Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis.


:Atopic Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier integrity. Infants with mutations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, but most do not develop or sustain the diseases, suggesting that there exist regulatory immune mechanisms to prevent aberrant inflammation. The absence of one single murine dermal cell type, the innate neonatal-derived IL-17 producing γδ T (Tγδ17) cells, from birth resulted in spontaneous, highly penetrant AD with many of the major hallmarks of human AD. In Tγδ17 cell-deficient mice, basal keratinocyte transcriptome was altered months in advance of AD induction. Tγδ17 cells respond to skin commensal bacteria and the fulminant disease in their absence was driven by skin commensal bacteria dysbiosis. AD in this model was characterized by highly expanded dermal αβ T clonotypes that produce the type three cytokines, IL-17 and IL-22. These results demonstrate that neonatal Tγδ17 cells are innate skin regulatory T cells that are critical for skin homeostasis, and that IL-17 has dual homeostatic and inflammatory function in the skin.






Spidale NA,Malhotra N,Frascoli M,Sylvia K,Miu B,Freeman C,Stadinski BD,Huseby E,Kang J




Has Abstract


2020-02-17 00:00:00










  • Shorter cortical adaptation in dyslexia is broadly distributed in the superior temporal lobe and includes the primary auditory cortex.

    abstract::Studies of the performance of individuals with dyslexia in perceptual tasks suggest that their implicit inference of sound statistics is impaired. Previously, using two-tone frequency discrimination, we found that the effect of previous trials' frequencies on the judgments of individuals with dyslexia decays faster th...


    pub_type: 杂志文章


    authors: Jaffe-Dax S,Kimel E,Ahissar M

    更新日期:2018-02-28 00:00:00

  • Mutationally-activated PI3'-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase.

    abstract::Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lung cancer, expression of the BRAFV600E oncoprotein kinase initiates the growth of benign tumors retaining characteristics of ...


    pub_type: 杂志文章


    authors: van Veen JE,Scherzer M,Boshuizen J,Chu M,Liu A,Landman A,Green S,Trejo C,McMahon M

    更新日期:2019-08-27 00:00:00

  • High-order thalamic inputs to primary somatosensory cortex are stronger and longer lasting than cortical inputs.

    abstract::Layer (L) 2/3 pyramidal neurons in the primary somatosensory cortex (S1) are sparsely active, spontaneously and during sensory stimulation. Long-range inputs from higher areas may gate L2/3 activity. We investigated their in vivo impact by expressing channelrhodopsin in three main sources of feedback to rat S1: primar...


    pub_type: 杂志文章


    authors: Zhang W,Bruno RM

    更新日期:2019-02-11 00:00:00

  • Endosomal Rab cycles regulate Parkin-mediated mitophagy.

    abstract::Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autop...


    pub_type: 杂志文章


    authors: Yamano K,Wang C,Sarraf SA,Münch C,Kikuchi R,Noda NN,Hizukuri Y,Kanemaki MT,Harper W,Tanaka K,Matsuda N,Youle RJ

    更新日期:2018-01-23 00:00:00

  • The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor.

    abstract::Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow precursor that differ...


    pub_type: 杂志文章


    authors: Yu X,Wang Y,Deng M,Li Y,Ruhn KA,Zhang CC,Hooper LV

    更新日期:2014-10-13 00:00:00

  • Seeing is believing.

    abstract::A small transparent crustacean called Parhyale hawaiensis has become a powerful model system for the study of limb and appendage regeneration. ...


    pub_type: 评论,杂志文章


    authors: Amaya E

    更新日期:2016-10-25 00:00:00

  • Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time.

    abstract::Advances in DNA sequencing have revolutionized our ability to read genomes. However, even in the most well-studied of organisms, the bacterium Escherichia coli, for ≈65% of promoters we remain ignorant of their regulation. Until we crack this regulatory Rosetta Stone, efforts to read and write genomes will remain haph...


    pub_type: 杂志文章


    authors: Ireland WT,Beeler SM,Flores-Bautista E,McCarty NS,Röschinger T,Belliveau NM,Sweredoski MJ,Moradian A,Kinney JB,Phillips R

