Genomic data sharing in Europe is stumbling-Could a code of conduct prevent its fall?


:Genomic data sharing is becoming more important as scientists join forces across borders in biomedical research for the benefit of patients and society. The EU's General Data Protection Regulation (GDPR) helps simplify sharing of such data at the European and international level. However, initial optimism has dried up as EU member states go their own ways in implementing the GDPR into national laws, and as legal cases challenging data sharing reach courts. Codes of conduct could facilitate data sharing in Europe and better connect it to global health research. This commentary explains the potential of codes of conduct for addressees and drafters. Codes are no panacea though; other measures may be necessary to ensure that Europe remains collaborative and competitive in biomedical research. Nevertheless, codes of conduct would bring immediate benefits and, in the long term, could foster a true European ecosystem for joint biomedical research and easier international data sharing.


EMBO Mol Med


EMBO molecular medicine


Molnár-Gábor F,Korbel JO




Has Abstract


2020-03-06 00:00:00












  • Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.

    abstract::A homozygous mutation in the gene for sigma 1 receptor (Sig1R) is a cause of inherited juvenile amyotrophic lateral sclerosis (ALS16). Sig1R localizes to the mitochondria-associated membrane (MAM), which is an interface of mitochondria and endoplasmic reticulum. However, the role of the MAM in ALS is not fully elucida...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Watanabe S,Ilieva H,Tamada H,Nomura H,Komine O,Endo F,Jin S,Mancias P,Kiyama H,Yamanaka K

    更新日期:2016-12-01 00:00:00

  • Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.

    abstract::In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. In particular, a therapeutic ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Cronin T,Vandenberghe LH,Hantz P,Juttner J,Reimann A,Kacsó AE,Huckfeldt RM,Busskamp V,Kohler H,Lagali PS,Roska B,Bennett J

    更新日期:2014-09-01 00:00:00

  • PHD1 regulates p53-mediated colorectal cancer chemoresistance.

    abstract::Overcoming resistance to chemotherapy is a major challenge in colorectal cancer (CRC) treatment, especially since the underlying molecular mechanisms remain unclear. We show that silencing of the prolyl hydroxylase domain protein PHD1, but not PHD2 or PHD3, prevents p53 activation upon chemotherapy in different CRC ce...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Deschoemaeker S,Di Conza G,Lilla S,Martín-Pérez R,Mennerich D,Boon L,Hendrikx S,Maddocks OD,Marx C,Radhakrishnan P,Prenen H,Schneider M,Myllyharju J,Kietzmann T,Vousden KH,Zanivan S,Mazzone M

    更新日期:2015-10-01 00:00:00

  • Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

    abstract::Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. W...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Stebbing J,Krishnan V,de Bono S,Ottaviani S,Casalini G,Richardson PJ,Monteil V,Lauschke VM,Mirazimi A,Youhanna S,Tan YJ,Baldanti F,Sarasini A,Terres JAR,Nickoloff BJ,Higgs RE,Rocha G,Byers NL,Schlichting DE,Nirula A

    更新日期:2020-08-07 00:00:00

  • Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

    abstract::The lack of actionable mutations in patients with non-small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this disease. Here, we identify somatically mutated ABL1 as a genetic dependency that is required to maintain NSCLC cell survival. We demonstrate that NSCLC cells w...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Testoni E,Stephenson NL,Torres-Ayuso P,Marusiak AA,Trotter EW,Hudson A,Hodgkinson CL,Morrow CJ,Dive C,Brognard J

    更新日期:2016-02-01 00:00:00

  • Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea.

    abstract::Sterile inflammation underlies many diseases of the cornea including serious chemical burns and the common dry eye syndrome. In search for therapeutic targets for corneal inflammation, we defined the kinetics of neutrophil infiltration in a model of sterile injury to the cornea and identified molecular and cellular me...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Oh JY,Choi H,Lee RH,Roddy GW,Ylöstalo JH,Wawrousek E,Prockop DJ

    更新日期:2012-05-01 00:00:00

  • Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.

    abstract::Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor deficits. However,...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Morais VA,Verstreken P,Roethig A,Smet J,Snellinx A,Vanbrabant M,Haddad D,Frezza C,Mandemakers W,Vogt-Weisenhorn D,Van Coster R,Wurst W,Scorrano L,De Strooper B

