Prevalence of Filaggrin Gene R501X Mutation in Indian Children with Allergic Diseases.

Abstract:

OBJECTIVE:To determine the prevalence of R501X mutation of Filaggrin gene in children with allergic diseases. METHODS:Ninety patients recruited from Allergy and Asthma clinic of Advanced Pediatric Centre, PGIMER, Chandigarh and 81 healthy controls from local schools matched for age, gender and BMI were enroled in the present study. The R501X mutation analysis was done by PCR-RFLP method. RESULTS:Out of the 90 enroled allergic children, 5 (5.5%) were mutant (AA) for R501X genotype, 44 (43.3%) had (AA+Aa) genotype and 46 (51.1%) had (aa) genotype. However, in the control group there were no mutant (AA) for R501X, 36 (44.4%) had (AA+Aa) genotype and 45 had wild type homozygous (aa) genotype. There were 3.3% and 2.2% children with asthma and asthma concomitantly with eczema having mutant R501X genotype. CONCLUSIONS:In the present study, the prevalence of Filaggrin mutant genotype (R501X) was detected in approximately 5.5% of children with allergic diseases.

journal_name

Indian J Pediatr

authors

Chauhan A,Panigrahi I,Singh M,Attri SV,Agarwal A,Singh M

doi

10.1007/s12098-020-03231-0

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

587-590

issue

8

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-020-03231-0

journal_volume

87

pub_type

杂志文章
  • Pulse steroid therapy.

    abstract::Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because they are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indic...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-008-0210-7

    authors: Sinha A,Bagga A

    更新日期:2008-10-01 00:00:00

  • Field Testing of Appropriate Technological Tool of Individualised Color Coded Any Day Neonatal Growth Monitoring Charts for Neonatal Care at Primary Health Care Level.

    abstract:OBJECTIVE:To field test the Individualised Color Coded Any Day (ICCAD) growth monitoring charts at primary health care level in three districts of Maharashtra. METHODS:The present study was conducted in three districts of Maharashtra - Pune, Satara and Kolhapur and included newborns with weight ≥ 1500 g born during 1s...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-015-2027-5

    authors: Pratinidhi AK,Doke PP,Kakade SV,Aundhkar CD,Ingale SY,Patil SS,Patil SV

    更新日期:2016-07-01 00:00:00

  • Association of Child Neurology-Indian Epilepsy Society Consensus Document on Parental Counseling of Children with Epilepsy.

    abstract::When a child is diagnosed with epilepsy, counseling regarding the same is done by the treating doctor. Most parents are frightened and have poor knowledge about epilepsy. Therapeutic advice including drug dosage, administration and side effects takes up the major part of physician's time, thereby neglecting important ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-019-02946-z

    authors: Srivastava K,Sehgal R,Konanki R,Jain R,Sharma S,Mittal R,Association of Child Neurology (AOCN)-Indian Epilepsy Society (IES) SOLACE Expert Group.,Hedge A,Aggarwal A,Chattopadhyay A,Patra B,Kaushik JS,Lingappa L,Sankhyan N,Kap

    更新日期:2019-07-01 00:00:00

  • Sodium stibogluconate and polymorphic ventricular tachycardia.

    abstract::Numerous antimicrobials including pentavalent antimonials are implicated in causing prolong QT-interval and ventricular tachycardia. Torsades de pointes is rarely documented with use of sodium stibogluconate. Here is described a 12-yr-old girl with visceral leishmaniasis, who developed syncopal attacks, prolong QT-int...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:

    authors: Baranwal AK,Mandal RN,Singh R,Singhi SC

    更新日期:2005-03-01 00:00:00

  • Are our donors safe?

    abstract::Blood is defined as a 'drug' under the Drugs and Cosmetics Act. The Standard of drugs is laid down in the Indian Pharmacopoeia. The first step towards blood safety is to encourage blood donations, which are voluntary, non-remunerated and obtained from low-risk and regular donors. A regular donor is one who donates blo...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02728866

    authors: Viswanathan C

    更新日期:2001-01-01 00:00:00

  • Caudal dysplasia, femoral hypoplasia-unusual facies syndrome and absent radius: a new association in infant of diabetic mother?

