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Polymorphism of simple sequence repeats may quantitatively regulate gene transcription.

Abstract：

:The degree of polymorphism, i.e., DNA sequence divergence, of short AT-rich tandemly arranged simple sequence repeats at or near promoters and 5'- untranslated regions of mRNA may quantitatively regulate transcription of tissue-specific genes. Less polymorphic repeats allow greater gene expression. Preferential binding of hypophosphorylated H1 histone to these repeats may diminish binding of transcription factors. Preferential binding of hypophosphorylated high mobility group chromatin proteins would increase this binding. Shorter simple sequence repeats have undergone fewer point mutations than longer repeats, hence they are less polymorphic and more conserved. The role of transcribed simple sequence repeats in frog embryo germ layer determination is considered.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Flickinger R

doi

10.1016/j.yexcr.2020.111969

subject

Has Abstract

pub_date

2020-05-15 00:00:00

pages

111969

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(20)30182-8

journal_volume

390

pub_type

杂志文章,评审

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