    更新日期:2009-05-01 00:00:00

  • A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.

    abstract::Diabetic nephropathy is the leading cause of end-stage renal disease. Although dysfunction of podocytes, also termed glomerular visceral epithelial cells, is critically associated with diabetic nephropathy, the mechanism underlying podocyte dysfunction still remains obscure. Here, we identify that KDM6A, a histone lys...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Lin CL,Hsu YC,Huang YT,Shih YH,Wang CJ,Chiang WC,Chang PJ

    更新日期:2019-05-01 00:00:00

  • An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer.

    abstract::The prostate-specific membrane antigen (PSMA) has been demonstrated in numerous studies to be expressed specifically on prostate carcinoma cells and on the neovasculature of several other cancer entities. However, the simultaneous expression of PSMA on both, tumor cells as well as tumor vessels remains unclear, even i...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Zekri L,Vogt F,Osburg L,Müller S,Kauer J,Manz T,Pflügler M,Maurer A,Heitmann JS,Hagelstein I,Märklin M,Hörner S,Todenhöfer T,Calaminus C,Stenzl A,Pichler B,la Fougère C,Schneider MA,Rammensee HG,Zender L,Sipos B,

    更新日期:2020-12-29 00:00:00

  • Reprogramming-derived gene cocktail increases cardiomyocyte proliferation for heart regeneration.

    abstract::Although remnant cardiomyocytes (CMs) possess a certain degree of proliferative ability, efficiency is too low for cardiac regeneration after injury. In this study, we identified a distinct stage within the initiation phase of CM reprogramming before the MET process, and microarray analysis revealed the strong up-regu...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Cheng YY,Yan YT,Lundy DJ,Lo AH,Wang YP,Ruan SC,Lin PJ,Hsieh PC

    更新日期:2017-02-01 00:00:00

  • Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts.

    abstract::Chimeric antigen receptor (CAR) T cell therapy, together with checkpoint inhibition, has been celebrated as a breakthrough technology due to the substantial benefit observed in clinical trials with patients suffering from relapsed or refractory B-cell malignancies. In this review, we provide a comprehensive overview o...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章,评审


    authors: Hartmann J,Schüßler-Lenz M,Bondanza A,Buchholz CJ

    更新日期:2017-09-01 00:00:00

  • GDF15 is a heart-derived hormone that regulates body growth.

    abstract::The endocrine system is crucial for maintaining whole-body homeostasis. Little is known regarding endocrine hormones secreted by the heart other than atrial/brain natriuretic peptides discovered over 30 years ago. Here, we identify growth differentiation factor 15 (GDF15) as a heart-derived hormone that regulates body...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Wang T,Liu J,McDonald C,Lupino K,Zhai X,Wilkins BJ,Hakonarson H,Pei L

    更新日期:2017-08-01 00:00:00

  • Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.

    abstract::Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carrying POLG mutations, we generated iPSCs and then neural stem cells. These neural...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Liang KX,Kristiansen CK,Mostafavi S,Vatne GH,Zantingh GA,Kianian A,Tzoulis C,Høyland LE,Ziegler M,Perez RM,Furriol J,Zhang Z,Balafkan N,Hong Y,Siller R,Sullivan GJ,Bindoff LA

    更新日期:2020-10-07 00:00:00

  • Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.

    abstract::Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT6 receptor-operated mTOR act...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Berthoux C,Hamieh AM,Rogliardo A,Doucet EL,Coudert C,Ango F,Grychowska K,Chaumont-Dubel S,Zajdel P,Maldonado R,Bockaert J,Marin P,Bécamel C

    更新日期:2020-05-08 00:00:00

  • The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.

    abstract::Mitochondrial (mt) diseases are multisystem disorders due to mutations in nuclear or mtDNA genes. Among the latter, more than 50% are located in transfer RNA (tRNA) genes and are responsible for a wide range of syndromes, for which no effective treatment is available at present. We show that three human mt aminoacyl-t...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Perli E,Giordano C,Pisano A,Montanari A,Campese AF,Reyes A,Ghezzi D,Nasca A,Tuppen HA,Orlandi M,Di Micco P,Poser E,Taylor RW,Colotti G,Francisci S,Morea V,Frontali L,Zeviani M,d'Amati G

