Intravenous vs. intraosseous administration of drugs during cardiac arrest: A systematic review.

Abstract:

AIM:To perform a systematic review of the literature on intravenous (IV) vs. intraosseous (IO) administration of drugs during cardiac arrest in order to inform an update of international guidelines. METHODS:The review was performed according to PRISMA guidelines and registered on PROSPERO. Medline, Embase and Evidence-Based Medicine Reviews were searched on December 17, 2019 for studies comparing IV to IO administration of drugs. The population included neonatal, paediatric, and adult patients with cardiac arrest. Two investigators reviewed each search for study relevance, extracted data, and assessed the risk of bias of individual studies. Meta-analyses were performed for studies without a critical risk of bias. Certainty of evidence was evaluated using GRADE. RESULTS:We included six observational studies comparing IV to IO administration of drugs and two randomized trials assessing the effect of specific drugs in subgroups related to IV vs. IO administration. All studies included adult out-of-hospital cardiac arrest patients. No studies were identified in neonatal or paediatric patients. The risk of bias for the observational studies was overall assessed as critical or serious, with confounding and selection bias being the primary sources of bias. The meta-analyses excluding studies with a critical risk of bias favoured IV access for all outcomes. Using GRADE, the certainty of evidence was judged at very low. Subgroup analyses of the two randomized trials demonstrated no statistically significant interactions between the route of access and study drugs on outcomes. However, these trials were underpowered to assess such interactions. CONCLUSIONS:We identified a limited number of studies comparing IV vs. IO administration of drugs during cardiac arrest. Pooled results from four observational studies favoured IV access with very low certainty of evidence. From the subgroup analyses of two randomized clinical trials, there was no statistically significant interaction between the route of access and study drug on outcomes.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Granfeldt A,Avis SR,Lind PC,Holmberg MJ,Kleinman M,Maconochie I,Hsu CH,Fernanda de Almeida M,Wang TL,Neumar RW,Andersen LW

doi

10.1016/j.resuscitation.2020.02.025

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

150-157

eissn

0300-9572

issn

1873-1570

pii

S0300-9572(20)30091-5

journal_volume

149

pub_type

杂志文章,评审
  • Aetiology of in-hospital cardiac arrest on general wards.

    abstract:AIM:Aetiology of in-hospital cardiac arrests (IHCAs) on general wards has not been studied. We aimed to determine the underlying causes for IHCAs by the means of autopsy records and clinical judgement of the treating consultants. Furthermore, we investigated whether aetiology and preceding vital dysfunctions are associ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2016.07.007

    authors: Tirkkonen J,Hellevuo H,Olkkola KT,Hoppu S

    更新日期:2016-10-01 00:00:00

  • The effect of seeing the rhythm display on performance of cardiopulmonary resuscitation.

    abstract::Semiautomated external defibrillators are widely used by prehospital emergency personnel. Some of the devices have a rhythm display and some show only text commands on the screen. To evaluate the effects on cardiopulmonary resuscitation (CPR) performance of seeing the rhythm during resuscitation, 60 fire-fighter stude...

    journal_title:Resuscitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0300-9572(02)00208-3

    authors: Silfvast T,Paakkonen H,Gorski J

    更新日期:2002-10-01 00:00:00

  • Looking over the wall: Using a Haddon Matrix to guide public policy making on the problem of sudden cardiac arrest.

    abstract::Sudden cardiac arrest remains an important health care problem. If survival rates of all regions would equal those of the best performers, literally thousands of lives would be saved. Similar to injury, there is a need for an epidemiology-based approach for planning and execution of countermeasures. In this policy pap...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2014.01.032

    authors: Van de Voorde P,Monsieurs KG,Perkins GD,Castren M

    更新日期:2014-05-01 00:00:00

  • Can thoracic impedance monitor the depth of chest compressions during out-of-hospital cardiopulmonary resuscitation?

