Left ventricular global function index by magnetic resonance imaging - a novel marker for differentiating cardiac amyloidosis from hypertrophic cardiomyopathy.

abstract：:Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, espe...

journal_title：Scientific reports

authors： Lu J,Shao Y,Qin X,Liu D,Chen A,Li D,Liu M,Wang X

更新日期：2017-02-20 00:00:00

abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

journal_title：Scientific reports

authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

更新日期：2019-04-10 00:00:00

abstract：:Chlorpyrifos is one of the most widely used pesticides that acts on the nervous system by inhibiting acetylcholinesterase. Prolonged use of chlorpyrifos causes severe neurological, autoimmune, and persistent developmental disorders in humans. Therefore, in this study, a highly sensitive and robust biosensor platform w...

journal_title：Scientific reports

authors： Islam S,Shukla S,Bajpai VK,Han YK,Huh YS,Ghosh A,Gandhi S

更新日期：2019-01-22 00:00:00

abstract：:Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who und...

journal_title：Scientific reports

authors： Kim YG,Shim J,Oh SK,Park HS,Lee KN,Hwang SH,Choi JI,Kim YH

更新日期：2018-05-18 00:00:00

abstract：:Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...

journal_title：Scientific reports

authors： Zhang H,Wang D,Zhong H,Luo R,Shang M,Liu D,Chen H,Fang L,Xiao S

更新日期：2015-06-10 00:00:00

abstract：:Statins present many beneficial effects in chronic liver disease, but concerns about safety exist. We evaluated the hepatic effects of a nitric oxide-releasing atorvastatin (NCX 6560) compared to conventional statins. Simvastatin, atorvastatin and NCX 6560 were evaluated in four-week bile duct-ligated rats (BDL) simul...

journal_title：Scientific reports

authors： Rodríguez S,Raurell I,Torres-Arauz M,García-Lezana T,Genescà J,Martell M

更新日期：2017-01-13 00:00:00

abstract：:The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...

journal_title：Scientific reports

authors： Takaji M,Takemoto A,Yokoyama C,Watakabe A,Mizukami H,Ozawa K,Onoe H,Nakamura K,Yamamori T

更新日期：2016-11-02 00:00:00

abstract：:Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of 13C-methacetin can be ...

journal_title：Scientific reports

authors： Haimerl M,Probst U,Poelsterl S,Beyer L,Fellner C,Selgrad M,Hornung M,Stroszczynski C,Wiggermann P

更新日期：2018-06-13 00:00:00

abstract：:The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understand...

journal_title：Scientific reports

authors： Faber M,Shaw S,Yoon S,de Paiva Alves E,Wang B,Qi Z,Okamura B,Hartikainen H,Secombes CJ,Holland JW

更新日期：2021-01-25 00:00:00

abstract：:Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...

journal_title：Scientific reports

authors： Hegarty SV,Wyatt SL,Howard L,Stappers E,Huylebroeck D,Sullivan AM,O'Keeffe GW

更新日期：2017-08-17 00:00:00

abstract：:Microbubble contrast agents are widely used in ultrasound imaging and therapy, typically with transmission center frequencies in the MHz range. Currently, an ultrasound center frequency near 250 kHz is proposed for clinical trials in which ultrasound combined with microbubble contrast agents is applied to open the blo...

journal_title：Scientific reports

authors： Ilovitsh T,Ilovitsh A,Foiret J,Caskey CF,Kusunose J,Fite BZ,Zhang H,Mahakian LM,Tam S,Butts-Pauly K,Qin S,Ferrara KW

更新日期：2018-11-05 00:00:00

abstract：:CHF5633 is a novel synthetic clinical pulmonary surfactant preparation composed by two phospholipid species, dipalmitoyl phosphatidylcholine (DPPC) and palmitoyloleoyl phosphatidylglycerol (POPG), and synthetic analogues of the hydrophobic surfactant proteins SP-B and SP-C. In this study, the interfacial properties of...

journal_title：Scientific reports

authors： Echaide M,Autilio C,López-Rodríguez E,Cruz A,Pérez-Gil J

更新日期：2020-01-28 00:00:00

abstract：:Solar thermal energy conversion has attracted substantial renewed interest due to its applications in industrial heating, air conditioning, and electricity generation. Achieving stagnation temperatures exceeding 200 °C, pertinent to these technologies, with unconcentrated sunlight requires spectrally selective absorbe...

journal_title：Scientific reports

authors： Thomas NH,Chen Z,Fan S,Minnich AJ

更新日期：2017-07-13 00:00:00

abstract：:In this study we measured the degrees to which the Schottky barrier heights (SBHs) are lowered in ZnO nanowire (NW) devices under illumination with UV light. We measured the I-V characteristics of ZnO nanowire devices to confirm that ZnO is an n-type semiconductor and that the on/off ratio is approximately 10(4). From...

journal_title：Scientific reports

authors： Lu MY,Lu MP,You SJ,Chen CW,Wang YJ

更新日期：2015-10-12 00:00:00

abstract：:Polymorphisms contribute to inter-individual differences and show a promising predictive role for chemotherapy-related toxicity in colon cancer (CC). TOSCA is a multicentre, randomized, non-inferiority, phase III study conducted in high-risk stage II/stage III CC patients treated with 6 vs 3 months of FOLFOX-4 or XELO...

