Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain.


:Perinatal hypoxic-ischemic (HI)-related brain injury is an important cause of morbidity and long-standing disability in newborns. The only currently approved therapeutic strategy available to reduce brain injury in the newborn is hypothermia. Therapeutic hypothermia can only be used to treat HI encephalopathy in full-term infants and survivors remain at high risk for a wide spectrum of neurodevelopmental abnormalities as a result of residual brain injury. Therefore, there is an urgent need for adjunctive therapeutic strategies. Inflammation and neurovascular damage are important factors that contribute to the pathophysiology of HI-related brain injury and represent exciting potential targets for therapeutic intervention. In this review, we address the role of each component of the neurovascular unit (NVU) in the pathophysiology of HI-related injury in the neonatal brain. Disruption of the blood-brain barrier (BBB) observed in the early hours after an HI-related event is associated with a response at the basal lamina level, which comprises astrocytes, pericytes, and immune cells, all of which could affect BBB function to further exacerbate parenchymal injury. Future research is required to determine potential drugs that could prevent or attenuate neurovascular damage and/or augment repair. However, some studies have reported beneficial effects of hypothermia, erythropoietin, stem cell therapy, anti-cytokine therapy and metformin in ameliorating several different facets of damage to the NVU after HI-related brain injury in the perinatal period.


J Neurosci Res


Disdier C,Stonestreet BS




Has Abstract


2020-07-01 00:00:00












  • Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice.

    abstract::Scar formation after injury of the brain or spinal cord is a common event. While glial scar formation by astrocytes has been extensively studied, much less is known about the fibrotic scar, in particular after stroke. Platelet-derived growth factor receptor ß-expressing (PDGFRß+ ) pericytes have been suggested as a so...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Roth M,Enström A,Aghabeick C,Carlsson R,Genové G,Paul G

    更新日期:2020-05-01 00:00:00

  • 4-Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant astrocytoma cell lines.

    abstract::Among the ion channels and pumps activated by growth factor stimulation, K+ channels have been implicated in the growth and proliferation of several cancer cell lines. The role of these channels in central nervous system tumors, however, has not been described. This study used the malignant astrocytoma cell lines U87 ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Chin LS,Park CC,Zitnay KM,Sinha M,DiPatri AJ Jr,Perillán P,Simard JM

    更新日期:1997-04-15 00:00:00

  • Acute ammonia neurotoxicity in vivo involves increase in cytoplasmic protein P53 without alterations in other markers of apoptosis.

    abstract::Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Kosenko E,Kaminsky Y,Solomadin I,Marov N,Venediktova N,Felipo V,Montoliu C

    更新日期:2007-08-15 00:00:00

  • Serotonin regulation of nerve growth factor synthesis in neonatal and adult astrocytes: comparison to the beta-adrenergic agonist isoproterenol.

    abstract::Although serotonin regulates synthesis of the neurotrophic factor S-100 beta by astrocytes, its ability to affect nerve growth factor (NGF) synthesis has never been examined. We report here that there is a correlation between the effect of serotonin on cyclic adenosine monophosphate (cAMP) content and on NGF content i...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Krzan M,Wu VW,Schwartz JP

    更新日期:2001-05-01 00:00:00

  • NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells.

    abstract::In an effort to identify genes involved in neuronal differentiation, we have used representational difference analysis (RDA) to clone cDNAs that are preferentially induced by nerve growth factor (NGF) vs. epidermal growth factor (EGF) in PC12 pheochromocytoma cells. We now report the cloning of a previously unknown pr...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Vician L,Silver AL,Farias-Eisner R,Herschman HR

    更新日期:2001-04-15 00:00:00

  • Time-to-contact perception in the brain.

    abstract::Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Baurès R,Fourteau M,Thébault S,Gazard C,Pasquio L,Meneghini G,Perrin J,Rosito M,Durand JB,Roux FE

    更新日期:2021-02-01 00:00:00

  • Cholesterol reutilization during myelination of regenerating PNS axons is impaired in Niemann-Pick disease type C mice.

    abstract::Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We found in a prelimi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Goodrum JF,Pentchev PG

    更新日期:1997-08-01 00:00:00

  • Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1.

    abstract::Glutamate-induced neurotoxicity consequent to N-methyl-D-aspartic acid (NMDA) and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid (AMPA) receptor activation underlies the pathogenesis of a wide range of central nervous system disorders, including brain ischemia. Prevention of ischemia/reperfusion (I/R)-ind...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Liu L,Zhang R,Liu K,Zhou H,Tang Y,Su J,Yu X,Yang X,Tang M,Dong Q

    更新日期:2009-12-01 00:00:00

  • Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus.

    abstract::The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Cheng CM,Cohen M,Tseng V,Bondy CA

    更新日期:2001-05-15 00:00:00

  • Interaction between protein kinase C and protein kinase A can modulate transmitter release at the rat neuromuscular synapse.

    abstract::We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

    更新日期:2009-02-15 00:00:00

  • Neurotransmitter phenotype plasticity in cultured dissociated adult rat dorsal root ganglia: an immunocytochemical study.

    abstract::Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Schoenen J,Delree P,Leprince P,Moonen G

