Google's Project Nightingale highlights the necessity of data science ethics review.


:On November 14 last year, the British Guardian published an account from an anonymous whistleblower at Google, accusing the company of misconduct in regard to handling sensitive health data. The whistleblower works for Project Nightingale, an attempt by Google to get into the lucrative US healthcare market, by storing and processing the personal medical data of up to 50 million customers of Ascension, one of America's largest healthcare providers. As the Wall Street Journal had already reported 3 days earlier, and as the whistleblower confirmed, neither was the data anonymized when transmitted from Ascension nor were patients or their doctors notified, let alone asked for consent to sharing their data with Google (Copeland, 2019; Pilkington, 2019). As a result, Google employees had full access to non-anonymous patient health data. Google Health chief David Feinberg commented that all Google employees involved had gone through medical ethics training and were approved by Ascension (Feinberg, 2019).


EMBO Mol Med


EMBO molecular medicine


Schneble CO,Elger BS,Shaw DM




Has Abstract


2020-03-06 00:00:00












  • A single epidermal stem cell strategy for safe ex vivo gene therapy.

    abstract::There is a widespread agreement from patient and professional organisations alike that the safety of stem cell therapeutics is of paramount importance, particularly for ex vivo autologous gene therapy. Yet current technology makes it difficult to thoroughly evaluate the behaviour of genetically corrected stem cells be...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Droz-Georget Lathion S,Rochat A,Knott G,Recchia A,Martinet D,Benmohammed S,Grasset N,Zaffalon A,Besuchet Schmutz N,Savioz-Dayer E,Beckmann JS,Rougemont J,Mavilio F,Barrandon Y

    更新日期:2015-04-01 00:00:00

  • WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.

    abstract::Wnt/β-catenin signalling has been suggested to be active in basal-like breast cancer. However, in highly aggressive metastatic triple-negative breast cancers (TNBC) the role of β-catenin and the underlying mechanism(s) for the aggressiveness of TNBC remain unknown. We illustrate that WNT10B induces transcriptionally a...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Wend P,Runke S,Wend K,Anchondo B,Yesayan M,Jardon M,Hardie N,Loddenkemper C,Ulasov I,Lesniak MS,Wolsky R,Bentolila LA,Grant SG,Elashoff D,Lehr S,Latimer JJ,Bose S,Sattar H,Krum SA,Miranda-Carboni GA

    更新日期:2013-02-01 00:00:00

  • Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.

    abstract::Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT6 receptor-operated mTOR act...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Berthoux C,Hamieh AM,Rogliardo A,Doucet EL,Coudert C,Ango F,Grychowska K,Chaumont-Dubel S,Zajdel P,Maldonado R,Bockaert J,Marin P,Bécamel C

    更新日期:2020-05-08 00:00:00

  • Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.

    abstract::Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder. Unraveling the responsible molecular pathology helps illuminate mechanisms r...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Bosakova M,Abraham SP,Nita A,Hruba E,Buchtova M,Taylor SP,Duran I,Martin J,Svozilova K,Barta T,Varecha M,Balek L,Kohoutek J,Radaszkiewicz T,Pusapati GV,Bryja V,Rush ET,Thiffault I,Nickerson DA,Bamshad MJ,Universit

    更新日期:2020-11-06 00:00:00

  • Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture.

    abstract::Follistatin-like 1 (Fstl1) is a secreted protein that is acutely induced in heart following myocardial infarction (MI). In this study, we investigated cell type-specific regulation of Fstl1 and its function in a murine model of MI Fstl1 was robustly expressed in fibroblasts and myofibroblasts in the infarcted area com...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Maruyama S,Nakamura K,Papanicolaou KN,Sano S,Shimizu I,Asaumi Y,van den Hoff MJ,Ouchi N,Recchia FA,Walsh K

    更新日期:2016-08-01 00:00:00

  • Targeting senescent cells in translational medicine.

    abstract::Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs durin...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章,评审


    authors: Paez-Ribes M,González-Gualda E,Doherty GJ,Muñoz-Espín D

    更新日期:2019-12-01 00:00:00

  • FGF21 gene therapy as treatment for obesity and insulin resistance.