    更新日期:2020-09-21 00:00:00

  • Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes.

    abstract::Previous studies had shown that the integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mou...


    pub_type: 杂志文章


    authors: Hasin-Brumshtein Y,Khan AH,Hormozdiari F,Pan C,Parks BW,Petyuk VA,Piehowski PD,Brümmer A,Pellegrini M,Xiao X,Eskin E,Smith RD,Lusis AJ,Smith DJ

    更新日期:2016-09-13 00:00:00

  • Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

    abstract::Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole e...


    pub_type: 杂志文章


    authors: Pettinati I,Grzechnik P,Ribeiro de Almeida C,Brem J,McDonough MA,Dhir S,Proudfoot NJ,Schofield CJ

    更新日期:2018-12-03 00:00:00

  • Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress.

    abstract::Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fea...


    pub_type: 杂志文章


    authors: Inoue R,Abdou K,Hayashi-Tanaka A,Muramatsu SI,Mino K,Inokuchi K,Mori H

    更新日期:2018-06-26 00:00:00

  • Population genomics of intrapatient HIV-1 evolution.

    abstract::Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolved and genome wide data including rare variants are essential. We performed whole-genome deep sequencing of HIV-1 populations in 9 untreate...


    pub_type: 杂志文章


    authors: Zanini F,Brodin J,Thebo L,Lanz C,Bratt G,Albert J,Neher RA

    更新日期:2015-12-11 00:00:00

  • Multiple selection filters ensure accurate tail-anchored membrane protein targeting.

    abstract::Accurate protein localization is crucial to generate and maintain organization in all cells. Achieving accuracy is challenging, as the molecular signals that dictate a protein's cellular destination are often promiscuous. A salient example is the targeting of an essential class of tail-anchored (TA) proteins, whose so...


    pub_type: 杂志文章


    authors: Rao M,Okreglak V,Chio US,Cho H,Walter P,Shan SO

    更新日期:2016-12-07 00:00:00

  • Localizing order to boost signaling.

    abstract::B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...


    pub_type: 评论,杂志文章


    authors: Bálint Š,Dustin ML

    更新日期:2017-03-30 00:00:00

  • PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM.

    abstract::Peptidoglycan (PG) is the main component of bacterial cell walls and the target for many antibiotics. PG biosynthesis is tightly coordinated with cell wall growth and turnover, and many of these control activities depend upon PASTA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that se...


    pub_type: 杂志文章


    authors: Wamp S,Rutter ZJ,Rismondo J,Jennings CE,Möller L,Lewis RJ,Halbedel S

    更新日期:2020-05-29 00:00:00

  • Molecular and anatomical organization of the dorsal raphe nucleus.

    abstract::The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, and its complex cellular organization has impeded efforts to investiga...


    pub_type: 杂志文章


    authors: Huang KW,Ochandarena NE,Philson AC,Hyun M,Birnbaum JE,Cicconet M,Sabatini BL

    更新日期:2019-08-14 00:00:00

  • Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2.

    abstract::During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make Xenopus pluripoten...


    pub_type: 杂志文章


    authors: Scerbo P,Marchal L,Kodjabachian L

    更新日期:2017-06-27 00:00:00

  • Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation.

    abstract::Many pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing...


    pub_type: 杂志文章


    authors: Laine AL,Barrès B,Numminen E,Siren JP

    更新日期:2019-06-18 00:00:00

  • Why we need to report more than 'Data were Analyzed by t-tests or ANOVA'.

    abstract::Transparent reporting is essential for the critical evaluation of studies. However, the reporting of statistical methods for studies in the biomedical sciences is often limited. This systematic review examines the quality of reporting for two statistical tests, t-tests and ANOVA, for papers published in a selection of...


    pub_type: 杂志文章


    authors: Weissgerber TL,Garcia-Valencia O,Garovic VD,Milic NM,Winham SJ

    更新日期:2018-12-21 00:00:00

  • Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development.