    更新日期:2014-02-01 00:00:00

  • Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation.

    abstract::Growing evidence supports that LKB1-deficient KRAS-driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance. Here we find that murine lung tumors from the KrasLSL-G12D/+ ; Lkb1flox/flox (KL) model show strong plasticity, which...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Tong X,Chen Y,Zhu X,Ye Y,Xue Y,Wang R,Gao Y,Zhang W,Gao W,Xiao L,Chen H,Zhang P,Ji H

    更新日期:2021-01-13 00:00:00

  • A transcriptional network underlies susceptibility to kidney disease progression.

    abstract::The molecular networks that control the progression of chronic kidney diseases (CKD) are poorly defined. We have recently shown that the susceptibility to development of renal lesions after nephron reduction is controlled by a locus on mouse chromosome 6 and requires epidermal growth factor receptor (EGFR) activation....

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Laouari D,Burtin M,Phelep A,Bienaime F,Noel LH,Lee DC,Legendre C,Friedlander G,Pontoglio M,Terzi F

    更新日期:2012-08-01 00:00:00

  • Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.

    abstract::Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or down regulation of full-length...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Pierrot N,Tyteca D,D'auria L,Dewachter I,Gailly P,Hendrickx A,Tasiaux B,Haylani LE,Muls N,N'kuli F,Laquerrière A,Demoulin JB,Campion D,Brion JP,Courtoy PJ,Kienlen-Campard P,Octave JN

    更新日期:2013-04-01 00:00:00

  • TSC22D4 is a molecular output of hepatic wasting metabolism.

    abstract::In mammals, proper storage and distribution of lipids in and between tissues is essential for the maintenance of energy homeostasis. Here, we show that tumour growth triggers hepatic metabolic dysfunction as part of the cancer cachectic phenotype, particularly by reduced hepatic very-low-density-lipoprotein (VLDL) sec...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Jones A,Friedrich K,Rohm M,Schäfer M,Algire C,Kulozik P,Seibert O,Müller-Decker K,Sijmonsma T,Strzoda D,Sticht C,Gretz N,Dallinga-Thie GM,Leuchs B,Kögl M,Stremmel W,Diaz MB,Herzig S

    更新日期:2013-02-01 00:00:00

  • A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury.

    abstract::Group B streptococci (GBS) are Gram-positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. However, mechanisms utilized by the hemolytic pigment to induce host cell lysis a...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Whidbey C,Vornhagen J,Gendrin C,Boldenow E,Samson JM,Doering K,Ngo L,Ezekwe EA Jr,Gundlach JH,Elovitz MA,Liggitt D,Duncan JA,Adams Waldorf KM,Rajagopal L

    更新日期:2015-04-01 00:00:00

  • An essential role for decorin in bladder cancer invasiveness.

    abstract::Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murin...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: El Behi M,Krumeich S,Lodillinsky C,Kamoun A,Tibaldi L,Sugano G,De Reynies A,Chapeaublanc E,Laplanche A,Lebret T,Allory Y,Radvanyi F,Lantz O,Eiján AM,Bernard-Pierrot I,Théry C

    更新日期:2013-12-01 00:00:00

  • FGF21 gene therapy as treatment for obesity and insulin resistance.

    abstract::Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous obese/T2D population, hence the need for novel treatments. Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic agent for T2D/obesity. Native ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Jimenez V,Jambrina C,Casana E,Sacristan V,Muñoz S,Darriba S,Rodó J,Mallol C,Garcia M,León X,Marcó S,Ribera A,Elias I,Casellas A,Grass I,Elias G,Ferré T,Motas S,Franckhauser S,Mulero F,Navarro M,Haurigot V,Rube

    更新日期:2018-08-01 00:00:00

  • A surrogate marker for Abeta42 production in the CNS.

    abstract::Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and bi...

    journal_title:EMBO molecular medicine

    pub_type: 评论,杂志文章


    authors: Holtzman DM

    更新日期:2009-07-01 00:00:00

  • Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.

