Abstract:
:Recent studies have suggested that an increased peripheral monocyte count predicts a poor outcome in fibrosing interstitial lung disease (ILD). However, the association between an increased monocyte count and acute exacerbations (AEs) of fibrosing ILD remains to be elucidated. Our retrospective cohort study aimed to assess the impact of peripheral monocyte count on AEs of fibrosing ILD. We analyzed the electronic medical records of 122 consecutive patients with fibrosing ILD and no prior history of an AE, who were treated with anti-fibrotic agents from August 2015 to December 2018. We determined their peripheral monocyte counts at anti-fibrotic agent initiation and performed univariate and multivariate Cox regression analyses of time-to-first AE after anti-fibrotic agent initiation to assess the impact of monocyte count on AEs of fibrosing ILD. Twenty-six patients developed an AE during the follow-up period, and there was an increased monocyte count at anti-fibrotic agent initiation in these patients compared to those who did not develop an AE. There was also a significantly shorter time-to-first AE of fibrosing ILD in patients with a higher absolute monocyte count. Subgroup analyses indicated similar results regardless of the idiopathic pulmonary fibrosis diagnoses. This association was independently significant after adjusting for the severity of the fibrosing ILD. Using our results, we developed a simple scoring system consisting of two factors-monocyte count (<>380 µL-1) and ILD-gender, age, physiology score (<>4 points). Our findings suggest that the absolute monocyte count is an independent significant risk factor for AE in patients with fibrosing ILD. Our simple scoring system may be a predictor for AEs of fibrosing ILD, although further studies are needed to verify our findings.
journal_name
Chron Respir Disjournal_title
Chronic respiratory diseaseauthors
Kawamura K,Ichikado K,Anan K,Yasuda Y,Sekido Y,Suga M,Ichiyasu H,Sakagami Tdoi
10.1177/1479973120909840subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1479973120909840eissn
1479-9723issn
1479-9731journal_volume
17pub_type
杂志文章abstract::We report here an unusual case of a 25-year old male with juvenile onset recurrent respiratory papillomatosis who developed an infestation of papillomata 'papillomatization' of an old abscess cavity that, when removed, was coincidently found to contain a 2 cm well differentiated squamous cell carcinoma. The abscess ca...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1191/1479972304cd042cr
更新日期:2004-01-01 00:00:00
abstract::Cough-suppression physiotherapy is a novel self-help therapy for chronic cough. We evaluated the effectiveness of cough physiotherapy in a pilot prospective observational study. We assessed cough-specific health-related quality of life (HRQOL) with the Leicester Cough Questionnaire (LCQ) and subjectively reported coug...
journal_title:Chronic respiratory disease
pub_type: 临床试验,杂志文章
doi:10.1177/1479972311422547
更新日期:2011-01-01 00:00:00
abstract::Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating condition that frequently occurs in the advanced stage of IPF. However, the clinical features in AE of connective tissue disease-associated interstitial pneumonia (AE-CTD-IP) have not been well-established. The aim of this study was to clari...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972318809476
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Effective asthma management requires a multidisciplinary approach that includes; the physician, the patient, and the patient's family. OBJECTIVES:The current study aimed to assess the roles played by community pharmacists toward asthma control together with the barriers hindering their practice and possible...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973120952679
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Many deaths are now preceded by an end of life decision, particularly in the intensive care unit (ICU), but such practices vary considerably between countries, ICUs and individuals, depending on many factors including cultural and religious background, family and peer pressure and local practice. AIMS:In th...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1191/1479972304cd021rs
更新日期:2004-01-01 00:00:00
abstract::The spread of the SARS-CoV-2 infection among population has imposed a re-organization of healthcare services, aiming at stratifying patients and dedicating specific areas where patients with suspected COVID-related respiratory disease could receive the necessary health care assistance while waiting for the confirmatio...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973120961843
更新日期:2020-01-01 00:00:00
abstract::Sleep-disordered breathing (SDB) is a chronic condition characterized by repeated breathing pauses during sleep. The reported prevalence of SDB in the general population has increased over time. Furthermore, in the literature, a distinction is made between SDB, obstructive sleep apnea (OSA), and "OSA syndrome" (OSAS)....
