Abstract：
:Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (n = 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included. ALOX5, LPA, MMP9 and TPO gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of ALOX5, LPA, MMP9 and TPO polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.
journal_name
R Soc Open Scijournal_title
Royal Society open scienceauthors
Camacho-Mejorado R,Gómez R,Torres-Sánchez LE,Alhelí Hernández-Tobías E,Noris G,Santana C,Magaña JJ,Orozco L,de la Peña-Díaz A,de la Luz Arenas-Sordo M,Meraz-Ríos MA,Majluf-Cruz Adoi
10.1098/rsos.190775subject
Has Abstractpub_date
2020-01-15 00:00:00pages
190775issue
1issn
2054-5703pii
rsos190775journal_volume
7pub_type
杂志文章abstract：:Waptia fieldensis Walcott, 1912 is one of the iconic animals from the middle Cambrian Burgess Shale biota that had lacked a formal description since its discovery at the beginning of the twentieth century. This study, based on over 1800 specimens, finds that W. fieldensis shares general characteristics with pancrustac...
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abstract：:[This corrects the article DOI: 10.1098/rsos.180442.]. ...
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