Very high sensitivity of African rice to artificial ultraviolet-B radiation caused by genotype and quantity of cyclobutane pyrimidine dimer photolyase.

abstract：:Targetting the ubiquitin pathway is an attractive strategy for cancer therapy. The inhibitor of the ubiquitin-like molecule NEDD8 pathway, MLN4924 (Pevonedistat) is in Phase II clinical trials. Protection of healthy cells from the induced toxicity of the treatment while preserving anticancer efficacy is a highly antic...

journal_title：Scientific reports

authors： Malhab LJ,Descamps S,Delaval B,Xirodimas DP

更新日期：2016-11-30 00:00:00

abstract：:A fast Endospore Germinability Assay (EGA) was validated with traditional plate counts to enumerate single endospore germination events for monitoring surface sterilization. The assay is based on a time-gated luminescence microscopy technique enabling visualization and enumeration of individual germinating endospores....

journal_title：Scientific reports

authors： Yung PT,Lester E,Ponce A

更新日期：2020-01-16 00:00:00

abstract：:For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...

journal_title：Scientific reports

authors： Shimura K,Nagai T

更新日期：2016-12-15 00:00:00

abstract：:Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of t...

journal_title：Scientific reports

authors： Liang LF,Chen WT,Li XW,Wang HY,Guo YW

更新日期：2017-04-21 00:00:00

abstract：:Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...

journal_title：Scientific reports

authors： Lavrnja I,Smiljanic K,Savic D,Mladenovic-Djordjevic A,Tesovic K,Kanazir S,Pekovic S

更新日期：2017-06-02 00:00:00

abstract：:Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34+ cells (henceforth CD34+ cells) effective therapy, tested in cutaneous wound...

journal_title：Scientific reports

authors： Kanji S,Das M,Joseph M,Aggarwal R,Sharma SM,Ostrowski M,Pompili VJ,Mao HQ,Das H

更新日期：2019-06-10 00:00:00

abstract：:People mimic each other's actions and postures during everyday interactions. It is widely believed this mimicry acts as a social glue, leading to increased rapport. We present two studies using virtual reality to rigorously test this hypothesis. In Study 1, 50 participants interacted with two avatars who either mimick...

journal_title：Scientific reports

authors： Hale J,Hamilton AF

更新日期：2016-10-14 00:00:00

abstract：:Cardiac remodeling is characterized by overactivity of the renin-angiotensin system (RAS) and withdrawal of vagal activity. We hypothesized that improving vagal activity could attenuate cardiac fibrosis induced by angiotensin II (Ang II) in vivo and in vitro. Rats were subjected to abdominal aorta constriction (AAC) w...

journal_title：Scientific reports

authors： Liu JJ,Huang N,Lu Y,Zhao M,Yu XJ,Yang Y,Yang YH,Zang WJ

更新日期：2015-11-24 00:00:00

abstract：:Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...

journal_title：Scientific reports

authors： Feng Y,Ye F,Liu H,Yang J

更新日期：2015-11-18 00:00:00

abstract：:The biodosimetric information is critical for evaluating the human health hazards caused by radon and its progeny. Here, we demonstrated that the formation of phosphorylated histone variant H2AX (γ-H2AX), p53-binding protein 1 (53BP1) and phosphorylated KRAB-associated protein 1 (pKAP-1) foci and their linear tracks i...

journal_title：Scientific reports

authors： Ding D,Zhang Y,Wang J,Wang X,Fan D,He L,Zhang X,Gao Y,Li Q,Chen H

更新日期：2016-12-06 00:00:00

abstract：:Whether hybridization generates or erodes species diversity has long been debated, but to date most studies have been conducted at small taxonomic scales. Salamanders (order Caudata) represent a taxonomic order in which hybridization plays a prevalent ecological and evolutionary role. We employed a recently developed ...

journal_title：Scientific reports

authors： Patton AH,Margres MJ,Epstein B,Eastman J,Harmon LJ,Storfer A

更新日期：2020-04-16 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common liver cancer, with a very poor prognosis. There is an urgent need for an effective therapy for HCC. Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined. Here, we treated human ...

journal_title：Scientific reports

authors： Yang Z,Zhao T,Liu H,Zhang L

更新日期：2016-01-19 00:00:00

abstract：:In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an evolutionarily widespread and versatile silencing mechanism that plays an important role in various biological processes. Increasing evidences suggest that various components of RNA silencing pathway are involved in plant defense machinery against...

journal_title：Scientific reports

authors： Uddin MN,Akhter S,Chakraborty R,Baek JH,Cha JY,Park SJ,Kang H,Kim WY,Lee SY,Mackey D,Kim MG

更新日期：2017-08-29 00:00:00

abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

journal_title：Scientific reports

authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

更新日期：2014-07-28 00:00:00

abstract：:The accident at the Fukushima Daiichi nuclear power plant caused serious radiocesium ((137)Cs) contamination of forest ecosystems located in mountainous and hilly regions with steep terrain. To understand topographic effects on the redistribution and accumulation of (137)Cs on forest floor, we investigated the distrib...

journal_title：Scientific reports

authors： Koarashi J,Atarashi-Andoh M,Takeuchi E,Nishimura S

更新日期：2014-10-31 00:00:00

abstract：:TRPA1 is a Ca2+-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca2+, with low Ca2+ potentiating and high Ca2+ inactivating TRPA1. However, it remains unknown how Ca2+ exerts such contrasting effects. Here, we show that Ca2+ regulate...