    abstract::Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive. Using published and new datasets, we profile a time course of mature...


    pub_type: 杂志文章


    authors: Zhou L,Lim MYT,Kaur P,Saj A,Bortolamiol-Becet D,Gopal V,Tolwinski N,Tucker-Kellogg G,Okamura K

    更新日期:2018-07-19 00:00:00

  • Mapping mutational effects along the evolutionary landscape of HIV envelope.

    abstract::The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral growth of all amino a...


    pub_type: 杂志文章


    authors: Haddox HK,Dingens AS,Hilton SK,Overbaugh J,Bloom JD

    更新日期:2018-03-28 00:00:00

  • Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant.

    abstract::In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The forebrain knockout mice showed >90% del...


    pub_type: 杂志文章


    authors: Izumo M,Pejchal M,Schook AC,Lange RP,Walisser JA,Sato TR,Wang X,Bradfield CA,Takahashi JS

    更新日期:2014-12-19 00:00:00

  • KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis.

    abstract::Successful fertilization in angiosperms depends on the proper trajectory of pollen tubes through the pistil tissues to reach the ovules. Pollen tubes first grow within the cell wall of the papilla cells, applying pressure to the cell. Mechanical forces are known to play a major role in plant cell shape by controlling ...


    pub_type: 杂志文章


    authors: Riglet L,Rozier F,Kodera C,Bovio S,Sechet J,Fobis-Loisy I,Gaude T

    更新日期:2020-09-01 00:00:00

  • Molecular insights into the origin of the Hox-TALE patterning system.

    abstract::Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior-posterior axis. Hox proteins exert their function by interaction wit...


    pub_type: 杂志文章


    authors: Hudry B,Thomas-Chollier M,Volovik Y,Duffraisse M,Dard A,Frank D,Technau U,Merabet S

    更新日期:2014-03-18 00:00:00

  • Bitter taste receptors confer diverse functions to neurons.

    abstract::Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpr...


    pub_type: 杂志文章


    authors: Delventhal R,Carlson JR

    更新日期:2016-02-15 00:00:00

  • Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.

    abstract::Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 Å resoluti...


    pub_type: 杂志文章


    authors: Spaulding CN,Schreiber HL 4th,Zheng W,Dodson KW,Hazen JE,Conover MS,Wang F,Svenmarker P,Luna-Rico A,Francetic O,Andersson M,Hultgren S,Egelman EH

    更新日期:2018-01-18 00:00:00

  • Building for the future.

    abstract::As the staff of the MRC Laboratory of Molecular Biology settle into their new building in Cambridge, its director Hugh Pelham explains the challenges of living up to its prestigious past. ...


    pub_type: 杂志文章


    authors: Pelham H

    更新日期:2013-05-28 00:00:00

  • GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.

    abstract::Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans. However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether GnT1IP-L inhibits other N-glycan...


    pub_type: 杂志文章


    authors: Huang HH,Hassinen A,Sundaram S,Spiess AN,Kellokumpu S,Stanley P

    更新日期:2015-09-15 00:00:00

  • Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

    abstract::Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (KNa) channels. Progress in understanding KNa channels has been hampered by the absence of specific tools and methods for rigorous KNa identification in native cells. Here, we report the genetic disruption of both Kcnt1 and Kcnt...


    pub_type: 杂志文章


    authors: Martinez-Espinosa PL,Wu J,Yang C,Gonzalez-Perez V,Zhou H,Liang H,Xia XM,Lingle CJ

    更新日期:2015-11-11 00:00:00

  • Flies do the locomotion.

    abstract::Genetic techniques have shed new light on the organization of the neurons in the ventral nervous system of the fruit fly. ...


    pub_type: 评论,杂志文章


    authors: Lovick JK,Omoto JJ,Hartenstein V

    更新日期:2015-08-28 00:00:00

  • Listening in.

    abstract::Zebra finches communicate with each other in ways that are more complex than previously thought. ...


    pub_type: 杂志文章


    authors: Jarvis ED

    更新日期:2015-10-21 00:00:00