The effect of lymph node metastasis on overall survival and disease-free survival in vulvar cancer patients.

Abstract:

OBJECTIVES:To examine the effect of lymphadenectomy on survival in patients with squamous cell vulvar carcinoma. MATERIAL AND METHODS:Patients with squamous cell vulvar cancer who underwent surgery were retrospectively analyzed. All procedures were performed according to current recommendations/standard of treatment. The clinical and pathological features were examined. Sixty-eight patients were studied. The mean age was 64.7 ± 10.9 years. Twenty-three (33.8%) patients had nodal metastasis. Most patients (60.3%) were in stage IB. Adjuvant radiotherapy and chemo-radiotherapy were administered to 33.8% and 25% of the patients, respectively. The median follow-up time was 28.5 (4-183) months. Recurrence occurred in 18 (26.5%) cases. RESULTS:There was no significant difference between node-positive and node-negative patients in terms of age, number of dissected lymph nodes and recurrence. Tumor diameter was significantly higher in the metastatic group. Age and surgical margin positivity were independent prognostic factors for overall survival (OS). Surgical margin positivity and lymph node metastasis had no effect on disease-free survival (DFS). CONCLUSIONS:Our results showed that age and surgical margin positivity were independent prognostic factors for OS. Although surgical margin positivity increased the risk of recurrence in univariate analysis, it was not a significant factor affecting DFS. OS was significantly lower in patients with lymph node metastasis.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Karataşlı V,Erkılınç S,Çakır İ,Can B,Karadeniz T,Gökçü M,Sancı M

doi

10.5603/GP.2020.0018

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

62-67

issue

2

eissn

0017-0011

issn

2543-6767

pii

VM/OJS/J/65812

journal_volume

91

pub_type

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