    abstract::The Caudal dysplasia syndrome (CDS) and the femoral hypoplasia-unusual facies syndrome (FHUFS) have been reported to be more frequent among infants of diabetic mothers (IDMs). Infact, uncontrolled maternal diabetes is the most common cause of both the syndromes. Till now, there is no case report to suggest absent radi...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0650-3

    authors: Gupta P,Khatri PC,Agarwal R,Gupta P

    更新日期:2012-11-01 00:00:00

  • Vertically transmitted HIV infection having first clinical manifestations at 13 y of age.

    abstract::Untreated vertically transmitted human immunodeficiency virus (HIV) infection progresses rapidly with 50% mortality at 1 y and most of the remainder dying before 5 y of age. The authors present a case of a 13-y-old boy, a paternal orphan with vertically transmitted HIV infection, lost to follow up after diagnosis in i...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0670-z

    authors: Sagar A,Vasudevan B

    更新日期:2012-09-01 00:00:00

  • Randomized trial of spacers in asthma.

    abstract:OBJECTIVE:To compare the efficacy of all types of spacers commonly available to children in India. METHODS:150 children 5-14 yr of age with persistent asthma presenting with peak expiratory flow (PEF) < 70% of personal best were randomized to receive 200 mg salbutamol through one of five spacers: A) 750 ml spacer with...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12098-007-0112-0

    authors: Dahiya B,Mathew JL,Singh M

    更新日期:2007-07-01 00:00:00

  • Congenital tuberculosis.

    abstract::A 29 day old male infant presented with a history of fever, cough, increasing respiratory distress and abdominal distension from the 10th day of life. Examination revealed failure to thrive, marked tachypnea, pallor, hepatosplenomegaly and harsh vesicular breath sounds. Chest skiagram showed extensive broncho-pneumoni...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02752376

    authors: Balasubramanian S,Shivram R,Padmasani LN,Nagaraju

    更新日期:1999-01-01 00:00:00

  • Prevalence, correlates of and perceptions toward cigarette smoking among adolescents in South Korea.

    abstract:OBJECTIVE:To estimate the prevalence of current smoking, correlates of smoking and assess exposure to and perceptions towards smoking by gender. METHODS:We used data from the South Korea Global Youth Tobacco Survey (GYTS). Frequencies of selected characteristics and their 95% confidence were obtained. Current cigarett...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-009-0073-6

    authors: Rudatsikira E,Muula AS,Siziya S

    更新日期:2009-05-01 00:00:00

  • Approach to a child with bleeding in the emergency room.

    abstract::A bleeding child is a cause of great concern and often, panic, for parents and pediatricians alike. Causes of bleeding could be trivial or secondary to an underlying bleeding disorder or a potentially serious systemic illness. Based on etiology, they can be categorized into disorders affecting platelets or the coagula...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-012-0918-2

    authors: Bansal D,Oberoi S,Marwaha RK,Singhi SC

    更新日期:2013-05-01 00:00:00

  • Pathophysiology and current management of necrotizing enterocolitis.

    abstract::Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of morbidity and mortality in these infants. In this article, the authors review the pathophysiology and clinical presentation of NEC and provide a critical appraisal of t...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-014-1388-5

    authors: Kasivajjula H,Maheshwari A

    更新日期:2014-05-01 00:00:00

  • Liquid Mosquito Repellent Ingestion in Children.

    abstract:OBJECTIVES:Hydrocarbons are a common cause of accidental poisoning in children, with kerosene being the most implicated agent in rural parts of India. However, lately, liquid mosquito repellent ingestion is emerging as an important cause of hydrocarbon (kerosene) poisoning in urban households. METHODS:This is a retros...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-019-03088-y

    authors: Reddy MV,Ganesan SL,Narayanan K,Jayashree M,Singhi SC,Nallasamy K,Bansal A,Baranwal AK

    更新日期:2020-01-01 00:00:00

  • A to Z: vitamin A and zinc, the miracle duo.

