Influence of pancreatic status on circulating plasma sterols in patients with cystic fibrosis.

abstract：:Elevated plasma levels of angiotensin converting enzyme (ACE) are associated with granulomatous diseases. However, several families of autosomal dominant hyper-ACE-emia without disease association have already been reported. Recently, the ACE mutation c.3705C>T (Pro1199Leu) was identified as the genetic correlate in E...

journal_title：Clinical chemistry and laboratory medicine

authors： Semmler A,Stein RW,Caplan L,Danilov SM,Klockgether T,Linnebank M

更新日期：2006-01-01 00:00:00

abstract：:Background The accurate and precise measurement of triglycerides is important due to the adverse effects associated with hypertriglyceridaemia. Most laboratory methods are based on enzymatic hydrolysis of triglycerides with measurement of the total glycerol. An elevated free glycerol concentration may result in overes...

journal_title：Clinical chemistry and laboratory medicine

authors： van Heerden C,Magwete A,Mabuza D

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:We report a Dutch-Belgian multicentre evaluation of the Tosoh HLC-723G8 glycohaemoglobin analyser, an ion-exchange HPLC instrument for the separation and quantification of haemoglobin A1c (HbA1c) in whole blood. METHODS:We evaluated the analytical performances of the Tosoh G8 analyser and compared the resul...

journal_title：Clinical chemistry and laboratory medicine

authors： Chapelle JP,Teixeira J,Maisin D,Assink H,Barla G,Stroobants AK,Delzenne B,van den Eshof W

更新日期：2010-03-01 00:00:00

abstract：:This review presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The discussion focuses on the applicability of the methods for the identification of unknown toxic compounds, which is defined as systematic toxicological analysis (...

journal_title：Clinical chemistry and laboratory medicine

authors： Boone CM,Ensing K

更新日期：2003-06-01 00:00:00

abstract：:Measurement of total homocysteine (tHcy) in healthy and diseased children has documented the utility of this marker in pediatric research and diagnostics. This article focuses on novel data obtained in infants, children and adolescents, with emphasis on cobalamin status in infants. In children, determinants of plasma ...

journal_title：Clinical chemistry and laboratory medicine

authors： Ueland PM,Monsen AL

更新日期：2003-11-01 00:00:00

abstract：:Background Quantification of plasma amino acids is key to the diagnosis of inherited defects of amino acid synthesis, catabolism and transport, many of which present as clinical emergencies. The utility of this test is limited by the long analysis time and subsequent inability of laboratories to provide results in rea...

journal_title：Clinical chemistry and laboratory medicine

authors： Carling RS,John K,Churchus R,Turner C,Dalton RN

更新日期：2020-04-28 00:00:00

abstract：:The early diagnosis of rheumatoid arthritis (RA) has become a priority owing to the availability of effective disease-modifying agents that can improve patient wellbeing and influence the clinical outcome. However, this represents a real challenge, as no clinical, radiological or immunological features are pathognomon...

journal_title：Clinical chemistry and laboratory medicine

authors： Bizzaro N

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play an important role in tumor invasion and metastasis. This study aimed to determine the serum levels of MMP-2, MMP-9, 130- and 225-kDa gelatinolytic bands and conventional tumor markers, carcinoembryonic antigen (CEA) and cancer antigen (CA) 19...

journal_title：Clinical chemistry and laboratory medicine

authors： Emara M,Cheung PY,Grabowski K,Sawicki G,Wozniak M

更新日期：2009-01-01 00:00:00

abstract：:It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and disea...

journal_title：Clinical chemistry and laboratory medicine

authors： Arendt JF,Nexo E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Risk prediction algorithms for coronary heart disease (CHD) are recommended for clinical use. However, their predictive ability remains modest and the inclusion of genetic risk may improve their performance. METHODS:QRISK2 was used to assess CHD risk using conventional risk factors (CRFs). The performance o...