    abstract:AIM:To analyze the relationship between the depth of the chest compressions and the fluctuation caused in the thoracic impedance (TI) signal in out-of-hospital cardiac arrest (OHCA). The ultimate goal was to evaluate whether it is possible to identify compressions with inadequate depth using information of the TI wavef...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2013.12.035

    authors: Alonso E,González-Otero D,Aramendi E,Ruiz de Gauna S,Ruiz J,Ayala U,Russell JK,Daya M

    更新日期:2014-05-01 00:00:00

  • Standardising communication to improve in-hospital cardiopulmonary resuscitation.

    abstract:AIM:Recommendations for standardised communication to reduce chest compression (CC) pauses are lacking. We aimed to achieve consensus and evaluate feasibility and efficacy using standardised communication during cardiopulmonary resuscitation (CPR) events. METHODS:Modified Delphi consensus process to design standardise...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.12.013

    authors: Lauridsen KG,Watanabe I,Løfgren B,Cheng A,Duval-Arnould J,Hunt EA,Good GL,Niles D,Berg RA,Nishisaki A,Nadkarni VM

    更新日期:2020-02-01 00:00:00

  • Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest.

    abstract:AIM OF THE STUDY:Serum glial fibrillary acidic protein (GFAP) has recently been identified as a specific predictor of brain damage and neurological outcome in patients with head trauma. In this study, serum GFAP was assessed as a predictor of neurological outcome in post-cardiac-arrest (PCA) patients. METHODS:This stu...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.04.003

    authors: Kaneko T,Kasaoka S,Miyauchi T,Fujita M,Oda Y,Tsuruta R,Maekawa T

    更新日期:2009-07-01 00:00:00

  • Regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest in Australia and New Zealand: Results from the Aus-ROC Epistry.

    abstract:INTRODUCTION:The aim of this study was to investigate regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in Australia and New Zealand. METHODS:This was a population-based cohort study of OHCA using data from the Aus-ROC Australian and New Zealand OHCA Epistry ove...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2018.02.029

    authors: Beck B,Bray J,Cameron P,Smith K,Walker T,Grantham H,Hein C,Thorrowgood M,Smith A,Inoue M,Smith T,Dicker B,Swain A,Bosley E,Pemberton K,McKay M,Johnston-Leek M,Perkins GD,Nichol G,Finn J,Aus-ROC Steering Committee.

    更新日期:2018-05-01 00:00:00

  • BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats.

    abstract:OBJECTIVES:The main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats. METHODS:Thirty two adult male rats ...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2011.12.035

    authors: Gong J,Guo S,Li HB,Yuan SY,Shang Y,Yao SL

    更新日期:2012-07-01 00:00:00

  • A scoring system for the assessment of basic life support ability.

    abstract:INTRODUCTION:There are no current validated scoring systems for the assessment of adult single rescuer basic life support (BLS) ability. A system was proposed and prospectively validated. METHODS:The system was tested firstly on 12 skilled BLS providers (all instructors). It was then further evaluated on 75 undergradu...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/s0300-9572(99)00135-5

    authors: Graham CA,Lewis NF

    更新日期:2000-01-01 00:00:00

  • Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest.

    abstract:AIM OF THE STUDY:Piston based mechanical chest compression devices deliver compressions and decompressions in an accelerated pattern, resulting in superior haemodynamics compared to manual compression in animal studies. The present animal study compares haemodynamics during two different hybrid compression patterns to ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.12.028

    authors: Tømte Ø,Sjaastad I,Wik L,Kuzovlev A,Eriksen M,Norseng PA,Sunde K

    更新日期:2010-04-01 00:00:00

  • Cardiovascular function and neurologic outcome after cardiac arrest in dogs. The cardiovascular post-resuscitation syndrome.

