Temporal Relationship Between Depressive Symptoms and Cognition in Mid and Late Life: A Longitudinal Cohort Study.

Abstract:

OBJECTIVES:To examine the bidirectional temporal relationship between depressive symptoms and cognition in relation to risk, reaction, and prodrome. DESIGN:Cross-lag analysis of longitudinal data collected online at baseline and 12-month follow-up. SETTING AND PARTICIPANTS:A United Kingdom population cohort of 11,855 participants aged 50 years and over. MEASURES:Patient Health Questionnaire-9 (depressive symptoms), cognitive measures: Paired Associate Learning, Verbal Reasoning, Spatial Working Memory, and Digit Span. RESULTS:Depressive symptoms predicted a decline in paired associates learning [β = -.020, P = .013, (95% confidence interval [CI], ‒.036, -.004)] and verbal reasoning [β = -.014, P = .016, (95% CI ‒.025, -.003)] but not vice versa. Depressive symptoms predicted [β = -.043, P < .001, (95% CI ‒.060, -.026); β = -.029, P < .001, (95% CI ‒.043, -.015)] and were predicted by [β = -.030, P = < .001, (95% CI ‒.047, -.014); β = -.025, P = .003, (95% CI ‒.041, -.009)], a decline in spatial working memory and verbal digit span, respectively. CONCLUSIONS AND IMPLICATIONS:Depressive symptoms may be either a risk factor or prodrome for cognitive decline. In addition, a decline in attention predicts depressive symptoms. Clinical implications and implications for further research are discussed.

journal_name

J Am Med Dir Assoc

authors

Desai R,Charlesworth GM,Brooker HJ,Potts HWW,Corbett A,Aarsland D,Ballard CG

doi

10.1016/j.jamda.2020.01.106

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1108-1113

issue

8

eissn

1525-8610

issn

1538-9375

pii

S1525-8610(20)30144-4

journal_volume

21

pub_type

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