    abstract::Dietary micronutrients such as vitamins and trace minerals are known modulators of host immune responses against common pathogens. In this respect, vitamin A and zinc have recently received increased attention. Several in vivo and in vitro studies suggest that vitamin A may be a critical player in the mucosal immune r...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02905712

    authors: Molina EL,Patel JA

    更新日期:1996-07-01 00:00:00

  • Pulmonary function tests in Indian girls--prediction equations.

    abstract:OBJECTIVE:The present study was conducted to evaluate pulmonary functions and develop prediction equations in Indian girls. METHODS:1038 normal healthy schoolgirls in the age group of 5 to 15 years were selected for the present study. The anthropometrical parameters like height, weight, sitting height and chest circum...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02830828

    authors: Raju PS,Prasad KV,Ramana YV,Murthy KJ

    更新日期:2004-10-01 00:00:00

  • Aseptic meningitis: diagnosis and management.

    abstract::The term aseptic meningitis encompasses all types of inflammations of the brain meninges other than that caused by pus producing organisms. It is usually a benign illness. Etiology of aseptic meningitis is very wide and includes many infections - both viral and non viral, drugs, malignancy and systemic illness. The mo...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02760582

    authors: Kumar R

    更新日期:2005-01-01 00:00:00

  • Psychosocial problems in families of children with cancer.

    abstract:OBJECTIVE:The aim of this study is to assess the effect of diagnosis of cancer on the parents, to study the coping response adopted by the child and the family and to evolve counseling strategies. METHODS:Prospective questionnaire based. Thirty-four parents of children suffering from cancer were included, of which 15 ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-007-0149-0

    authors: Rajajee S,Ezhilarasi S,Indumathi D

    更新日期:2007-09-01 00:00:00

  • Hirschsprung's disease, associated rare congenital anomalies.

    abstract:OBJECTIVE:Hirschsprung's disease may be associated with a number of congenital anomalies of which Down's syndrome and intestinal atresias are commonly encountered. The study aimed to assess the impact of rare associated anomalies on the diagnosis and management of Hirschsprung's disease. METHODS:A retrospective review...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02762106

    authors: Das K,Alladi A,Kini U,Babu MK,D'Cruz AJ

    更新日期:2001-09-01 00:00:00

  • Growth of children with beta-thalassemia major.

    abstract::Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). Despite medical advances, growth failure and hypogonadism remain significant clinical problems in these patients in adolescence. Disproportionate truncal shortening which is common especially among ad...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02760702

    authors: Low LC

    更新日期:2005-02-01 00:00:00

  • Dengue shock syndrome with two atypical complications.

    abstract::The authors present 2 cases of dengue shock syndrome with unusual complications. In the first case, a 14-y-old boy with dengue shock syndrome who required aggressive fluid resuscitation, developed abdominal compartment syndrome (ACS). Patient developed severe shock, increased ventilator requirement and oliguria as a c...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-011-0551-5

    authors: Gala HC,Avasthi BS,Lokeshwar MR

    更新日期:2012-03-01 00:00:00

  • Fibrochondrogenesis.

    abstract::Fibrochondrogenesis is a rare lethal short-limb skeletal dysplasia. Till now only fifteen cases have been reported since Lazzaroni-Fossati first described it in 1978. Hence reported a case of fibrochondrogenesis in a child born to a consanguineously married couple with characteristic physical and radiological features...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02724021

    authors: Kulkarni ML,Matadh PS,Prabhu SP,Kulkarni PM

    更新日期:2005-04-01 00:00:00

  • Serum cardiac troponin-I in active rheumatic carditis.

    abstract:OBJECTIVE:The study was performed to investigate the level of serum cardiac troponin I (cTnI), a specific marker for myocardial cell damage, in the acute rheumatic carditis (RC). METHODS:Twenty seven consecutive patients with acute RC and 23 healthy children were enrolled. RESULT:cTnI level in both groups showed no s...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02722592

    authors: Oran B,Coban H,Karaaslan S,Atabek E,Gürbilek M,Erkul I

    更新日期:2001-10-01 00:00:00

  • Prevalence and predictors of decreased glomerular filtration rate in tibetan children with congenital heart disease.