journal_title：Scientific reports

authors： Hasan R,Leeson-Payne AT,Jaggar JH,Zhang X

更新日期：2017-03-23 00:00:00

abstract：:The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been differentiated from mouse and human PSCs, but not from porcine PSCs, which are considered an ideal model for stem cell applications. Here, we dev...

journal_title：Scientific reports

authors： Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J

更新日期：2016-06-06 00:00:00

abstract：:This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...

journal_title：Scientific reports

authors： Yamamoto K,Itoi T,Nagata N,Sofuni A,Tsuchiya T,Ishii K,Tanaka R,Tonozuka R,Honjo M,Mukai S,Asai Y,Matsunami Y,Yamaguchi H,Matsubayashi J,Joyama E,Nagakawa Y

更新日期：2021-01-12 00:00:00

abstract：:Celiac disease (CeD) is a multifactorial disease influenced by both genetic and environmental risk factors. CeD genetic components are mainly due to HLA class II genes, which account for approximately 40% of the disease heritability. The environmental factor is linked to gliadin ingestion. Despite genetic and epigenet...

journal_title：Scientific reports

authors： Auricchio R,Galatola M,Cielo D,Amoresano A,Caterino M,De Vita E,Illiano A,Troncone R,Greco L,Ruoppolo M

更新日期：2019-10-04 00:00:00

abstract：:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...

journal_title：Scientific reports

authors： Gao Z,Lai Q,Yang Q,Xu N,Liu W,Zhao F,Liu X,Zhang C,Zhang J,Jia L

更新日期：2018-11-30 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for the prevention and treatment of CVB3 infection. We found that Saururus chinensis Baill extract showed critic...

journal_title：Scientific reports

authors： Song JH,Ahn JH,Kim SR,Cho S,Hong EH,Kwon BE,Kim DE,Choi M,Choi HJ,Cha Y,Chang SY,Ko HJ

更新日期：2019-06-28 00:00:00

abstract：:Caspases are proteases traditionally associated with inflammation and cell death. Recently, they have also been shown to modulate cell proliferation and differentiation. The aim of the current research was to search for osteogenic molecules affected by caspase inhibition and to specify the individual caspases critical...

journal_title：Scientific reports

authors： Kratochvílová A,Veselá B,Ledvina V,Švandová E,Klepárník K,Dadáková K,Beneš P,Matalová E

更新日期：2020-05-04 00:00:00

abstract：:Clogging of porous media by soft particles has become a subject of extensive research in the last years and the understanding of the clogging mechanisms is of great importance for process optimization. The rise in the utilization of microfluidic devices brought the possibility to simulate membrane filtration and perfo...

journal_title：Scientific reports

authors： Bouhid de Aguiar I,Meireles M,Bouchoux A,Schroën K

更新日期：2019-06-25 00:00:00

abstract：:Some styrene/maleic acid (SMA) copolymers solubilise membrane lipids and proteins to form polymer-bounded nanodiscs termed SMA/lipid particles (SMALPs). Although SMALPs preserve a lipid-bilayer core, they appear to be more dynamic than other membrane mimics. We used time-resolved Förster resonance energy transfer and ...

journal_title：Scientific reports

authors： Cuevas Arenas R,Danielczak B,Martel A,Porcar L,Breyton C,Ebel C,Keller S

更新日期：2017-04-05 00:00:00

abstract：:We developed a new technique to observe macroautophagy in the brain in vivo, and examined whether fasting induced macroautophagy in neurons and how the induction was different between Alzheimer's disease (AD) model and control mice. Lentivirus for EGFP-LC3 injected into the brain successfully visualized autophagosome ...

journal_title：Scientific reports

authors： Chen X,Kondo K,Motoki K,Homma H,Okazawa H

更新日期：2015-07-14 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs, thereby making its treatment difficult. The molecular machinery driving PDAC metastasis is still poorly understood. In this study, we applied an unbiased appro...

journal_title：Scientific reports

authors： Oladimeji PO,Bakke J,Wright WC,Chen T

更新日期：2020-01-30 00:00:00

abstract：:Telomeres, the protective, terminal parts of the chromosomes erode during cell division and as a result of oxidative damage by reactive oxygen species (ROS). Ectotherms rely on the ambient temperature for maintaining temperature-dependent metabolic rate, regulated through behavioural thermoregulation. Their temperatur...

journal_title：Scientific reports

authors： Axelsson J,Wapstra E,Miller E,Rollings N,Olsson M

更新日期：2020-01-13 00:00:00

abstract：:Most male lepidopterans produce fertile eupyrene sperm and non-fertile apyrene sperm, both of which are transferred to the female in a spermatophore during mating. Apyrene sperm outnumbers eupyrene sperm and both sperm types migrate from the bursa copulatrix to the spermatheca after mating. While eupyrene sperm are ma...

journal_title：Scientific reports

authors： Konagaya T,Idogawa N,Watanabe M

更新日期：2020-12-01 00:00:00

abstract：:The bald eagle (Haliaeetus leucocephalus) once experienced near-extinction but has since rebounded. For decades, bald eagles near the Wisconsin River, USA, have experienced a lethal syndrome with characteristic clinical and pathological features but unknown etiology. Here, we describe a novel hepacivirus-like virus (F...

journal_title：Scientific reports

authors： Goldberg TL,Sibley SD,Pinkerton ME,Dunn CD,Long LJ,White LC,Strom SM

更新日期：2019-10-18 00:00:00

abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...

journal_title：Scientific reports

authors： Bhandare VV,Kumbhar BV,Kunwar A

更新日期：2019-07-25 00:00:00