Morula transfer achieves better clinical outcomes than post-thawed cleavage embryos after overnight culture in frozen embryo transfer (FET) cycles.

Abstract:

PURPOSE:This study aimed to investigate the clinical outcomes of morula stage transfer derived from post-thawed cleavage embryos undergoing overnight culture in frozen embryo transfer (FET) cycles. METHODS:We performed a retrospective study that included 392 FET cycles with 784 thawed embryos undergoing overnight culture between January 2014 and December 2018. Embryos were divided into three groups in terms of their status: 8-16 cells without morula (group I), one morula (group II), and two morulae (group III). The clinical outcomes of these cycles were then compared between the three groups. Logistic regression analysis was performed to control for confounders. RESULTS:Group III was associated with a significantly higher clinical pregnancy rate (odds ratio [OR] 2.35; 95% confidence interval [CI] 1.29-4.27; P = 0.005), implantation rate (OR 3.00; CI 1.75-5.16; P < 0.001), multiple pregnancy rate (OR 4.91; CI 2.11-11.40; P < 0.001), and live birth rate (OR 1.96; CI 1.10-3.49; P = 0.022) than group I. Group II had a higher live birth rate than group I after adjustment (OR 1.70; CI 1.04-2.79; P = 0.035). There was no difference in the rate of premature delivery when compared across the three groups after adjustment. CONCLUSION:The transfer of morula stage embryos following the overnight culture of post-thawed cleavage embryos led to an improvement in the clinical outcomes of FET cycles. It is important to reduce the number of morula embryos transferred in order to achieve a singleton pregnancy.

journal_name

J Assist Reprod Genet

authors

Hui D,Han X,Wang X,Ren W,Lei X,Liu J,Dong L,Li H

doi

10.1007/s10815-020-01708-7

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

945-952

issue

4

eissn

1058-0468

issn

1573-7330

pii

10.1007/s10815-020-01708-7

journal_volume

37

pub_type

杂志文章
  • Thin unresponsive endometrium--a possible complication of surgical curettage compromising ART outcome.

    abstract:PURPOSE:Endometrial thickness is important for implantation. Little data addresses the etiology of persistently thin endometrium. We present a patient cohort in order to define common features and draw conclusions. METHODS:Thirteen out of 1,405 IVF patients repeatedly had thin unresponsive endometrium (<7 mm). Age, hi...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-008-9245-y

    authors: Shufaro Y,Simon A,Laufer N,Fatum M

    更新日期:2008-08-01 00:00:00

  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes.

    abstract:OBJECTIVE:The aim of this study was to assess the fertilizability of unfertilized aged human oocytes from failed in vitro fertilization (IVF) cycles using SUZI and ICSI. METHODS:A total of 363 oocytes which showed no fertilization after conventional IVF was subjected to assisted fertilization using SUZI or ICSI. The m...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02211724

    authors: Tsirigotis M,Bennett V,Nicholson N,Khalifa Y,Hogewind G,Yazdani N,Craft I

    更新日期:1994-09-01 00:00:00

  • Pregnancy after endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination cycles-a randomized controlled trial.

    abstract:PURPOSE:To study the effect of endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination (IUI) cycles. METHODS:A prospective randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India. One hundred forty-four women wi...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10815-017-0949-8

    authors: Goel T,Mahey R,Bhatla N,Kalaivani M,Pant S,Kriplani A

    更新日期:2017-08-01 00:00:00

  • Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR.

    abstract::There are large variations in the number of oocytes within each woman, and biologically, the total quantity is at its maximum before the woman is born. Scientific knowledge is limited about factors controlling the oocyte pool and how to measure it. Within fertility clinics, there is no uniform agreement on the diagnos...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-017-1058-4

    authors: Pastore LM,Christianson MS,Stelling J,Kearns WG,Segars JH

    更新日期:2018-01-01 00:00:00

  • Intrauterine insemination: is the timing correct?

    abstract:OBJECTIVE:To evaluate the impact of follicle rupture on pregnancy rate in intrauterine insemination. MATERIAL AND METHOD:Retrospective cohort study. Evidence of follicle rupture was assessed by transvaginal ultrasonography following IUI. Two hundred ninety-six couples with unexplained infertility and 121 couples with ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-008-9247-9

    authors: Kucuk T

    更新日期:2008-08-01 00:00:00

  • Effect of Linolenic acid during in vitro maturation of ovine oocytes: embryonic developmental potential and mRNA abundances of genes involved in apoptosis.

