Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence.

Abstract:

:There is evidence that genetic polymorphisms and environmentally induced epigenetic changes play an important role in modifying disease risk. The commensal microbiota has the ability to affect the cellular environment throughout the body without requiring direct contact; for example, through the generation of a pro-inflammatory state. In this review, we discuss evidence that dysbiosis in intestinal, pharyngeal, oral, and ocular microbiome can lead to epigenetic reprogramming and inflammation making the host more susceptible to ocular disease such as autoimmune uveitis, age-related macular degeneration, and open angle glaucoma. Several mechanisms of action have been proposed to explain how changes to commensal microbiota contribute to these diseases. This is an evolving field that has potentially significant implications in the management of these conditions especially from a public health perspective.

journal_name

Hum Genomics

journal_title

Human genomics

authors

Nayyar A,Gindina S,Barron A,Hu Y,Danias J

doi

10.1186/s40246-020-00257-5

subject

Has Abstract

pub_date

2020-03-13 00:00:00

pages

11

issue

1

eissn

1473-9542

issn

1479-7364

pii

10.1186/s40246-020-00257-5

journal_volume

14

pub_type

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