A probiotic treatment increases the immune response induced by the nasal delivery of spore-adsorbed TTFC.

abstract：BACKGROUND:The industrially relevant filamentous fungus Aspergillus niger is widely used in industry for its secretion capabilities of enzymes and organic acids. Biotechnologically produced organic acids promise to be an attractive alternative for the chemical industry to replace petrochemicals. Itaconic acid (IA) has ...

journal_title：Microbial cell factories

authors： Hossain AH,Li A,Brickwedde A,Wilms L,Caspers M,Overkamp K,Punt PJ

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Bioethanol produced by the yeast Saccharomyces cerevisiae is currently one of the most promising alternatives to conventional transport fuels. Lignocellulosic hemicelluloses obtained after hydrothermal pretreatment are important feedstock for bioethanol production. However, hemicellulosic materials cannot be...

journal_title：Microbial cell factories

authors： Hasunuma T,Hori Y,Sakamoto T,Ochiai M,Hatanaka H,Kondo A

更新日期：2014-10-12 00:00:00

abstract：BACKGROUND:Molecular mechanisms generating genetic variation provide the basis for evolution and long-term survival of a population in a changing environment. In stable, laboratory conditions, the variation-generating mechanisms are dispensable, as there is limited need for the cell to adapt to adverse conditions. In f...

journal_title：Microbial cell factories

authors： Csörgo B,Fehér T,Tímár E,Blattner FR,Pósfai G

更新日期：2012-01-20 00:00:00

abstract：BACKGROUND:The understanding of the molecular basis of yeast tolerance to ethanol may guide the design of rational strategies to increase process performance in industrial alcoholic fermentations. A set of 21 genes encoding multidrug transporters from the ATP-Binding Cassette (ABC) Superfamily and Major Facilitator Sup...

journal_title：Microbial cell factories

authors： Teixeira MC,Godinho CP,Cabrito TR,Mira NP,Sá-Correia I

更新日期：2012-07-27 00:00:00

abstract：:Phytases are widely utilized in feed industry to increase the utilization of phosphorus, minerals, and amino acids for improvement of animal and human nutrition. At present, all known β-propeller phytases (BPP) have been generated from bacteria, particularly Bacillus. In this work we report for the first time a new fu...

journal_title：Microbial cell factories

authors： Hou X,Shen Z,Li N,Kong X,Sheng K,Wang J,Wang Y

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Probiotic bacteria are increasingly used as immunomodulatory agents. Yet detailed molecular knowledge on the immunomodulatory molecules of these bacteria is lagging behind. Lipoteichoic acid (LTA) is considered a major microbe-associated molecular pattern (MAMP) of Gram-positive bacteria. However, many detai...

journal_title：Microbial cell factories

authors： Claes IJ,Segers ME,Verhoeven TL,Dusselier M,Sels BF,De Keersmaecker SC,Vanderleyden J,Lebeer S

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Due to their high energy density and compatible physical properties, several monoterpenes have been investigated as potential renewable transportation fuels, either as blendstocks with petroleum or as drop-in replacements for use in vehicles (both heavy and light-weight) or in aviation. Sustainable microbial...

journal_title：Microbial cell factories

authors： Zhuang X,Kilian O,Monroe E,Ito M,Tran-Gymfi MB,Liu F,Davis RW,Mirsiaghi M,Sundstrom E,Pray T,Skerker JM,George A,Gladden JM

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:Recent years have seen a huge growth in the market of industrial yeasts with the need for strains affording better performance or to be used in new applications. Stress tolerance of commercial Saccharomyces cerevisiae yeasts is, without doubt, a trait that needs improving. Such trait is, however, complex, an...

journal_title：Microbial cell factories

authors： Pérez-Torrado R,Panadero J,Hernández-López MJ,Prieto JA,Randez-Gil F

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:In Saccharomyces cerevisiae, alpha-glucosidase (maltase) is a key enzyme in maltose metabolism. In addition, the overexpression of the alpha-glucosidase-encoding gene MAL62 has been shown to increase the freezing tolerance of yeast in lean dough. However, its cryoprotection mechanism is still not clear. RES...

journal_title：Microbial cell factories

authors： Sun X,Zhang J,Fan ZH,Xiao P,Li F,Liu HQ,Zhu WB

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Acetic acid bacteria (AAB) are widely applied in food, bioengineering and medicine fields. However, the acid stress at low pH conditions limits acetic acid fermentation efficiency and high concentration of vinegar production with AAB. Therefore, how to enhance resistance ability of the AAB remains as the maj...

