Abstract:
:Given the median survival of 15 months after diagnosis, novel treatment strategies are needed for glioblastoma. Beta-blockers have been demonstrated to inhibit angiogenesis and tumor cell proliferation in various cancer types. The aim of this study was to systematically review the evidence on the effect of beta-blockers on glioma growth. A systematic literature search was performed in the PubMed, Embase, Google Scholar, Web of Science, and Cochrane Central to identify all relevant studies. Preclinical studies concerning the pharmacodynamic effects of beta-blockers on glioma growth and proliferation were included, as well as clinical studies that studied the effect of beta-blockers on patient outcomes according to PRISMA guidelines. Among the 980 citations, 10 preclinical studies and 1 clinical study were included after title/abstract and full-text screening. The following potential mechanisms were identified: reduction of glioma cell proliferation (n = 9), decrease of glioma cell migration (n = 2), increase of drug sensitivity (n = 1), induction of glioma cell death (n = 1). Beta-blockers affect glioma proliferation by inducing a brief reduction of cAMP and a temporary cell cycle arrest in vitro. Contrasting results were observed concerning glioma cell migration. The identified clinical study did not find an association between beta-blockers and survival in glioma patients. Although preclinical studies provide scarce evidence for the use of beta-blockers in glioma, they identified potential pathways for targeting glioma. Future studies are needed to clarify the effect of beta-blockers on clinical endpoints including survival outcomes in glioma patients to scrutinize the value of beta-blockers in glioma care.
journal_name
Neurosurg Revjournal_title
Neurosurgical reviewauthors
Tewarie IA,Senders JT,Hulsbergen AFC,Kremer S,Broekman MLDdoi
10.1007/s10143-020-01277-4subject
Has Abstractpub_date
2020-03-14 00:00:00eissn
0344-5607issn
1437-2320pii
10.1007/s10143-020-01277-4pub_type
杂志文章,评审abstract::Head and neck paragangliomas (HNPs) are rare, usually benign hyper vascularized neuroendocrine tumors that traditionally have been treated by surgery, with or without endovascular embolization, or, more recently stereotactic radiosurgery (SRS). The aim of our study is to determine the clinical and radiographic effecti...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01292-5
更新日期:2020-04-21 00:00:00
abstract::A large variety of vertebral tumours undergoes transarterial embolisation (TAE) prior to surgery. However, the subsequent intra-operative blood loss is unpredictable. This retrospective analysis, aims to determine the impact of various factors that may potentially influence the estimated intra-operative blood loss (EB...
journal_title:Neurosurgical review
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doi:10.1007/s10143-018-1003-8
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abstract::Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecu...
journal_title:Neurosurgical review
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doi:10.1007/s10143-018-0978-5
更新日期:2020-02-01 00:00:00
abstract::Surgical access to deep intracranial lesions causing the least amount of iatrogenic trauma to the surrounding brain tissue remains a challenging task. In this article, we evaluate the use of a set of sequential tubes that dilate and provide retraction of the overlying brain tissue acting as a surgical corridor for dee...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-012-0442-x
更新日期:2013-04-01 00:00:00
abstract::The pathophysiology of syringomyelia development is not fully understood. Current prevailing theories suggest that increased pulse pressure in the subarachnoid space forces cerebrospinal fluid (CSF) through the spinal cord into the syrinx. It is generally accepted that the syrinx consists of CSF. The here-proposed int...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-006-0029-5
更新日期:2006-10-01 00:00:00
abstract::A 22-year-old woman presented with acute onset of headache and vomiting. Computed tomography (CT) demonstrated hydrocephalus and a huge midline mass with heterogeneous density involving both lateral ventricles. A small amount of hematoma was detected at the bottom of the left trigone. On magnetic resonance imaging (MR...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
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abstract::Three unusual cases of combined intraorbital-intracranial tumors of various types which were chosen from cases treated in the Clinic and Polyclinic of Neurosurgery of the University of Münster, to demonstrate the problems of surgical therapy. A list of indications for the various accesses to the orbita is worked out. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01794676
更新日期:1988-01-01 00:00:00
abstract::Glial tumors are the most common tumors of the nervous system, affecting individuals at any age. Since understanding of the molecular pathologies underlying human gliomas is still very poor, the treatment and therefore prognosis of this malignancy could not yet be improved. In order to determine whether different glio...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-003-0279-4
更新日期:2004-01-01 00:00:00
abstract::Our aim was to determine the effects of vitamin E and L-carnitine supplementation, individually or in combination, on radiation-induced brain and retinal damages in a rat model. Group 1 received no treatment (control arm). Group 2 received a total dose of 15 Gy external radiotherapy (RT) to whole brain by Cobalt-60 te...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-007-0118-0
更新日期:2008-04-01 00:00:00
abstract::Rare tumors with anecdotal reportage, oculomotor schwannomas are most often seen in the oculomotor cistern close to the anterior clinoidal region. Adding to the small series of reported cases of this unusual lesion, we report two male patients in their second decade who presented with different degrees of oculomotor p...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-011-0344-3
更新日期:2012-01-01 00:00:00
abstract::200 stereotactic biopsies were evaluated. The validity of the intraoperative histopathological results were compared with the final diagnosis using conventional embedding and staining techniques. Further comparison between the histology of the biopsy and the post mortem or open operative findings were possible in 41 c...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00309989
更新日期:1994-01-01 00:00:00
abstract::This short paper summarizes the basic concept and the technology of a new computed radiographic system which uses an energy-storage phosphorus panel called "Imaging Plate" as an image sensor. The "Imaging Plate" can be used to obtain radiographs in exactly the same way as the screen-film combination is used in convent...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01744878