    abstract::Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 2: FHM2) is caused by loss-of-function mutations in α2 Na(+),K(+) ATPase (α2 NKA), an isoform almost exclusively expressed in astrocytes in adult brain. Cortical spreading depression (CSD), the phenomenon ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Capuani C,Melone M,Tottene A,Bragina L,Crivellaro G,Santello M,Casari G,Conti F,Pietrobon D

    更新日期:2016-08-01 00:00:00

  • A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.

    abstract::Maladaptive plasticity involving increased expression of AMPA-type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we developed a cell-permeable, high-affinity (~2 nM) peptide inhibitor, Tat-P4 -(C5)...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Christensen NR,De Luca M,Lever MB,Richner M,Hansen AB,Noes-Holt G,Jensen KL,Rathje M,Jensen DB,Erlendsson S,Bartling CR,Ammendrup-Johnsen I,Pedersen SE,Schönauer M,Nissen KB,Midtgaard SR,Teilum K,Arleth L,Sørensen AT

    更新日期:2020-06-08 00:00:00

  • Sequence variation in PPP1R13L results in a novel form of cardio-cutaneous syndrome.

    abstract::Dilated cardiomyopathy (DCM) is a life-threatening disorder whose genetic basis is heterogeneous and mostly unknown. Five Arab Christian infants, aged 4-30 months from four families, were diagnosed with DCM associated with mild skin, teeth, and hair abnormalities. All passed away before age 3. A homozygous sequence va...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Falik-Zaccai TC,Barsheshet Y,Mandel H,Segev M,Lorber A,Gelberg S,Kalfon L,Ben Haroush S,Shalata A,Gelernter-Yaniv L,Chaim S,Raviv Shay D,Khayat M,Werbner M,Levi I,Shoval Y,Tal G,Shalev S,Reuveni E,Avitan-Hersh E,V

    更新日期:2017-03-01 00:00:00

  • Dynorphin-based "release on demand" gene therapy for drug-resistant temporal lobe epilepsy.

    abstract::Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges. In the quest of novel, disease-modifying treatment strategies of neuropeptides represent promising candidate...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Agostinho AS,Mietzsch M,Zangrandi L,Kmiec I,Mutti A,Kraus L,Fidzinski P,Schneider UC,Holtkamp M,Heilbronn R,Schwarzer C

    更新日期:2019-10-01 00:00:00

  • Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

    abstract::Transferring large or multiple genes into primary human stem/progenitor cells is challenged by restrictions in vector capacity, and this hurdle limits the success of gene therapy. A paradigm is Duchenne muscular dystrophy (DMD), an incurable disorder caused by mutations in the largest human gene: dystrophin. The combi...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Benedetti S,Uno N,Hoshiya H,Ragazzi M,Ferrari G,Kazuki Y,Moyle LA,Tonlorenzi R,Lombardo A,Chaouch S,Mouly V,Moore M,Popplewell L,Kazuki K,Katoh M,Naldini L,Dickson G,Messina G,Oshimura M,Cossu G,Tedesco FS

    更新日期:2018-02-01 00:00:00

  • A novel thermoregulatory role for PDE10A in mouse and human adipocytes.

    abstract::Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and is under evaluation as a drug target for several psychiatric/neurodegenerative diseases. Preclinical studies implicate PDE10A in the regulation of energy homeostasis, but the mechanisms remain unclear. By utilizing small-animal PET/MRI and the nove...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Hankir MK,Kranz M,Gnad T,Weiner J,Wagner S,Deuther-Conrad W,Bronisch F,Steinhoff K,Luthardt J,Klöting N,Hesse S,Seibyl JP,Sabri O,Heiker JT,Blüher M,Pfeifer A,Brust P,Fenske WK

    更新日期:2016-07-01 00:00:00

  • Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.

    abstract::Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Alsina-Beauchamp D,Escós A,Fajardo P,González-Romero D,Díaz-Mora E,Risco A,Martín-Serrano MA,Del Fresno C,Dominguez-Andrés J,Aparicio N,Zur R,Shpiro N,Brown GD,Ardavín C,Netea MG,Alemany S,Sanz-Ezquerro JJ,Cuenda A

    更新日期:2018-05-01 00:00:00