journal_title：Clinical chemistry and laboratory medicine

authors： Beaney KE,Cooper JA,Drenos F,Humphries SE

更新日期：2017-08-28 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP. METHODS:The study population consisted of 104 patients d...

journal_title：Clinical chemistry and laboratory medicine

authors： Lippi G,Dagostino C,Buonocore R,Aloe R,Bonaguri C,Fanelli G,Allegri M

更新日期：2017-08-28 00:00:00

abstract：BACKGROUND:Celiac disease (CD) is an immune-mediated disorder of the small bowel in which gluten and related cereal ingestion leads to chronic inflammation and damage to the small bowel mucosa in genetically susceptible individuals. The presence of IgA type tissue-transglutaminase antibodies (IgA-anti-tTG) in individua...

journal_title：Clinical chemistry and laboratory medicine

authors： Ress K,Harro J,Uibo O,Uibo R

更新日期：2011-06-01 00:00:00

abstract：:Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic...

journal_title：Clinical chemistry and laboratory medicine

authors： Hultberg B,Jensen E,Dehlin O,Hagberg B,Samuelsson G,Svensson T

更新日期：1999-10-01 00:00:00

abstract：:Quality in diagnostic testing represents a key target of laboratory medicine, for which an assurance around the quality of testing is expected from all involved in the process. Laboratories attempt to assure the quality of their testing by various processes, but especially by performance of internal quality control an...

journal_title：Clinical chemistry and laboratory medicine

authors： Favaloro EJ,Jennings I,Olson J,Van Cott EM,Bonar R,Gosselin R,Meijer P

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Autoantibodies against β1-adrenergic receptors (β1AR) that stimulate cardiac cAMP-production play a causal role in the pathogenesis of human heart failure. Patients can be subjected to specific therapies, if the presence of potentially cardio-noxious β1AR-autoantibodies is reliably diagnosed. This requires a...

journal_title：Clinical chemistry and laboratory medicine

authors： Bornholz B,Benninghaus T,Reinke Y,Felix SB,Roggenbuck D,Jahns-Boivin V,Jahns R,Boege F

更新日期：2016-04-01 00:00:00

abstract：:The etiology of cardiovascular diseases is known to be multi-factorial. Some forms of cardiovascular disease are influenced by unclear genetic factors but are predominantly affected by factors such as diet, obesity, cigarette smoking, diabetes mellitus and dyslipidaemia. Some are caused by specific gene defects, with ...

journal_title：Clinical chemistry and laboratory medicine

authors： Pang CP

更新日期：1998-08-01 00:00:00

abstract：:Reference intervals for healthy subjects and diseased populations are important benchmarks for the clinical interpretation of laboratory test values. It is important that the testing conditions used to collect the reference data be closely matched with the testing conditions used for patient data. Interlaboratory diff...

journal_title：Clinical chemistry and laboratory medicine

authors： Klee GG

更新日期：2004-01-01 00:00:00

abstract：:This paper reports on a pilot external quality assessment scheme for bone markers including serum bone alkaline phosphatase and procollagen 1-carboxy terminal propeptide together with urine deoxypyridinoline, N- and C-telopeptides. The data shows poor numerical agreement between commercial assays, between-laboratory i...

journal_title：Clinical chemistry and laboratory medicine

authors： Whitham KM,Milford-Ward A

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Accurate outcome prediction in gastroesophageal malignancies is challenging. Acute-phase response proteins (APRPs) have been claimed to be independent prognosticators, although the basis for their association with prognosis remains unexplained. We hypothesized that, similarly to pancreatic and lung cancers, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Krzystek-Korpacka M,Matusiewicz M,Diakowska D,Grabowski K,Blachut K,Kustrzeba-Wojcicka I,Terlecki G,Gamian A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:We verified the analytical performance of strip-based handheld glucose meters (GM) for prescription use, in a comparative split-sample protocol using blood gas samples from a surgical intensive care unit (ICU). METHODS:Freestyle Precision Pro (Abbott), StatStrip Connectivity Meter (Nova), ACCU-CHEK Inform I...

