Abstract:
:Identification of AD (Alzheimer's disease)-related genes obtained from blood samples is crucial for early AD diagnosis. We used three public datasets, ADNI, AddNeuroMed1 (ANM1), and ANM2, for this study. Five feature selection methods and five classifiers were used to curate AD-related genes and discriminate AD patients, respectively. In the internal validation (five-fold cross-validation within each dataset), the best average values of the area under the curve (AUC) were 0.657, 0.874, and 0.804 for ADNI, ANMI, and ANM2, respectively. In the external validation (training and test sets from different datasets), the best AUCs were 0.697 (training: ADNI to testing: ANM1), 0.764 (ADNI to ANM2), 0.619 (ANM1 to ADNI), 0.79 (ANM1 to ANM2), 0.655 (ANM2 to ADNI), and 0.859 (ANM2 to ANM1), respectively. These results suggest that although the classification performance of ADNI is relatively lower than that of ANM1 and ANM2, classifiers trained using blood gene expression can be used to classify AD for other data sets. In addition, pathway analysis showed that AD-related genes were enriched with inflammation, mitochondria, and Wnt signaling pathways. Our study suggests that blood gene expression data are useful in predicting the AD classification.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee T,Lee Hdoi
10.1038/s41598-020-60595-1subject
Has Abstractpub_date
2020-02-26 00:00:00pages
3485issue
1issn
2045-2322pii
10.1038/s41598-020-60595-1journal_volume
10pub_type
杂志文章abstract::Fibrosis-related events play a part in most blinding diseases worldwide. However, little is known about the mechanisms driving this complex multifactorial disease. Here we have carried out the first genome-wide RNA-Sequencing study in human conjunctival fibrosis. We isolated 10 primary fibrotic and 7 non-fibrotic conj...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05780-5
更新日期:2017-07-17 00:00:00
abstract::Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential emergence of different genotypes and strains. Despite the likely relevance in the emergence of new PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short transmission...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33849-2
更新日期:2018-10-19 00:00:00
abstract::Mechanochemical synthesis of Si/Cu3Si-based composite as negative electrode materials for lithium ion battery is investigated. Results indicate that CuO is decomposed and alloyed with Si forming amorphous Cu-Si solid solution due to high energy impacting during high energy mechanical milling (HEMM). Upon carbonization...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30703-3
更新日期:2018-08-23 00:00:00
abstract::The pressure dependence of the superconducting transition temperature (Tc) and unit cell metrics of tetragonal (NH3)yCs0.4FeSe were investigated in high pressures up to 41 GPa. The Tc decreases with increasing pressure up to 13 GPa, which can be clearly correlated with the pressure dependence of c (or FeSe layer spaci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09477
更新日期:2015-04-01 00:00:00
abstract::In using nanostructures to design solar thermal absorbers, computational methods, such as rigorous coupled-wave analysis and the finite-difference time-domain method, are often employed to simulate light-structure interactions in the solar spectrum. However, those methods require heavy computational resources and CPU ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51407-2
更新日期:2019-10-21 00:00:00
abstract::Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62042-7
更新日期:2020-04-14 00:00:00
abstract::Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02716-x
更新日期:2017-05-31 00:00:00
abstract::Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesized that the intestinal microbiota are altered during pregnancy in favor of species associated with pregnancy associated im...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28292-2
更新日期:2018-07-03 00:00:00
abstract::Graphene aerogels (GAs) with high mechanical strength, tunable density and volume have been prepared only via soaking graphene hydrogels (GHs) in ammonia solution. The density and volume of the obtained GAs are controlled by adjusting the concentration of ammonia solution. Although volume of the GAs decreases with inc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05025
更新日期:2014-05-22 00:00:00
abstract::The interfacial Dzyaloshinskii-Moriya interaction (DMI) is an essential ingredient for stabilizing chiral spin configurations in spintronic applications. Here, via first-principles calculations, we reveal the influence of lattice strain on DMI in Co/Pt interface. We observed a considerable enhancement for a certain la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69360-w
更新日期:2020-07-23 00:00:00
abstract::De novo mutations (DNMs), including germinal and postzygotic mutations (PZMs), are a strong source of causality for Autism Spectrum Disorder (ASD). However, the biological processes involved behind them remain unexplored. Our aim was to detect DNMs (germinal and PZMs) in a Spanish ASD cohort (360 trios) and to explore...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79412-w
更新日期:2021-01-11 00:00:00
abstract::More than a hundred different Transthyretin (TTR) mutations are associated with fatal systemic amyloidoses. They destabilize the protein tetrameric structure and promote the extracellular deposition of TTR as pathological amyloid fibrils. So far, only mutations R104H and T119M have been shown to stabilize significantl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44709