journal_title：Microbial cell factories

authors： Yin H,Zhang R,Xia M,Bai X,Mou J,Zheng Y,Wang M

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:The characterization of the molecular determinants of metal resistance has potential biotechnological application in biosensing and bioremediation. In this context, the bacterium Thermus thermophilus HB27 is a metal tolerant thermophile containing a set of genes involved in arsenic resistance which, differen...

journal_title：Microbial cell factories

authors： Antonucci I,Gallo G,Limauro D,Contursi P,Ribeiro AL,Blesa A,Berenguer J,Bartolucci S,Fiorentino G

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:The methylotrophic yeast Pichia pastoris is a well-studied host organism for recombinant protein production, which is usually regulated either by a constitutive promoter (e.g. promoter of glyceraldehyde-3-phosphate dehydrogenase; PGAP) or an inducible promoter (e.g. promoter of alcohol oxidase 1; PAOX1). Bot...

journal_title：Microbial cell factories

authors： Rajamanickam V,Metzger K,Schmid C,Spadiut O

更新日期：2017-09-13 00:00:00

abstract：BACKGROUND:The budding yeast Pichia pastoris is widely used for protein production. To determine the best suitable strategy for strain improvement, especially for high secretion, quantitative data of intracellular fluxes of recombinant protein are very important. Especially the balance between intracellular protein for...

journal_title：Microbial cell factories

authors： Pfeffer M,Maurer M,Köllensperger G,Hann S,Graf AB,Mattanovich D

更新日期：2011-06-26 00:00:00

abstract：BACKGROUND:The methylotrophic yeast Pichia pastoris is a common host for the production of recombinant proteins. However, hypermannosylation hinders the use of recombinant proteins from yeast in most biopharmaceutical applications. Glyco-engineered yeast strains produce more homogeneously glycosylated proteins, but can...

journal_title：Microbial cell factories

authors： Pekarsky A,Veiter L,Rajamanickam V,Herwig C,Grünwald-Gruber C,Altmann F,Spadiut O

更新日期：2018-11-24 00:00:00

abstract：BACKGROUND:Extracts and products (roots and/or aerial parts) from Echinacea ssp. represent a profitable market sector for herbal medicines thanks to different functional features. Alkamides and polyacetylenes, phenols like caffeic acid and its derivatives, polysaccharides and glycoproteins are the main bioactive compou...

journal_title：Microbial cell factories

authors： Rizzello CG,Coda R,Macías DS,Pinto D,Marzani B,Filannino P,Giuliani G,Paradiso VM,Di Cagno R,Gobbetti M

更新日期：2013-05-04 00:00:00

abstract：BACKGROUND:Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities. To improve production of GAs, a homologous farnesyl diphosphate synthase (FPS) gene was overexpressed in G. lucidum. Moreover, the influence of FPS gene overexpress...

journal_title：Microbial cell factories

authors： Fei Y,Li N,Zhang DH,Xu JW

更新日期：2019-06-28 00:00:00

abstract：:This article describes the use of biofilm reactors for the production of various chemicals by fermentation and wastewater treatment. Biofilm formation is a natural process where microbial cells attach to the support (adsorbent) or form flocs/aggregates (also called granules) without use of chemicals and form thick lay...

journal_title：Microbial cell factories

authors： Qureshi N,Annous BA,Ezeji TC,Karcher P,Maddox IS

更新日期：2005-08-25 00:00:00

abstract：BACKGROUND:Gene therapy has gained an increasing interest in its anti-tumor efficiency. However, numerous efforts are required to promote them to clinics. In this study, a novel and efficient delivery platform based on bacterial magnetosomes (BMs) were developed, and the efficiency of BMs in delivering small interferin...

journal_title：Microbial cell factories

authors： Dai Q,Long R,Wang S,Kankala RK,Wang J,Jiang W,Liu Y

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Recent interest has been focused on the production of platform chemicals from renewable biomass due to increasing concerns on global warming and depletion of fossil fuel reserves. Microbial production of platform chemicals in biorefineries has been suggested to be a promising solution for these problems. Gam...

journal_title：Microbial cell factories

authors： Baritugo KA,Kim HT,David Y,Khang TU,Hyun SM,Kang KH,Yu JH,Choi JH,Song JJ,Joo JC,Park SJ

