Heterogeneous Network Model to Identify Potential Associations Between Plasmodium vivax and Human Proteins.


:Integration of multiple sources and data levels provides a great insight into the complex associations between human and malaria systems. In this study, a meta-analysis framework was developed based on a heterogeneous network model for integrating human-malaria protein similarities, a human protein interaction network, and a Plasmodium vivax protein interaction network. An iterative network propagation was performed on the heterogeneous network until we obtained stabilized weights. The association scores were calculated for qualifying a novel potential human-malaria protein association. This method provided a better performance compared to random experiments. After that, the stabilized network was clustered into association modules. The potential association candidates were then thoroughly analyzed by statistical enrichment analysis with protein complexes and known drug targets. The most promising target proteins were the succinate dehydrogenase protein complex in the human citrate (TCA) cycle pathway and the nicotinic acetylcholine receptor in the human central nervous system. Promising associations and potential drug targets were also provided for further studies and designs in therapeutic approaches for malaria at a systematic level. In conclusion, this method is efficient to identify new human-malaria protein associations and can be generalized to infer other types of association studies to further advance biomedical science.


Int J Mol Sci


Suratanee A,Plaimas K




Has Abstract


2020-02-15 00:00:00










  • TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS.

    abstract::Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlyi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Quan X,Zhang L,Li Y,Liang C

    更新日期:2014-07-30 00:00:00

  • Podocyte Lysosome Dysfunction in Chronic Glomerular Diseases.

    abstract::Podocytes are visceral epithelial cells covering the outer surface of glomerular capillaries in the kidney. Blood is filtered through the slit diaphragm of podocytes to form urine. The functional and structural integrity of podocytes is essential for the normal function of the kidney. As a membrane-bound organelle, ly...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Li G,Kidd J,Li PL

    更新日期:2020-02-25 00:00:00

  • Comparative Proteomics Analyses of Pollination Response in Endangered Orchid Species Dendrobium Chrysanthum.

    abstract::Pollination is a crucial stage in plant reproductive process. The self-compatibility (SC) and self-incompatibility (SI) mechanisms determined the plant genetic diversity and species survival. D. chrysanthum is a highly valued ornamental and traditional herbal orchid in Asia but has been declared endangered. The sexual...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang W,Yu H,Li T,Li L,Zhang G,Liu Z,Huang T,Zhang Y

    更新日期:2017-11-23 00:00:00

  • How the Pathological Microenvironment Affects the Behavior of Mesenchymal Stem Cells in the Idiopathic Pulmonary Fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological microenvironment may af...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bonifazi M,Di Vincenzo M,Caffarini M,Mei F,Salati M,Zuccatosta L,Refai M,Mattioli-Belmonte M,Gasparini S,Orciani M

    更新日期:2020-10-30 00:00:00

  • The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance.

    abstract::Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Rudzińska M,Parodi A,Soond SM,Vinarov AZ,Korolev DO,Morozov AO,Daglioglu C,Tutar Y,Zamyatnin AA Jr

    更新日期:2019-07-23 00:00:00

  • The Immunogenicity of Colorectal Cancer in Relation to Tumor Development and Treatment.

    abstract::Although most cancer types have been viewed as immunologically silent until recently, it has become increasingly clear that the immune system plays key roles in the course of tumor development. Remarkable progress towards understanding cancer immunogenicity and tumor-immune system interactions has revealed important i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: de Vries NL,Swets M,Vahrmeijer AL,Hokland M,Kuppen PJ

    更新日期:2016-06-29 00:00:00

  • Insights into the FMNAT Active Site of FAD Synthase: Aromaticity is Essential for Flavin Binding and Catalysis.

    abstract::The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Serrano A,Arilla-Luna S,Medina M

    更新日期:2020-05-25 00:00:00

  • Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4'-Geranyloxyferulic Acid Extract from Quinoa Seeds.

