Abstract:
BACKGROUND:The programmed death 1/programmed death-ligand 1 (PD-L1) pathway reportedly is as an important factor determining effects of immunotherapy; however, its prognostic impact is controversial, and its association with the surrounding immune microenvironment has not yet been elucidated. PATIENTS AND METHODS:We retrospectively analyzed 126 patients with pathologic stage I non-small-cell lung cancer. Patients with lepidic-dominant adenocarcinoma were excluded. PD-L1 expression was evaluated with immunohistochemistry correlated with clinicopathologic features and surrounding immune microenvironment status, including CD4, CD8, regulatory T cells, and human leukocyte antigen class I. Factors affecting prognosis were assessed by Kaplan-Meier and Cox regression analyses. RESULTS:Twenty-three (18.3%) patients were positive for PD-L1 expression. No significant correlation was observed between PD-L1 expression and the surrounding immune microenvironment status. The PD-L1-positive group had a worse prognosis than the PD-L1-negative group (5-year recurrence-free survival rates, 63.4% vs. 81.0%; P = .061). Among surrounding immune cells, intratumoral CD8 status had the strongest impact on prognosis (P = .12). In the intratumoral CD8-high group, PD-L1 expression demonstrated no significant prognostic impact, whereas in the intratumoral CD8-low group, patients positive for PD-L1 demonstrated a significantly worse prognosis than those negative for PD-L1 (5-year recurrence-free survival rates, 41.7% vs. 78.6%; P = .034). Multivariable Cox regression analysis revealed that 'PD-L1-positive and intratumoral CD8-low' status was an independent prognostic factor (hazard ratio, 3.80; 95% confidence interval, 1.22-10.5; P = .023). CONCLUSIONS:The prognostic impact of the PD-1/PD-L1 pathway may be distinct according to concurrent intratumoral CD8 status.
journal_name
Clin Lung Cancerjournal_title
Clinical lung cancerauthors
Handa Y,Tsutani Y,Shiroma N,Kai Y,Mimae T,Miyata Y,Takeshima Y,Arihiro K,Okada Mdoi
10.1016/j.cllc.2020.01.013subject
Has Abstractpub_date
2020-07-01 00:00:00pages
e302-e314issue
4eissn
1525-7304issn
1938-0690pii
S1525-7304(20)30013-9journal_volume
21pub_type
杂志文章abstract:BACKGROUND:We investigated the effect of downstaging on OS in LD-SCLC patients treated with first-line treatment. PATIENTS AND METHODS:We retrospectively reviewed 210 LD-SCLC patients who were treated with first-line treatment at Seoul National University Hospital between April 1999 and November 2012. Compared with in...
journal_title:Clinical lung cancer
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journal_title:Clinical lung cancer
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doi:10.1016/j.cllc.2013.11.001
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journal_title:Clinical lung cancer
pub_type: 杂志文章,评审
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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journal_title:Clinical lung cancer
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journal_title:Clinical lung cancer
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journal_title:Clinical lung cancer
pub_type: 杂志文章,多中心研究
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journal_title:Clinical lung cancer
pub_type: 杂志文章
doi:10.1016/j.cllc.2013.05.001
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journal_title:Clinical lung cancer
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cllc.2015.05.009
更新日期:2015-11-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
doi:10.1016/j.cllc.2011.11.006
更新日期:2012-09-01 00:00:00
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journal_title:Clinical lung cancer
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doi:10.3816/CLC.2008.n.043
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journal_title:Clinical lung cancer
pub_type: 杂志文章
doi:10.3816/CLC.2009.n.032
更新日期:2009-07-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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journal_title:Clinical lung cancer
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pub_type: 杂志文章,随机对照试验
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章,多中心研究
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journal_title:Clinical lung cancer
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
doi:10.1016/j.cllc.2017.05.013
更新日期:2018-01-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章
doi:10.1016/j.cllc.2020.02.010
更新日期:2020-07-01 00:00:00
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journal_title:Clinical lung cancer
pub_type: 杂志文章,评审
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