Abstract:
:The changes in ganglioside composition and metabolism of deafferentiated rat hippocampus were estimated after septal lesion. A significant decrease in total ganglioside concentration was found 7 days after the lesion. The reduced level of total gangliosides persisted at 17 and 25 days. Relative increase in the proportion of GD1b and GX (O-acetylated GT1b) and decrease in GM1 were found in hippocampus only at 25 days post-lesion. The incorporation of 3H-N-acetylmannoseamine into gangliosides was examined in rats whose hippocampi were lesioned 25 days prior to radioprecursor injection. Differences in the labeling pattern of total and individual gangliosides were found. Increases in the label in GM1, GD3, and GD1a and decreases in GT1b and GQ1b were found 10 hr after isotope injection. However, decreases in the specific activity of all gangliosides except GT1b and GQ1b were observed 24 hr after 3H-N-acetylomannosamine injection, suggesting the activated turnover of gangliosides in postlesioned hippocampus. The significance of these changes has been discussed in terms of cellular damage and repair in the hippocampal tissue.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Domańska-Janik Kdoi
10.1002/jnr.490210107subject
Has Abstractpub_date
1988-09-01 00:00:00pages
45-50issue
1eissn
0360-4012issn
1097-4547journal_volume
21pub_type
杂志文章abstract::The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360207
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journal_title:Journal of neuroscience research
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更新日期:1994-08-01 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:1993-10-15 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:1989-03-01 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:1992-01-01 00:00:00
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journal_title:Journal of neuroscience research
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doi:10.1002/(SICI)1097-4547(20000601)60:5<594::AID-JNR
更新日期:2000-06-01 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:1995-07-01 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-10-15 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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