli-Belmonte M,Gasparini S,Orciani M

    更新日期：2020-10-30 00:00:00

  • Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells.

    abstract：:Epithelial-mesenchymal transition (EMT) is a key process in cancer development and progression. Communication (crosstalk) between cancer cells and normal (nonmalignant) cells may facilitate cancer progression. Conditioned medium (CM) obtained from cultured cancer cells contains secreted factors capable of affecting ph...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18081528

    authors： Guo J,Liu C,Zhou X,Xu X,Deng L,Li X,Guan F

    更新日期：2017-08-01 00:00:00

  • Molecular Signature of Indeterminate Thyroid Lesions: Current Methods to Improve Fine Needle Aspiration Cytology (FNAC) Diagnosis.

    abstract：:Fine needle aspiration cytology (FNAC) represents the gold standard for determining the nature of thyroid nodules. It is a reliable method with good sensitivity and specificity. However, indeterminate lesions remain a diagnostic challenge and researchers have contributed molecular markers to search for in cytological ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18040775

    authors： Cantara S,Marzocchi C,Pilli T,Cardinale S,Forleo R,Castagna MG,Pacini F

    更新日期：2017-04-06 00:00:00

  • Exploiting Gene Expression Profiles for the Automated Prediction of Connectivity between Brain Regions.

    abstract：:The brain comprises a complex system of neurons interconnected by an intricate network of anatomical links. While recent studies demonstrated the correlation between anatomical connectivity patterns and gene expression of neurons, using transcriptomic information to automatically predict such patterns is still an open...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20082035

    authors： Roberti I,Lovino M,Di Cataldo S,Ficarra E,Urgese G

    更新日期：2019-04-25 00:00:00

  • Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine.

    abstract：:Obesity causes a significant negative impact on health of human beings world-wide. The main reason for weight gain, which eventually leads to obesity, is excessive ingestion of energy above the body's homeostatic needs. Therefore, the elucidation of detailed mechanisms for appetite control is necessary to prevent and ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17071081

    authors： Sasaki T,Matsui S,Kitamura T

    更新日期：2016-07-07 00:00:00

  • 3D radiation therapy boost improves the outcome of whole brain radiation therapy treated RPA II patients with one or two brain metastases.

    abstract：PURPOSE:to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. METHODS AND MATERIALS:the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15057554

    authors： Antoni D,Clavier JB,Pop M,Schumacher C,Lefebvre F,Noël G

    更新日期：2014-05-02 00:00:00

  • The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma.

    abstract：:Near infrared fluorescence (NIRF) imaging has strong potential for widespread use in noninvasive tumor imaging. Indocyanine green (ICG) is the only Food and Drug Administration (FDA) -approved NIRF dye for clinical diagnosis; however, it is unstable and poorly targets tumors. DZ-1 is a novel heptamethine cyanine NIRF ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18061332

    authors： Zhang C,Zhao Y,Zhang H,Chen X,Zhao N,Tan D,Zhang H,Shi C

    更新日期：2017-06-21 00:00:00

  • Implications of a Soy-Based Diet for Animal Models.

    abstract：:The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020774

    authors： Dhot J,Prat V,Ferron M,Aillerie V,Erraud A,Rozec B,Waard M,Gauthier C,Lauzier B

    更新日期：2021-01-14 00:00:00

  • Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation.

    abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital associated kidney damage. Potential mechanisms of CI-AKI may involve diminished renal hemodynamics, inflammatory responses, and direct cytotoxicity. The hypothesis for this study is that diatrizoic acid (DA) induces direct cytotox...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20174074

    authors： Ward DB,Brown KC,Valentovic MA

    更新日期：2019-08-21 00:00:00

  • Use of H2O2 to Cause Oxidative Stress, the Catalase Issue.

    abstract：:Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally high with regard to physiological oxygen concentration (low micromolar). In this study using polarographic measurement of oxygen concentratio...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21239149

    authors： Ransy C,Vaz C,Lombès A,Bouillaud F

    更新日期：2020-11-30 00:00:00

  • Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres.

    abstract：:Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Sil...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113745

    authors： Honda M,Kawanobe Y,Nagata K,Ishii K,Matsumoto M,Aizawa M

    更新日期：2020-05-26 00:00:00

  • Responsiveness of Carnosine Homeostasis Genes in the Pancreas and Brain of Streptozotocin-Treated Mice Exposed to Dietary Carnosine.

    abstract：:In excitable tissues, the endogenous dipeptide carnosine (CAR, β-Ala-l-His) sustains homeostatic responses to various challenges. By eliciting hypoglycemic effects via actions on the autonomic nervous system and protection of pancreatic beta-cells, CAR is also relevant in diabetes. We investigated the expression of ge...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19061713

    authors： Barca A,Gatti F,Spagnolo D,Ippati S,Vetrugno C,Verri T

    更新日期：2018-06-09 00:00:00