    abstract::We studied cardiovascular changes and neurologic outcome at 72 h in 42 healthy dogs after normothermic ventricular fibrillation cardiac arrest (no blood flow) of 7.5, 10, or 12.5 min duration, reversed by standard external cardiopulmonary resuscitation (CPR) (< or = 10 min) and followed by controlled ventilation to 20...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(93)90003-9

    authors: Cerchiari EL,Safar P,Klein E,Cantadore R,Pinsky M

    更新日期:1993-02-01 00:00:00

  • Prehospital cardiac arrest--a critical analysis of factors affecting survival.

    abstract::During a 10-year period, 5631 cardiac arrests were treated in our paramedic system. In all, 4216 resuscitations were attempted, of which 533 (12.6%) resulted in saves, defined as hospital discharges. Patients presenting with an initial rhythm of coarse ventricular fibrillation or ventricular tachycardia were found to ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(89)90041-5

    authors: Stueven HA,Waite EM,Troiano P,Mateer JR

    更新日期:1989-06-01 00:00:00

  • Mechanical active compression-decompression cardiopulmonary resuscitation (ACD-CPR) versus manual CPR according to pressure of end tidal carbon dioxide (P(ET)CO2) during CPR in out-of-hospital cardiac arrest (OHCA).

    abstract:AIM:In animal and human studies, measuring the pressure of end tidal carbon dioxide (P(ET)CO2) has been shown to be a practical non-invasive method that correlates well with the pulmonary blood flow and cardiac output (CO) generated during cardiopulmonary resuscitation (CPR). This study aims to compare mechanical activ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.08.006

    authors: Axelsson C,Karlsson T,Axelsson AB,Herlitz J

    更新日期:2009-10-01 00:00:00

  • Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C.

    abstract:AIM:In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of th...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2014.09.025

    authors: Koopmans M,Kuiper MA,Endeman H,Veenstra G,Vellinga NA,de Vos R,Boerma EC

    更新日期:2015-01-01 00:00:00

  • CPR quality during out-of-hospital cardiac arrest transport.

    abstract:BACKGROUND:Previous studies have demonstrated significant associations between cardiopulmonary resuscitation (CPR) quality metrics and survival to hospital discharge. No adequately powered study has explored the relationship between location of resuscitation (scene vs. transport) and CPR quality. METHODS:We analyzed C...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2017.02.016

    authors: Cheskes S,Byers A,Zhan C,Verbeek PR,Ko D,Drennan IR,Buick JE,Brooks SC,Lin S,Taher A,Morrison LJ,Rescu Epistry Investigators.

    更新日期:2017-05-01 00:00:00

  • cDNA array analysis of gene expression following hemorrhagic shock and resuscitation in rats.

    abstract:UNLABELLED:The aim of this study was to characterize gene expression following hemorrhagic shock and resuscitation with emphasis on the differences between various resuscitation strategies. METHODS:Male Sprague Dawley rats (n = 25; 5/group) were subjected to a three stage hemorrhage and resuscitated as follows: (1) sh...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/s0300-9572(02)00095-3

    authors: Alam HB,Stegalkina S,Rhee P,Koustova E

    更新日期:2002-08-01 00:00:00

  • Mechanisms of the beneficial effect of NHE1 inhibitor in traumatic hemorrhage: inhibition of inflammatory pathways.

    abstract::This study evaluated the effects of sodium-hydrogen exchanger (NHE1) inhibition on enhancing fluid resuscitation outcomes in traumatic hemorrhagic shock, and examined the mechanisms related to NHE1 inhibitor-induced protection and recovery from hemorrhagic shock. Traumatic hemorrhage was modeled in anesthetized pigs b...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2011.11.025

    authors: Wu D,Qi J

    更新日期:2012-06-01 00:00:00

  • Testosterone related good neurologic outcome on the patients with return of spontaneous circulation after cardiac arrest: a prospective cohort study.