    abstract:PURPOSE:To study the effect of α-linolenic acid (ALA) on meiotic maturation, mRNA abundance of apoptosis-related (Bax and Bcl-2) molecules, and blastocyst formation in ovine oocytes. METHODS:A preliminary experiment was conducted to analyze the concentration of ALA in "small" (≤2 mm) and "large" (≥6 mm) follicles usin...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-015-0439-9

    authors: Veshkini A,Asadi H,Khadem AA,Mohammadi-Sangcheshmeh A,Khazabi S,Aminafshar M,Deldar H,Soleimani M,Cinar MU

    更新日期:2015-04-01 00:00:00

  • Morphologic and proliferative characteristics of goat type A spermatogonia in the presence of different sets of growth factors.

    abstract:PURPOSE:The present study by using different growth factors was aimed to develop the best practical culture condition for purification of goat undifferentiated SSCs and their colonization under in vitro and in vivo conditions. METHODS:The enzymatically isolated SSCs obtained from one month old goat testes were culture...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-014-0301-5

    authors: Shirazi MS,Heidari B,Shirazi A,Zarnani AH,Jeddi-Tehrani M,Rahmati-Ahmadabadi M,Naderi MM,Behzadi B,Farab M,Sarvari A,Borjian-Boroujeni S,Akhondi MM

    更新日期:2014-11-01 00:00:00

  • Performance comparison of two whole genome amplification techniques in frame of multifactor preimplantation genetic testing.

    abstract:PURPOSE:To compare multiple displacement amplification and OmniPlex whole genome amplification technique performance during array comparative genome hybridization (aCGH), Sanger sequencing, SNaPshot and fragment size analysis downstream applications in frame of multifactor embryo preimplantation genetic testing. METHO...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-018-1187-4

    authors: Volozonoka L,Perminov D,Korņejeva L,Alkšere B,Novikova N,Pīmane EJ,Blumberga A,Kempa I,Miskova A,Gailīte L,Fodina V

    更新日期:2018-08-01 00:00:00

  • Combined intrauterine triplet and ectopic pregnancy following pronuclear embryo transfer in a patient with elevated serum progesterone during ovulation induction.

    abstract::We present a case of heterotopic pregnancy occurring after ET of pronuclear-stage embryos. This case demonstrates that pronuclear embryos have a good implantation potential and suggests that the potentially adverse effect of high follicular-phase serum progesterone levels on endometrial development might be offset by ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/BF01212937

    authors: Smith S,Scott L,Hosid S

    更新日期:1993-10-01 00:00:00

  • Extracellular microRNA profiling in human follicular fluid: new biomarkers in female reproductive potential.

    abstract::MicroRNAs (miRNAs) are small, about 22 nucleotides, non-coding RNAs which regulate a wide range of gene expression during post-transcriptional stage. They are released into intra- and extracellular microenvironments and play vital roles in different physiological and pathological pathways. Due to easy accessibility, d...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-020-01860-0

    authors: Qasemi M,Amidi F

    更新日期:2020-08-01 00:00:00

  • Association study between single-nucleotide variants rs12097821, rs2477686, and rs10842262 and idiopathic male infertility risk in Serbian population with meta-analysis.

    abstract:PURPOSE:A genome-wide association study conducted in the Han Chinese population identified three single nucleotide variants rs12097821, rs2477686, and rs10842262 as being significantly associated with non-obstructive azoospermia. Our aim was to evaluate the possible association between these susceptibility loci and idi...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-020-01920-5

    authors: Nemanja V,Zorana D,Nevena K,Suzana M,Ivan V,Branko B,Mirka D,Dusanka SP,Goran B

    更新日期:2020-11-01 00:00:00

  • Unbalanced human embryos secrete more hyperglycosylated human chorionic gonadotrophin (hCG-H) than balanced ones.

    abstract:PURPOSE:The aim of this study was to compare the levels of hyperglycosylated human chorionic gonadotropin (hCG-H) secreted from balanced and unbalanced human embryos. METHODS:Single-step culture media samples from 155 good quality embryos, derived from 90 good prognosis patients undergoing intracytoplasmic sperm injec...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-020-01776-9

    authors: Parvanov D,Nikolova D,Ganeva R,Nikolova K,Vasileva M,Rangelov I,Pancheva M,Serafimova M,Staneva R,Hadjidekova S,Scarpellini F,Stamenov G

    更新日期:2020-06-01 00:00:00

  • Intracytoplasmic injection using spermatids and subsequent pregnancies: round versus elongated spermatids.