    abstract::Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous obese/T2D population, hence the need for novel treatments. Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic agent for T2D/obesity. Native ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Jimenez V,Jambrina C,Casana E,Sacristan V,Muñoz S,Darriba S,Rodó J,Mallol C,Garcia M,León X,Marcó S,Ribera A,Elias I,Casellas A,Grass I,Elias G,Ferré T,Motas S,Franckhauser S,Mulero F,Navarro M,Haurigot V,Rube

    更新日期:2018-08-01 00:00:00

  • Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts.

    abstract::Chimeric antigen receptor (CAR) T cell therapy, together with checkpoint inhibition, has been celebrated as a breakthrough technology due to the substantial benefit observed in clinical trials with patients suffering from relapsed or refractory B-cell malignancies. In this review, we provide a comprehensive overview o...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章,评审


    authors: Hartmann J,Schüßler-Lenz M,Bondanza A,Buchholz CJ

    更新日期:2017-09-01 00:00:00

  • mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.

    abstract::Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. It is therefore important to identify novel regulators of NST and cold-induced glucose ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Albert V,Svensson K,Shimobayashi M,Colombi M,Muñoz S,Jimenez V,Handschin C,Bosch F,Hall MN

    更新日期:2016-03-01 00:00:00

  • Inducing mitophagy in diabetic platelets protects against severe oxidative stress.

    abstract::Diabetes mellitus (DM) is a growing international concern. Considerable mortality and morbidity associated with diabetes mellitus arise predominantly from thrombotic cardiovascular events. Oxidative stress-mediated mitochondrial damage contributes significantly to enhanced thrombosis in DM A basal autophagy process ha...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Lee SH,Du J,Stitham J,Atteya G,Lee S,Xiang Y,Wang D,Jin Y,Leslie KL,Spollett G,Srivastava A,Mannam P,Ostriker A,Martin KA,Tang WH,Hwa J

    更新日期:2016-07-01 00:00:00

  • Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis.

    abstract::Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory cells in the artery wall. Aberrant expression of microRNAs has been implicated in the pathophysiological processes underlying the progression of atherosclerosis. He...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Canfrán-Duque A,Rotllan N,Zhang X,Fernández-Fuertes M,Ramírez-Hidalgo C,Araldi E,Daimiel L,Busto R,Fernández-Hernando C,Suárez Y

    更新日期:2017-09-01 00:00:00

  • Transparency and accountability.

    abstract::EMBO Molecular Medicine is enriched by a number of innovative policies designed to enhance the editorial process: peer review process files, de-emphasis of confidential referee comments and cross-refereeing. ...

    journal_title:EMBO molecular medicine

    pub_type: 社论


    authors: Pulverer B

    更新日期:2010-09-01 00:00:00

  • Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.

    abstract::Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI) algorithms, to be useful for COVID-19 infection via proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. W...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Stebbing J,Krishnan V,de Bono S,Ottaviani S,Casalini G,Richardson PJ,Monteil V,Lauschke VM,Mirazimi A,Youhanna S,Tan YJ,Baldanti F,Sarasini A,Terres JAR,Nickoloff BJ,Higgs RE,Rocha G,Byers NL,Schlichting DE,Nirula A

    更新日期:2020-08-07 00:00:00

  • A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.

    abstract::Gene therapy critically relies on vectors that combine high transduction efficiency with a high degree of target specificity and that can be administered through a safe intravenous route. The lack of suitable vectors, especially for gene therapy of brain disorders, represents a major obstacle. Therefore, we applied an...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Körbelin J,Dogbevia G,Michelfelder S,Ridder DA,Hunger A,Wenzel J,Seismann H,Lampe M,Bannach J,Pasparakis M,Kleinschmidt JA,Schwaninger M,Trepel M

    更新日期:2016-06-01 00:00:00

  • VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption.

    abstract::Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target for treatment of cancer and lymphedema, the physiological functions of VEGF-C in adult vas...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Nurmi H,Saharinen P,Zarkada G,Zheng W,Robciuc MR,Alitalo K