    abstract::Chenopodium quinoa Wild is a "pseudocereal" grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids in the ethanol extract of commercially available quinoa seeds. We claim that 4'-G...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Franceschelli S,Gatta DMP,Pesce M,Ferrone A,Quiles JL,Genovese S,Epifano F,Fiorito S,Taddeo VA,Patruno A,Grilli A,Felaco M,Speranza L

    更新日期:2019-07-02 00:00:00

  • Immune-Specific Expression and Estrogenic Regulation of the Four Estrogen Receptor Isoforms in Female Rainbow Trout (Oncorhynchus mykiss).

    abstract::Genomic actions of estrogens in vertebrates are exerted via two intracellular estrogen receptor (ER) subtypes, ERα and ERβ, which show cell- and tissue-specific expression profiles. Mammalian immune cells express ERs and are responsive to estrogens. More recently, evidence became available that ERs are also present in...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Casanova-Nakayama A,Wernicke von Siebenthal E,Kropf C,Oldenberg E,Segner H

    更新日期:2018-03-21 00:00:00

  • Bacteria Residing at Root Canals Can Induce Cell Proliferation and Alter the Mechanical Properties of Gingival and Cancer Cells.

    abstract::Understanding the importance of oral microbiota in human health and disease also leads to an expansion of the knowledge on functional, metabolic, and molecular alterations directly contributing to oral and systemic pathologies. To date, a compelling number of studies have documented the crucial role of some oral cavit...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Suprewicz Ł,Tokajuk G,Cieśluk M,Deptuła P,Sierpińska T,Wolak P,Wollny T,Tokajuk J,Głuszek S,Piktel E,Bucki R

    更新日期:2020-10-24 00:00:00

  • Responsiveness of Carnosine Homeostasis Genes in the Pancreas and Brain of Streptozotocin-Treated Mice Exposed to Dietary Carnosine.

    abstract::In excitable tissues, the endogenous dipeptide carnosine (CAR, β-Ala-l-His) sustains homeostatic responses to various challenges. By eliciting hypoglycemic effects via actions on the autonomic nervous system and protection of pancreatic beta-cells, CAR is also relevant in diabetes. We investigated the expression of ge...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Barca A,Gatti F,Spagnolo D,Ippati S,Vetrugno C,Verri T

    更新日期:2018-06-09 00:00:00

  • AHR Signaling Interacting with Nutritional Factors Regulating the Expression of Markers in Vascular Inflammation and Atherogenesis.

    abstract::There is strong evidence that exposure to fine particulate matter (PM2.5) and a high-fat diet (HFD) increase the risk of mortality from atherosclerotic cardiovascular diseases. Recent studies indicate that PM2.5 generated by combustion activates the Aryl Hydrocarbon Receptor (AHR) and inflammatory cytokines contributi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dahlem C,Kado SY,He Y,Bein K,Wu D,Haarmann-Stemmann T,Kado NY,Vogel CFA

    更新日期:2020-11-05 00:00:00

  • Clouded Issues for PHACTR1.

    abstract::I have read with interest the recent paper by Han and coworkers on the putative effects of a PHACTR1 variant in the context of coronary artery disease. The authors conclude to a significant risk-enhancing role of rs12526453 on the grounds of 19 earlier case-control studies. ...

    journal_title:International journal of molecular sciences

    pub_type: 评论,杂志文章


    authors: Sand PG

    更新日期:2015-04-29 00:00:00

  • Homeostatic Model Assessment of Insulin Resistance for Predicting the Recurrence of Hepatocellular Carcinoma after Curative Treatment.

    abstract::Diabetes mellitus (DM) is a risk factor for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the impact of the disorder of glucose metabolism on the recurrence of HCC after curative treatment. Two hundred and eleven patients with HCC who received curative treatment in our hospital from 2006...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Imai K,Takai K,Hanai T,Suetsugu A,Shiraki M,Shimizu M