    abstract::The purpose of this clinical trial study was to report the outcome of intracytoplasmic injection of round (RS) and elongated (ES) spermatids retrieved from the testis of nonobstructive men. Seven and three cycles using RS and ES injections were performed, respectively. Only one cycle utilizing the late stage of ES (Sd...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1014447731630

    authors: Khalili MA,Aflatoonian A,Zavos PM

    更新日期:2002-02-01 00:00:00

  • Multi-chorionic pregnancies following single embryo transfer at the blastocyst stage: a case series and review of the literature.

    abstract:OBJECTIVE:To report cases of in vitro fertilization-frozen embryo transfer (IVF-FET) with single blastocyst transfer resulting in di- or tri-chorionic pregnancies, and to review the literature on monozygotic, multi-chorionic pregnancies originating at the blastocyst stage. DESIGN:Retrospective case series and literatu...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-018-1329-8

    authors: Sundaram V,Ribeiro S,Noel M

    更新日期:2018-12-01 00:00:00

  • Leukemia inhibitory factor expression in different endometrial locations between fertile and infertile women throughout different menstrual phases.

    abstract:PURPOSE:The purpose was to demonstrate the leukemia inhibitory factor (LIF) expression in different endometrial locations between fertile and infertile women throughout different menstrual phases. The relationship between progesterone level and LIF expression were evaluated. METHODS:Endometrial biopsies were performed...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1023/a:1009457016871

    authors: Tsai HD,Chang CC,Hsieh YY,Lo HY

    更新日期:2000-09-01 00:00:00

  • Ovarian hyperstimulation syndrome: pathophysiology and prevention.

    abstract:PURPOSE:To review and discuss the pathophysiology and prevention strategies for ovarian hyperstimulation syndrome (OHSS), which is a condition that may occur in up to 20% of the high risk women submitted to assisted reproductive technology cycles. METHODS:The English language literature on these topics were reviewed t...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10815-010-9387-6

    authors: Nastri CO,Ferriani RA,Rocha IA,Martins WP

    更新日期:2010-02-01 00:00:00

  • The original Beckman Coulter Generation II assay significantly underestimates AMH levels compared with the revised protocol.

    abstract:PURPOSE:Anti-Müllerian hormone (AMH) is used as a marker for ovarian reserve. Since 2011, the standard test for AMH has been the Beckman Coulter Generation (Gen) II assay. However, in July 2013, the protocol was revised due to falsely low readings. The aim of this study was to compare AMH levels measured with the origi...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-015-0579-y

    authors: Bonifacio M,Bradley CK,Karia S,Livingstone M,Bowman MC,McArthur SJ

    更新日期:2015-11-01 00:00:00

  • Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: a meta-analysis.

    abstract:PURPOSE:The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship. METHOD(S):We searched the PubMed, Embase, and Web of Science data- bases for studies ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10815-013-0118-7

    authors: Meng HX,Qi MG,Yi YY,Liu YP

    更新日期:2013-12-01 00:00:00

  • Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

    abstract::A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-020-01954-9

    authors: Murtinger M,Wirleitner B,Hradecký L,Comploj G,Okhowat J,Spitzer D,Stadler J,Haidbauer R,Schuff M,Yildirim S,Soepenberg T,Eibner K,Gagsteiger F

    更新日期:2020-11-01 00:00:00

  • Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort.

    abstract:PURPOSE:To investigate interactions on gestational age among two environmental risk factors and four maternal genetic polymorphisms: organic solvents, passive smoking, CYP1A1 rs4646903 (MspI), EPHX1 rs2234922 (His139Arg), GSTT1 and PON2 rs12026 (Ala148Gly). METHODS:A pregnant women cohort was conducted at Beijing Yans...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-014-0256-6

    authors: Li S,Fang K,Wang W,Hu Y,Chen D

    更新日期:2014-07-01 00:00:00

  • Determining an anti-Mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve.

    abstract:PURPOSE:Serum anti-Mullerian hormone (AMH) levels estimate ovarian reserve. The purpose of this study was to identify a minimum serum AMH level that correlates with acceptable clinical pregnancy rate (CPR) in women with severe diminished ovarian reserve (DOR) undergoing in vitro fertilization (IVF). METHODS(S):A histo...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-013-0077-z

    authors: Merhi Z,Zapantis A,Berger DS,Jindal SK

    更新日期:2013-10-01 00:00:00

  • Case report: Goldenhar syndrome following donor oocyte IVF.

    abstract:PURPOSE:To describe a case of Goldenhar syndrome in a couple receiving donated oocytes in an 'egg sharing' IVF cycle where the recipient of donor oocytes had Turner syndrome, hypothyroidism and gestational diabetes. METHODS:Case report RESULTS:Child born to oocyte recipient with Goldenhar syndrome CONCLUSIONS:We bel...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-010-9448-x

    authors: Gittins V,Kasraie J

    更新日期:2010-09-01 00:00:00

  • For whom the egg thaws: insights from an analysis of 10 years of frozen egg thaw data from two UK clinics, 2008-2017.