    更新日期:2015-11-01 00:00:00

  • Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases.

    abstract::Patients affected by mitochondrial OXPHOS disorders are still faced with a grim lack of therapeutic options. In this Closeup, Carlos Moraes revisits the recent data by Giovanni Manfredi on PKA's functions in the mitochondria and now its modulation can improve respiration and ATP production in COX-defective cells. ...

    journal_title:EMBO molecular medicine

    pub_type: 评论,杂志文章


    authors: Moraes CT

    更新日期:2009-11-01 00:00:00

  • Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis.

    abstract::Telomerase is expressed in the neonatal brain, in distinct regions of adult brain, and was shown to protect developing neurons from apoptosis. Telomerase reactivation by gene manipulation reverses neurodegeneration in aged telomerase-deficient mice. Hence, we and others hypothesized that increasing telomerase expressi...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Eitan E,Tichon A,Gazit A,Gitler D,Slavin S,Priel E

    更新日期:2012-04-01 00:00:00

  • A transcriptional network underlies susceptibility to kidney disease progression.

    abstract::The molecular networks that control the progression of chronic kidney diseases (CKD) are poorly defined. We have recently shown that the susceptibility to development of renal lesions after nephron reduction is controlled by a locus on mouse chromosome 6 and requires epidermal growth factor receptor (EGFR) activation....

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Laouari D,Burtin M,Phelep A,Bienaime F,Noel LH,Lee DC,Legendre C,Friedlander G,Pontoglio M,Terzi F

    更新日期:2012-08-01 00:00:00

  • Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF.

    abstract::Hypoxic microenvironment plays an important role in determining stem cell fates. However, it is controversial to which direction between self-renewal and differentiation the hypoxia drives the stem cells. Here, we investigated whether a short exposure to hypoxia (termed 'hypoxic-priming') efficiently directed and prom...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Lee SW,Jeong HK,Lee JY,Yang J,Lee EJ,Kim SY,Youn SW,Lee J,Kim WJ,Kim KW,Lim JM,Park JW,Park YB,Kim HS

    更新日期:2012-09-01 00:00:00

  • Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies.

    abstract::Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity-on-Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TNF-based AcTakine targeted to CD13 enables selective activation of the tumor neovas...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Huyghe L,Van Parys A,Cauwels A,Van Lint S,De Munter S,Bultinck J,Zabeau L,Hostens J,Goethals A,Vanderroost N,Verhee A,Uzé G,Kley N,Peelman F,Vandekerckhove B,Brouckaert P,Tavernier J

    更新日期:2020-02-07 00:00:00

  • Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.

    abstract::Gene targeting constitutes a new step in the development of gene therapy for inherited diseases. Although previous studies have shown the feasibility of editing fibroblasts from Fanconi anemia (FA) patients, here we aimed at conducting therapeutic gene editing in clinically relevant cells, such as hematopoietic stem c...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Diez B,Genovese P,Roman-Rodriguez FJ,Alvarez L,Schiroli G,Ugalde L,Rodriguez-Perales S,Sevilla J,Diaz de Heredia C,Holmes MC,Lombardo A,Naldini L,Bueren JA,Rio P

    更新日期:2017-11-01 00:00:00

  • Antimicrobial peptides and gut microbiota in homeostasis and pathology.

    abstract::We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while not initiating ongoing inflammatory processes and risking collateral damage to the host. Major players in this scenario are antimicrobial peptides (AMPs). Such b...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章,评审


    authors: Ostaff MJ,Stange EF,Wehkamp J

    更新日期:2013-10-01 00:00:00

  • Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens.

    abstract::Neuroblastoma (NB) is the most deadly extra-cranial solid tumour in children necessitating an urgent need for effective and less toxic treatments. One reason for the lack of efficacious treatments may be the inability of existing drugs to target the tumour-initiating or cancer stem cell population responsible for sust...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Smith KM,Datti A,Fujitani M,Grinshtein N,Zhang L,Morozova O,Blakely KM,Rotenberg SA,Hansford LM,Miller FD,Yeger H,Irwin MS,Moffat J,Marra MA,Baruchel S,Wrana JL,Kaplan DR