    更新日期:1989-04-01 00:00:00

  • Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-κB-ERK-dependent pathway.

    abstract::Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

    更新日期:2011-11-01 00:00:00

  • Formation of new sensory cells in deafferented tuberous organs of the gymnotid fish Eigenmannia virescens.

    abstract::The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Bensouilah M,Denizot JP

    更新日期:1994-12-01 00:00:00

  • Time course of polyglutamine aggregate body formation and cell death: enhanced growth in nucleus and an interval for cell death.

    abstract::Polyglutamine (polyQ) aggregate bodies are a hallmark of dentatorubral-pallidoluysian atrophy and related neurodegenerative disorders, although the relationship between aggregate body formation and cell death is not clear. We analyzed the kinetics of polyQ aggregate formation and the time intervals for cell death, tra...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Toyoshima I,Sugawara M,Kato K,Wada C,Shimohata T,Koide R,Onodera O,Tsuji S

    更新日期:2002-05-15 00:00:00

  • Amino acid modification of proteins in regenerating sciatic nerves of rats.

    abstract::Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Chakraborty G,Yu M,Luo D,Sturman JA,Ingoglia NA

    更新日期:1990-04-01 00:00:00

  • Dopamine receptors on isolated membranes of rat lymphocytes.

    abstract::Using [3H]-dopamine (DA) as the ligand of choice, we have shown that rat lymphocytes possess DA binding sites. The binding of [3H]-DA was specific, saturable, and of high affinity. The specific binding in membranes obtained from Con A-activated lymphoblasts was greater than the binding in respective unactivated lympho...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Ovadia H,Abramsky O

    更新日期:1987-01-01 00:00:00

  • A quantitative study of growth cone filopodial extension.

    abstract::The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Argiro V,Bunge MB,Johnson MI

    更新日期:1985-01-01 00:00:00

  • Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia.

    abstract::Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Walker EJ,Rosenberg GA

    更新日期:2010-03-01 00:00:00

  • Interactions among memory-related centers in the brain.

    abstract::The structures associated with learning and memory have been widely studied for over 100 years. The idea of the famous neuropsychologist K.S. Lashley, that learning and memory are stored diffusely in the brain, dominated neuroscience in the early half of Twentieth Century. Since Scoville reported in 1957 a persistent ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审


    authors: Shu SY,Wu YM,Bao XM,Leonard B

    更新日期:2003-03-01 00:00:00

  • Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle.

    abstract::Progressive "dying back" neurodegenerative diseases are debilitating due to loss of connectivity after nerve terminal and axonal withdrawal, which impairs peripheral nerve function and leads ultimately to neuronal cell death. The mutant mouse (Wallerian degeneration slow; Wld(s)) provides an accessible model system to...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Parson SH,Ribchester RR,Davie N,Gandhi NP,Malik RQ,Gillingwater TH,Thomson D

    更新日期:2004-04-01 00:00:00

  • Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone.

    abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Mandyam CD,Norris RD,Eisch AJ

    更新日期:2004-06-15 00:00:00

  • Cannabinoid receptor agonist-stimulated [35S]guanosine triphosphate gammaS binding in the brain of C57BL/6 and DBA/2 mice.

    abstract::The two inbred strains of mice C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) mice have been shown to differ significantly in their preference for alcohol (EtOH). We have previously demonstrated the differences in the density and the affinity of cannabinoid (CB1) receptors in the brains of the two inbred C5...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Basavarajappa BS,Hungund BL

    更新日期:2001-05-15 00:00:00

  • Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

    abstract::Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated w...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Pflibsen L,Stang KA,Sconce MD,Wilson VB,Hood RL,Meshul CK,Mitchell SH

    更新日期:2015-12-01 00:00:00

  • Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.

    abstract::Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

    更新日期:2016-01-01 00:00:00

  • Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain.

    abstract::Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Pellerin L,Bergersen LH,Halestrap AP,Pierre K

    更新日期:2005-01-01 00:00:00

  • Characterization of NTera2/D1 cells as a model system for the investigation of cannabinoid function in human neurons and astrocytes.

    abstract::The limited availability and potential to culture primary human brain cells means that there is still a need for cell lines that reliably model human neurons and glial cells. The human-derived NTera2/D1 (NT2) cell line is a promising tool from which both neuronal (NT2N) and astrocytic (NT2A) cells can be derived in vi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Goodfellow CE,Graham SE,Dragunow M,Glass M

    更新日期:2011-10-01 00:00:00

  • GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia.

    abstract::Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

    更新日期:2004-05-15 00:00:00

  • Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.

    abstract::Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Dineley KT,Kayed R,Neugebauer V,Fu Y,Zhang W,Reese LC,Taglialatela G

    更新日期:2010-10-01 00:00:00

  • Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice.

    abstract::We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

    更新日期:2014-08-01 00:00:00

  • Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

    abstract::Although protein kinase Cdk5-p35 is important in many aspects of the development and function of the central nervous system, relatively little is known about its regulation. In the present study, we examined the relationship between the association of this kinase with membranes and its activity in perinatal and adult ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章


    authors: Sato K,Zhu YS,Saito T,Yotsumoto K,Asada A,Hasegawa M,Hisanaga S

    更新日期:2007-11-01 00:00:00