    abstract:PURPOSE:To better understand the characteristics of patients who returned to thaw their frozen eggs to attempt conception and their outcomes. METHODS:A retrospective analysis of clinical records for all own egg thaw patients in two UK fertility clinics across 10 years, 2008-2017. RESULTS:There were 129 patients who r...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-019-01429-6

    authors: Gürtin ZB,Morgan L,O'Rourke D,Wang J,Ahuja K

    更新日期:2019-06-01 00:00:00

  • Power Doppler endometrial evaluation as a method for the prognosis of embryo implantation in an ICSI program.

    abstract:PURPOSE:The objective of the present study was to evaluate power Doppler of the endometrium as a parameter for the prognosis of embryo implantation in patients who underwent intracytoplasmic sperm injection (ICSI). METHODS:The power Doppler was performed on a transverse section at the level of the uterine fundus on th...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1023/a:1009405128160

    authors: Contart P,Baruffi RL,Coelho J,Mauri AL,Petersen C,Franco Júnior JG

    更新日期:2000-07-01 00:00:00

  • Natural conception after age 45 in Bedouin women, a uniquely fertile population.

    abstract:PURPOSE:Women conceiving naturally and delivering after age 45 are an exceptionally fertile population that may serve as a model to identify factors associated with delayed reproductive aging. This work studies this phenomenon in Bedouin women. METHODS:The study is an observational retrospective analysis of all Bedoui...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-006-9058-9

    authors: Gielchinsky Y,Mazor M,Simon A,Mor-Yossef S,Laufer N

    更新日期:2006-07-01 00:00:00

  • Should intrauterine human chorionic gonadotropin infusions ever be used prior to embryo transfer?

    abstract:PURPOSE:The aim of this study was to explore the factors that influence the outcome of intrauterine human chorionic gonadotropin (hCG) infusion at the time of embryo transfer (ET), in particular, the effect of hCG infusions on fresh and frozen embryo transfers (FETs) and whether prior recurrent implantation failure (RI...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-017-1049-5

    authors: Volovsky M,Healey M,MacLachlan V,Vollenhoven BJ

    更新日期:2018-02-01 00:00:00

  • Sex determination in single mouse blastomeres by polymerase chain reaction.

    abstract::In sex determination of mammalian preimplantation embryos, viability of biopsied embryos and accuracy of sexing are together important. In consideration of this point, single blastomeres were mechanically isolated from mouse embryos using a micromanipulator and then sexed by polymerase chain reaction (PCR) using mouse...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/BF01207739

    authors: Han YM,Yoo OJ,Lee KK

    更新日期:1993-02-01 00:00:00

  • Are zona pellucida genes involved in recurrent oocyte lysis observed during in vitro fertilization?

    abstract:PURPOSE:Complete oocyte lysis in in vitro fertilization (IVF) is a rare event, but one against which we remain helpless. The recurrence of this phenomenon in some women in each of their IVF attempts, regardless of treatment, together with the results of animal experiments led us to investigate the possible involvement ...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-013-0141-8

    authors: Ferré M,Amati-Bonneau P,Morinière C,Ferré-L'Hôtellier V,Lemerle S,Przyrowski D,Procaccio V,Descamps P,Reynier P,May-Panloup P

    更新日期:2014-02-01 00:00:00

  • Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.

    abstract:PURPOSE:The purpose of this study was to investigate a novel mutation in the luteinizing hormone beta-subunit (LHB) gene in one male patient with hypogonadism due to selective luteinizing hormone (LH) deficiency. METHODS:Sanger sequencing of one 28-year-old man born to consanguineous parents was performed. Treatment w...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-018-1133-5

    authors: Yang X,Ochin H,Shu L,Liu J,Shen J,Liu J,Lin C,Cui Y

    更新日期:2018-05-01 00:00:00

  • Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles-a prospective study.

    abstract:BACKGROUND:Obesity is associated with several fertility disorders. This prospective cohort study was designed to evaluate the effect of body mass index (BMI) (kg/m2) on oocyte diameter and treatment. METHODS:Women undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) were enrolled in the...

    journal_title:Journal of assisted reproduction and genetics

    pub_type: 杂志文章

    doi:10.1007/s10815-017-0975-6

    authors: Atzmon Y,Shoshan-Karchovsky E,Michaeli M,Aslih N,Shrem G,Ellenbogen A,Shalom-Paz E

    更新日期:2017-09-01 00:00:00