    更新日期:2019-01-30 00:00:00

  • Adipose Tissue and Brain Metabolic Responses to Western Diet-Is There a Similarity between the Two?

    abstract::Dietary fats and sugars were identified as risk factors for overweight and neurodegeneration, especially in middle-age, an earlier stage of the aging process. Therefore, our aim was to study the metabolic response of both white adipose tissue and brain in middle aged rats fed a typical Western diet (high in saturated ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mazzoli A,Spagnuolo MS,Gatto C,Nazzaro M,Cancelliere R,Crescenzo R,Iossa S,Cigliano L

    更新日期:2020-01-25 00:00:00

  • Analogies between digital radio and chemical orthogonality as a method for enhanced analysis of molecular recognition events.

    abstract::Acoustic wave biosensors are a real-time, label-free biosensor technology, which have been exploited for the detection of proteins and cells. One of the conventional biosensor approaches involves the immobilization of a monolayer of antibodies onto the surface of the acoustic wave device for the detection of a specifi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Edmonson PJ,Hunt WD,Stubbs DD,Lee SH

    更新日期:2008-02-01 00:00:00

  • Interventional Left Atrial Appendage Closure Affects the Metabolism of Acylcarnitines.

    abstract:BACKGROUND:Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of ac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Fastner C,Behnes M,Sartorius B,Wenke A,Lang S,Yücel G,Sattler K,Rusnak J,Saleh A,Barth C,Mashayekhi K,Hoffmann U,Borggrefe M,Akin I

    更新日期:2018-02-07 00:00:00

  • Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors.

    abstract::The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In this study, we utiliz...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sassetti E,Durante Cruz C,Tammela P,Winterhalter M,Augustyns K,Gribbon P,Windshügel B

    更新日期:2019-05-31 00:00:00

  • Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

    abstract::Carbonic anhydrase II (CAII) is a zinc-containing metalloenzyme whose aberrant activity is associated with various diseases such as glaucoma, osteoporosis, and different types of tumors; therefore, the development of CAII inhibitors, which can represent promising therapeutic agents for the treatment of these pathologi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Poli G,Jha V,Martinelli A,Supuran CT,Tuccinardi T

    更新日期:2018-06-23 00:00:00

  • Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease.

    abstract::The basal forebrain is home to the largest population of cholinergic neurons in the brain. These neurons are involved in a number of cognitive functions including attention, learning and memory. Basal forebrain cholinergic neurons (BFCNs) are particularly vulnerable in a number of neurological diseases with the most n...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kwakowsky A,Milne MR,Waldvogel HJ,Faull RL

    更新日期:2016-12-17 00:00:00

  • Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice.

    abstract::Osteoporosis morphology is characterized by bone resorption and decreases in micro-architecture parameters. Anti-osteoporosis therapy targets osteoclasts because bone resorption is a unique function of osteoclasts. Anti-c-fms antibodies against the receptor for macrophage colony-stimulating factor (M-CSF) inhibit oste...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Nara Y,Kitaura H,Ogawa S,Shen WR,Qi J,Ohori F,Noguchi T,Marahleh A,Pramusita A,Kinjo R,Mizoguchi I

    更新日期:2020-08-25 00:00:00

  • The interplay between QSAR/QSPR studies and partial order ranking and formal concept analyses.

    abstract::The often observed scarcity of physical-chemical and well as toxicological data hampers the assessment of potentially hazardous chemicals released to the environment. In such cases Quantitative Structure-Activity Relationships/Quantitative Structure-Property Relationships (QSAR/QSPR) constitute an obvious alternative ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Carlsen L

    更新日期:2009-04-17 00:00:00

  • Circulating microRNA: The Potential Novel Diagnostic Biomarkers to Predict Drug Resistance in Temporal Lobe Epilepsy, a Pilot Study.