journal_title：Scientific reports

authors： Ruzzo A,Graziano F,Galli F,Galli F,Rulli E,Lonardi S,Ronzoni M,Massidda B,Zagonel V,Pella N,Mucciarini C,Labianca R,Ionta MT,Bagaloni I,Veltri E,Sozzi P,Barni S,Ricci V,Foltran L,Nicolini M,Biondi E,Bramati A,

更新日期：2019-08-08 00:00:00

abstract：:Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement the cortico-striatal pathways in order to interrupt/change planned actions. To explore the previo...

journal_title：Scientific reports

authors： Froux L,Le Bon-Jego M,Miguelez C,Normand E,Morin S,Fioramonti S,Barresi M,Frick A,Baufreton J,Taupignon A

更新日期：2018-06-11 00:00:00

abstract：:Surface Temperature (ST) over India has increased by ~0.055 K/decade during 1860-2005 and follows the global warming trend. Here, the natural and external forcings (e.g., natural and anthropogenic) responsible for ST variability are studied from Coupled Model Inter-comparison phase 5 (CMIP5) models during the 20th cen...

journal_title：Scientific reports

authors： Basha G,Kishore P,Ratnam MV,Jayaraman A,Agha Kouchak A,Ouarda TBMJ,Velicogna I

更新日期：2017-06-07 00:00:00

abstract：:Herein, we examined the association between cytomegalovirus (CMV) coinfection and the progression of liver fibrosis in hepatitis C virus (HCV) infection, and investigated the effect of CMV coinfection on JAK-STAT pathway. CMV DNAemia was detected by PCR in DNA from controls (n = 120), and HCV patients with early (F0-F...

journal_title：Scientific reports

authors： Ibrahim MK,Khedr A,Bader El Din NG,Khairy A,El Awady MK

更新日期：2017-09-04 00:00:00

abstract：:This study aims to evaluate the radiation dosimetry of a new technetium-99m‒labelled small-molecule inhibitor of prostate-specific membrane antigen (HYNIC-Glu-Urea-A, 99mTc-HYNIC-PSMA) and its feasibility as a tumor-imaging agent in prostate cancer (PCa) patients. A total of 15 PCa patients were enrolled in this study...

journal_title：Scientific reports

authors： Zhang J,Zhang J,Xu X,Lu L,Hu S,Liu C,Cheng J,Song S,Zhang Y,Shi LQ

更新日期：2020-03-06 00:00:00

abstract：:Based on an inverted bulk band order, antimony thin films presumably could become topological insulators if quantum confinement effect opens up a gap in the bulk bands. Coupling between topological surface states (TSS) from opposite surfaces, however, tends to degrade or even destroy their novel characters. Here the e...

journal_title：Scientific reports

authors： Yao G,Luo Z,Pan F,Xu W,Feng YP,Wang XS

更新日期：2013-01-01 00:00:00

abstract：:Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to Ap...

journal_title：Scientific reports

authors： Yoon BR,Leem AY,Park MS,Kim YS,Chung KS

更新日期：2019-08-19 00:00:00

abstract：:While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with...

journal_title：Scientific reports

authors： Pineda G,Lennon KM,Delos Santos NP,Lambert-Fliszar F,Riso GL,Lazzari E,Marra MA,Morris S,Sakaue-Sawano A,Miyawaki A,Jamieson CH

更新日期：2016-04-04 00:00:00

abstract：:The objective of this study was to assess the diagnosis value of urinary inflammatory index (UII) and systemic immune-inflammation index (SII) for UTI. Nine inflammatory indexes including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, SII and six UIIs were calculated for Receiver operating characteristi...

journal_title：Scientific reports

authors： Gu W,Huang W,Zhang J,Qian S,Cao H,Ge L

更新日期：2020-11-09 00:00:00

abstract：:The aim of our study was to compare soft tissue measurements with 3D imaging methods in individuals with untreated skeletal and pseudo-Class III malocclusions. The study sample consisted of 75 patients (38 males, 37 females, mean age 12.41 ± 2.35 years) with pseudo- and true skeletal Class III malocclusions and skelet...

journal_title：Scientific reports

authors： Kale B,Buyukcavus MH

更新日期：2020-09-07 00:00:00

abstract：:Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...

journal_title：Scientific reports

authors： Li J,Yang B,Shi M,Yuan K,Guo W,Wang Q,Wang G

更新日期：2017-03-02 00:00:00

abstract：:Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the disco...

journal_title：Scientific reports

authors： Rodrigues AMS,Eparvier V,Odonne G,Amusant N,Stien D,Houël E

更新日期：2019-06-19 00:00:00

abstract：:Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-D...

journal_title：Scientific reports

authors： Fortea JI,Fernández-Mena C,Puerto M,Ripoll C,Almagro J,Bañares J,Bellón JM,Bañares R,Vaquero J

更新日期：2018-06-15 00:00:00

abstract：:Magnetic resonance imaging provides a noninvasive method for in situ monitoring of electrochemical processes involved in charge/discharge cycling of batteries. Determining how the electrochemical processes become irreversible, ultimately resulting in degraded battery performance, will aid in developing new battery mat...

journal_title：Scientific reports

authors： Tang JA,Dugar S,Zhong G,Dalal NS,Zheng JP,Yang Y,Fu R

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： El-Zahar ER,Rashad AM,Saad W,Seddek LF

更新日期：2020-09-24 00:00:00

abstract：:In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay s...

journal_title：Scientific reports

authors： Liu P,Sun L,Zhou DS,Zhang P,Wang YH,Li D,Li QH,Feng RJ

更新日期：2015-12-01 00:00:00