    abstract:AIM:To evaluate the gonadal hormones in patients with return of spontaneous circulation (ROSC) after cardiac arrest following prospectively good (cerebral-performance category [CPC] 1-2) and poor (CPC 3-5) neurologic outcomes. METHODS:The patients in an emergency center who had been admitted to the center's intensive ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2012.10.022

    authors: Kim JJ,Oh SJ,Shin JH,Hwang SY,Hyun SY,Yang HJ,Lee G

    更新日期:2013-05-01 00:00:00

  • Excellent coronary perfusion pressure during cardiopulmonary resuscitation is not good enough to ensure long-term survival with good neurologic outcome: a porcine case report.

    abstract:PURPOSE:To report a case of cerebral ischemia confirmed by magnetic resonance imaging after successful cardiopulmonary resuscitation (CPR) complicated by acute respiratory injury. MATERIALS AND METHODS:After 4 min of cardiac arrest, followed by 3 min of basic life support CPR, a female pig weighing 38 kg received ever...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/s0300-9572(00)00200-8

    authors: Enna B,Wenzel V,Schocke M,Krismer AC,Voelckel WG,Klima G,Felber S,Pfaller K,Lindner KH

    更新日期:2000-09-01 00:00:00

  • Increased frequency of thorax injuries with ACD-CPR.

    abstract::A prospective, randomised out-of-hospital study in a two-tiered system with active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) versus standard (STD) CPR in patients following non-traumatic cardiac arrest was planned to test the hypothesis that ACD-CPR by the first tier may increase the occurren...

    journal_title:Resuscitation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0300-9572(99)00033-7

    authors: Baubin M,Sumann G,Rabl W,Eibl G,Wenzel V,Mair P

    更新日期:1999-06-01 00:00:00

  • A moderate dose of propofol and rapidly induced mild hypothermia with extracorporeal lung and heart assist (ECLHA) improve the neurological outcome after prolonged cardiac arrest in dogs.

    abstract:BACKGROUND AND PURPOSE:Propofol has been shown to protect against neuronal damage induced by brain ischaemia in small animal models. We reported previously that mild hypothermia (33 degrees C) in combination with extracorporeal lung and heart assist (ECLHA) improved the neurological outcome in dogs with cardiac arrest ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2005.12.011

    authors: Ichinose K,Okamoto T,Tanimoto H,Taguchi H,Tashiro M,Sugita M,Takeya M,Terasaki H

    更新日期:2006-08-01 00:00:00

  • A new positive end-expiratory pressure valve for manually operated artificial ventilation.

    abstract::The application of positive end-expiratory pressure (PEEP) as part of artificial ventilation is currently considered a basic provision to provide adequate treatment of critically ill patients in intensive care units. Hitherto only the application of intermittent positive pressure ventilation (IPPV) with an end-expirat...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(78)90030-8

    authors: Dick W,Milewski P,Lotz P,Ahnefeld FW

    更新日期:1978-01-01 00:00:00

  • Very high survival among patients defibrillated at an early stage after in-hospital ventricular fibrillation on wards with and without monitoring facilities.

    abstract:BACKGROUND:The association between the interval between collapse and defibrillation and outcome is well described in out of hospital cardiac arrest but not as well in in-hospital cardiac arrest. We report the outcome among patients who suffered an in-hospital cardiac arrest and were found in ventricular fibrillation (V...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2005.03.018

    authors: Herlitz J,Aune S,Bång A,Fredriksson M,Thorén AB,Ekström L,Holmberg S

    更新日期:2005-08-01 00:00:00

  • Prospective, randomized trial of the effectiveness and retention of 30-min layperson training for cardiopulmonary resuscitation and automated external defibrillators: The American Airlines Study.

    abstract:OBJECTIVE:A head-to-head trial was conducted to compare laypersons' long-term retention of life-saving psychomotor and cognitive skills learned in the traditional multi-hour training format for basic cardiopulmonary resuscitation and automated external defibrillator use to those learned in an abbreviated (30 min) cours...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2006.12.017

    authors: Roppolo LP,Pepe PE,Campbell L,Ohman K,Kulkarni H,Miller R,Idris A,Bean L,Bettes TN,Idris AH