    abstract::MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously described in the literature as biomarkers for the diagnosis of temporal lobe epilepsy (TLE) and/or as predictive biomarkers to antiepileptic drug resp...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: De Benedittis S,Fortunato F,Cava C,Gallivanone F,Iaccino E,Caligiuri ME,Castiglioni I,Bertoli G,Manna I,Labate A,Gambardella A

    更新日期:2021-01-12 00:00:00

  • Crossing the border: molecular control of motor axon exit.

    abstract::Living organisms heavily rely on the function of motor circuits for their survival and for adapting to ever-changing environments. Unique among central nervous system (CNS) neurons, motor neurons (MNs) project their axons out of the CNS. Once in the periphery, motor axons navigate along highly stereotyped trajectories...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Bravo-Ambrosio A,Kaprielian Z

    更新日期:2011-01-01 00:00:00

  • Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells.

    abstract::Mucin1 (MUC1) is aberrantly glycosylated and overexpressed in various cancers, and it plays a crucial role in cancerogenesis. MUC1 is a type I membranous protein composed of α and β subunits. MUC1-α can be cleaved in cancers, exposing MUC1-β (MUC1-C). MUC1-C is involved with multiple cancer cellular functions, which m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim MJ,Choi JR,Tae N,Wi TM,Kim KM,Kim DH,Lee ES

    更新日期:2020-05-05 00:00:00

  • Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

    abstract::We have tested the hypothesis that neuropathic pain acting as a stressor drives functional plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal medulla function was studied with behavioral, immunohistochemical and electrophysiological techniques in rats subjected to chronic const...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Arribas-Blázquez M,Olivos-Oré LA,Barahona MV,Sánchez de la Muela M,Solar V,Jiménez E,Gualix J,McIntosh JM,Ferrer-Montiel A,Miras-Portugal MT,Artalejo AR

    更新日期:2019-01-03 00:00:00

  • Fluorescence Enhancement Effect of TiO2 Nanoparticles and Application for Photodynamic Diagnosis.

    abstract::Photodynamic diagnosis (PDD) can improve diagnostic accuracy by using PDD agents such as 5-aminolevulinic acid (ALA). However, the weakness and photobleaching of fluorescence of PDD agents may lead to insufficient fluorescence visibility for the detection of cancer during resection operations. We focused on the "fluor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kanehira K,Yano Y,Hasumi H,Fukuhara H,Inoue K,Hanazaki K,Yao M

    更新日期:2019-07-28 00:00:00

  • The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy.

    abstract::In the absence of lymphatics, fluid and solutes such as amyloid-β (Aβ) are eliminated from the brain along basement membranes in the walls of cerebral capillaries and arteries-the Intramural Peri-Arterial Drainage (IPAD) pathway. IPAD fails with age and insoluble Aβ is deposited as plaques in the brain and in IPAD pat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Owasil R,O'Neill R,Keable A,Nimmo J,MacGregor Sharp M,Kelly L,Saito S,Simpson JE,Weller RO,Smith C,Attems J,Wharton SB,Yuen HM,Carare RO

    更新日期:2020-02-12 00:00:00

  • Molecular Mechanisms of Sex-Related Differences in Arthritis and Associated Pain.

    abstract::Clinical conditions leading to chronic pain show important sex-related differences in the prevalence, severity, and degree of functional disability. Decades of epidemiological and clinical studies have demonstrated that women are more sensitive to pain than men. Arthritis, including rheumatoid arthritis (RA) and osteo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kim JR,Kim HA

    更新日期:2020-10-26 00:00:00

  • Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.

    abstract::Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs). Understanding central nervous system (CNS) pathophysiology in neuronopathic MPS II (nMPS II) has been hi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bhalla A,Ravi R,Fang M,Arguello A,Davis SS,Chiu CL,Blumenfeld JR,Nguyen HN,Earr TK,Wang J,Astarita G,Zhu Y,Fiore D,Scearce-Levie K,Diaz D,Cahan H,Troyer MD,Harris JM,Escolar ML

    更新日期:2020-07-22 00:00:00