    更新日期:2010-09-01 00:00:00

  • STAMP2 increases oxidative stress and is critical for prostate cancer.

    abstract::The six transmembrane protein of prostate 2 (STAMP2) is an androgen-regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared with benign prostate that is also correlated with tumor grade and treatment response. We also s...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Jin Y,Wang L,Qu S,Sheng X,Kristian A,Mælandsmo GM,Pällmann N,Yuca E,Tekedereli I,Gorgulu K,Alpay N,Sood A,Lopez-Berestein G,Fazli L,Rennie P,Risberg B,Wæhre H,Danielsen HE,Ozpolat B,Saatcioglu F

    更新日期:2015-03-01 00:00:00

  • Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

    abstract::Transferring large or multiple genes into primary human stem/progenitor cells is challenged by restrictions in vector capacity, and this hurdle limits the success of gene therapy. A paradigm is Duchenne muscular dystrophy (DMD), an incurable disorder caused by mutations in the largest human gene: dystrophin. The combi...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Benedetti S,Uno N,Hoshiya H,Ragazzi M,Ferrari G,Kazuki Y,Moyle LA,Tonlorenzi R,Lombardo A,Chaouch S,Mouly V,Moore M,Popplewell L,Kazuki K,Katoh M,Naldini L,Dickson G,Messina G,Oshimura M,Cossu G,Tedesco FS

    更新日期:2018-02-01 00:00:00

  • DNA methylation profiling reveals a predominant immune component in breast cancers.

    abstract::Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and it...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Dedeurwaerder S,Desmedt C,Calonne E,Singhal SK,Haibe-Kains B,Defrance M,Michiels S,Volkmar M,Deplus R,Luciani J,Lallemand F,Larsimont D,Toussaint J,Haussy S,Rothé F,Rouas G,Metzger O,Majjaj S,Saini K,Putmans P,Ham

    更新日期:2011-12-01 00:00:00

  • Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.

    abstract::The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course. In the mouse mammary gland, Numb/p53 downregulation leads to aberrant tissue morphogenesis, expansion of the stem cell compartment, and emergence of cancer stem cell...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Tosoni D,Pambianco S,Ekalle Soppo B,Zecchini S,Bertalot G,Pruneri G,Viale G,Di Fiore PP,Pece S

    更新日期:2017-05-01 00:00:00

  • A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation.

    abstract::Translational read-through-inducing drugs (TRIDs) promote read-through of nonsense mutations, placing them in the spotlight of current gene-based therapeutic research. Here, we compare for the first time the relative efficacies of new-generation aminoglycosides NB30, NB54 and the chemical compound PTC124 on retinal to...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Goldmann T,Overlack N,Möller F,Belakhov V,van Wyk M,Baasov T,Wolfrum U,Nagel-Wolfrum K

    更新日期:2012-11-01 00:00:00

  • Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain.

    abstract::Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the 1 year survival rate among these patients remains less than 20%. However, the pathological mechanism of brain metastasis is as yet poorly understood. In this report, we found that metastat...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Xing F,Kobayashi A,Okuda H,Watabe M,Pai SK,Pandey PR,Hirota S,Wilber A,Mo YY,Moore BE,Liu W,Fukuda K,Iiizumi M,Sharma S,Liu Y,Wu K,Peralta E,Watabe K

    更新日期:2013-03-01 00:00:00

  • Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.

    abstract::Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. ...

    journal_title:EMBO molecular medicine

    pub_type: 杂志文章


    authors: Alsina-Beauchamp D,Escós A,Fajardo P,González-Romero D,Díaz-Mora E,Risco A,Martín-Serrano MA,Del Fresno C,Dominguez-Andrés J,Aparicio N,Zur R,Shpiro N,Brown GD,Ardavín C,Netea MG,Alemany S,Sanz-Ezquerro JJ,Cuenda A

    更新日期:2018-05-01 00:00:00