Journey towards a personalised medicine approach for OSA: Can a similar approach to adult OSA be applied to paediatric OSA?

Abstract:

:The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea.

journal_name

Paediatr Respir Rev

authors

Siriwardhana LS,Nixon GM,Horne RSC,Edwards BA

doi

10.1016/j.prrv.2020.01.002

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

128-135

eissn

1526-0542

issn

1526-0550

pii

S1526-0542(20)30018-X

journal_volume

36

pub_type

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