Abstract:
OBJECTIVE:To determine the prevalence of R501X mutation of Filaggrin gene in children with allergic diseases. METHODS:Ninety patients recruited from Allergy and Asthma clinic of Advanced Pediatric Centre, PGIMER, Chandigarh and 81 healthy controls from local schools matched for age, gender and BMI were enroled in the present study. The R501X mutation analysis was done by PCR-RFLP method. RESULTS:Out of the 90 enroled allergic children, 5 (5.5%) were mutant (AA) for R501X genotype, 44 (43.3%) had (AA+Aa) genotype and 46 (51.1%) had (aa) genotype. However, in the control group there were no mutant (AA) for R501X, 36 (44.4%) had (AA+Aa) genotype and 45 had wild type homozygous (aa) genotype. There were 3.3% and 2.2% children with asthma and asthma concomitantly with eczema having mutant R501X genotype. CONCLUSIONS:In the present study, the prevalence of Filaggrin mutant genotype (R501X) was detected in approximately 5.5% of children with allergic diseases.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Chauhan A,Panigrahi I,Singh M,Attri SV,Agarwal A,Singh Mdoi
10.1007/s12098-020-03231-0subject
Has Abstractpub_date
2020-08-01 00:00:00pages
587-590issue
8eissn
0019-5456issn
0973-7693pii
10.1007/s12098-020-03231-0journal_volume
87pub_type
杂志文章abstract::Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because they are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indic...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-015-2027-5
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02728866
更新日期:2001-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0650-3
更新日期:2012-11-01 00:00:00
abstract::Untreated vertically transmitted human immunodeficiency virus (HIV) infection progresses rapidly with 50% mortality at 1 y and most of the remainder dying before 5 y of age. The authors present a case of a 13-y-old boy, a paternal orphan with vertically transmitted HIV infection, lost to follow up after diagnosis in i...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0670-z
更新日期:2012-09-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12098-007-0112-0
更新日期:2007-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752376
更新日期:1999-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0073-6
更新日期:2009-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-012-0918-2
更新日期:2013-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-014-1388-5
更新日期:2014-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03088-y
更新日期:2020-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02905712
更新日期:1996-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02830828
更新日期:2004-10-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02760582
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to assess the effect of diagnosis of cancer on the parents, to study the coping response adopted by the child and the family and to evolve counseling strategies. METHODS:Prospective questionnaire based. Thirty-four parents of children suffering from cancer were included, of which 15 ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-007-0149-0
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Hirschsprung's disease may be associated with a number of congenital anomalies of which Down's syndrome and intestinal atresias are commonly encountered. The study aimed to assess the impact of rare associated anomalies on the diagnosis and management of Hirschsprung's disease. METHODS:A retrospective review...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02762106
更新日期:2001-09-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02760702
更新日期:2005-02-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0551-5
更新日期:2012-03-01 00:00:00
abstract::Fibrochondrogenesis is a rare lethal short-limb skeletal dysplasia. Till now only fifteen cases have been reported since Lazzaroni-Fossati first described it in 1978. Hence reported a case of fibrochondrogenesis in a child born to a consanguineously married couple with characteristic physical and radiological features...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02724021
更新日期:2005-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722592
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of decreased glomerular filtration rate (GFR) in Tibetan children with congenital heart disease (CHD) and its associated risk factors. METHODS:A total of 207 Tibetan children attending authors' center for treatment of CHD from May 2012 through November 2012, were included in the stu...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1351-5
更新日期:2014-10-01 00:00:00
abstract::Juvenile dermatomyositis and juvenile scleroderma are rare multisystem autoimmune disorders. Although they share some pathognomonic hallmarks with adult onset myositis or scleroderma, there are significant differences in presentation, characteristics and associated features when the diseases present in childhood. In v...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-015-1907-z
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To document the immunization rates, factors associated with incomplete immunization, and missed opportunities for immunizations in children affected by HIV presenting for routine outpatient follow-up. METHODS:A cross-sectional study of immunization status of children affected by HIV presenting for routine ou...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1049-0
更新日期:2014-09-01 00:00:00
abstract::Adrenal hemorrhage has many etiologies including bleeding diathesis. A 10-day-old female baby was admitted to our clinic with the complaint of abdominal distention. Hemorrhage was determined on the right adrenal gland with abdominal ultrasonography and computerized tomography. Laboratory investigations showed PT 44 se...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723786
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To understand the problems of school going adolescents in selected schools in the first phase and to provide class based family life education in the second phase. METHODS:Step 1: Identification of the study sample, Step 2: Each adolescent was individually administered TSQ-T by trained project staff , Step ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1132-6
更新日期:2013-11-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03117-w
更新日期:2020-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2561-4
更新日期:2018-09-01 00:00:00
abstract::The study was conducted to assess copper and zinc levels in neonate's serum, mother's serum, neonate's hair and urine and to ascertain association between them. It is of concern whether zinc and copper deficiency is present at birth and maternal blood and breast milk zinc and copper levels have any effect on this. The...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726255
更新日期:1999-09-01 00:00:00