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Transcriptional engineering has presented a strong ability of phenotypic improvement in microorganisms. However, it could not be directly applied to Actinoplanes teichomyceticus L-27 because of the paucity of endogenous transcription factors in the strain. In this study, exogenous transcription factors were ...

journal_title：Microbial cell factories

authors： Wang H,Yang L,Wu K,Li G

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:Streptomycetes produce a plethora of natural products including antibiotics and anticancer drugs, as well as many industrial enzymes. Their mycelial life style is a major bottleneck for industrial exploitation and over decades strain improvement programs have selected production strains with better growth pr...

journal_title：Microbial cell factories

authors： van Dissel D,Claessen D,Roth M,van Wezel GP

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Under aerobic conditions, acetic acid is the major byproduct produced by E. coli during the fermentation. And acetic acid is detrimental to cell growth as it destroys transmembrane pH gradients. Hence, how to reduce the production of acetic acid and how to utilize it as a feedstock are of intriguing interest...

journal_title：Microbial cell factories

authors： Yang J,Nie Q

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:L-arabinose is an important intermediate for anti-virus drug synthesis and has also been used in food additives for diets-controlling in recent years. Commercial production of L-arabinose is a complex progress consisting of acid hydrolysis of gum arabic, followed by multiple procedures of purification, thus ...

journal_title：Microbial cell factories

authors： Cheng H,Wang H,Lv J,Jiang M,Lin S,Deng Z

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:Recombinant protein expression in bacteria often leads to the formation of intracellular insoluble protein deposits, a major bottleneck for the production of soluble and active products. However, in recent years, these bacterial protein aggregates, commonly known as inclusion bodies (IBs), have been shown to...

journal_title：Microbial cell factories

authors： Gil-Garcia M,Navarro S,Ventura S

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Crocin is a carotenoid-derived natural product found in the stigma of Crocus spp., which has great potential in medicine, food and cosmetics. In recent years, microbial production of crocin has drawn increasing attention, but there were no reports of successful implementation. Escherichia coli has been engin...

journal_title：Microbial cell factories

authors： Wang W,He P,Zhao D,Ye L,Dai L,Zhang X,Sun Y,Zheng J,Bi C

更新日期：2019-07-05 00:00:00

abstract：:L-arginine (ARG) is an important amino acid for both medicinal and industrial applications. For almost six decades, the research has been going on for its improved industrial level production using different microorganisms. While the initial approaches involved random mutagenesis for increased tolerance to ARG and con...

journal_title：Microbial cell factories

authors： Shin JH,Lee SY

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:Mannosylglycerate (MG) is one of the most widespread compatible solutes among marine microorganisms adapted to hot environments. This ionic solute holds excellent ability to protect proteins against thermal denaturation, hence a large number of biotechnological and clinical applications have been put forward...

journal_title：Microbial cell factories

authors： Faria C,Borges N,Rocha I,Santos H

更新日期：2018-11-16 00:00:00

abstract：:Like natural viruses, manmade protein cages for drug delivery are to be ideally formed by repetitive subunits with self-assembling properties, mimicking viral functions and molecular organization. Naturally formed nanostructures (such as viruses, flagella or simpler protein oligomers) can be engineered to acquire spec...

journal_title：Microbial cell factories

authors： Vázquez E,Villaverde A

更新日期：2010-12-30 00:00:00

abstract：BACKGROUND:The production of high yields of recombinant proteins is an enduring bottleneck in the post-genomic sciences that has yet to be addressed in a truly rational manner. Typically eukaryotic protein production experiments have relied on varying expression construct cassettes such as promoters and tags, or cultur...

journal_title：Microbial cell factories

authors： Bonander N,Darby RA,Grgic L,Bora N,Wen J,Brogna S,Poyner DR,O'Neill MA,Bill RM

更新日期：2009-01-29 00:00:00

abstract：BACKGROUND:The thermostable serine protease pernisine originates from the hyperthermophilic Archaeaon Aeropyrum pernix and has valuable industrial applications. Due to its properties, A. pernix cannot be cultivated in standard industrial fermentation facilities. Furthermore, pernisine is a demanding target for heterolo...

journal_title：Microbial cell factories

authors： Šnajder M,Carrillo Rincón AF,Magdevska V,Bahun M,Kranjc L,Paš M,Juntes P,Petković H,Poklar Ulrih N

更新日期：2019-11-07 00:00:00