Abstract:
:Stem rust is an important disease of wheat that can be controlled using resistance genes. The gene SuSr-D1 identified in cultivar 'Canthatch' suppresses stem rust resistance. SuSr-D1 mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identify SuSr-D1 by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hiebert CW,Moscou MJ,Hewitt T,Steuernagel B,Hernández-Pinzón I,Green P,Pujol V,Zhang P,Rouse MN,Jin Y,McIntosh RA,Upadhyaya N,Zhang J,Bhavani S,Vrána J,Karafiátová M,Huang L,Fetch T,Doležel J,Wulff BBH,Lagudah E,doi
10.1038/s41467-020-14937-2subject
Has Abstractpub_date
2020-02-28 00:00:00pages
1123issue
1issn
2041-1723pii
10.1038/s41467-020-14937-2journal_volume
11pub_type
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