    abstract:OBJECTIVES:To assess the prevalence of decreased glomerular filtration rate (GFR) in Tibetan children with congenital heart disease (CHD) and its associated risk factors. METHODS:A total of 207 Tibetan children attending authors' center for treatment of CHD from May 2012 through November 2012, were included in the stu...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-014-1351-5

    authors: Zheng JY,Tian HT,Li DT,Zhu ZM,Chen Y,Cao Y,Qiu YG,Liu YM,Li XF,He JC,Wang ZC,Li TC

    更新日期:2014-10-01 00:00:00

  • A Practical Approach to Juvenile Dermatomyositis and Juvenile Scleroderma.

    abstract::Juvenile dermatomyositis and juvenile scleroderma are rare multisystem autoimmune disorders. Although they share some pathognomonic hallmarks with adult onset myositis or scleroderma, there are significant differences in presentation, characteristics and associated features when the diseases present in childhood. In v...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s12098-015-1907-z

    authors: McCann LJ,Pain CE

    更新日期:2016-02-01 00:00:00

  • Risk factors for incomplete immunization in children with HIV infection.

    abstract:OBJECTIVE:To document the immunization rates, factors associated with incomplete immunization, and missed opportunities for immunizations in children affected by HIV presenting for routine outpatient follow-up. METHODS:A cross-sectional study of immunization status of children affected by HIV presenting for routine ou...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-013-1049-0

    authors: Bhattacharya SD,Bhattacharyya S,Chatterjee D,Niyogi SK,Chauhan N,Sudar A

    更新日期:2014-09-01 00:00:00

  • Adrenal hemorrhage due to vitamin-K deficiency.

    abstract::Adrenal hemorrhage has many etiologies including bleeding diathesis. A 10-day-old female baby was admitted to our clinic with the complaint of abdominal distention. Hemorrhage was determined on the right adrenal gland with abdominal ultrasonography and computerized tomography. Laboratory investigations showed PT 44 se...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02723786

    authors: Totan M

    更新日期:2002-01-01 00:00:00

  • ARSH 8: Family life education and counseling: a school based model.

    abstract:OBJECTIVES:To understand the problems of school going adolescents in selected schools in the first phase and to provide class based family life education in the second phase. METHODS:Step 1: Identification of the study sample, Step 2: Each adolescent was individually administered TSQ-T by trained project staff , Step ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-013-1132-6

    authors: Nair MK,Leena ML,Menon P,George B,Indira MS,Russell PS

    更新日期:2013-11-01 00:00:00

  • Infantile Tremor Syndrome or a Neurocutaneous Infantile B12 Deficiency (NIB) Syndrome?

    abstract:OBJECTIVES:To prospectively study the clinical and developmental profile; hematological profile and the B-12 status using multiple parameters in children with Infantile tremor syndrome (ITS). METHODS:In this observational study (NCT02762682) (July 2015 through December 2016) children (and their mothers) with a clinica...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-019-03117-w

    authors: Chaudhary H,Verma S,Bhatia P,Vaidya PC,Singhi P,Sankhyan N

    更新日期:2020-03-01 00:00:00

  • Seasonality in Pediatric Cancer.

    abstract::Although seasonal trends in incidence and diagnosis of pediatric cancers have been widely investigated, the results have been inconclusive. A consistent seasonal trend may possibly provide etiological insights into pediatric cancers. This study aims to determine if there is a seasonal variation in cancer diagnoses in ...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/s12098-017-2561-4

    authors: Nurullah R,Kuhle S,Maguire B,Kulkarni K

    更新日期:2018-09-01 00:00:00

  • Zinc and copper in preterm neonates: relationship with breast milk.

    abstract::The study was conducted to assess copper and zinc levels in neonate's serum, mother's serum, neonate's hair and urine and to ascertain association between them. It is of concern whether zinc and copper deficiency is present at birth and maternal blood and breast milk zinc and copper levels have any effect on this. The...

    journal_title:Indian journal of pediatrics

    pub_type: 杂志文章

    doi:10.1007/BF02726255

    authors: Sharda B,Adhikari R,Ajmera M,Gambhir R,Singh PP

    更新日期:1999-09-01 00:00:00