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973120928103
更新日期:2020-01-01 00:00:00
abstract::To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972317743756
更新日期:2018-08-01 00:00:00
abstract::Patients with chronic obstructive pulmonary disease (COPD) complain of dyspnea and fatigue. We sought to estimate the prevalence of high fatigue in this population and to determine whether individuals with high fatigue had a different response to pulmonary rehabilitation. This observational study was embedded within a...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972310396737
更新日期:2011-01-01 00:00:00
abstract::Recent advances in information communication technology allow contact with patients at home through e-Health services (telemedicine, in particular). We provide insights on the state of the art of e-Health and telemedicine for possible wider future clinical use. Telemedicine opportunities are summarized as i) home tele...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972309102805
更新日期:2009-01-01 00:00:00
abstract::In a primary care setting, our aim was to investigate characteristics of patients classified as having chronic obstructive pulmonary disease (COPD) and currently being prescribed inhaled corticosteroids (ICSs). The electronic patient record system in each participating general practice was searched for patients coded ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973119867949
更新日期:2019-01-01 00:00:00
abstract::Obstructive sleep apnoea (OSA) is increasingly considered as a risk factor for metabolic disturbances, such as diabetes mellitus or dyslipidaemia. Continuous positive airway pressure (CPAP) therapy, the standard treatment for patients with OSA, may improve various metabolic variables, such as insulin sensitivity, gluc...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972313516882
更新日期:2014-02-01 00:00:00
abstract::Bronchiectasis is a chronic inflammatory lung disease, which has similarities to chronic obstructive pulmonary disease (COPD). Comorbidities of COPD include increased risk of cardiovascular (CV) disease, loss of bone mineral density (BMD) and loss of skeletal muscle mass and function, all linked to systemic inflammati...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972312459973
更新日期:2012-01-01 00:00:00
abstract::Acute effects of music and relaxation have not been evaluated in hospitalized subjects with chronic obstructive pulmonary disease (COPD). This study aims to evaluate the acute effects of music and progressive muscle relaxation (PMR) in hospitalized COPD subjects after a recent episode of exacerbation. A Randomized con...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1479972309346754
更新日期:2009-01-01 00:00:00
abstract::It has been well defined that obesity is strongly linked with several respiratory symptoms and diseases, but no convincing evidence has been provided for chronic obstructive pulmonary disease (COPD). In the current study, we aim to assess the possible prevalence of obesity in patients with COPD in a cross-sectional ca...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972313504940
更新日期:2013-01-01 00:00:00
abstract::Shifts in natural or spontaneous language have been reported with psychological and physical changes, as well as shifts in predetermined words selected to describe dyspnea. Less evidence exists for natural language shifts and breathing intensity, particularly for everyday life and for negative emotion. Therefore, this...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972308096710
更新日期:2008-01-01 00:00:00
abstract::Patients with bronchiectasis (BE) present exacerbations that increase with severity of the disease. We aimed to determine the annual cost of BE treatment according to its severity, determined by FACED score, as well as the parameters associated with higher costs. Multicentre historical cohorts study with patients from...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972316643698
更新日期:2016-11-01 00:00:00
abstract::Home noninvasive ventilation (NIV) is widely used to correct nocturnal alveolar hypoventilation in patients with chronic respiratory failure of various etiologies. The most commonly used ventilation mode is pressure support with a backup respiratory rate. This mode requires six main settings, as well as some additiona...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479973119844090
更新日期:2019-01-01 00:00:00
abstract::Pulmonary rehabilitation (PR) is recommended for people with interstitial lung disease (ILD); however, the educational content of PR was not designed for this group. This study explored the perspectives of patients and ILD clinicians regarding the educational content of PR for ILD. A qualitative study using individual...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315571925
更新日期:2015-05-01 00:00:00
abstract::The aim of this study is to conduct a systematic review of published studies that evaluate the impact of pulmonary rehabilitation (PR) on survival and fall (including balance) in patients with chronic obstructive pulmonary disease at stability. OVID, Medline, EMBASE, and Cochrane collaboration library were searched fo...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972316661925
更新日期:2017-02-01 00:00:00
abstract::Pulmonary rehabilitation (PR) can improve aerobic exercise capacity, health-related quality of life and dyspnoea in patients with chronic obstructive pulmonary disease (COPD). Recent studies have suggested that exercise training may improve blood pressure and arterial stiffness, albeit in small highly selected cohorts...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315587515
更新日期:2015-08-01 00:00:00
abstract::Nutritional status has been associated with clinical outcome in chronic airflow limitation (CAL), but epidemiological studies are scarce. We aimed to assess the relationship between body mass index (BMI) and CAL, taking into account confounding factors. 18,606 participants (49% male, 21% smokers, mean age: 55.8 ± 11.2...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315626012
更新日期:2016-05-01 00:00:00
abstract::Pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD) improves exercise tolerance and health status, however, these effects have been shown to decline after termination of the rehabilitation program. This study has examined the long-term effect of a 7-week supervised rehabilitation program combined ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972307087366
更新日期:2008-01-01 00:00:00
abstract::Pulmonary rehabilitation (PR) is an effective treatment for people with chronic obstructive pulmonary disease (COPD). However, uptake and adherence to rehabilitation is poor and non-adherence is associated with poorer clinical outcomes. This study investigated the factors that might predict an individual completing hi...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972314527469
更新日期:2014-05-01 00:00:00
abstract::Dyspnea-related anxiety may lead to reduced quality of life and functional disability through fearful avoidance of dyspnea-evoking activity. We describe the validation of a generic - diagnosis-independent - instrument assessing dyspnea-related anxiety. A total of 187 patients with respiratory diseases completed the Br...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972310383592
更新日期:2011-01-01 00:00:00
abstract::The association between motor vehicle accidents (MVAs) and obstructive sleep apnea syndrome (OSAS) has always been quantified as risk of MVAs for individual drivers with OSAS. We evaluated the expected injured patients per year attributable to OSAS-dependent MVAs in a general population. By combining OSAS prevalence a...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315594624
更新日期:2015-11-01 00:00:00
abstract::The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state e...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972317743757
更新日期:2018-08-01 00:00:00
abstract::This pilot study investigated the benefits of adjunctive psychological intervention for smokers accessing standard smoking cessation interventions. Chronic obstructive pulmonary disease (COPD) smokers attending a smoking cessation service were offered up to 12 adjunctive clinical psychology sessions. Baseline data inc...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315586198
更新日期:2015-08-01 00:00:00
abstract::The aim of the study was to determine if there was a difference in 6-minute walk distance (6MWD) when two 6-minute walk tests (6MWTs) were performed at the initial assessment prior to attendance at the pulmonary hypertension (PH) clinic and at the 6-month follow-up. Two 6MWTs were performed at both visits on a 32-m co...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972317752762
更新日期:2018-11-01 00:00:00
abstract::The objective of this study is to review available functional status measures (FSMs) validated for use in the chronic obstructive pulmonary disease (COPD) population and categorizing the measures by their commonalities to formulate a framework that supports clinicians in the selection and application of FSMs. A litera...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479973118816464
更新日期:2019-01-01 00:00:00