Abstract:
:The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Siriwardhana LS,Nixon GM,Horne RSC,Edwards BAdoi
10.1016/j.prrv.2020.01.002subject
Has Abstractpub_date
2020-11-01 00:00:00pages
128-135eissn
1526-0542issn
1526-0550pii
S1526-0542(20)30018-Xjournal_volume
36pub_type
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