更新日期:2017-03-24 00:00:00
abstract::Test anxiety is a condition in which people experience extreme distress and anxiety before and in test situations. It affects up to 40 percent of all students. Conventional treatment includes both medication and psychotherapy, but studies also demonstrated that placebos affect anxiety symptoms. Although in the traditi...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-49466-6
更新日期:2019-09-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57947-2
更新日期:2020-01-30 00:00:00
abstract::We developed a novel, erythropoietin-derived, non-erythropoiesis, cyclic helix B peptide (CHBP) that displays potent renoprotection against acute kidney injury (AKI). To determine the mechanism of CHBP-mediated protection, we investigated the proteomic profile of mice treated with CHBP in a kidney ischemia-reperfusion...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18045
更新日期:2015-12-10 00:00:00
abstract::Geothermal waters from the Semi, Dagejia and Kawu hot springs in the Shiquanhe-Yarlung Zangbo geothermal field of southern Tibet (China) are highly enriched in rare alkali metals (RAM). However, the enrichment mechanism is still hotly debated. Here, we report the first silicon isotope data of these geothermal waters t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44249-5
更新日期:2019-05-27 00:00:00
abstract::Low-noise millimetre-wave signals are valuable for digital sampling systems, arbitrary waveform generation for ultra-wideband communications, and coherent radar systems. However, the phase noise of widely used conventional signal generators (SGs) will increase as the millimetre-wave frequency increases. Our goal has b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24621
更新日期:2016-05-17 00:00:00
abstract::Sweetness is one of the main drivers of consumer preference, and thus is given high priority in apple breeding programmes. Due to the complexity of sweetness evaluation, soluble solid content (SSC) is commonly used as an estimation of this trait. Nevertheless, it has been demonstrated that SSC and sweet taste are poor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44950
更新日期:2017-03-21 00:00:00
abstract::Pepper (Capsicum annuum L.) fruit is sensitive to temperatures below 10 °C, which severely diminish fruit quality during cold chain distribution. Seed browning was a major chilling symptom in 36 genotypes of C. annuum fruit screened after storage at 2 °C for 3 weeks. Among them, pepper fruits of chilling-insensitive '...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75055-z
更新日期:2020-10-21 00:00:00
abstract::Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00731
更新日期:2012-01-01 00:00:00
abstract::High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been confirmed. In this study, we (1) investigated whether VEGF participa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06242-8
更新日期:2017-07-18 00:00:00
abstract::We propose an internal (on-chip) Wheatstone bridge configuration to evaluate the efficiency of near-field transducers (NFT) as used in heat-assisted magnetic recording (HAMR). The electric field enhancement between the transducer and the image plane is monitored by measuring the resistance of metal electrodes composin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24423
更新日期:2016-04-14 00:00:00
abstract::In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40224
更新日期:2017-01-06 00:00:00
abstract::Networks are mathematical structures that are universally used to describe a large variety of complex systems such as the brain or the Internet. Characterizing the geometrical properties of these networks has become increasingly relevant for routing problems, inference and data mining. In real growing networks, topolo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10073
更新日期:2015-05-18 00:00:00
abstract::Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes (dLNs). To quantify the spatiotemporal regulation of skin-derived DCs in vivo, we generated knock-in mice expressing the photoconvertible fl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06030
更新日期:2014-08-12 00:00:00
abstract::Barley is a kind of cereal grass belonging to the family Poaceae. To examine viruses infecting winter barley in Korea, we carried out a comprehensive study of barley RNA viromes using next-generation sequencing (NGS). A total of 110 barley leaf samples from 17 geographical locations were collected. NGS followed by ext...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31671-4
更新日期:2018-09-05 00:00:00
abstract::We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14398-6
更新日期:2017-10-25 00:00:00
abstract::Heparin is a widely used anticoagulant which inhibits factor Xa and thrombin through potentiation of antithrombin. We recently identified that the nucleic acid stain SYTOX reacts with platelet polyphosphate due to molecular similarities, some of which are shared by heparin. We attempted to study heparin in flowing blo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54818-3
更新日期:2019-12-04 00:00:00
abstract::The Great East Japan Earthquake on 11 March 2011, caused the release of radioactive materials from the Fukushima Daiichi Nuclear Power Plant (FDNPP), contaminating eastern Japan, particularly in part of Fukushima Prefecture. In 2012 and 2014, the radiocaesium concentration in brown rice did not exceed regulatory level...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20386
更新日期:2016-02-04 00:00:00
abstract::Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21282-4
更新日期:2018-02-16 00:00:00