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abstract::Esthesioneuroblastoma is an uncommon malignant neoplasm that arises from olfactory mucosa, often with intracranial extension. A case report of the youngest victim in the literature (2-year-old boy) is presented. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01390528
更新日期:1997-01-01 00:00:00
abstract::The objective of this study was to ascertain if stereotactic neurosurgical biopsy (SNB) optimizes the therapy of undefined CNS masses. The design was of retrospective treatment and outcome analysis and the setting was a large general hospital. We studied a total of 141 patients with undefined, space-occupying CNS lesi...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s101430050043
更新日期:1999-10-01 00:00:00
abstract::Massive hemorrhage is a very uncommon event among hemangioblastomas. Forty-four cases have been reported before this review. Thorough analysis of all reported cases on literature was accomplished. The majority presented as parenchymatous or subarachnoid bleedings. Subarachnoid hemorrhage was only associated with spina...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-009-0217-1
更新日期:2010-01-01 00:00:00
abstract::Fifteen cases of chronic vegetative state (CVS), following severe head injury and lasting for two years or more, are reported. Vegetative state, in most instances after a period of coma, consists of a return of wakefulness accompanied by an apparent total lack of higher mental activity. A protracted period of vegetati...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF01790694
更新日期:1989-01-01 00:00:00
abstract::With the increasing number of endovascular interventions during the last years, the number of procedure-related complications has risen accordingly. Despite sophisticated and effective endovascular treatments for acute thromboembolic events during intervention, vessel occlusion can remain refractory to medical and end...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-010-0283-4
更新日期:2011-01-01 00:00:00
abstract::Case reports and postmortem neuropathological findings of a wide spectrum of diseases affecting the vertebral arteries, in particular vasculitis, traumatic lesions, degenerative changes and congenital abnormalities, are discussed. ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00638894
更新日期:1990-01-01 00:00:00
abstract::Cerebral vasospasm is delayed narrowing of the large arteries of the circle of Willis occurring 4 to 14 days after aneurysmal subarachnoid hemorrhage (SAH). It is but one cause of delayed deterioration after SAH but, in general, is the most important potentially treatable cause of morbidity and mortality after SAH. De...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-005-0013-5
更新日期:2006-07-01 00:00:00
abstract::It is well known that radiation can induce meningiomas. These tumors usually arise in patients with a history of low-dose radiation to the scalp for treatment of tinea capitis or high-dose radiation for a previous brain tumor. Radiation-associated meningiomas (RAMs) morphologically resemble their spontaneously arising...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-004-0366-1
更新日期:2005-04-01 00:00:00
abstract::Although endovascular or surgical treatment has been performed for preventing the rupture of saccular cerebral aneurysms (sCA), in some patients, the aneurysms may recur and require retreatment. We aimed to investigate the clinical and radiological outcomes of treating recurrent sCA. We retrospectively evaluated the d...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-020-01259-6
更新日期:2020-02-21 00:00:00
abstract::This study sought to describe and evaluate any relationship between D-dimer values and progressive hemorrhagic injury (PHI) after traumatic brain injury (TBI). In patients with TBI, plasma D-dimer was measured while a computed tomography (CT) scan was conducted as soon as the patient was admitted to the emergency depa...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-010-0251-z
更新日期:2010-07-01 00:00:00
abstract::Patients with craniocervical disorders (CCD) show a wide variety of symptoms and signs suggesting cerebellar and/or high cervical lesion. The anatomic localization of respiratory centers and their possible injury may explain the presence of respiratory disturbances in these diseases. The aim of this preliminary study ...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/pl00011947
更新日期:2000-09-01 00:00:00
abstract::Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- an...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-017-0880-6
更新日期:2018-04-01 00:00:00
abstract::Optic pathway glioma (OPG) encompasses a spectrum of findings ranging from lesions confined to the optic nerve only, lesions affecting the optic chiasm and hypothalamus, and lesions with diffuse involvement of a large part of the optic pathway and neighboring structures. The majority of pediatric low-grade astrocytoma...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-016-0747-2
更新日期:2017-01-01 00:00:00
abstract::Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-018-01074-0
更新日期:2019-06-01 00:00:00
abstract::The use of simulation in surgical training is ever growing. Evidence suggests such training may have beneficial clinically relevant effects. The objective of this research is to investigate the effects of surgical simulation training on clinically relevant patient outcomes by evaluating randomized controlled trials (R...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01314-2
更新日期:2020-05-13 00:00:00
abstract::A retrospective clinical study was made on 987 patients with lumbar disc disease treated by discectomy. All patients had been operated on in the Department of Neurosurgery (University-Hospital Mainz). 545 patients were males, and 442 females (1.2:1). Patients in the 4th decade of life were affected most often (33.5%)....
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/BF00313019
更新日期:1990-01-01 00:00:00
abstract::The purpose of this paper is to provide a comprehensive review encompassing the syndromes associated with the lower cranial nerves (LCNs). We will discuss the anatomy of some of these syndromes and the historical contributors after whom they were named. The LCNs can be affected individually or in combination, since th...
journal_title:Neurosurgical review
pub_type: 杂志文章,评审
doi:10.1007/s10143-020-01344-w
更新日期:2020-07-08 00:00:00
abstract::Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a safe and effective treatment for moyamoya disease, although recent evidence suggests its substantial risk for symptomatic cerebral hyperperfusion. The diagnostic value of single-photon emission computed tomography (SPECT) for postoperative h...
journal_title:Neurosurgical review
pub_type: 杂志文章
doi:10.1007/s10143-008-0147-3
更新日期:2008-10-01 00:00:00