    更新日期:2007-08-01 00:00:00

  • Impact of a standardized nurse observation protocol including MEWS after Intensive Care Unit discharge.

    abstract:BACKGROUND:Analysis of in-hospital mortality after serious adverse events (SAE's) in our hospital showed the need for more frequent observation in medical and surgical wards. We hypothesized that the incidence of SAE's could be decreased by introducing a standard nurse observation protocol. AIM:To investigate the effe...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2012.06.017

    authors: De Meester K,Das T,Hellemans K,Verbrugghe W,Jorens PG,Verpooten GA,Van Bogaert P

    更新日期:2013-02-01 00:00:00

  • Effect of time and day of admission on 1-month survival and neurologically favourable 1-month survival in out-of-hospital cardiopulmonary arrest patients.

    abstract:AIM:We sought to examine whether the outcomes of out-of-hospital cardiopulmonary arrest (OHCA) patients differed between weekday and weekend/holiday admissions, or between daytime and nighttime admissions. METHODS:From a national registry of OHCA events in Japan between 2005 and 2008, 173,137 cases where the call-to-h...

    journal_title:Resuscitation

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.resuscitation.2011.02.007

    authors: Koike S,Tanabe S,Ogawa T,Akahane M,Yasunaga H,Horiguchi H,Matsumoto S,Imamura T

    更新日期:2011-07-01 00:00:00

  • The immediate life support (ILS) course--the Italian experience.

    abstract:AIM OF THE STUDY:The 1-day immediate life support course (ILS) was started in the United Kingdom and adopted by the ERC to train healthcare professionals who attend cardiac arrests only occasionally. Currently, there are no reports about the ILS course from outside the UK. In this paper we describe our initial Italian ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2006.07.024

    authors: Scapigliati A,Sanna T,Zamparelli R,Sandroni C,Colizzi C,Fenici P,Arlotta G,Nuzzo C,Bonarrigo C,Bellocci F,Schiavello R,Possati G

    更新日期:2007-03-01 00:00:00

  • Endothelium-dependent responses and their potential relevance to the distribution of blood flow during hemorrhagic shock.

    abstract::The endothelium releases vasoactive substances in response to several circulating hormones and to changes in shear stress of the flowing blood across the endothelial surface. Because the distribution of receptors mediating the release of endothelium-derived factors is not uniform along the vascular bed, the vascular e...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/0300-9572(89)90019-1

    authors: Miller VM,Vanhoutte PM

    更新日期:1989-12-01 00:00:00

  • Disposable laryngeal tube suction: standard insertion technique versus two modified insertion techniques for patients with a simulated difficult airway.

    abstract:OBJECTIVE:The disposable laryngeal tube suction (LTS-D) is a supraglottic airway device that can be used as an alternative to tracheal tube to provide ventilation. We tested the hypothesis that, with a frontal jaw thrust insertion technique (FIT/JT), the rate of correct placement attempts in patients with a simulated d...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2010.09.474

    authors: Schalk R,Engel S,Meininger D,Zacharowski K,Holzer L,Scheller B,Byhahn C

    更新日期:2011-02-01 00:00:00

  • CaRdiac Arrest Survival Score (CRASS) - A tool to predict good neurological outcome after out-of-hospital cardiac arrest.

    abstract:AIM:The aim of this study was to develop a score to predict the outcome for patients brought to hospital following out-of-hospital cardiac arrest (OHCA). METHODS:All patients recorded in the German Resuscitation Registry (GRR) who suffered OHCA 2010-2017, who had ROSC or ongoing CPR at hospital admission were included...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.10.036

    authors: Seewald S,Wnent J,Lefering R,Fischer M,Bohn A,Jantzen T,Brenner S,Masterson S,Bein B,Scholz J,Gräsner JT

    更新日期:2020-01-01 00:00:00