journal_title：Clinical chemistry and laboratory medicine

authors： Claerhout H,De Prins M,Mesotten D,Van den Berghe G,Mathieu C,Van Eldere J,Vanstapel F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE) and choline acetyltransferase (ChAT) have been suggested as candidate genes for determining the risk of late-onset Alzheimer's disease. The aim of this study was to simultaneously detect polymorphisms in codons 112 and 158 of APOE and codon 2 of ChAT by hybridization probe multiplexin...

journal_title：Clinical chemistry and laboratory medicine

authors： Park HD,Park KU,Kim KW,Song J,Chang HE,Heo SR,Lee HJ,Kim JQ

更新日期：2007-01-01 00:00:00

abstract：:The mutant of CYP2D6*3 allele with A2637 deletion in exon 5 and the mutant of CYP2D6*4 allele G1934-->A, splice site defect are among the most common polymorphic alleles of CYP2D6 gene, resulting in a decreased or no activity of CYP isoenzyme. In this study, a reliable polymerase chain reaction-restriction fragment le...

journal_title：Clinical chemistry and laboratory medicine

authors： Topić E,Stefanović M,Nikolić V,Zoricić I,Ivanisević AM,Zuntar I

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Blood biomarkers are subject to pre-analytical variability. In many cases, the stability of important new tissue biomarkers during freeze cycles and storage has not been studied sufficiently. METHODS:To test the stability of matrix metalloproteinases-7 (MMP-7) and their tissue inhibitors (TIMP-1), vascular ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kisand K,Kerna I,Kumm J,Jonsson H,Tamm A

更新日期：2011-02-01 00:00:00

abstract：:In our efforts to develop diagnostic tests for complex multifactorial disorders, and to assist the research community in evaluating genetic markers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel w...

journal_title：Clinical chemistry and laboratory medicine

authors： Cheng S,Pallaud C,Grow MA,Scharf SJ,Erlich HA,Klitz W,Pullinger CR,Malloy MJ,Kane JP,Siest G,Visvikis S

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be ...

journal_title：Clinical chemistry and laboratory medicine

authors： Conti M,Moutereau S,Zater M,Lallali K,Durrbach A,Manivet P,Eschwège P,Loric S

更新日期：2006-01-01 00:00:00

abstract：:The application of turbidimetric homogeneous immunoassays made the determination of several plasma components widely available. The sensitivity and accuracy of these assays are appropriate enough for routine laboratory use; however, in the case of many pathologically high concentration samples, prozone effect (high do...

journal_title：Clinical chemistry and laboratory medicine

authors： Papik K,Molnar B,Fedorcsak P,Schaefer R,Lang F,Sreter L,Feher J,Tulassay Z

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Efficient laboratory service is the cornerstone of modern health care systems. Scientific innovations have contributed to substantial improvements in the field of laboratory science, but errors still prevail. These errors are classified as preanalytical, analytical and postanalytical, depending upon the time...

journal_title：Clinical chemistry and laboratory medicine

authors： Goswami B,Singh B,Chawla R,Mallika V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Measurement of late-night salivary cortisol concentrations is increasingly used as a screening test in suspected Cushing's syndrome. Cortisol concentrations are typically extremely low in late-night samples and discordant assay-specific reference ranges have been reported. Therefore, the aim of our study was...

journal_title：Clinical chemistry and laboratory medicine

authors： Vogeser M,Durner J,Seliger E,Auernhammer C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This paper describes the evolution, structure, operation and some outcomes of the Brazilian Laboratory Indicators Program created by the Brazilian Society of Clinical Pathology/Laboratory Medicine (Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial, or SBPC/ML), in partnership with ControlLab, a...

journal_title：Clinical chemistry and laboratory medicine

authors： Shcolnik W,de Oliveira CA,de São José AS,de Oliveira Galoro CA,Plebani M,Burnett D

更新日期：2012-11-01 00:00:00