当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Hyaluronic acid-coated ZIF-8 for the treatment of pneumonia caused by methicillin-resistant Staphylococcus aureus.

Hyaluronic acid-coated ZIF-8 for the treatment of pneumonia caused by methicillin-resistant Staphylococcus aureus.

Abstract：

:Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital infection. Here, we showed that hyaluronic acid modified organic metal framework material ZIF-8 could be a Trojan horse of vancomycin (Van) for effective treatment of MRSA infections. The Van-loaded nanoparticles were readily up-taken by macrophages via a CD44-mediated process and collapsed in the acidic condition of endosome/lysosome, as a consequence, it could eradicate MRSA with high efficiency in macrophages. This drug delivery system with negligible toxicity could resolve MRSA infections in a well-established mouse pneumonia model.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Liu Y,Li Z,Zou S,Lu C,Xiao Y,Bai H,Zhang X,Mu H,Zhang X,Duan J

doi

10.1016/j.ijbiomac.2020.03.187

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

103-109

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)32773-2

journal_volume

155

pub_type

杂志文章

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