Abstract：
BACKGROUND:The detection of epidural space is usually performed by the technique of loss of resistance (LOR) without technological support, although there are few commercial options. In this work, we aimed to assess the feasibility of a new, non-invasive, mechatronic system for LOR detection in clinical settings. The system allows monitoring the pressure exerted on the syringe plunger by the clinician during the puncture. The LOR is related to the mentioned pressure. METHODS:Pressure exerted on the syringe plunger by an expert anesthesiologist was monitored using the proposed system. 58 epidural punctures were performed on 34 patients using six configurations with different sensitivities and ranges of measurements. The system capability in LOR detection was evaluated comparing the LOR detected by the system with the feedback provided by the clinician. The procedure time was estimated using the system and without its use. RESULTS:The detection of LOR is strongly related to the system configuration; it ranged from 93.3% to 27.7%, while 3 configurations never detected it. The procedure time showed a non-significant increase (p=0.56) using the proposed system (average time 71 s vs. 62 s). CONCLUSIONS:The proposed mechatronic system successfully detected the LOR in the large part of cases using the configurations characterized by the best trade-off between system sensitivity and range of measurements. A non-significant increment of the procedure time is related to the use of the system.
journal_name
Minerva Anestesioljournal_title
Minerva anestesiologicaauthors
Carassiti M,Cataldo R,Formica D,Massaroni C,De Filippis A,Palermo P,Di Tocco J,Setola R,Valenti C,Schena Edoi
10.23736/S0375-9393.20.14031-8subject
Has Abstractpub_date
2020-07-01 00:00:00pages
736-741issue
7eissn
0375-9393issn
1827-1596pii
S0375-9393.20.14031-8journal_volume
86pub_type
杂志文章abstract：:Ziconotide is a synthetic peptide equivalent of an w-conotoxin, obtained from the marine snail Conus magus, which acts by blocking N-type calcium channels in the spinal cord, reducing the perception of pain. It is a newly marketed drug, exclusively for intrathecal use, indicated for severe chronic pain. Ziconotide cam...
journal_title：Minerva anestesiologica
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journal_title：Minerva anestesiologica
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journal_title：Minerva anestesiologica
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